<SEC-DOCUMENT>0000950170-25-002463.txt : 20250106
<SEC-HEADER>0000950170-25-002463.hdr.sgml : 20250106
<ACCEPTANCE-DATETIME>20250106195003
ACCESSION NUMBER:		0000950170-25-002463
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20250106
DATE AS OF CHANGE:		20250106

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Zymeworks Inc.
		CENTRAL INDEX KEY:			0001937653
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-41535
		FILM NUMBER:		25513137

	BUSINESS ADDRESS:	
		STREET 1:		108 PATRIOT DRIVE, SUITE A
		CITY:			MIDDLETOWN
		STATE:			DE
		ZIP:			19709
		BUSINESS PHONE:		302-274-8744

	MAIL ADDRESS:	
		STREET 1:		108 PATRIOT DRIVE, SUITE A
		CITY:			MIDDLETOWN
		STATE:			DE
		ZIP:			19709

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Zymeworks Delaware Inc.
		DATE OF NAME CHANGE:	20220712

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Smith Jeffrey T L
		CENTRAL INDEX KEY:			0001604800
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		11804 NORTH CREEK PARKWAY SOUTH
		CITY:			BOTHELL
		STATE:			WA
		ZIP:			98011
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<headerData>
<submissionType>144</submissionType>
<filerInfo>
<filer>
<filerCredentials>
<cik>0001604800</cik>
<ccc>XXXXXXXX</ccc>
</filerCredentials>
</filer>
<liveTestFlag>LIVE</liveTestFlag>
</filerInfo>
</headerData>
<formData>
<issuerInfo>
<issuerCik>0001937653</issuerCik>
<issuerName>Zymeworks Inc.</issuerName>
<secFileNumber>001-41535</secFileNumber>
<issuerAddress>
<street1 xmlns="http://www.sec.gov/edgar/common">108 Patriot Drive</street1>
<street2 xmlns="http://www.sec.gov/edgar/common">Suite A</street2>
<city xmlns="http://www.sec.gov/edgar/common">Middletown</city>
<stateOrCountry xmlns="http://www.sec.gov/edgar/common">DE</stateOrCountry>
<zipCode xmlns="http://www.sec.gov/edgar/common">19709</zipCode>
</issuerAddress>
<issuerContactPhone>302-274-8744</issuerContactPhone>
<nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Smith Jeffrey T L</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
<relationshipsToIssuer>
<relationshipToIssuer>Officer</relationshipToIssuer>
</relationshipsToIssuer>
</issuerInfo>
<securitiesInformation>
<securitiesClassTitle>Common Stock</securitiesClassTitle>
<brokerOrMarketmakerDetails>
<name>Morgan Stanley</name>
<address>
<street1 xmlns="http://www.sec.gov/edgar/common">1585 Broadway</street1>
<city xmlns="http://www.sec.gov/edgar/common">New York</city>
<stateOrCountry xmlns="http://www.sec.gov/edgar/common">NY</stateOrCountry>
<zipCode xmlns="http://www.sec.gov/edgar/common">10036</zipCode>
</address>
</brokerOrMarketmakerDetails>
<noOfUnitsSold>11110</noOfUnitsSold>
<aggregateMarketValue>160651</aggregateMarketValue>
<noOfUnitsOutstanding>68877526</noOfUnitsOutstanding>
<approxSaleDate>01/06/2025</approxSaleDate>
<securitiesExchangeName>Nasdaq</securitiesExchangeName>
</securitiesInformation>
<securitiesToBeSold>
<securitiesClassTitle>Common Stock</securitiesClassTitle>
<acquiredDate>01/06/2025</acquiredDate>
<natureOfAcquisitionTransaction>Vesting of Restricted Stock Units</natureOfAcquisitionTransaction>
<nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
<isGiftTransaction>N</isGiftTransaction>
<amountOfSecuritiesAcquired>20000</amountOfSecuritiesAcquired>
<paymentDate>01/06/2025</paymentDate>
<natureOfPayment>Vesting of Award</natureOfPayment>
</securitiesToBeSold>
<nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
<remarks>The shares of common stock to be sold represent shares to be sold to cover tax withholding obligations and other fees in connection with the vesting of RSUs pursuant to mandatory "sell to cover" provisions contained in the applicable RSU grant agreement.</remarks>
<noticeSignature>
<noticeDate>01/06/2025</noticeDate>
<signature>/s/ Jeffrey T L Smith</signature>
</noticeSignature>
</formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
