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Condensed Consolidated Statements of Changes in Stockholders' Equity (Unaudited) - USD ($) $ in Thousands | Total | Common Stock | Additional Paid-in Capital | Accumulated Other Comprehensive Income (Loss) | Accumulated Deficit
--- | --- | --- | --- | --- | ---
Balances at Dec. 31, 2017 | $ 50,337 | $ 2 | $ 122,950 | $ (102) | $ (72,513)
Balances (in shares) at Dec. 31, 2017 |  | 16,670,000 |  |  |
Issuance of common stock in connection with employee stock purchase plan | 78 |  | 78 |  |
Issuance of common stock in connection with employee stock purchase plan (in shares) |  | 31,000 |  |  |
Issuance of common stock in connection with exercise of stock options | 785 |  | 785 |  |
Issuance of common stock in connection with exercise of stock options (in shares) |  | 109,000 |  |  |
Stock-based compensation expense | 835 |  | 835 |  |
Unrealized gain on marketable securities | 4 |  |  | 4 |
Net loss | (8,119) |  |  |  | (8,119)
Balances at Mar. 31, 2018 | 43,920 | $ 2 | 124,648 | (98) | (80,632)
Balances (in shares) at Mar. 31, 2018 |  | 16,810,000 |  |  |
Balances at Dec. 31, 2017 | 50,337 | $ 2 | 122,950 | (102) | (72,513)
Balances (in shares) at Dec. 31, 2017 |  | 16,670,000 |  |  |
Unrealized gain on marketable securities | 46 |  |  |  |
Net loss | (17,533) |  |  |  |
Balances at Jun. 30, 2018 | 73,447 | $ 2 | 163,547 | (56) | (90,046)
Balances (in shares) at Jun. 30, 2018 |  | 21,908,000 |  |  |
Balances at Mar. 31, 2018 | 43,920 | $ 2 | 124,648 | (98) | (80,632)
Balances (in shares) at Mar. 31, 2018 |  | 16,810,000 |  |  |
Issuance of common stock in connection with exercise of stock options | 248 |  | 248 |  |
Issuance of common stock in connection with exercise of stock options (in shares) |  | 51,000 |  |  |
Issuance of common stock in connection with public offering, net of offering costs | 37,655 |  | 37,655 |  |
Issuance of common stock in connection with public offering,net of offering costs (in shares) |  | 5,047,000 |  |  |
Stock-based compensation expense | 996 |  | 996 |  |
Unrealized gain on marketable securities | 42 |  |  | 42 |
Net loss | (9,414) |  |  |  | (9,414)
Balances at Jun. 30, 2018 | 73,447 | $ 2 | 163,547 | (56) | (90,046)
Balances (in shares) at Jun. 30, 2018 |  | 21,908,000 |  |  |
Balances at Dec. 31, 2018 | 67,428 | $ 2 | 184,314 | (27) | (116,861)
Balances (in shares) at Dec. 31, 2018 |  | 24,140,000 |  |  |
Issuance of common stock in connection with employee stock purchase plan | 143 |  | 143 |  |
Issuance of common stock in connection with employee stock purchase plan (in shares) |  | 20,000 |  |  |
Issuance of common stock in connection with exercise of stock options | 261 |  | 261 |  |
Issuance of common stock in connection with exercise of stock options (in shares) |  | 52,000 |  |  |
Issuance of common stock and pre-funded warrants in connection with public offering, net of offering costs | 64,503 | $ 1 | 64,502 |  |
Issuance of common stock and pre-funded warrants in connection with public offering, net of offering costs (in shares) |  | 4,625,000 |  |  |
Stock-based compensation expense | 1,081 |  | 1,081 |  |
Unrealized gain on marketable securities | 40 |  |  | 40 |
Net loss | (17,167) |  |  |  | (17,167)
Balances at Mar. 31, 2019 | 116,289 | $ 3 | 250,301 | 13 | (134,028)
Balances (in shares) at Mar. 31, 2019 |  | 28,837,000 |  |  |
Balances at Dec. 31, 2018 | 67,428 | $ 2 | 184,314 | (27) | (116,861)
Balances (in shares) at Dec. 31, 2018 |  | 24,140,000 |  |  |
Unrealized gain on marketable securities | 94 |  |  |  |
Net loss | (35,186) |  |  |  |
Balances at Jun. 30, 2019 | 99,615 | $ 3 | 251,592 | 67 | (152,047)
Balances (in shares) at Jun. 30, 2019 |  | 28,848,000 |  |  |
Balances at Mar. 31, 2019 | 116,289 | $ 3 | 250,301 | 13 | (134,028)
Balances (in shares) at Mar. 31, 2019 |  | 28,837,000 |  |  |
Issuance of common stock in connection with exercise of stock options | 46 |  | 46 |  |
Issuance of common stock in connection with exercise of stock options (in shares) |  | 11,000 |  |  |
Stock-based compensation expense | 1,245 |  | 1,245 |  |
Unrealized gain on marketable securities | 54 |  |  | 54 |
Net loss | (18,019) |  |  |  | (18,019)
Balances at Jun. 30, 2019 | $ 99,615 | $ 3 | $ 251,592 | $ 67 | $ (152,047)
Balances (in shares) at Jun. 30, 2019 |  | 28,848,000 |  |  |

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