The following table summarizes the computation of basic and diluted net loss per share of the Company:

	Year ended December 31,
	2022			2021
Numerator:
Net loss	$	(101,067	)	$	(85,805	)
Denominator:
Weighted-average number of common shares, basic and diluted		38,897,442			36,739,269
Net loss per share, basic and diluted	$	(2.60	)	$	(2.34	)

The Company’s potential dilutive securities, which include common stock options and ESPP purchase rights, have been excluded from the computation of diluted net loss per share as the effect would be anti-dilutive. Therefore, the weighted average number of common shares outstanding used to calculate both basic and diluted net loss per share is the same.

The Company excluded the following potential common shares, presented based on amounts outstanding at period end, from the computation of diluted net loss per share for the periods indicated because including them would have had an anti-dilutive effect:

	December 31,
	2022		2021
Outstanding options to purchase common stock		8,274,647		5,435,304