<SEC-DOCUMENT>0001567619-19-019921.txt : 20191023
<SEC-HEADER>0001567619-19-019921.hdr.sgml : 20191023
<ACCEPTANCE-DATETIME>20191023160850
ACCESSION NUMBER:		0001567619-19-019921
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20191021
FILED AS OF DATE:		20191023
DATE AS OF CHANGE:		20191023

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Hanley Jr. Michael Conick
		CENTRAL INDEX KEY:			0001791413

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-37722
		FILM NUMBER:		191163869

	MAIL ADDRESS:	
		STREET 1:		C/O AEGLEA THERAPEUTICS, INC.
		STREET 2:		901 S. MOPAC EXPRESSWAY, #250
		CITY:			AUSTIN
		STATE:			TX
		ZIP:			78746

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Aeglea BioTherapeutics, Inc.
		CENTRAL INDEX KEY:			0001636282
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				464312787
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		901 S. MOPAC EXPRESSWAY, STE. 250
		STREET 2:		BARTON OAKS PLAZA ONE
		CITY:			AUSTIN
		STATE:			TX
		ZIP:			78746
		BUSINESS PHONE:		(512) 942-2935

	MAIL ADDRESS:	
		STREET 1:		901 S. MOPAC EXPRESSWAY, STE. 250
		STREET 2:		BARTON OAKS PLAZA ONE
		CITY:			AUSTIN
		STATE:			TX
		ZIP:			78746
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>doc1.xml
<DESCRIPTION>FORM 3
<TEXT>
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<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2019-10-21</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001636282</issuerCik>
        <issuerName>Aeglea BioTherapeutics, Inc.</issuerName>
        <issuerTradingSymbol>AGLE</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001791413</rptOwnerCik>
            <rptOwnerName>Hanley Jr. Michael Conick</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>901 S. MOPAC EXPRESSWAY, #250</rptOwnerStreet1>
            <rptOwnerStreet2>BARTON OAKS PLAZA ONE</rptOwnerStreet2>
            <rptOwnerCity>AUSTIN</rptOwnerCity>
            <rptOwnerState>TX</rptOwnerState>
            <rptOwnerZipCode>78746</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Chief Commercial Officer</officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes></footnotes>

    <ownerSignature>
        <signatureName>/s/ Charles N. York II, by power of attorney</signatureName>
        <signatureDate>2019-10-23</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-24.1
<SEQUENCE>2
<FILENAME>poa_hanley.htm
<DESCRIPTION>POWER OF ATTORNEY
<TEXT>
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    <title></title>
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  <div>
    <div style="text-align: center; margin-bottom: 12pt; font-weight: bold;"><u>POWER OF ATTORNEY</u></div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt;"><font style="font-weight: bold;">KNOW ALL MEN BY THESE PRESENTS</font>, that the undersigned hereby constitutes and appoints Charles N. York II, Joey Perrone and Laurie Blain, and each of them, as his true and lawful attorney-in-fact to:</div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 72pt; margin-bottom: 12pt;">(1)<font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; width: 36pt;">&#160;</font>execute for and on behalf of the undersigned, in the undersigned&#8217;s capacity as a representative of Aeglea BioTherapeutics, Inc. (the &#8220;<font style="font-family: 'Times New Roman',Times,serif; font-weight: bold; font-style: italic;">Company</font>&#8221;), any and all Form ID, or Form 3, 4 or 5 reports and any amendments thereto required to be filed by the undersigned in accordance
        with Section 16(a) of the Securities Exchange Act of 1934 (the &#8220;Exchange Act&#8221;) and the rules thereunder with respect to transactions in the Company&#8217;s securities;</div>
    <div style="text-align: justify; text-indent: 72pt; margin-bottom: 12pt;">(2)<font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; width: 36pt;">&#160;</font>do and perform any and all acts for and on behalf of the undersigned which may be necessary or desirable to complete and execute any such Form
        ID, or Form 3, 4 or 5 report and any amendments thereto and timely file such report with the U.S. Securities and Exchange Commission and any stock exchange or similar authority; and</div>
    <div style="text-align: justify; text-indent: 72pt; margin-bottom: 12pt;">(3)<font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; width: 36pt;">&#160;</font>take any other action of any type whatsoever in connection with the foregoing which, in the opinion of such attorney&#8209;in-fact, may be of benefit
        to, in the best interest of, or legally required by, the undersigned, it being understood that the documents executed by such attorney&#8209;in-fact on behalf of the undersigned, pursuant to this Power of Attorney, shall be in such form and shall contain
        such terms and conditions as such attorney&#8209;in-fact may approve in his or her discretion.</div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;">The undersigned hereby grants to each such attorney-in-fact full power and authority to do and perform each and
      every act and thing whatsoever requisite, necessary, and proper to be done in the exercise of any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned might or could do if personally present, with full
      power of substitution or revocation, hereby ratifying and confirming all that such attorney-in-fact, or his or her substitute or substitutes, shall lawfully do or cause to be done by virtue of this Power of Attorney and the rights and powers herein
      granted.&#160; The undersigned acknowledges that no such attorney&#8209;in-fact, in serving in such capacity at the request of the undersigned, is hereby assuming, nor is the Company hereby assuming, any of the undersigned&#8217;s responsibilities to comply with
      Section 16 of the Exchange Act.</div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;">This Power of Attorney shall remain in full force and effect until the undersigned is no longer required to file
      Form 3, 4 or 5 reports with respect to the undersigned&#8217;s holdings of and transactions in securities issued by the Company, unless earlier revoked by the undersigned in a signed writing delivered to the foregoing attorneys&#8209;in-fact.</div>
    <div style="text-align: justify; text-indent: 36pt;"><font style="font-weight: bold;">IN WITNESS WHEREOF</font>, the undersigned has caused this Power of Attorney to be executed as of this 15th day of October, 2019.</div>
    <div><br>
    </div>
    <div style="margin-left: 252pt;"><u>/s/ Michael Conick Hanley, Jr.</u><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; width: 216pt;">&#160;</font><font style="font-family: 'Times New Roman',Times,serif;"><br>
        </font>Signature</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="margin-left: 252pt;"><font style="font-family: 'Times New Roman',Times,serif;"><u>Michael Conick Hanley, Jr.</u></font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; width: 216pt;">&#160;</font><font style="font-family: 'Times New Roman',Times,serif;"><br>
        </font>Full Name (Including middle name)</div>
    <div><br>
    </div>
    <div style="margin-bottom: 12pt;"><br>
    </div>
  </div>


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</SEC-DOCUMENT>
