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Stock-Based Compensation - Summary of Stock-Based Compensation Expense (Details) - 2018 Equity Inducement Plan and 2016 Employee Stock Purchase Plan - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended
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Sep. 30, 2018 | Sep. 30, 2017 | Sep. 30, 2018 | Sep. 30, 2017
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items] |  |  |  |
Total stock-based compensation expense | $ 1,072 | $ 728 | $ 2,903 | $ 1,794
Research and Development |  |  |  |
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items] |  |  |  |
Total stock-based compensation expense | 377 | 277 | 1,090 | 672
General and Administrative |  |  |  |
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items] |  |  |  |
Total stock-based compensation expense | $ 695 | $ 451 | $ 1,813 | $ 1,122

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