<SEC-DOCUMENT>0001213900-20-039684.txt : 20201127
<SEC-HEADER>0001213900-20-039684.hdr.sgml : 20201127
<ACCEPTANCE-DATETIME>20201127165836
ACCESSION NUMBER:		0001213900-20-039684
CONFORMED SUBMISSION TYPE:	SC 13D/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20201127
DATE AS OF CHANGE:		20201127
GROUP MEMBERS:		ATP III GP, LTD.
GROUP MEMBERS:		SETH L. HARRISON

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Stoke Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001623526
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				471144582
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-91051
		FILM NUMBER:		201355730

	BUSINESS ADDRESS:	
		STREET 1:		3 PRESTON COURT
		CITY:			BEDFORD
		STATE:			MA
		ZIP:			01730
		BUSINESS PHONE:		781-430-8200

	MAIL ADDRESS:	
		STREET 1:		3 PRESTON COURT
		CITY:			BEDFORD
		STATE:			MA
		ZIP:			01730

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ASOthera Pharmaceuticals, Inc.
		DATE OF NAME CHANGE:	20141028

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Apple Tree Partners IV, L.P.
		CENTRAL INDEX KEY:			0001593440
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			E9
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A

	BUSINESS ADDRESS:	
		STREET 1:		230 PARK AVENUE, SUITE 2800
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10169
		BUSINESS PHONE:		212-468-5800

	MAIL ADDRESS:	
		STREET 1:		230 PARK AVENUE, SUITE 2800
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10169
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D/A
<SEQUENCE>1
<FILENAME>ea130656-sc13daapple_stoke.htm
<DESCRIPTION>FROM SC 13D/A
<TEXT>
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<P>&nbsp;</P>

<!-- Field: Rule-Page --><DIV STYLE="margin-top: 0; margin-bottom: 0; width: 100%"><DIV STYLE="font-size: 1pt; border-top: Black 2pt solid; border-bottom: Black 1pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->

<P>&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>UNITED STATES </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Washington, D.C. 20549</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SCHEDULE 13D/A</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Under the Securities Exchange Act of 1934
</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>(Amendment No. 1)* </B></P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Stoke Therapeutics, Inc.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>(Name of Issuer)</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Common Stock, $0.0001 par value per share
</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>(Title of Class&nbsp;of Securities)</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>86150R107 </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>(CUSIP Number)</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Daniel P. Finkelman<BR>
General Counsel </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Apple Tree Partners </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>230 Park Avenue, 28<SUP>th</SUP> Floor </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>New York, NY 10169 </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>(212) 468-5848 </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>(Name, Address and Telephone Number of Person
Authorized to Receive Notices and Communications)</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>November 20, 2020</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>(Date of Event which Requires Filing of this
Statement) </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">If the filing person has previously filed a statement on Schedule&nbsp;13G
to report the acquisition that is the subject of this Schedule&nbsp;13D, and is filing this schedule because of &sect;&sect;240.13d-1(e),
240.13d-1(f) or 240.13d-1(g), check the following box.&nbsp;&nbsp;&#9744;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>Note:</B> Schedules filed in paper format shall include a signed
original and five copies of the schedule, including all exhibits. See &sect;240.13d-7 for other parties to whom copies are to be
sent.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 4%; font-size: 10pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">*</FONT></TD>
    <TD STYLE="font-size: 10pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">The remainder of this cover page shall be filled out for a reporting person&rsquo;s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">The information required on the remainder of this cover page shall
not be deemed to be &ldquo;filed&rdquo; for the purpose of Section 18 of the Securities Exchange Act of 1934 (&ldquo;Act&rdquo;)
or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however,
see the Notes).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Persons who respond to the collection of
information contained in this form are not </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>required to respond unless the form displays
a currently valid OMB control number. </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="margin-top: 0; margin-bottom: 0"></P>

