<SEC-DOCUMENT>0001567619-19-013624.txt : 20190618
<SEC-HEADER>0001567619-19-013624.hdr.sgml : 20190618
<ACCEPTANCE-DATETIME>20190618210021
ACCESSION NUMBER:		0001567619-19-013624
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20190618
FILED AS OF DATE:		20190618
DATE AS OF CHANGE:		20190618

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Krainer Adrian R.
		CENTRAL INDEX KEY:			0001780081

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38938
		FILM NUMBER:		19904910

	MAIL ADDRESS:	
		STREET 1:		C/O STOKE THERAPEUTICS, INC.
		STREET 2:		45 WIGGINS AVE
		CITY:			BEDFORD
		STATE:			MA
		ZIP:			01730

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Stoke Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001623526
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				471144582
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		3 PRESTON COURT
		CITY:			BEDFORD
		STATE:			MA
		ZIP:			01730
		BUSINESS PHONE:		781-430-8200

	MAIL ADDRESS:	
		STREET 1:		3 PRESTON COURT
		CITY:			BEDFORD
		STATE:			MA
		ZIP:			01730

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ASOthera Pharmaceuticals, Inc.
		DATE OF NAME CHANGE:	20141028
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>doc1.xml
<DESCRIPTION>FORM 3
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2019-06-18</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001623526</issuerCik>
        <issuerName>Stoke Therapeutics, Inc.</issuerName>
        <issuerTradingSymbol>STOK</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001780081</rptOwnerCik>
            <rptOwnerName>Krainer Adrian R.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O STOKE THERAPEUTICS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>45 WIGGINS AVENUE</rptOwnerStreet2>
            <rptOwnerCity>BEDFORD</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>01730</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Employee Stock Option (Right to Buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>2.19</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2028-12-12</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>64312</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">This option vests 1/48th of the shares monthly, subject to reporting person's continued service through each vesting date.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Stephen Tulipano, Attorney-in-Fact</signatureName>
        <signatureDate>2019-06-18</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-24.1
<SEQUENCE>2
<FILENAME>poa_krainer.htm
<DESCRIPTION>EXHIBIT 24.1 - POWER OF ATTORNEY
<TEXT>
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  <head>
    <title></title>
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  <div>
    <div>Exhibit 24.1</div>
    <div style="text-align: center; margin-bottom: 12pt; font-weight: bold;"><u>POWER OF ATTORNEY</u></div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;">KNOW ALL BY THESE PRESENTS, that the undersigned hereby constitutes and appoints Edward M. Kaye, M.D., Huw M. Nash, Ph.D., and Stephen
      J. Tulipano, and each of them, his true and lawful attorney-in-fact to:</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;">(1)<font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 36pt">&#160;</font>execute for and on behalf of the undersigned, in the undersigned&#8217;s capacity as a representative of Stoke Therapeutics, Inc. (the &#8220;<font style="font-weight: bold; font-style: italic;">Company</font>&#8221;), any and all Form 3, 4 or 5 reports required to be filed by the undersigned in accordance with Section 16(a) of the
        Securities Exchange Act of 1934, as amended (&#8220;<font style="font-weight: bold; font-style: italic;">Exchange Act</font>&#8221;), and the rules thereunder with respect to transactions in
        securities of the Company;</div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;">(2)<font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 36pt">&#160;</font>do and perform any and all acts for and on behalf of the undersigned which may be necessary or desirable to complete and execute any such Form 3, 4 or
        5 report and timely file such report with the U.S. Securities and Exchange Commission and any stock exchange or similar authority; and</div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;">(3)<font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 36pt">&#160;</font>take any other action of any type whatsoever in connection with the foregoing which, in the opinion of such attorney&#8209;in-fact, may be of benefit to, in
        the best interest of, or legally required by, the undersigned, it being understood that the documents executed by such attorney&#8209;in-fact on behalf of the undersigned, pursuant to this Power of Attorney, shall be in such form and shall contain such
        terms and conditions as such attorney-in-fact may approve in her/his discretion.</div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;">The undersigned hereby grants to each such attorney-in-fact full power and authority to do and perform each and
      every act and thing whatsoever requisite, necessary and proper to be done in the exercise of any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned might or could do if personally present, with full power
      of substitution or revocation, hereby ratifying and confirming all that such attorney-in-fact, or her/his substitute or substitutes, shall lawfully do or cause to be done by virtue of this Power of Attorney and the rights and powers herein granted.&#160;
      The undersigned acknowledges that no such attorney&#8209;in-fact, in serving in such capacity at the request of the undersigned, is hereby assuming, nor is the Company hereby assuming, any of the undersigned&#8217;s responsibilities to comply with Section 16 of
      the Exchange Act.</div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;">This Power of Attorney shall remain in full force and effect until the undersigned is no longer required to file
      Form 3, 4 or 5 reports with respect to the undersigned&#8217;s holdings of and transactions in securities issued by the Company, unless earlier revoked by the undersigned in a signed writing delivered to the foregoing attorneys-in-fact.</div>
    <div style="text-align: justify; text-indent: 36pt;">IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be executed as of the 11th day of June, 2019.</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="text-align: justify;"><u>/s Adrian R. Krainer</u></div>
    <div style="text-align: justify;">Adrian R. Krainer, Ph.D.</div>
    <div><br>
    </div>
    <div><br>
    </div>
  </div>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
