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Consolidated statements of cash flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Cash flows from operating activities:    
Net loss $ (101,067) $ (85,805)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation 1,546 974
Amortization and accretion of marketable securities (211) 143
Stock-based compensation 22,854 16,450
Loss on disposal of property and equipment   29
Reduction in the carrying amount of right of use assets 1,989 1,256
Changes in assets and liabilities:    
Prepaid expenses and other current assets (5,183) (2,851)
Accounts payable and accrued liabilities (3,530) 2,897
Deferred revenue 51,736  
Net cash used in operating activities (31,866) (66,907)
Cash flows from investing activities:    
Purchases of property and equipment (3,962) (1,200)
Purchases of marketable securities (201,320) (87,226)
Sales of marketable securities 159,400 12,000
Net cash used in investing activities (45,882) (76,426)
Cash flows from financing activities:    
Proceeds from issuance of common stock upon exercise of stock options 494 777
Proceeds from Employee Stock Purchase Plan 570 509
Proceeds from controlled equity offering sales agreement 45,344  
Other 1 (2)
Net cash provided by financing activities 46,409 1,284
Net decrease in cash, cash equivalents and restricted cash (31,339) (142,049)
Cash, cash equivalents and restricted cash—beginning of year 145,464 287,513
Cash, cash equivalents and restricted cash—end of year 114,125 145,464
Supplemental Disclosure of Non-Cash Investing and Financing Activities:    
Right-of-use assets recognized in exchange for operating leases 1,802 5,081
Property and equipment included in accrued expense and accounts payable $ 121 $ 1,267