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Segment Information (Tables)

3 Months Ended

Mar. 31, 2025

Segment Reporting [Abstract]

Summary of Segment Information

The following table reconciles segment direct profit or loss to the Company’s consolidated results (in thousands):

		Three Months Ended March 31,
		2025				2024
Revenue		$	158,569			$	4,216
Zorevunersen(1)			17,674				8,780
ADOA(1)			1,201				1,722
SYNGAP1(1)			342				284
MECP2(1)			147				242
Other external program costs			1,829				2,043
Payroll and other personnel costs - R&D (2)			11,012				8,163
Payroll and other personnel costs - G&A (2)			8,929				6,850
Other non-program costs - R&D (3)			1,407				1,460
Other non-program costs - G&A (3)			4,788				3,044
Subtotal			(47,329	)			(32,588	)
Other segment items
Interest expense			(1	)			(22	)
Interest income			2,890				2,448
Other income (expense)			28				(428	)
Provision for income taxes			(1,278	)			—
Total other segment items			1,639				1,998
Segment net income (loss)		$	112,879			$	(26,374	)

(1) Includes external research and development and general and administrative expenses associated with programs.

(2) Includes salaries, benefits and other personnel related expenses, including stock based compensation expense, of relevant personnel.

(3) Includes costs incurred for conducting non-program activities related to Company activities.

X

- Definition

Tabular disclosure of the profit or loss and total assets for each reportable segment. An entity discloses certain information on each reportable segment if the amounts (a) are included in the measure of segment profit or loss reviewed by the chief operating decision maker or (b) are otherwise regularly provided to the chief operating decision maker, even if not included in that measure of segment profit or loss.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 25
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482810/280-10-50-25

Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 22
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482810/280-10-50-22

Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 30
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482810/280-10-50-30

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X

- References

No definition available.

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