<P STYLE="margin-top: 0; margin-bottom: 2pt">&nbsp;</P>

<TABLE ALIGN="CENTER" BORDER="0" CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt/normal Times New Roman, Times, Serif; border-collapse: collapse; font-size-adjust: none; font-stretch: normal; width: 100%">
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; width: 34%"><B>CUSIP No. 86150R107</B></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top; width: 32%"><B>13D</B></TD>
    <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
    <TD STYLE="text-align: right; vertical-align: top; width: 32%"><B>Page 2 of 7 Pages</B></TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>

<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt/normal Times New Roman, Times, Serif; border-collapse: collapse; font-size-adjust: none; font-stretch: normal; width: 100%">
<TR>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 1%; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 1%; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="width: 86%">&nbsp;</TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; border-top: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;1&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; border-top: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="vertical-align: top; border-top: rgb(0, 0, 0) 1px solid; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">NAMES OF REPORTING PERSONS.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS
        (ENTITIES ONLY).</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">Apple Tree Partners IV, L.P.</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;2</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">CHECK THE APPROPRIATE BOX IF A MEMBER OF A
        GROUP (SEE INSTRUCTIONS)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">(a)&nbsp;&nbsp;&#9744;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;&nbsp;&#9744;</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 1pt">&nbsp;</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;3</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">SEC USE ONLY</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 1pt">&nbsp;</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;4</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">SOURCE OF FUNDS (SEE INSTRUCTIONS)</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">WC</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;5</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS
        REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">&#9744;</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;6</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">CITIZENSHIP OR PLACE OF ORGANIZATION</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">Cayman Islands</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD ROWSPAN="4" COLSPAN="3" STYLE="vertical-align: middle; border-left: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0"><B>NUMBER&nbsp;OF</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0"><B>SHARES</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0"><B>BENEFICIALLY</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0"><B>OWNED&nbsp;BY</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0"><B>EACH</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0"><B>REPORTING</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0"><B>PERSON</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0"><B>WITH</B></P>
        <P STYLE="font-size: 10pt; text-align: left; margin-top: 0; margin-bottom: 1pt">&nbsp;</P></TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;</TD>
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;7&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;</TD>
    <TD STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">SOLE VOTING POWER</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">0</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;</TD>
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;8</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;</TD>
    <TD STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">SHARED VOTING POWER</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">17,206,045</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;</TD>
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;9</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;</TD>
    <TD STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">SOLE DISPOSITIVE POWER</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">0</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: bottom; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;</TD>
    <TD STYLE="vertical-align: top">10</TD>
    <TD STYLE="vertical-align: bottom; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;</TD>
    <TD STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">SHARED DISPOSITIVE POWER</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">17,206,045</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; border-top: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">11&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; border-top: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="vertical-align: top; border-top: rgb(0, 0, 0) 1px solid; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
        REPORTING PERSON</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">17,206,045</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">12</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">CHECK IF THE AGGREGATE AMOUNT IN ROW (11)&nbsp;EXCLUDES
        CERTAIN SHARES (SEE INSTRUCTIONS)</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">&#9744;</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">13</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">PERCENT OF CLASS REPRESENTED BY AMOUNT IN
        ROW (11)</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">47.5%*</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">14</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">PN</P></TD></TR>
</TABLE>
<P></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">* Percentage calculated based on 36,236,188
shares of common stock, par value $0.0001 per share, of Stoke Therapeutics, Inc. (the &ldquo;Issuer&rdquo;) issued and outstanding
immediately following the Issuer&rsquo;s public offering in November 2020, taking into account the exercise in full of the underwriters&rsquo;
overallotment option, as reported in the prospectus filed by the Issuer on November 20, 2020.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

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<P></P>

<TABLE ALIGN="CENTER" BORDER="0" CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt/normal Times New Roman, Times, Serif; border-collapse: collapse; font-size-adjust: none; font-stretch: normal; width: 100%">
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; width: 34%"><B>CUSIP No. 86150R107 </B></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top; width: 32%"><B>13D</B></TD>
    <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
    <TD STYLE="text-align: right; vertical-align: top; width: 32%"><B>Page 3 of 7 Pages</B></TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>

