<SEC-DOCUMENT>0001193125-23-286398-index.html : 20231130
<SEC-HEADER>0001193125-23-286398.hdr.sgml : 20231130
<ACCEPTANCE-DATETIME>20231130171810
ACCESSION NUMBER:		0001193125-23-286398
CONFORMED SUBMISSION TYPE:	424B3
PUBLIC DOCUMENT COUNT:		5
FILED AS OF DATE:		20231130
DATE AS OF CHANGE:		20231130

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Spyre Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001636282
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				464312787
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B3
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-273769
		FILM NUMBER:		231456653

	BUSINESS ADDRESS:	
		STREET 1:		221 CRESCENT STREET
		STREET 2:		BUILDING 23, SUITE 105
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			02453
		BUSINESS PHONE:		6176515940

	MAIL ADDRESS:	
		STREET 1:		221 CRESCENT STREET
		STREET 2:		BUILDING 23, SUITE 105
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			02453

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Aeglea BioTherapeutics, Inc.
		DATE OF NAME CHANGE:	20150311
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B3
<SEQUENCE>1
<FILENAME>d855916d424b3.htm
<DESCRIPTION>424B3
<TEXT>
Document 1 - file: d855916d424b3.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>g855916dsp14a.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 2 - file: g855916dsp14a.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>g855916dsp14b.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 3 - file: g855916dsp14b.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>g855916g1128084939980.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 4 - file: g855916g1128084939980.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>5
<FILENAME>g855916g1201013539729.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 5 - file: g855916g1201013539729.jpg

</DOCUMENT>
</SEC-DOCUMENT>