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Stock-based Compensation - Summary of Stock-Based Compensation Included in Statement of Operations (Details) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2019 | Jun. 30, 2018 | Jun. 30, 2019 | Jun. 30, 2018
Stock-based compensation |  |  |  |
Total stock-based compensation expense | $ 4,162 | $ 3,526 | $ 8,425 | $ 6,254
Research and development expenses |  |  |  |
Stock-based compensation |  |  |  |
Total stock-based compensation expense | 514 | 380 | 1,081 | 703
Selling, general and administrative expenses |  |  |  |
Stock-based compensation |  |  |  |
Total stock-based compensation expense | $ 3,648 | $ 3,146 | $ 7,344 | $ 5,551

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