<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt/normal Times New Roman, Times, Serif; border-collapse: collapse; font-size-adjust: none; font-stretch: normal; width: 100%">
<TR>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 1%; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 1%; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="width: 86%">&nbsp;</TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; border-top: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;1&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; border-top: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="vertical-align: top; border-top: rgb(0, 0, 0) 1px solid; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">NAMES OF REPORTING PERSONS.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS
        (ENTITIES ONLY).</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">ATP III GP, Ltd.</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;2</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">CHECK THE APPROPRIATE BOX IF A MEMBER OF A
        GROUP (SEE INSTRUCTIONS)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">(a)&nbsp;&nbsp;&#9744;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;&nbsp;&#9744;</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 1pt">&nbsp;</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;3</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">SEC USE ONLY</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 1pt">&nbsp;</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;4</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">SOURCE OF FUNDS (SEE INSTRUCTIONS)</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">AF</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;5</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS
        REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">&#9744;</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;6</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">CITIZENSHIP OR PLACE OF ORGANIZATION</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">Cayman Islands</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD ROWSPAN="4" COLSPAN="3" STYLE="vertical-align: middle; border-left: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0"><B>NUMBER&nbsp;OF</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0"><B>SHARES</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0"><B>BENEFICIALLY</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0"><B>OWNED&nbsp;BY</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0"><B>EACH</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0"><B>REPORTING</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0"><B>PERSON</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0"><B>WITH</B></P>
        <P STYLE="font-size: 10pt; text-align: left; margin-top: 0; margin-bottom: 1pt">&nbsp;</P></TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;</TD>
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;7&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;</TD>
    <TD STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">SOLE VOTING POWER</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">0</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;</TD>
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;8</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;</TD>
    <TD STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">SHARED VOTING POWER</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">17,206,045</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;</TD>
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;9</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;</TD>
    <TD STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">SOLE DISPOSITIVE POWER</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">0</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: bottom; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;</TD>
    <TD STYLE="vertical-align: top">10</TD>
    <TD STYLE="vertical-align: bottom; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;</TD>
    <TD STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">SHARED DISPOSITIVE POWER</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">17,206,045</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; border-top: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">11&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; border-top: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="vertical-align: top; border-top: rgb(0, 0, 0) 1px solid; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
        REPORTING PERSON</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">17,206,045</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">12</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">CHECK IF THE AGGREGATE AMOUNT IN ROW (11)&nbsp;EXCLUDES
        CERTAIN SHARES (SEE INSTRUCTIONS)</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">&#9744;</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">13</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">PERCENT OF CLASS REPRESENTED BY AMOUNT IN
        ROW (11)</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">47.5%*</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">14</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">CO</P></TD></TR>
</TABLE>
<P>&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">* Percentage calculated based on 36,236,188
shares of common stock, par value $0.0001 per share, of Stoke Therapeutics, Inc. (the &ldquo;Issuer&rdquo;) issued and outstanding
immediately following the Issuer&rsquo;s public offering in November 2020, taking into account the exercise in full of the underwriters&rsquo;
overallotment option, as reported in the prospectus filed by the Issuer on November 20, 2020.</P>

<P></P>

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<P></P>

<TABLE ALIGN="CENTER" BORDER="0" CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt/normal Times New Roman, Times, Serif; border-collapse: collapse; font-size-adjust: none; font-stretch: normal; width: 100%">
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; width: 34%"><B>CUSIP No. 86150R107</B></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: top; width: 32%"><B>13D</B></TD>
    <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
    <TD STYLE="text-align: right; vertical-align: top; width: 32%"><B>Page 4 of 7 Pages</B></TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>

