<SEC-DOCUMENT>0000899140-22-000301.txt : 20220214
<SEC-HEADER>0000899140-22-000301.hdr.sgml : 20220214
<ACCEPTANCE-DATETIME>20220214162549
ACCESSION NUMBER:		0000899140-22-000301
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20220214
DATE AS OF CHANGE:		20220214
GROUP MEMBERS:		CUBIST SYSTEMATIC STRATEGIES, LLC
GROUP MEMBERS:		POINT72 CAPITAL ADVISORS, INC.
GROUP MEMBERS:		POINT72 HONG KONG LTD
GROUP MEMBERS:		STEVEN A. COHEN

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Aeglea BioTherapeutics, Inc.
		CENTRAL INDEX KEY:			0001636282
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				464312787
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-89456
		FILM NUMBER:		22632715

	BUSINESS ADDRESS:	
		STREET 1:		805 LAS CIMAS PARKWAY
		STREET 2:		SUITE 100
		CITY:			AUSTIN
		STATE:			TX
		ZIP:			78746
		BUSINESS PHONE:		(512) 942-2935

	MAIL ADDRESS:	
		STREET 1:		805 LAS CIMAS PARKWAY
		STREET 2:		SUITE 100
		CITY:			AUSTIN
		STATE:			TX
		ZIP:			78746

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Point72 Asset Management, L.P.
		CENTRAL INDEX KEY:			0001603466
		IRS NUMBER:				465064661
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		72 CUMMINGS POINT ROAD
		CITY:			STAMFORD
		STATE:			CT
		ZIP:			06902
		BUSINESS PHONE:		203-890-2000

	MAIL ADDRESS:	
		STREET 1:		72 CUMMINGS POINT ROAD
		CITY:			STAMFORD
		STATE:			CT
		ZIP:			06902
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>a011822a.htm
<DESCRIPTION>SCHEDULE 13G (AMENDMENT #2)
<TEXT>
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    <div style="font-size: 12pt; font-weight: bold;">240.13d-102 Schedule 13G - Information to be included in statements filed</div>
    <div style="font-size: 12pt; font-weight: bold;">pursuant to 240.13d-1(b), (c), and (d) and amendments thereto</div>
    <div style="font-size: 12pt; font-weight: bold;">filed pursuant to 240.13d-2.</div>
    <div>
      <div style="text-indent: -24pt; margin-left: 24pt; margin-top: 10pt; margin-bottom: 5pt; font-size: 12pt;">Securities and Exchange Commission, Washington, D.C. 20549</div>
    </div>
    <div>
      <div style="margin-top: 10pt; margin-bottom: 12pt; font-size: 12pt;">Schedule 13G</div>
      <div style="margin-top: 10pt; margin-bottom: 12pt; font-size: 12pt;">Under the Securities Exchange Act of 1934</div>
      <div style="margin-top: 10pt; margin-bottom: 12pt; font-size: 12pt;">(Amendment No. 2)*</div>
      <div style="margin-top: 10pt; margin-bottom: 12pt; font-size: 12pt;">(Name of Issuer)</div>
      <div style="margin-top: 10pt; margin-bottom: 12pt; font-size: 12pt;">Aeglea Biotherapeutics, Inc.</div>
      <div style="margin-top: 10pt; margin-bottom: 12pt; font-size: 12pt;">(Title of Class of Securities)</div>
    </div>
    <div>
      <div style="font-size: 12pt;">Common Stock, $0.0001 Par Value Per Share</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">(CUSIP Number)</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">00773J103</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">(Date of Event Which Requires Filing of this Statement)</div>
    </div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">December 31, 2021</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">Check the appropriate box to designate the rule pursuant to which this</div>
    <div style="font-size: 12pt;">Schedule is filed:</div>
    <div>
      <div style="text-indent: -24pt; margin-left: 24pt; margin-top: 10pt; margin-bottom: 5pt; font-size: 12pt;">[&#160; ] Rule 13d-1(b)</div>
      <div style="text-indent: -24pt; margin-left: 24pt; margin-top: 10pt; margin-bottom: 5pt; font-size: 12pt;">[ x ] Rule 13d-1(c)</div>
      <div style="text-indent: -24pt; margin-left: 24pt; margin-top: 10pt; margin-bottom: 5pt; font-size: 12pt;">[&#160; ] Rule 13d-1(d)</div>
    </div>
    <div>
      <div style="margin-top: 10pt; margin-bottom: 5pt;"><font style="font-size: 12pt;">*The remainder of this cover page shall be filled out for a reporting person's<br>
          initial filing on this form with respect to the subject class of securities, and<br>
          for any subsequent amendment containing information which would alter the<br>
          disclosures provided in a prior cover page.<br>
          <br>
          The information required in the remainder of this cover page shall not be<br>
          deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the Securities Exchange<br>
          Act of 1934 (&#8220;Act&#8221;) or otherwise subject to the liabilities of that section of the<br>
          Act but shall be subject to all other provisions of the Act (however, see<br>
          the Notes).<br>
          </font><br>
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          <td style="width: 100%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);" colspan="2">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">CUSIP No. 00773J103</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.47%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(1) Names of reporting persons&#160; &#160; Point72 Asset Management, L.P.</div>
          </td>
          <td style="width: 6.53%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.47%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(2) Check the appropriate box if a member of a group</div>
          </td>
          <td style="width: 6.53%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(a)</div>
          </td>
        </tr>
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          <td style="width: 93.47%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-indent: 176.2pt; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 6.53%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(b)X</div>
          </td>
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          <td style="width: 93.47%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(3) SEC use only</div>
          </td>
          <td style="width: 6.53%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.47%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(4) Citizenship or place of organization Delaware</div>
