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Related Party Transactions - Narrative (Details) $ in Thousands |  |  | 1 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | --- | --- | ---
Sep. 29, 2023 | Jun. 22, 2023 USD ($) BOARDSEAT | Jul. 31, 2023 USD ($) PROGRAMOPTION | Sep. 30, 2023 USD ($) BOARDSEAT | Sep. 30, 2023 USD ($) BOARDSEAT | Sep. 30, 2022 USD ($) | Dec. 31, 2022 USD ($) | Dec. 31, 2021 USD ($) | Dec. 31, 2020 USD ($) | Jul. 12, 2023 USD ($)
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |
Number of board seats held by related party | BOARDSEAT |  | 2 |  |  |  |  |  |  |  |
Stock compensation expense |  |  |  |  | $ 8,405 | $ 5,684 | $ 7,111 | $ 8,038 | $ 6,256 |
Related Party |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |
Accounts payable |  |  |  | $ 19,800 | $ 19,800 |  | 0 |  |  |
Appoint Of Board | Related Party |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |
Number of board seats held by related party | BOARDSEAT |  |  |  | 2 | 2 |  |  |  |  |
Paragon Agreement | Related Party |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |
Related party expenses incurred prior to asset acquisition |  | $ 19,000 |  |  |  |  |  |  |  |
Research initiation fees |  | 3,000 |  |  |  |  |  |  |  |
Reimbursable research costs |  | 16,000 |  |  |  |  |  |  |  |
Related party expenses unpaid prior to asset acquisition |  | $ 19,000 |  |  |  |  |  |  |  |
Percentage of annual equity grant of options |  |  |  | 1.00% | 1.00% |  |  |  |  |
Share-based payment award, term | 10 years |  |  |  |  |  |  |  |  |
Stock compensation expense |  |  |  | $ 2,700 | $ 2,900 |  |  |  |  |
Stock Compensation And Research And Development Expense | Related Party |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |
Amount of related party transaction |  |  |  | 19,400 | 20,800 |  |  |  |  |
Reimbursable Costs Under Paragon Agreement | Related Party |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |
Accounts payable |  |  |  | 16,800 | 16,800 |  | $ 0 |  |  |
Milestone Payments | Related Party |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |
Amount of related party transaction |  |  |  | $ 20,000 | $ 20,000 |  |  |  |  |
Licensing Agreements | Related Party |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |
Number of program options outstanding | PROGRAMOPTION |  |  | 3 |  |  |  |  |  |  |
SPY001 License Agreement | Maximum | Related Party |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |
Contingent obligation based on milestones |  |  |  |  |  |  |  |  |  | $ 22,000
Paragon Therapeutics Inc | Ownership Interest | Maximum | Related Party |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |
Percentage of ownership by noncontrolling owner |  |  |  | 5.00% | 5.00% |  |  |  |  |
Paragon Therapeutics Inc | SPY001 License Agreement | Maximum |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |
Contingent obligation based on milestones |  |  | $ 22,000 |  |  |  |  |  |  |
Fairmount Funds Management LLC | Ownership Interest | Minimum | Related Party |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |
Percentage of ownership by noncontrolling owner |  | 5.00% |  | 5.00% | 5.00% |  |  |  |  |
Percentage of ownership held in third party |  | 5.00% |  | 5.00% | 5.00% |  |  |  |  |
Paragon and Parapyre Holding LLC | Ownership Interest | Maximum | Related Party |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |
Percentage of ownership by noncontrolling owner |  | 5.00% |  |  |  |  |  |  |  |

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