<TABLE BORDER="0" CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt/normal Times New Roman, Times, Serif; border-collapse: collapse; font-size-adjust: none; font-stretch: normal; width: 100%">
<TR>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 1%; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 1%; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="width: 86%">&nbsp;</TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; border-top: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;1&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; border-top: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="vertical-align: top; border-top: rgb(0, 0, 0) 1px solid; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">NAMES OF REPORTING PERSONS.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS
        (ENTITIES ONLY).</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">Seth L. Harrison</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;2</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">CHECK THE APPROPRIATE BOX IF A MEMBER OF A
        GROUP (SEE INSTRUCTIONS)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">(a)&nbsp;&nbsp;&#9744;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;&nbsp;&#9744;</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 1pt">&nbsp;</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;3</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">SEC USE ONLY</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 1pt">&nbsp;</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;4</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">SOURCE OF FUNDS (SEE INSTRUCTIONS)</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">AF</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;5</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS
        REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">&#9744;</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;6</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">CITIZENSHIP OR PLACE OF ORGANIZATION</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">United States citizen</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD ROWSPAN="4" COLSPAN="3" STYLE="vertical-align: middle; border-left: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0"><B>NUMBER&nbsp;OF</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0"><B>SHARES</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0"><B>BENEFICIALLY</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0"><B>OWNED&nbsp;BY</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0"><B>EACH</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0"><B>REPORTING</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0"><B>PERSON</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0"><B>WITH</B></P>
        <P STYLE="font-size: 10pt; text-align: left; margin-top: 0; margin-bottom: 1pt">&nbsp;</P></TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;</TD>
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;7&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;</TD>
    <TD STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">SOLE VOTING POWER</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">0</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;</TD>
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;8</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;</TD>
    <TD STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">SHARED VOTING POWER</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">17,206,045</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;</TD>
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;9</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;</TD>
    <TD STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">SOLE DISPOSITIVE POWER</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">0</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: bottom; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;</TD>
    <TD STYLE="vertical-align: top">10</TD>
    <TD STYLE="vertical-align: bottom; border-left: rgb(0, 0, 0) 1px solid">&nbsp;&nbsp;</TD>
    <TD STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">SHARED DISPOSITIVE POWER</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">17,206,045</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; border-top: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">11&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; border-top: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="vertical-align: top; border-top: rgb(0, 0, 0) 1px solid; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
        REPORTING PERSON</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">17,206,045</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">12</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">CHECK IF THE AGGREGATE AMOUNT IN ROW (11)&nbsp;EXCLUDES
        CERTAIN SHARES (SEE INSTRUCTIONS)</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">&#9744;</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">13</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">PERCENT OF CLASS REPRESENTED BY AMOUNT IN
        ROW (11)</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">47.5%*</P></TD></TR>
<TR STYLE="font-size: 10pt; font-size-adjust: none; font-stretch: normal">
    <TD STYLE="vertical-align: top; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">14</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: rgb(0, 0, 0) 1px solid; border-left: rgb(0, 0, 0) 1px solid">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="vertical-align: top; border-right: rgb(0, 0, 0) 1px solid; border-bottom: rgb(0, 0, 0) 1px solid">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0">TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)</P>
        <P STYLE="font-size: 10pt; margin-top: 0; margin-bottom: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 1pt">IN</P></TD></TR>
</TABLE>
<P></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">* Percentage calculated based on 36,236,188
shares of common stock, par value $0.0001 per share, of Stoke Therapeutics, Inc. (the &ldquo;Issuer&rdquo;) issued and outstanding
immediately following the Issuer&rsquo;s public offering in November 2020, taking into account the exercise in full of the underwriters&rsquo;
overallotment option, as reported in the prospectus filed by the Issuer on November 20, 2020.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

