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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017
OPERATING ACTIVITIES: |  |  |
Net income | $ 50,201,000 | $ 60,801,000 | $ 64,743,000
Adjustments to reconcile net income to net cash provided by operating activities: |  |  |
Depreciation and amortization | 109,462,000 | 110,730,000 | 88,945,000
Non-cash in-process research and development expense | 64,916,000 | 0 | 0
Non-cash impairment charges | 5,764,000 | 4,941,000 | 3,290,000
Deferred income tax benefit | (19,046,000) | (8,184,000) | (67,304,000)
Share-based compensation | 21,255,000 | 20,779,000 | 21,550,000
Amortization of debt issuance costs | 5,390,000 | 6,270,000 | 2,722,000
Non-cash lease expense | 5,060,000 |  |
Non-cash lease expense |  | 0 | 0
Realized loss on sale of short-term investments | 0 | 0 | 2,287,000
Loss on disposal of property and equipment | 1,821,000 | 1,385,000 | 6,989,000
Gain on divestiture of business | 0 | 0 | (2,645,000)
Change in fair value of contingent consideration and others | 1,119,000 | 1,214,000 | (4,710,000)
Changes in assets and liabilities, net of business acquisitions: |  |  |
Accounts receivable | (9,428,000) | (17,021,000) | (89,698,000)
Inventories | (43,308,000) | 8,300,000 | 99,000
Prepaid expenses and other current assets | 13,071,000 | 3,933,000 | (33,808,000)
Other non-current assets | 13,156,000 | 1,052,000 | (914,000)
Accounts payable, accrued expenses and other current liabilities | 14,666,000 | 3,588,000 | 95,321,000
Contract liabilities | (607,000) | 1,504,000 | 3,874,000
Other non-current liabilities | (2,059,000) | 391,000 | 23,803,000
Net cash provided by operating activities | 231,433,000 | 199,683,000 | 114,544,000
INVESTING ACTIVITIES: |  |  |
Proceeds from sale of short-term investments | 0 | 0 | 16,951,000
Proceeds from note receivable | 752,000 | 910,000 | 483,000
Cash used in business acquisitions, net of cash acquired | (30,509,000) | 26,704,000 | (1,241,946,000)
Acquired in-process research and development | (64,995,000) | 0 | 0
Purchases of property and equipment | (69,537,000) | (77,741,000) | (43,503,000)
Proceeds from sales of property and equipment | 37,000 | 422,000 | 293,000
Proceeds from divestiture of business | 0 | 0 | 46,387,000
Net proceeds on swaps designated as net investment hedges | 1,584,000 | 0 | 0
Net cash used in investing activities | (162,668,000) | (49,705,000) | (1,221,335,000)
FINANCING ACTIVITIES: |  |  |
Proceeds from borrowings of long-term indebtedness | 236,900,000 | 171,200,000 | 1,307,000,000
Payments on debt | (246,100,000) | (660,000,000) | (117,000,000)
Net cash paid for contingent consideration | 0 | (38,196,000) | (4,661,000)
Proceeds from the issuance of common stock, net of issuance costs | 0 | 349,590,000 | 0
Debt issuance costs | 0 | (5,037,000) | (19,043,000)
Proceeds from exercised stock options | 6,948,000 | 9,392,000 | 9,774,000
Cash taxes paid in net equity settlement | (6,514,000) | (7,821,000) | (7,123,000)
Net cash provided by (used in) financing activities | (8,766,000) | (180,872,000) | 1,168,947,000
Effect of exchange rate changes on cash and cash equivalents | 74,000 | (5,203,000) | 10,724,000
Net increase (decrease) in cash and cash equivalents | 60,073,000 | (36,097,000) | 72,880,000
Cash and cash equivalents at beginning of period | 138,838,000 | 174,935,000 | 102,055,000
Cash and cash equivalents at end of period | $ 198,911,000 | $ 138,838,000 | $ 174,935,000

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- Definition Amount of cash outflow, not made soon after acquisition date of business combination, to settle contingent consideration liability up to amount recognized at acquisition date, including, but not limited to, measurement period adjustment and less amount paid soon after acquisition date. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (f) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3291-108585 + Details
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- Definition The net amount paid (received) by the reporting entity through acquisition or sale and maturities of short-term investments with an original maturity that is three months or less which qualify for treatment as an investing activity based on management's intention and intended by management to be liquidated, if necessary, within the current operating cycle. Includes cash flows from securities classified as trading securities that were acquired for reasons other than sale in the short-term. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3213-108585 Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 9 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3098-108585 Reference 3: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3179-108585 + Details
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- Definition The cash outflow paid to third parties in connection with debt origination, which will be amortized over the remaining maturity period of the associated long-term debt. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (e) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3291-108585 + Details
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- Definition Amount of cash outflow to satisfy grantee's tax withholding obligation for award under share-based payment arrangement. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3291-108585 + Details
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- Definition The cash outflow associated with the acquisition of a business, net of the cash acquired from the purchase. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3213-108585 + Details
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- Definition The cash outflows from the purchase of net carrying value allocated to in-process research and development costs and materials acquired in a business combination. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3213-108585 + Details
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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3213-108585 + Details
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- Definition The cash inflow associated with principal collections from a borrowing supported by a written promise to pay an obligation. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3179-108585 + Details
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- Definition The cash inflow provided by derivative instruments during the period, which are classified as investing activities, excluding those designated as hedging instruments. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3179-108585 + Details
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- Definition The cash inflow associated with the amount received from the sale of a portion of the company's business, for example a segment, division, branch or other business, during the period. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3179-108585 + Details
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- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3255-108585 + Details
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- Definition The cash inflow from amounts received from issuance of long-term debt that is wholly or partially secured by collateral. Excludes proceeds from tax exempt secured debt. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3255-108585 + Details
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- Definition The cash inflow from the sale of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3179-108585 + Details
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- Definition Amount of cash inflow from exercise of option under share-based payment arrangement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2A -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=116856206&loc=SL79508275-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3255-108585 + Details
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- Definition The cash outflow to repay long-term debt that is wholly or partially secured by collateral. Excludes repayments of tax exempt secured debt. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3291-108585 + Details
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- Definition Amount of noncash expense for share-based payment arrangement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3602-108585 + Details
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