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v3.23.4

Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 9 Months Ended | 12 Months Ended
--- | --- | ---
Sep. 30, 2023 | Sep. 30, 2022 | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
CASH FLOWS FROM OPERATING ACTIVITIES |  |  |  |  |
Net loss | $ (275,610) | $ (64,993) | $ (83,815) | $ (65,801) | $ (80,893)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |  |  |
Depreciation and amortization | 744 | 1,182 | 1,567 | 1,576 | 996
Stock-based compensation | 8,405 | 5,684 | 7,111 | 8,038 | 6,256
Acquired in-process research and development | 130,188 | 0 |  |  |
Gain on sale of in-process research and development asset | (14,609) | 0 |  |  |
Lease ROU asset and leasehold improvement impairment loss | 2,580 | 0 |  |  |
Loss on disposal of long-lived assets | 915 | 0 |  |  |
Amortization of operating lease assets | 220 | 292 |  |  |
Net accretion of discount on marketable securities | (612) | (175) | (327) | 548 | 73
Other | 18 | 351 | (2) | 9 | (9)
Purchase net (premium) discount on marketable securities |  |  | 428 | (344) | (286)
Non-cash operating lease expense |  |  | 397 | 425 | 628
Changes in operating assets and liabilities: |  |  |  |  |
Prepaid expenses and other assets | 3,310 | (2,863) | (1,144) | (1,216) | (1,101)
Accounts payable | 1,001 | 859 |  |  |
Deferred revenue | 575 | (897) | (880) | 3,576 | 0
Development receivables | 212 | 146 | 440 | (815) | 0
Operating lease liabilities | (2,326) | (297) |  |  |
Accrued and other liabilities | (4,000) | (1,293) | (843) | (373) | (1,146)
Related party payable | (2,115) | 0 |  |  |
Accounts payable |  |  | (2,641) | 1,065 | (544)
Operating lease liabilities |  |  | (435) | (404) | 251
Net cash used in operating activities | (68,874) | (62,004) | (80,144) | (53,716) | (75,775)
CASH FLOWS FROM INVESTING ACTIVITIES |  |  |  |  |
Cash assumed from asset acquisition of Spyre | 3,035 | 0 |  |  |
Proceeds from sale of in-process research & development asset | 15,000 | 0 |  |  |
Purchases of property and equipment | 0 | (38) | (38) | (573) | (4,280)
Proceeds from sale of property and equipment | 475 | 0 |  |  |
Purchases of marketable securities | (112,631) | (35,000) | (39,500) | (133,079) | (129,000)
Proceeds from maturities and sales of marketable securities | 21,000 | 78,046 | 96,546 | 111,033 | 125,676
Net cash (used in) and provided by investing activities | (73,121) | 43,008 | 57,008 | (22,619) | (7,604)
CASH FLOWS FROM FINANCING ACTIVITIES |  |  |  |  |
Proceeds from issuance of Series A non-voting convertible preferred stock in connection with private placement, net of placement and other offering costs | 197,364 | 0 |  |  |
Proceeds from issuance of common stock and pre-funded warrants in registered direct offering, net of offering costs | 0 | 42,874 | 42,874 | 0 | 153,716
Proceeds from employee stock plan purchases and stock option exercises | 123 | 222 | 222 | 1,903 | 816
Principal payments on finance lease obligation | (16) | (410) | (418) | (510) | (20)
Net cash provided by financing activities | 197,471 | 42,686 | 42,678 | 1,393 | 154,512
Effect of exchange rate on cash, cash equivalents, and restricted cash | 7 | (152) | (106) | (15) | 51
NET INCREASE IN CASH, CASH EQUIVALENTS, AND RESTRICTED CASH | 55,483 | 23,538 | 19,436 | (74,957) | 71,184
CASH, CASH EQUIVALENTS, AND RESTRICTED CASH |  |  |  |  |
Beginning of period | 36,416 | 16,980 | 16,980 |  |
End of period | 91,899 | 40,518 | 36,416 | 16,980 |
Beginning of period | 36,416 | 16,980 | 16,980 | 91,937 | 20,753
End of period |  |  | 36,416 | 16,980 | 91,937
Supplemental Disclosure of Non-Cash Investing and Financing Information: |  |  |  |  |
Settlement of forward contract liability and issuance of Series A non-voting convertible preferred stock in connection with the asset acquisition of Spyre | 189,741 | 0 |  |  |
Leased assets obtained in exchange for lease obligations |  |  | 21 | 872 | 172
Unpaid amounts related to purchase of property and equipment |  |  | $ 0 | $ 0 | $ 224
CVR liability |  |  |  |  |
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |  |  |
Change in fair value of forward contract liability | (1,300) | 0 |  |  |
Forward contract liability |  |  |  |  |
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |  |  |
Change in fair value of forward contract liability | $ 83,530 | $ 0 |  |  |

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