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<P>&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0">Schedule 13D</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center"><FONT STYLE="font-weight: normal"><U>Explanatory
Note</U></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">This Amendment No. 1 (this &ldquo;Amendment&rdquo;)
amends and supplements the Schedule 13D filed with the Securities and Exchange Commission on July 1, 2019 by the Reporting Persons
(as amended from time to time, the &ldquo;Schedule 13D&rdquo;), relating to their beneficial ownership in Stoke Therapeutics, Inc.
(the &ldquo;Issuer&rdquo;). Except to the extent set forth in this Amendment, all material information disclosed in the Schedule
13D remains unchanged. Capitalized terms used but not defined in this Amendment have the respective meanings set forth in the Schedule
13D.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 12pt 0 0">Item 3. <U>Source and Amount of Funds or Other Consideration</U>.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 12pt 0 0">Item 3 of the Schedule 13D is amended and restated in its
entirety as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 12pt 0 0; text-align: justify; text-indent: 0.5in">The information
set forth in or incorporated by reference in Items 4, 5 and 6 of this Schedule 13D is incorporated by reference in its entirety
into this Item 3. The source of the funds to purchase the shares of Common Stock acquired by ATP IV reported in Item 5(c) was the
working capital of ATP IV.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 12pt 0 0">Item 5. <U>Interest in Securities of the Issuer</U>.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 12pt 0 0">Item 5 of the Schedule 13D is amended and supplemented as
follows:</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 9.05pt; margin-bottom: 0px; font-size-adjust: none; font-stretch: normal; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 0.45in">&nbsp;</TD>
    <TD STYLE="width: 0.55in">(a)</TD>
    <TD STYLE="text-align: justify">ATP IV directly holds 17,161,713 shares of Common Stock, and Dr. Harrison has been granted stock options exercisable for 44,332 shares of Common Stock. Dr. Harrison was granted 29,555 stock options on September 10, 2019 and such options have vested or will vest in accordance with the following schedule: (i) 1/12th of the total shares on June 21, 2019; and then (ii) quarterly as to 1/12th of the total shares, commencing the first quarter following June 21, 2019, subject to Dr. Harrison&rsquo;s continued service with the Issuer through each vesting date. Dr. Harrison was granted 14,777 stock options on June 3, 2020, and such options will fully vest on June 3, 2021 or, if earlier, the next annual meeting of the Issuer&rsquo;s stockholders, subject to Dr. Harrison&rsquo;s continued service with the Issuer on such vesting date. Dr. Harrison holds the stock options for the benefit of ATP IV under his arrangement with Apple Tree Venture Management, LLC.</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 9.05pt 0 0 1in; text-align: justify; text-indent: 0in">ATP IV, ATP
GP and Dr. Harrison may be deemed to own beneficially 47.5% of the Common Stock, which percentage is calculated based on 36,236,188
shares of Common Stock issued and outstanding immediately following the November 2020 Public Offering (as defined herein) taking
into account the exercise in full of the underwriters&rsquo; overallotment option, as reported in the Issuer&rsquo;s prospectus
filed on November 20, 2020.</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 9.3pt; margin-bottom: 0px; font-size-adjust: none; font-stretch: normal; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 0.45in">&nbsp;</TD>
    <TD STYLE="width: 0.55in">(c)</TD>
    <TD STYLE="text-align: justify">On November 20, 2020, ATP IV purchased 375,000 shares of Common Stock at a purchase price of $39.00 per share in connection with a public offering by the Issuer (the &ldquo;November 2020 Public Offering&rdquo;). Except as set forth in this Item 5(c), none of the Reporting Persons has effected any transaction in the Common Stock during the last 60 days.</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 12pt 0 0">Item 6. <U>Contracts, Arrangements, Undertakings or Relationships
with Respect to Securities of the Issuer.</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-right: 0; margin-bottom: 0; margin-left: 0"><U STYLE="text-decoration: none">&nbsp;</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0.2pt 0 0">Item 6 of the Schedule 13D is amended and supplemented
as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0.2pt 0 0">&nbsp;</P>