          </td>
          <td style="width: 6.53%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.47%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">Number of shares beneficially owned by each reporting person with:</div>
          </td>
          <td style="width: 6.53%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.47%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(5) Sole voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; 0</div>
          </td>
          <td style="width: 6.53%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.47%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(6) Shared voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; 0 (see Item 4)</div>
          </td>
          <td style="width: 6.53%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.47%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(7) Sole dispositive power&#160; &#160; &#160; &#160; &#160;&#160; 0</div>
          </td>
          <td style="width: 6.53%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.47%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(8) Shared dispositive power&#160; &#160; &#160;&#160; 0 (see Item 4)</div>
          </td>
          <td style="width: 6.53%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.47%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(9) Aggregate amount beneficially owned by each reporting person</div>
            <div style="margin-left: 21.6pt; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">0 (see Item 4)</div>
          </td>
          <td style="width: 6.53%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.47%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(10) Check if the aggregate amount in Row (9) excludes certain shares</div>
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 6.53%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
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          <td style="width: 93.47%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(11) Percent of class represented by amount in Row (9) 0% (see Item 4)</div>
          </td>
          <td style="width: 6.53%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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          <td style="width: 93.47%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(12) Type of reporting person (see instructions) PN</div>
          </td>
          <td style="width: 6.53%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">&#160;</td>
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          <td style="width: 100%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);" colspan="2">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">CUSIP No. 00773J103</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.47%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(1) Names of reporting persons&#160; &#160; Point72 Capital Advisors, Inc.</div>
          </td>
          <td style="width: 6.53%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.47%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(2) Check the appropriate box if a member of a group</div>
          </td>
          <td style="width: 6.53%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(a)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.47%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-indent: 176.2pt; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 6.53%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(b)X</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.47%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(3) SEC use only</div>
          </td>
          <td style="width: 6.53%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.47%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(4) Citizenship or place of organization Delaware</div>
          </td>
          <td style="width: 6.53%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.47%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">Number of shares beneficially owned by each reporting person with:</div>
          </td>
          <td style="width: 6.53%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.47%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(5) Sole voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; 0</div>
          </td>
          <td style="width: 6.53%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.47%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(6) Shared voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; 0 (see Item 4)</div>
          </td>
          <td style="width: 6.53%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.47%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(7) Sole dispositive power&#160; &#160; &#160; &#160; &#160;&#160; 0</div>
          </td>
          <td style="width: 6.53%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.47%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(8) Shared dispositive power&#160; &#160; &#160;&#160; 0 (see Item 4)</div>
          </td>
          <td style="width: 6.53%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.47%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(9) Aggregate amount beneficially owned by each reporting person</div>
            <div style="margin-left: 21.6pt; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">0 (see Item 4)</div>
          </td>
          <td style="width: 6.53%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.47%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(10) Check if the aggregate amount in Row (9) excludes certain shares</div>
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 6.53%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.47%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(11) Percent of class represented by amount in Row (9) 0% (see Item 4)</div>
          </td>
          <td style="width: 6.53%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(12) Type of reporting person (see instructions) CO</div>
