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Stockholders' Equity - Narrative (Details) - USD ($)
$ / shares in Units, $ in Thousands
 3 Months Ended 12 Months Ended
Jul. 19, 2024
Dec. 28, 2023
Oct. 13, 2022
Jul. 14, 2006
Mar. 31, 2025
Mar. 31, 2024
Dec. 31, 2024
Aug. 01, 2024
Oct. 12, 2022
Jan. 05, 2022
Temporary Equity [Line Items]                    
All classes of stock, shares authorized (in shares)         1,000,000,000          
Common stock, shares authorized (in shares)         900,000,000   900,000,000      
Common stock, par value per share (in dollars per share)         $ 0.00001   $ 0.00001 $ 0.00001    
Preferred stock, shares authorized (in shares)         100,000,000   100,000,000      
Preferred stock, par value (in dollars per share)         $ 0.00001   $ 0.00001      
Preferred stock, shares issued (in shares)         1   1      
Preferred stock, shares outstanding (in shares)         1   1      
Common shares issued (in shares)         69,584,811   68,964,319      
Common shares outstanding (in shares)         69,584,811   68,964,319      
Exchangeable shares, shares outstanding (in shares)         569,902   570,637      
Shares granted with respect to maximum fixed amount equal, percentage       20.00%            
Options granted under original plan exercisable period         10 years          
Number of shares available for grant (in shares)         5,326,769   5,196,630      
Proceeds from stock options exercised         $ 772          
Unamortized compensation expense related to unvested options         $ 18,105          
Remaining unamortized compensation expense, weighted-average period         1 year 9 months 10 days          
Inducement Plan                    
Temporary Equity [Line Items]                    
Number of shares available for grant (in shares) 1,450,000       390,000   390,000      
Number of common shares reserved for issuance (in shares)                   750,000
Number of additional shares authorized (in shares) 700,000                  
Restricted Share Units (RSUs)                    
Temporary Equity [Line Items]                    
Nonvested award, cost not yet recognized, amount         $ 11,678          
Nonvested award, cost not yet recognized, period for recognition         1 year 6 months 29 days          
Compensation charge         $ 2,280 $ 1,022        
Pre-Funded Warrant                    
Temporary Equity [Line Items]                    
Pre-funded warrants (in shares)   5,086,521                
Shares called by warrants (in shares)   5,086,521                
Exercise price of warrants (in dollars per share)   $ 0.0001                
Warrants outstanding (in shares)         5,086,521   5,086,521      
Stock Repurchase Program                    
Temporary Equity [Line Items]                    
Share repurchase program, authorized amount               $ 60,000    
Treasury stock repurchased (in shares)             2,545,402      
Treasury stock repurchased value             $ 30,000      
Commission expense on share repurchases             51      
Excise tax on share repurchases             $ 152      
Retirement of treasury stock ( in shares)             2,545,402      
Common stock                    
Temporary Equity [Line Items]                    
Redomicile transaction, number of shares issued (in shares)     60,274,854              
Exchangeable shares                    
Temporary Equity [Line Items]                    
Temporary equity, stock issued during period, shares, new issues (in shares)     1,424,533              
Zymeworks BC Inc                    
Temporary Equity [Line Items]                    
Common shares issued (in shares)                 61,699,387  
Common shares outstanding (in shares)                 61,699,387