<SEC-DOCUMENT>0001172661-19-000427-index.html : 20190213
<SEC-HEADER>0001172661-19-000427.hdr.sgml : 20190213
<ACCEPTANCE-DATETIME>20190212174244
ACCESSION NUMBER:		0001172661-19-000427
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20190213
DATE AS OF CHANGE:		20190212

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Aeglea BioTherapeutics, Inc.
		CENTRAL INDEX KEY:			0001636282
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				464312787
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-89456
		FILM NUMBER:		19592306

	BUSINESS ADDRESS:	
		STREET 1:		901 S. MOPAC EXPRESSWAY, STE. 250
		STREET 2:		BARTON OAKS PLAZA ONE
		CITY:			AUSTIN
		STATE:			TX
		ZIP:			78746
		BUSINESS PHONE:		(512) 942-2935

	MAIL ADDRESS:	
		STREET 1:		901 S. MOPAC EXPRESSWAY, STE. 250
		STREET 2:		BARTON OAKS PLAZA ONE
		CITY:			AUSTIN
		STATE:			TX
		ZIP:			78746

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ORBIMED ADVISORS LLC
		CENTRAL INDEX KEY:			0001055951
		IRS NUMBER:				133976876
		STATE OF INCORPORATION:			DE

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		601 LEXINGTON AVENUE
		STREET 2:		54TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		(212) 739-6400

	MAIL ADDRESS:	
		STREET 1:		601 LEXINGTON AVENUE
		STREET 2:		54TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>orbimed-agle123118a2.htm
<DESCRIPTION>SCHEDULE 13G HOLDINGS REPORT AMENDMENT
<TEXT>
Document 1 - file: orbimed-agle123118a2.htm

</DOCUMENT>
</SEC-DOCUMENT>