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Commitments and Contingencies - Additional Information (Details) | 1 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | ---
Sep. 30, 2021 USD ($) ft² | Jun. 30, 2021 USD ($) ft² | Dec. 31, 2018 USD ($) ft² Option | Aug. 31, 2018 USD ($) ft² | Jul. 31, 2015 | Dec. 31, 2021 USD ($) | Dec. 31, 2020 USD ($) | Dec. 31, 2021 GBP (£) | Jan. 01, 2020 USD ($)
Commitments And Contingencies [Line Items] |  |  |  |  |  |  |  |  |
Area of space subject to operating lease | ft² |  |  | 2,485 | 23,000 |  |  |  |  |
Operating lease term |  |  | 3 years | 3 years |  |  |  |  |
Operating lease cost per year |  |  | $ 200,000 | $ 900,000 |  |  |  |  |
Annual base rent increase percentage for operating lease |  |  | 2.50% | 3.00% |  |  |  |  |
Operating lease commencement date |  |  | May 01, 2019 | Dec. 10, 2018 |  |  |  |  |
Operating lease right-of-use assets |  |  |  |  |  | $ 4,939,000 | $ 1,115,000 |  |
Operating lease liabilities |  |  |  |  |  | 6,975,000 |  |  |
Number of options to renewal operating lease term | Option |  |  | 1 |  |  |  |  |  |
Operating lease, renewal term |  |  | 2 years |  |  |  |  |  |
Liabilities recorded under agreement |  |  |  |  |  | 21,088,000 | 11,847,000 |  |
CSHL Agreement |  |  |  |  |  |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |  |  |  |  |  |
Percentage of maximum required payment of sublicense revenue |  |  |  |  | 20.00% |  |  |  |
Annual license maintenance fee |  |  |  |  |  | 10,000.00 |  |  |
Maximum aggregate potential milestone payments payable |  |  |  |  |  | 900,000 |  |  |
Expenses related to reimbursable patent costs |  |  |  |  |  | 0 | 0 |  |
Southampton Agreement |  |  |  |  |  |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |  |  |  |  |  |
Maximum aggregate potential milestone payments payable |  |  |  |  |  | 500,000 |  | £ 400,000 |
Expenses related to reimbursable patent costs |  |  |  |  |  | 120,000 | 90,000.00 |  |
Liabilities recorded under agreement |  |  |  |  |  | $ 0 | 0 |  |
Member of Board of Directors |  |  |  |  |  |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |  |  |  |  |  |
Consulting services expenses |  |  |  |  |  |  | 20,000.00 |  |
Consulting services agreement term |  |  |  |  |  | 5 years |  |  |
Scientific advisory services expenses |  |  |  |  |  | $ 50,000.00 | 50,000.00 |  |
Scientific advisory services agreement term |  |  |  |  |  | 12 months |  |  |
ASU 2016-02 |  |  |  |  |  |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |  |  |  |  |  |
Operating lease right-of-use assets |  |  |  |  |  |  |  |  | $ 2,200,000
Operating lease liabilities |  |  |  |  |  |  |  |  | $ 2,200,000
Operating leases expense |  |  |  |  |  | $ 1,400,000 | $ 1,100,000 |  |
Lease Commencement on December 15, 2021 |  |  |  |  |  |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |  |  |  |  |  |
Area of space subject to operating lease | ft² | 23,000 |  |  |  |  |  |  |  |
Operating lease term | 3 years |  |  |  |  |  |  |  |
Operating lease commencement date | Dec. 15, 2021 |  |  |  |  |  |  |  |
Operating lease right-of-use assets | $ 3,500,000 |  |  |  |  |  |  |  |
Operating lease liabilities | $ 3,500,000 |  |  |  |  |  |  |  |
Operating lease expiration date | Dec. 31, 2024 |  |  |  |  |  |  |  |
Lease Commencement on April 2022 |  |  |  |  |  |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |  |  |  |  |  |
Area of space subject to operating lease | ft² | 15,000 |  |  |  |  |  |  |  |
Operating lease right-of-use assets | $ 0 |  |  |  |  |  |  |  |
Operating lease liabilities | $ 0 |  |  |  |  |  |  |  |
Operating lease expiration date | Dec. 31, 2024 |  |  |  |  |  |  |  |
Operating lease commencement month and year | 2022-04 |  |  |  |  |  |  |  |
Lease Extension End Date April 30, 2025 |  |  |  |  |  |  |  |  |
Commitments And Contingencies [Line Items] |  |  |  |  |  |  |  |  |
Area of space subject to operating lease | ft² |  | 2,485 |  |  |  |  |  |  |
Operating lease term |  | 3 years |  |  |  |  |  |  |
Operating lease commencement date |  | May 01, 2022 |  |  |  |  |  |  |
Operating lease right-of-use assets |  | $ 700,000 |  |  |  |  |  |  |
Operating lease liabilities |  | $ 700,000 |  |  |  |  |  |  |
Operating lease expiration date |  | Apr. 30, 2025 |  |  |  |  |  |  |
Operating lease, renewal term |  | 2 years |  |  |  |  |  |  |
Area of additional space subject to operating lease | ft² |  | 2,357 |  |  |  |  |  |  |
Additional operating lease commencement date |  | Jul. 06, 2021 |  |  |  |  |  |  |
Additional operating lease expiration date |  | Apr. 30, 2025 |  |  |  |  |  |  |
Additional operating lease, right-of-use asset |  | $ 800,000 |  |  |  |  |  |  |
Additional operating lease, liabilities |  | $ 800,000 |  |  |  |  |  |  |
Operating lease, option to extend |  | The amended lease provides the Company with the option to extend the term of the lease for an additional two years. |  |  |  |  |  |  |
Operating lease, existence of option to extend [true false] |  | true |  |  |  |  |  |  |

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