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v3.22.0.1

Consolidated statements of cash flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020
Cash flows from operating activities: |  |
Net loss | $ (85,805) | $ (52,243)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation | 974 | 888
Amortization and accretion of marketable securities | 143 |
Stock-based compensation | 16,450 | 5,768
Loss on disposal of property and equipment | 29 | 3
Reduction in the carrying amount of right of use assets | 1,256 | 1,038
Changes in assets and liabilities: |  |
Prepaid expenses and other current assets | (2,851) | (2,878)
Accounts payable and accrued liabilities | 2,897 | 5,203
Net cash used in operating activities | (66,907) | (42,221)
Cash flows from investing activities: |  |
Purchases of property and equipment | (1,200) | (1,050)
Purchases of marketable securities | (87,226) |
Sales of marketable securities | 12,000 |
Net cash used in investing activities | (76,426) | (1,050)
Cash flows from financing activities: |  |
Proceeds from issuance of common stock upon public offerings |  | 105,398
Payment of offering costs |  | (306)
Proceeds from issuance of common stock upon exercise of stock options | 777 | 2,843
Proceeds from Employee Stock Purchase Plan | 509 | 352
Deferred financing costs |  | (179)
Other | (2) |
Net cash provided by financing activities | 1,284 | 108,108
Net increase (decrease) in cash, cash equivalents and restricted cash | (142,049) | 64,837
Cash, cash equivalents and restricted cash—beginning of year | 287,513 | 222,676
Cash, cash equivalents and restricted cash—end of year | 145,464 | 287,513
Supplemental Disclosure of Non-Cash Investing and Financing Activities: |  |
Right-of-use assets recognized in exchange for operating leases under Topic 842 | 5,081 | 2,153
Property and equipment included in accrued expense and accounts payable | $ 1,267 | 6
Deferred offering costs not yet paid |  | $ 162

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