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Consolidated statements of cash flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Cash flows from operating activities:    
Net loss $ (85,805) $ (52,243)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation 974 888
Amortization and accretion of marketable securities 143  
Stock-based compensation 16,450 5,768
Loss on disposal of property and equipment 29 3
Reduction in the carrying amount of right of use assets 1,256 1,038
Changes in assets and liabilities:    
Prepaid expenses and other current assets (2,851) (2,878)
Accounts payable and accrued liabilities 2,897 5,203
Net cash used in operating activities (66,907) (42,221)
Cash flows from investing activities:    
Purchases of property and equipment (1,200) (1,050)
Purchases of marketable securities (87,226)  
Sales of marketable securities 12,000  
Net cash used in investing activities (76,426) (1,050)
Cash flows from financing activities:    
Proceeds from issuance of common stock upon public offerings   105,398
Payment of offering costs   (306)
Proceeds from issuance of common stock upon exercise of stock options 777 2,843
Proceeds from Employee Stock Purchase Plan 509 352
Deferred financing costs   (179)
Other (2)  
Net cash provided by financing activities 1,284 108,108
Net increase (decrease) in cash, cash equivalents and restricted cash (142,049) 64,837
Cash, cash equivalents and restricted cash—beginning of year 287,513 222,676
Cash, cash equivalents and restricted cash—end of year 145,464 287,513
Supplemental Disclosure of Non-Cash Investing and Financing Activities:    
Right-of-use assets recognized in exchange for operating leases under Topic 842 5,081 2,153
Property and equipment included in accrued expense and accounts payable $ 1,267 6
Deferred offering costs not yet paid   $ 162