    <SEC-DOCUMENT>0001193125-23-205011-index.html : 20230807
    <SEC-HEADER>0001193125-23-205011.hdr.sgml : 20230807
    <ACCEPTANCE-DATETIME>20230807162535
    ACCESSION NUMBER:		0001193125-23-205011
    CONFORMED SUBMISSION TYPE:	S-3
    PUBLIC DOCUMENT COUNT:		8
    FILED AS OF DATE:		20230807
    DATE AS OF CHANGE:		20230807

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Aeglea BioTherapeutics, Inc.
    		CENTRAL INDEX KEY:			0001636282
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				464312787
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		S-3
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-273769
    		FILM NUMBER:		231147951

    	BUSINESS ADDRESS:
    		STREET 1:		221 CRESCENT STREET
    		STREET 2:		BUILDING 17, SUITE 102B
    		CITY:			WALTHAM
    		STATE:			MA
    		ZIP:			02453
    		BUSINESS PHONE:		6176515940

    	MAIL ADDRESS:
    		STREET 1:		221 CRESCENT STREET
    		STREET 2:		BUILDING 17, SUITE 102B
    		CITY:			WALTHAM
    		STATE:			MA
    		ZIP:			02453
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>S-3
    <SEQUENCE>1
    <FILENAME>d541146ds3.htm
    <DESCRIPTION>S-3
    <TEXT>
    Document 1 - file: d541146ds3.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-5.1
    <SEQUENCE>2
    <FILENAME>d541146dex51.htm
    <DESCRIPTION>EX-5.1
    <TEXT>
    Document 2 - file: d541146dex51.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-23.1
    <SEQUENCE>3
    <FILENAME>d541146dex231.htm
    <DESCRIPTION>EX-23.1
    <TEXT>
    Document 3 - file: d541146dex231.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-FILING FEES
    <SEQUENCE>4
    <FILENAME>d541146dexfilingfees.htm
    <DESCRIPTION>EX-FILING FEES
    <TEXT>
    Document 4 - file: d541146dexfilingfees.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>5
    <FILENAME>g541146g0806211048287.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 5 - file: g541146g0806211048287.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>6
    <FILENAME>g541146g13n03.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 6 - file: g541146g13n03.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>7
    <FILENAME>g541146g13n10.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 7 - file: g541146g13n10.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>8
    <FILENAME>g541146g45k65.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 8 - file: g541146g45k65.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>