    <SEC-DOCUMENT>0001193125-22-266752-index.html : 20221021
    <SEC-HEADER>0001193125-22-266752.hdr.sgml : 20221021
    <ACCEPTANCE-DATETIME>20221021161642
    ACCESSION NUMBER:		0001193125-22-266752
    CONFORMED SUBMISSION TYPE:	424B5
    PUBLIC DOCUMENT COUNT:		4
    FILED AS OF DATE:		20221021
    DATE AS OF CHANGE:		20221021

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Zymeworks Inc.
    		CENTRAL INDEX KEY:			0001937653
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				000000000
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		424B5
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-259970-01
    		FILM NUMBER:		221323939

    	BUSINESS ADDRESS:
    		STREET 1:		108 PATRIOT DRIVE, SUITE A
    		CITY:			MIDDLETOWN
    		STATE:			DE
    		ZIP:			19709
    		BUSINESS PHONE:		206-337-1030

    	MAIL ADDRESS:
    		STREET 1:		108 PATRIOT DRIVE, SUITE A
    		CITY:			MIDDLETOWN
    		STATE:			DE
    		ZIP:			19709

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Zymeworks Delaware Inc.
    		DATE OF NAME CHANGE:	20220712
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>424B5
    <SEQUENCE>1
    <FILENAME>d410387d424b5.htm
    <DESCRIPTION>424B5
    <TEXT>
    Document 1 - file: d410387d424b5.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-FILING FEES
    <SEQUENCE>2
    <FILENAME>d410387dexfilingfees.htm
    <DESCRIPTION>EX-FILING FEES
    <TEXT>
    Document 2 - file: d410387dexfilingfees.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>g410387g00a31.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 3 - file: g410387g00a31.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>4
    <FILENAME>g410387g71w59.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 4 - file: g410387g71w59.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>