<SEC-DOCUMENT>0001123292-25-000298.txt : 20250623
<SEC-HEADER>0001123292-25-000298.hdr.sgml : 20250623
<ACCEPTANCE-DATETIME>20250623164725
ACCESSION NUMBER:		0001123292-25-000298
CONFORMED SUBMISSION TYPE:	SCHEDULE 13D/A
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20250623
DATE AS OF CHANGE:		20250623

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Stoke Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001623526
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				471144582
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-91051
		FILM NUMBER:		251065471

	BUSINESS ADDRESS:	
		STREET 1:		45 WIGGINS AVENUE
		CITY:			BEDFORD
		STATE:			MA
		ZIP:			01730
		BUSINESS PHONE:		781-430-8200

	MAIL ADDRESS:	
		STREET 1:		45 WIGGINS AVENUE
		CITY:			BEDFORD
		STATE:			MA
		ZIP:			01730

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ASOthera Pharmaceuticals, Inc.
		DATE OF NAME CHANGE:	20141028

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Skorpios Trust
		CENTRAL INDEX KEY:			0001869333
		ORGANIZATION NAME:           	
		EIN:				000000000
		STATE OF INCORPORATION:			G4
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13D/A

	BUSINESS ADDRESS:	
		STREET 1:		195 ARCH. MAKARIOS III AVE.
		STREET 2:		NEOCLEOUS HOUSE
		CITY:			LIMASSOL
		STATE:			G4
		ZIP:			3030
		BUSINESS PHONE:		3-572-511-0165

	MAIL ADDRESS:	
		STREET 1:		195 ARCH. MAKARIOS III AVE.
		STREET 2:		NEOCLEOUS HOUSE
		CITY:			LIMASSOL
		STATE:			G4
		ZIP:			3030
</SEC-HEADER>
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<TYPE>SCHEDULE 13D/A
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<amendmentNo>5</amendmentNo>
<securitiesClassTitle>Common Stock, $0.0001 par value per share</securitiesClassTitle>
<dateOfEvent>06/18/2025</dateOfEvent>
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<issuerCIK>0001623526</issuerCIK>
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<issuerName>Stoke Therapeutics, Inc.</issuerName>
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<com:street1>45 Wiggins Ave.</com:street1>
<com:city>Bedford</com:city>
<com:stateOrCountry>MA</com:stateOrCountry>
<com:zipCode>01730</com:zipCode>
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<personName>Patrik Blochlinger, Chief</personName>
<personPhoneNum>41 44 287 2498</personPhoneNum>
<personAddress>
<com:street1>Legal Officer, Rigmora (Switzerland) Ltd</com:street1>
<com:street2>Stockerstrasse 8</com:street2>
<com:city>Zurich</com:city>
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<reportingPersonCIK>0001869057</reportingPersonCIK>
<reportingPersonName>Blue Horizon Enterprise Ltd</reportingPersonName>
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<fundType>OO</fundType>
<citizenshipOrOrganization>D8</citizenshipOrOrganization>
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<commentContent>The percentages used herein and in the rest of this Schedule 13D are calculated based upon 54,596,924 shares of the Issuer's common stock outstanding as of April 30, 2025, as reported in the Company's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on May 13, 2025.</commentContent>
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<reportingPersonCIK>0001869027</reportingPersonCIK>
<reportingPersonName>Ezbon International Ltd</reportingPersonName>
<memberOfGroup>a</memberOfGroup>
<fundType>OO</fundType>
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<reportingPersonCIK>0001869331</reportingPersonCIK>
<reportingPersonName>Montrago Trustees Ltd</reportingPersonName>
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<percentOfClass>6</percentOfClass>
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<securityTitle>Common Stock, $0.0001 par value per share</securityTitle>
<issuerName>Stoke Therapeutics, Inc.</issuerName>
<issuerPrincipalAddress>
<com:street1>45 Wiggins Ave.</com:street1>
<com:city>Bedford</com:city>
<com:stateOrCountry>MA</com:stateOrCountry>
<com:zipCode>01730</com:zipCode>
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<commentText>This Amendment No. 5 (the "Amendment No. 5") is filed by Skorpios Trust, Montrago Trustees Limited ("Montrago Trustees"), Ezbon International Limited ("Ezbon") and Blue Horizon Enterprise Ltd. ("Blue Horizon" and, collectively, the "Reporting Persons") and amends the Schedule 13D filed by the Reporting Persons on June 30, 2021, as amended by Amendment No. 1 to Schedule 13D filed by the Reporting Persons on April 18, 2024, Amendment No. 2 to Schedule 13D filed by the Reporting Persons on September 23, 2024, Amendment No. 3 to Schedule 13D filed by the Reporting Persons on December 27, 2024 and Amendment No. 4 to Schedule 13D filed by the Reporting Persons on June 6, 2025 (as amended, the "Schedule 13D"). The Items below amend the information disclosed under the corresponding Items of the Schedule 13D as described below. Except as specifically provided herein, this Amendment No. 5 does not modify any of the information previously reported in the Schedule 13D. Capitalized terms used herein and not otherwise defined have the meanings ascribed to them in the Schedule 13D.</commentText>
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<item4>
<transactionPurpose>Item 4 is hereby amended and supplemented by adding the following:&#13;
&#13;
On June 18, 2025, Ezbon sold 650,000 Shares of the Issuer in an open market transaction at a price of $11.00 per share.</transactionPurpose>
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<percentageOfClassSecurities>Item 5(a) is hereby amended and restated as follows: (a) The responses of the Reporting Persons to rows (7) through (13) of the cover pages of this Schedule 13D are incorporated herein by reference.</percentageOfClassSecurities>
<numberOfShares>Item 5(b) is hereby amended and restated as follows: (b) The responses of the Reporting Persons to rows (7) through (13) of the cover pages of this Schedule 13D are incorporated herein by reference.</numberOfShares>
<transactionDesc>Item 5(c) is hereby amended and restated as follows: (c) The information reported in Item 4 is incorporated herein by reference. Other than as disclosed in that item, no transactions in the Shares have been effected by the Reporting Person during the past sixty (60) days.</transactionDesc>
</item5>
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<filedExhibits>Exhibit 1	- Joint Filing Agreement, dated as of June 23, 2025, by and among the Reporting Persons.</filedExhibits>
</item7>
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<signatureReportingPerson>Blue Horizon Enterprise Ltd</signatureReportingPerson>
<signatureDetails>
<signature>/s/ Eleni Constantinou Kyriacou</signature>
<title>Eleni Constantinou Kyriacou, Director</title>
<date>06/23/2025</date>
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<signatureReportingPerson>Ezbon International Ltd</signatureReportingPerson>
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<signature>/s/ Eleni Constantinou Kyriacou</signature>
<title>Eleni Constantinou Kyriacou, Director</title>
<date>06/23/2025</date>
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<signatureReportingPerson>Montrago Trustees Ltd</signatureReportingPerson>
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<signature>/s/ Androulla Papadopoulou</signature>
<title>Androulla Papadopoulou, Director</title>
<date>06/23/2025</date>
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<signatureReportingPerson>Skorpios Trust</signatureReportingPerson>
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<signature>/s/ Androulla Papadopoulou</signature>
<title>Androulla Papadopoulou, Director</title>
<date>06/23/2025</date>
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