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          <td style="width: 6.53%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">&#160;</td>
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            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">CUSIP No. 00773J103</div>
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            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(1) Names of reporting persons&#160; &#160; Cubist Systematic Strategies, LLC</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(2) Check the appropriate box if a member of a group</div>
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          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(a)</div>
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            <div style="text-indent: 176.2pt; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(see instructions)</div>
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          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(b)X</div>
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            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(3) SEC use only</div>
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          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(4) Citizenship or place of organization Delaware</div>
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          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">Number of shares beneficially owned by each reporting person with:</div>
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          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(5) Sole voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; 0</div>
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          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(6) Shared voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; 55,945 (see Item 4)</div>
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          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(7) Sole dispositive power&#160; &#160; &#160; &#160; &#160;&#160; 0</div>
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          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(8) Shared dispositive power&#160; &#160; &#160;&#160; 55,945 (see Item 4)</div>
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          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(9) Aggregate amount beneficially owned by each reporting person</div>
            <div style="margin-left: 21.6pt; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">55,945 (see Item 4)</div>
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          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(10) Check if the aggregate amount in Row (9) excludes certain shares</div>
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(see instructions)</div>
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          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(11) Percent of class represented by amount in Row (9) 0.1% (see Item 4)</div>
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          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(12) Type of reporting person (see instructions) OO</div>
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            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">CUSIP No. 00773J103</div>
          </td>
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          <td style="width: 93.74%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(1) Names of reporting persons&#160; &#160; Point72 Hong Kong Limited</div>
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          <td style="width: 6.26%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(2) Check the appropriate box if a member of a group</div>
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          <td style="width: 6.26%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(a)</div>
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            <div style="text-indent: 176.2pt; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(see instructions)</div>
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          <td style="width: 6.26%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(b)X</div>
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            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(3) SEC use only</div>
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          <td style="width: 6.26%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(4) Citizenship or place of organization Hong Kong</div>
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          <td style="width: 93.74%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">Number of shares beneficially owned by each reporting person with:</div>
          </td>
          <td style="width: 6.26%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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          <td style="width: 93.74%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(5) Sole voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; 0</div>
          </td>
          <td style="width: 6.26%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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          <td style="width: 93.74%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(6) Shared voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; 153 (see Item 4)</div>
          </td>
          <td style="width: 6.26%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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          <td style="width: 93.74%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(7) Sole dispositive power&#160; &#160; &#160; &#160; &#160;&#160; 0</div>
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          <td style="width: 6.26%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(8) Shared dispositive power&#160; &#160; &#160;&#160; 153 (see Item 4)</div>
