EX-FILING FEES 14 d843142dexfilingfees.htm EX-FILING FEES

Exhibit 107

Calculation of Filing Fee Table

Form S-1

(Form Type)

Upstream Bio, Inc.

(Exact Name of Registrant as Specified in its Charter)

Table 1: Newly Registered Securities

|  | Security Type |  | Security Class Title |  | Fee Calculation Rule |  | Amount Registered |  | Proposed Maximum Offering Price Per Unit |  | Proposed Maximum Aggregate Offering Price(1) |  | Fee Rate |  | Amount of Registration Fee
Fees to be Paid |  | Equity |  | Common Stock, par value $0.001 per share |  | 457(a) |  | 14,375,000(1) |  | $17.00(2) |  | $244,375,000 |  | $0.00015310 |  | $22,103.81(3)
Fees Previously Paid |  | Equity |  | Common Stock, $0.001 par value per share |  | 457(a) |  |  |  |  |  | $100,000,000 |  | $0.00014760 |  | $14,760.00
|  | Total Offering Amounts |  |  |  |  |  | $244,375,000 |  |  |  | $36,863.81
|  | Total Fees Previously Paid |  |  |  |  |  |  |  |  |  | $14,760.00
|  | Total Fee Offsets |  |  |  |  |  |  |  |  |  | —
|  | Net Fee Due |  |  |  |  |  |  |  |  |  | $22,103.81

(1) | Includes 1,875,000 shares that the underwriters have the option to purchase.

(2) | Estimated solely for the purpose of computing the registration fee in accordance with Rule 457(a) under the Securities Act of 1933, as amended.

(3) | This registration fee only includes the payment of $22,103.81 for an additional $144,375,000 of shares, as the registrant previously paid $14,760.00 for the registration of $100,000,000 of shares under the Securities and Exchange Commission’s prior fee rate in effect until September 30, 2024.