<SEC-DOCUMENT>0001193125-25-328911.txt : 20251222
<SEC-HEADER>0001193125-25-328911.hdr.sgml : 20251222
<ACCEPTANCE-DATETIME>20251222170002
ACCESSION NUMBER:		0001193125-25-328911
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20251222
DATE AS OF CHANGE:		20251222

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Zymeworks Inc.
		CENTRAL INDEX KEY:			0001937653
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				883099146
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-41535
		FILM NUMBER:		251593198

	BUSINESS ADDRESS:	
		STREET 1:		108 PATRIOT DRIVE, SUITE A
		CITY:			MIDDLETOWN
		STATE:			DE
		ZIP:			19709
		BUSINESS PHONE:		302-274-8744

	MAIL ADDRESS:	
		STREET 1:		108 PATRIOT DRIVE, SUITE A
		CITY:			MIDDLETOWN
		STATE:			DE
		ZIP:			19709

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Zymeworks Delaware Inc.
		DATE OF NAME CHANGE:	20220712

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Galbraith Kenneth
		CENTRAL INDEX KEY:			0001567045
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		OCEAN PARK RPO PO BOX 45025
		STREET 2:		12851 16TH AVE
		CITY:			SURREY
		STATE:			A1
		ZIP:			V4A9L1
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<headerData>
<submissionType>144</submissionType>
<filerInfo>
<filer>
<filerCredentials>
<cik>0001567045</cik>
<ccc>XXXXXXXX</ccc>
</filerCredentials>
</filer>
<liveTestFlag>LIVE</liveTestFlag>
</filerInfo>
</headerData>
<formData>
<issuerInfo>
<issuerCik>0001937653</issuerCik>
<issuerName>Zymeworks Inc.</issuerName>
<secFileNumber>001-41535</secFileNumber>
<issuerAddress>
<street1 xmlns="http://www.sec.gov/edgar/common">108 Patriot Drive</street1>
<street2 xmlns="http://www.sec.gov/edgar/common">Suite A</street2>
<city xmlns="http://www.sec.gov/edgar/common">Middletown</city>
<stateOrCountry xmlns="http://www.sec.gov/edgar/common">DE</stateOrCountry>
<zipCode xmlns="http://www.sec.gov/edgar/common">19709</zipCode>
</issuerAddress>
<issuerContactPhone>302-274-8744</issuerContactPhone>
<nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Galbraith, Kenneth</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
<relationshipsToIssuer>
<relationshipToIssuer>Officer</relationshipToIssuer>
<relationshipToIssuer>Director</relationshipToIssuer>
</relationshipsToIssuer>
</issuerInfo>
<securitiesInformation>
<securitiesClassTitle>Common Stock</securitiesClassTitle>
<brokerOrMarketmakerDetails>
<name>Morgan Stanley Wealth Management Canada</name>
<address>
<street1 xmlns="http://www.sec.gov/edgar/common">140 4th Ave. SW</street1>
<street2 xmlns="http://www.sec.gov/edgar/common">Suite 2740</street2>
<city xmlns="http://www.sec.gov/edgar/common">Calgary</city>
<stateOrCountry xmlns="http://www.sec.gov/edgar/common">A0</stateOrCountry>
<zipCode xmlns="http://www.sec.gov/edgar/common">AB T2P 3N3</zipCode>
</address>
</brokerOrMarketmakerDetails>
<noOfUnitsSold>47528</noOfUnitsSold>
<aggregateMarketValue>1294187.44</aggregateMarketValue>
<noOfUnitsOutstanding>74836534</noOfUnitsOutstanding>
<approxSaleDate>12/22/2025</approxSaleDate>
<securitiesExchangeName>Nasdaq</securitiesExchangeName>
</securitiesInformation>
<securitiesToBeSold>
<securitiesClassTitle>Common Stock</securitiesClassTitle>
<acquiredDate>12/22/2025</acquiredDate>
<natureOfAcquisitionTransaction>Vesting of Restricted Stock Units</natureOfAcquisitionTransaction>
<nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
<isGiftTransaction>N</isGiftTransaction>
<amountOfSecuritiesAcquired>100000</amountOfSecuritiesAcquired>
<paymentDate>12/22/2025</paymentDate>
<natureOfPayment>Vesting of Award</natureOfPayment>
</securitiesToBeSold>
<nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
<remarks>The shares of common stock to be sold represent shares to be sold to cover tax withholding obligations and other fees in connection with the vesting of RSUs pursuant to mandatory "sell to cover" provisions contained in the applicable RSU grant agreement.</remarks>
<noticeSignature>
<noticeDate>12/22/2025</noticeDate>
<signature>/s/ Kenneth Galbraith</signature>
</noticeSignature>
</formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