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          <td style="width: 6.26%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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          <td style="width: 93.74%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(9) Aggregate amount beneficially owned by each reporting person</div>
            <div style="margin-left: 21.6pt; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">153 (see Item 4)</div>
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          <td style="width: 6.26%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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          <td style="width: 93.74%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(10) Check if the aggregate amount in Row (9) excludes certain shares</div>
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 6.26%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(11) Percent of class represented by amount in Row (9) &lt;0.1% (see Item 4)</div>
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          <td style="width: 6.26%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(12) Type of reporting person (see instructions) OO</div>
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          <td style="width: 6.26%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">&#160;</td>
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            <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">CUSIP No. 00773J103</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(1) Names of reporting persons&#160; &#160; Steven A. Cohen</div>
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          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(2) Check the appropriate box if a member of a group</div>
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          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(a)</div>
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          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-indent: 176.2pt; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(see instructions)</div>
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          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(b)X</div>
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            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(3) SEC use only</div>
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          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(4) Citizenship or place of organization United States</div>
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          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">Number of shares beneficially owned by each reporting person with:</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(5) Sole voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; 0</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(6) Shared voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; 56,098 (see Item 4)</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(7) Sole dispositive power&#160; &#160; &#160; &#160; &#160;&#160; 0</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(8) Shared dispositive power&#160; &#160; &#160;&#160; 56,098 (see Item 4)</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(9) Aggregate amount beneficially owned by each reporting person</div>
            <div style="margin-left: 21.6pt; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">56,098 (see Item 4)</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(10) Check if the aggregate amount in Row (9) excludes certain shares</div>
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(11) Percent of class represented by amount in Row (9) 0.1% (see Item 4)</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(12) Type of reporting person (see instructions) IN</div>
          </td>
          <td style="width: 6.38%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">&#160;</td>
        </tr>

    </table>
    <div>
      <div><br>
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      </div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">Item 1(a) Name of issuer:</div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">Aeglea Biotherapeutics, Inc.</div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">Item 1(b) Address of issuer's principal executive offices:</div>
    </div>
    <div>
      <div style="margin-top: 10pt; margin-bottom: 12pt; font-size: 12pt;">805 Las Cimas Parkway, Suite 100, Austin, TX 78746</div>
    </div>
    <div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">2(a) Name of person filing:</div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">This statement is filed by: (i) Point72 Asset Management, L.P. (&#8220;Point72 Asset<br>
        Management&#8221;) with respect to shares of common stock, par value $0.0001 per share<br>
        (&#8220;Shares&#8221;), of the Issuer held by certain investment funds it manages; (ii)<br>
        Point72 Capital Advisors, Inc. (&#8220;Point72 Capital Advisors Inc.&#8221;) with respect<br>
        to Shares held by certain investment funds managed by Point72 Asset<br>
        Management; (iii) Cubist Systematic Strategies, LLC (&#8220;Cubist Systematic<br>
        Strategies&#8221;) with respect to Shares held by certain investment funds it<br>
        manages; (iv) Point72 Hong Kong Limited (&#8220;Point72 Hong Kong&#8221;) with respect to<br>
        Shares held by certain investment funds it manages; and (v) Steven A. Cohen<br>
        (&#8220;Mr. Cohen&#8221;) with respect to Shares beneficially owned by Point72 Asset<br>
        Management, Point72 Capital Advisors Inc., Cubist Systematic Strategies, and<br>
        Point72 Hong Kong.</div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">2(b) Address or principal business office or, if none, residence:</div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">The address of the principal business office of (i) Point72 Asset Management,<br>
