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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2018 | Sep. 30, 2017
CASH FLOWS FROM OPERATING ACTIVITIES |  |
Net loss | $ (29,450) | $ (20,753)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 221 | 183
Purchase net discount on marketable securities | 539 | 2
Net (accretion of discount) amortization of premium on marketable securities | (311) | 82
Stock-based compensation | 2,903 | 1,794
Research and development services settled with stock | 107 | 15
Other, net | (30) | (15)
Changes in operating assets and liabilities: |  |
Accounts receivable-grant | 656 | (1,237)
Prepaid expenses and other assets | (1,520) | 275
Accounts payable | 727 | 447
Deferred revenue | (20) | (21)
Accrued and other liabilities | 1,185 | 486
Net cash used in operating activities | (24,993) | (18,742)
CASH FLOWS FROM INVESTING ACTIVITIES |  |
Purchases of property and equipment | (219) | (428)
Purchases of marketable securities | (35,500) | (62,115)
Proceeds from maturities of marketable securities | 22,620 | 35,170
Net cash used in investing activities | (13,099) | (27,373)
CASH FLOWS FROM FINANCING ACTIVITIES |  |
Proceeds from issuance of common stock in public offering, net of offering costs | 37,654 | 11,380
Proceeds from employee stock plan purchases and stock option exercises | 2,153 | 149
Net cash provided by financing activities | 39,807 | 11,529
NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS | 1,715 | (34,586)
CASH AND CASH EQUIVALENTS |  |
Beginning of period | 12,817 | 47,748
End of period | 14,532 | $ 13,162
Supplemental Disclosure of Non-Cash Investing and Financing Information: |  |
Unpaid amounts related to purchase of property and equipment | $ 51 |

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