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<P></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B><U>November 2020 Lock-Up Agreement </U></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 12pt 0 0; text-align: justify">In connection with the November 2020
Public Offering, each of Dr. Harrison and ATP IV entered into a lock-up agreement (each such agreement, a &ldquo;November 2020
Lock-Up Agreement&rdquo;) with J.P. Morgan Securities LLC, Cowen and Company, LLC, and Credit Suisse Securities (USA) LLC, as representatives
of the several underwriters. Pursuant to the terms of the November 2020 Lock-Up Agreements, each of Dr. Harrison and ATP IV has
agreed, with certain exceptions, during the period ending 90 days after November 19, 2020, that they may not, without the prior
written consent of J.P. Morgan Securities LLC:</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 12pt; margin-bottom: 0px; font-size-adjust: none; font-stretch: normal; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 0.25in">&nbsp;</TD>
    <TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="background-color: white">(1) offer, pledge, announce the intention to sell, sell, contract to sell, sell any option or contract to purchase, purchase any option or contract to sell, grant any option, right or warrant to purchase, or otherwise transfer or dispose of, directly or indirectly, any shares of Common Stock or any securities convertible into or exercisable or exchangeable for Common Stock (including, without limitation, Common Stock or such other securities that may be deemed to be beneficially owned by them in accordance with the rules and regulations of the Securities and Exchange Commission and securities that may be issued upon exercise of a stock option or warrant);</FONT></TD></TR>
</TABLE>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 12pt; margin-bottom: 0px; font-size-adjust: none; font-stretch: normal; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 0.25in">&nbsp;</TD>
    <TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="background-color: white">(2) enter into any swap or other agreement that transfers, in whole or in part, any of the economic consequences of ownership of Common Stock or such other securities, whether any such transaction described in clause (1)&nbsp;or (2) above is to be settled by delivery of Common Stock or such other securities, in cash or otherwise, or </FONT></TD></TR>
</TABLE>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 12pt; margin-bottom: 0px; font-size-adjust: none; font-stretch: normal; width: 100%">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 0.25in">&nbsp;</TD>
    <TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="background-color: white">(3)&nbsp;make any demand for or exercise any right with respect to the registration of any shares of Common Stock or any security convertible into or exercisable or exchangeable for Common Stock.</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 12pt 0 0; text-align: justify; text-indent: 0.5in">ATP IV&rsquo;s covenants
under its November 2020 Lock-Up Agreement do not apply with respect to the 375,000 Shares purchased by ATP IV in the November 2020
Public Offering. The foregoing description of the November 2020 Lock-Up Agreements is qualified in its entirety by reference to
the full text of the form of the November 2020 Lock-Up Agreement, a copy of which is filed as Exhibit 4 hereto, and is incorporated
by reference into this Item 6.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 12pt 0 0"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Item
7. <U>Material to be Filed as Exhibits</U></FONT>.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 12pt 0 0">Item 7 of the Schedule 13D is hereby amended and supplemented
to add the following:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 12pt 0 0; text-indent: 0.5in">Exhibit 4 Form of November 2020 Lock-Up
Agreement (incorporated by reference to Exhibit A to Exhibit 1.1 to the Issuer&rsquo;s Form 8-K filed on November 20, 2020).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 12pt 0 0; text-indent: 0.5in">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0; margin-bottom: 0"><B><U>SIGNATURE </U></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; text-indent: 4%; margin-top: 12pt; margin-bottom: 0">After reasonable inquiry
and to the best of its knowledge and belief, each of the undersigned certifies that the information set forth in this statement
is true, complete and correct.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 12pt 0 0">Date: November 27, 2020</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Apple Tree Partners IV, L.P.</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="width: 4%">&nbsp;</TD>
    <TD STYLE="width: 4%">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 20%">&nbsp;</TD>
    <TD STYLE="width: 72%">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">By:&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="vertical-align: top">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">ATP III GP, Ltd.</P></TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="vertical-align: top">General Partner</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">By: </FONT></TD>
    <TD STYLE="border-bottom: Black 1.5pt solid; vertical-align: top"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ Seth L. Harrison</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"></TD>
    <TD STYLE="vertical-align: top">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Seth L. Harrison</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Director</P></TD>
    <TD>&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">ATP III GP, Ltd.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 4%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">By:</FONT></TD>
    <TD STYLE="border-bottom: Black 1.5pt solid; width: 20%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">/s/ Seth L. Harrison</FONT></TD>
    <TD STYLE="width: 76%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Seth L. Harrison</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Director</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">/s/ Seth L. Harrison </FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Seth L. Harrison</FONT></TD>
    <TD>&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 8pt">&nbsp;</P>

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