        Point72 Capital Advisors Inc., and Mr. Cohen is 72 Cummings Point Road,<br>
        Stamford, CT 06902; (ii) Cubist Systematic Strategies is 55 Hudson Yards,<br>
        New York, NY 10001; and (iii) Point72 Hong Kong is 12th Floor, Chater House, 8<br>
        Connaught Road Central, Hong Kong.</div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">2(c) Citizenship:</div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">Point72 Asset Management is a Delaware limited partnership. Point72 Capital <br>
        Advisors Inc. is a Delaware corporation. Cubist Systematic Strategies is a Delaware <br>
        limited liability company. Point72 Hong Kong is a Hong Kong limited liability <br>
        company. Mr. Cohen is a United States citizen.</div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">2(d) Title of class of securities:</div>
    </div>
    <div>
      <div style="font-size: 12pt;">Common Stock, $0.0001 Par Value Per Share</div>
    </div>
    <div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">2(e) CUSIP Number:</div>
      <div><br>
      </div>
    </div>
    <div>
      <div style="font-size: 12pt;">00773J103</div>
    </div>
    <div>
      <div><br>
      </div>
    </div>
    <div style="font-size: 12pt; font-style: italic;">Item 3.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">Not applicable</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;"><font style="font-style: italic;">Item 4. </font>Ownership</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">As of the close of business on December 31, 2021:</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">1. Point72 Asset Management, L.P.</div>
    <div style="font-size: 12pt;">(a) Amount beneficially owned: 0</div>
    <div><font style="font-size: 12pt;">(b) Percent of class: 0%</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 144pt">&#160;</font></div>
    <div style="font-size: 12pt;">(c) Number of shares as to which the person has:</div>
    <div style="font-size: 12pt;">(i) Sole power to vote or to direct the vote: 0</div>
    <div><font style="font-size: 12pt;">(ii) Shared power to vote or to direct the vote: 0</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 288pt">&#160;</font></div>
    <div style="font-size: 12pt;">(iii) Sole power to dispose or to direct the disposition of: 0</div>
    <div style="font-size: 12pt;">(iv) Shared power to dispose or to direct the disposition of: 0</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">2. Point72 Capital Advisors, Inc.</div>
    <div style="font-size: 12pt;">(a) Amount beneficially owned: 0</div>
    <div><font style="font-size: 12pt;">(b) Percent of class: 0%</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 144pt">&#160;</font></div>
    <div style="font-size: 12pt;">(c) Number of shares as to which the person has:</div>
    <div style="font-size: 12pt;">(i) Sole power to vote or to direct the vote: 0</div>
    <div><font style="font-size: 12pt;">(ii) Shared power to vote or to direct the vote: 0</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 288pt">&#160;</font></div>
    <div style="font-size: 12pt;">(iii) Sole power to dispose or to direct the disposition of: 0</div>
    <div style="font-size: 12pt;">(iv) Shared power to dispose or to direct the disposition of: 0</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">3. Cubist Systematic Strategies, LLC</div>
    <div style="font-size: 12pt;">(a) Amount beneficially owned: 55,945</div>
    <div><font style="font-size: 12pt;">(b) Percent of class: 0.1%</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 144pt">&#160;</font></div>
    <div style="font-size: 12pt;">(c) Number of shares as to which the person has:</div>
    <div style="font-size: 12pt;">(i) Sole power to vote or to direct the vote: 0</div>
    <div><font style="font-size: 12pt;">(ii) Shared power to vote or to direct the vote: 55,945</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 288pt">&#160;</font></div>
    <div style="font-size: 12pt;">(iii) Sole power to dispose or to direct the disposition of: 0</div>
    <div style="font-size: 12pt;">(iv) Shared power to dispose or to direct the disposition of: 55,945</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">4. Point72 Hong Kong Limited</div>
    <div style="font-size: 12pt;">(a) Amount beneficially owned: 153</div>
    <div><font style="font-size: 12pt;">(b) Percent of class: &lt;0.1%</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 180pt">&#160;</font></div>
    <div style="font-size: 12pt;">(c) Number of shares as to which the person has:</div>
    <div style="font-size: 12pt;">(i) Sole power to vote or to direct the vote: 0</div>
    <div><font style="font-size: 12pt;">(ii) Shared power to vote or to direct the vote: 153</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 288pt">&#160;</font></div>
    <div style="font-size: 12pt;">(iii) Sole power to dispose or to direct the disposition of: 0</div>
    <div style="font-size: 12pt;">(iv) Shared power to dispose or to direct the disposition of: 153</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">5. Steven A. Cohen</div>
    <div style="font-size: 12pt;">(a) Amount beneficially owned: 56,098</div>
    <div><font style="font-size: 12pt;">(b) Percent of class: 0.1%</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 144pt">&#160;</font></div>
    <div style="font-size: 12pt;">(c) Number of shares as to which the person has:</div>
    <div style="font-size: 12pt;">(i) Sole power to vote or to direct the vote: 0</div>
    <div><font style="font-size: 12pt;">(ii) Shared power to vote or to direct the vote: 56,098</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 288pt">&#160;</font></div>
    <div style="font-size: 12pt;">(iii) Sole power to dispose or to direct the disposition of: 0</div>
    <div style="font-size: 12pt;">(iv) Shared power to dispose or to direct the disposition of: 56,098</div>
    <div>
      <div><br>
