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Segment Information | 3 Months Ended
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Mar. 31, 2025
Segment Reporting [Abstract] |
Segment Information | 11. Segment Information The Company comprises of one reportable segment, Stoke. As of March 31, 2025, this segment has not generated any product revenue since inception, as it does not yet have approved products for sale. The Company primarily generates revenue in North America, with its long-lived assets also concentrated in this region, and manages its business activities on a consolidated basis. Decisions concerning the allocation of the Company’s resources are made by the Company’s Chief Operating Decision Maker (“CODM”), which is the Company’s Interim Chief Executive Officer. The CODM views the Company’s operations as a single operating segment which is the business of discovering and developing RNA-based medicines, using the Targeted Augmentation of Nuclear Gene Output (“TANGO”) approach and developing antisense oligonucleotides (“ASOs”) to selectively restore protein levels. The CODM assesses performance for the Company's operations segment and decides how to allocate resources based on net income or loss that is also reported on the income statement as consolidated net income or loss and the measure of segment assets as reported on the balance sheet as total consolidated assets. Net income or loss is used to monitor budget vs actual results as well as assess the general performance of the segment in a given period. The following table reconciles segment direct profit or loss to the Company’s consolidated results (in thousands):
|  | Three Months Ended March 31, |
|  | 2025 |  |  | 2024 |
Revenue |  | $ | 158,569 |  |  | $ | 4,216 |
Zorevunersen(1) |  |  | 17,674 |  |  |  | 8,780 |
ADOA(1) |  |  | 1,201 |  |  |  | 1,722 |
SYNGAP1(1) |  |  | 342 |  |  |  | 284 |
MECP2(1) |  |  | 147 |  |  |  | 242 |
Other external program costs |  |  | 1,829 |  |  |  | 2,043 |
Payroll and other personnel costs - R&D (2) |  |  | 11,012 |  |  |  | 8,163 |
Payroll and other personnel costs - G&A (2) |  |  | 8,929 |  |  |  | 6,850 |
Other non-program costs - R&D (3) |  |  | 1,407 |  |  |  | 1,460 |
Other non-program costs - G&A (3) |  |  | 4,788 |  |  |  | 3,044 |
Subtotal |  |  | (47,329 | ) |  |  | (32,588 | )
Other segment items |  |  |  |  |  |
Interest expense |  |  | (1 | ) |  |  | (22 | )
Interest income |  |  | 2,890 |  |  |  | 2,448 |
Other income (expense) |  |  | 28 |  |  |  | (428 | )
Provision for income taxes |  |  | (1,278 | ) |  |  | — |
Total other segment items |  |  | 1,639 |  |  |  | 1,998 |
Segment net income (loss) |  | $ | 112,879 |  |  | $ | (26,374 | )
(1) Includes external research and development and general and administrative expenses associated with programs. (2) Includes salaries, benefits and other personnel related expenses, including stock based compensation expense, of relevant personnel. (3) Includes costs incurred for conducting non-program activities related to Company activities.

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- Definition The entire disclosure for reporting segments including data and tables. Reportable segments include those that meet any of the following quantitative thresholds a) it's reported revenue, including sales to external customers and intersegment sales or transfers is 10 percent or more of the combined revenue, internal and external, of all operating segments b) the absolute amount of its reported profit or loss is 10 percent or more of the greater, in absolute amount of 1) the combined reported profit of all operating segments that did not report a loss or 2) the combined reported loss of all operating segments that did report a loss c) its assets are 10 percent or more of the combined assets of all operating segments. + References Reference 1: http://www.xbrl.org/2003/role/exampleRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 55 -Paragraph 48 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482785/280-10-55-48 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name Accounting Standards 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