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Consolidated statements of operations and comprehensive loss - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Income Statement [Abstract]    
Revenue $ 12,405  
Operating expenses:    
Research and development 77,837 $ 54,168
General and administrative 38,924 31,897
Total operating expenses 116,761 86,065
Loss from operations (104,356) (86,065)
Other income (expense):    
Interest income (expense), net 3,122 120
Other income (expense), net 167 140
Total other income (expense) 3,289 260
Net loss $ (101,067) $ (85,805)
Net loss per share, basic $ (2.60) $ (2.34)
Net loss per share, diluted $ (2.60) $ (2.34)
Weighted-average common shares outstanding, basic 38,897,442 36,739,269
Weighted-average common shares outstanding, diluted 38,897,442 36,739,269
Comprehensive loss:    
Net loss $ (101,067) $ (85,805)
Other comprehensive loss:    
Unrealized loss on marketable securities (1,007) (168)
Total other comprehensive loss (1,007) (168)
Comprehensive loss $ (102,074) $ (85,973)