      </div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">Point72 Asset Management, Point72 Capital Advisors Inc., Cubist Systematic<br>
        Strategies, Point72 Hong Kong, and Mr. Cohen own directly no Shares. Pursuant<br>
        to an investment management agreement, Point72 Asset Management maintains<br>
        investment and voting power with respect to the securities held by certain<br>
        investment funds it manages. Point72 Capital Advisors Inc. is the general<br>
        partner of Point72 Asset Management. Pursuant to an investment management<br>
        agreement, Cubist Systematic Strategies maintains investment and voting power<br>
        with respect to the securities held by certain investment funds it manages.<br>
        Pursuant to an investment management agreement, Point72 Hong Kong maintains<br>
        investment and voting power with respect to the securities held by certain<br>
        investment funds it manages. Mr. Cohen controls each of Point72 Asset<br>
        Management, Point72 Capital Advisors Inc., Cubist Systematic Strategies, and<br>
        Point72 Hong Kong. As of December 31, 2021, by reason of the provisions of <br>
        Rule 13d-3 of the Securities Exchange Act of 1934, as amended, each of (i) Cubist <br>
        Systematic Strategies and Mr. Cohen may be deemed to beneficially own 55,945 <br>
        Shares (constituting approximately 0.1% of the Shares outstanding) and (ii) Point72 <br>
        Hong Kong and Mr. Cohen may be deemed to beneficially own 153 Shares <br>
        (constituting &lt;0.1% of the Shares outstanding). Each of Point72 Asset Management, <br>
        Point72 Capital Advisors Inc., Cubist Systematic Strategies, Point72 Hong Kong, <br>
        and Mr. Cohen disclaims beneficial ownership of any of the securities covered by <br>
        this statement.</div>
    </div>
    <div style="font-size: 12pt;"><font style="font-style: italic;">Item 5.&#160; </font>Ownership of 5 Percent or Less of a Class.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">If this statement is being filed to report the fact that as of the date hereof</div>
    <div style="font-size: 12pt;">the reporting person has ceased to be the beneficial owner of more than</div>
    <div style="font-size: 12pt;">5 percent of the class of securities, check the following [X].</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;"><font style="font-style: italic;">Item 6.</font>&#160; Ownership of More than 5 Percent on Behalf of
      Another Person.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">Not applicable</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;"><font style="font-style: italic;">Item 7.</font>&#160; Identification and Classification of the
      Subsidiary Which Acquired</div>
    <div style="font-size: 12pt;">the Security Being Reporting on by the Parent Holding Company or Control</div>
    <div style="font-size: 12pt;">Person.</div>
    <div>
      <div style="margin-top: 10pt; margin-bottom: 5pt; font-size: 12pt;">Not applicable</div>
      <div style="margin-top: 10pt; margin-bottom: 5pt; font-size: 12pt;"><font style="font-style: italic;">Item 8. </font>Identification
        and Classification of Members of the Group</div>
      <div><br>
      </div>
    </div>
    <div style="font-size: 12pt;">Not applicable</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;"><font style="font-style: italic;">Item 9.</font>&#160; Notice of Dissolution of Group.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">Not applicable</div>
    <div><br>
    </div>
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    </div>
    <div style="font-size: 12pt;"><font style="font-style: italic;">Item 10. </font>Certifications</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">By signing below I certify that, to the best of my knowledge and belief, the <br>
        securities referred to above were not acquired and are not held for the purpose <br>
        of or with the effect of changing or influencing the control of the issuer of the <br>
        securities and were not acquired and are not held in connection with or as a <br>
        participant in any transaction having that purpose or effect, other than activities <br>
        solely in connection with a nomination under&#167; 240.14a-11.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;"><font style="font-style: italic;">Signature.</font>&#160; After reasonable inquiry and to the best
      of my knowledge and belief,</div>
    <div style="font-size: 12pt;">I certify that the information set forth in this statement is true, complete</div>
    <div style="font-size: 12pt;">and correct.</div>
    <div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">Dated: <u>February 14, 2022</u></div>
      <div><br>
      </div>
    </div>
    <div style="margin-bottom: 10pt; font-size: 12pt;">POINT72 ASSET MANAGEMENT, L.P.</div>
    <div style="margin-bottom: 10pt; font-size: 12pt;">By: <u>/s/ Jason M. Colombo</u><br>
      Name: Jason M. Colombo<br>
      Title: Authorized Person</div>
    <div><br>
    </div>
    <div style="margin-bottom: 10pt; font-size: 12pt;">POINT72 CAPITAL ADVISORS, INC.</div>
    <div style="margin-bottom: 10pt; font-size: 12pt;">By: <u>/s/ Jason M. Colombo</u><br>
      Name: Jason M. Colombo<br>
      Title: Authorized Person</div>
    <div><br>
    </div>
    <div style="margin-bottom: 10pt; font-size: 12pt;">CUBIST SYSTEMATIC STRATEGIES, LLC</div>
    <div style="margin-bottom: 10pt; font-size: 12pt;">By: <u>/s/ Jason M. Colombo</u><br>
      Name: Jason M. Colombo<br>
      Title: Authorized Person<br>
      <br>
      <br>
      POINT72 HONG KONG LIMITED</div>
    <div style="margin-bottom: 10pt; font-size: 12pt;">By: <u>/s/ Jason M. Colombo</u><br>
      Name: Jason M. Colombo<br>
      Title: Authorized Person<br>
      <br>
      <br>
      STEVEN A. COHEN</div>
    <div style="margin-bottom: 10pt; font-size: 12pt;">By: <u>/s/ Jason M. Colombo</u><br>
      Name: Jason M. Colombo<br>
      Title: Authorized Person</div>
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