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Share-Based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2022
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] |
Summary of Stock Option Activity for Awards | A summary of stock option activity for awards is presented below:
|  | Number of shares |  |  | Weighted average exercise price |  |  | Weighted average remaining contractual life (years) |  |  | Aggregate intrinsic value(1) |
Outstanding as of December 31, 2021 |  |  | 5,435,304 |  |  | $ | 19.77 |  |  |  | 8.0 |  |  | $ | 64,981 |
Granted |  |  | 3,459,500 |  |  |  | 15.97 |  |  |  |  |  |  |  |  |
Exercised |  |  | (270,376 | ) |  |  | 1.83 |  |  |  |  |  |  |  |  |
Forfeitures |  |  | (254,450 | ) |  |  | 29.77 |  |  |  |  |  |  |  |  |
Expired |  |  | (95,331 | ) |  |  | 34.72 |  |  |  |  |  |  |  |  |
Outstanding as of December 31, 2022 |  |  | 8,274,647 |  |  | $ | 18.28 |  |  |  | 7.6 |  |  | $ | 20,598 |
Exercisable as of December 31, 2022 |  |  | 4,286,461 |  |  | $ | 14.70 |  |  |  | 6.4 |  |  | $ | 18,454 |
Summary of Stock-based Compensation Expense | Stock-based compensation expense recorded as research and development and general and administrative expenses in the accompanying consolidated statements of operations and comprehensive loss is as follows:
|  | Year ended December 31, |
|  | 2022 |  |  | 2021 |
Research and development |  | $ | 8,901 |  |  | $ | 6,215 |
General and administrative |  |  | 13,953 |  |  |  | 10,235 |
|  | $ | 22,854 |  |  | $ | 16,450 |
Summary of Fair Values of Options Granted to Employees and Directors | The Company uses the Black-Scholes option pricing model to calculate the grant-date fair value of an award. The fair values of the options granted to employees and directors were calculated using the following assumptions for the years ended December 31, 2022 and 2021:
|  | Year ended December 31,
|  | 2022 |  | 2021
Risk-free interest rate |  | 1.82-4.15% |  | 0.78-1.51%
Expected dividend yield |  | 0% |  | 0%
Expected life |  | 5.5-6.25 years |  | 5.5-6.25 years
Expected volatility |  | 70-71% |  | 70-73%

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- Definition Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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