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Related Party Transactions - Narrative (Details) $ / shares in Units, $ in Thousands |  |  |  |  | 1 Months Ended | 12 Months Ended
--- | --- | --- | --- | --- | --- | ---
Dec. 14, 2023 USD ($) | Nov. 22, 2023 installment $ / shares shares | Jul. 12, 2023 USD ($) | Jun. 22, 2023 USD ($) | May 31, 2023 USD ($) | Dec. 31, 2023 USD ($) seat shares | Dec. 31, 2022 USD ($) | Dec. 31, 2021 USD ($)
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |
Stock compensation expense |  |  |  |  |  | $ 25,675 | $ 7,111 | $ 8,038
Related party accounts payable and other current liabilities |  |  |  |  |  | 16,584 | 0 |
Proceeds from issuance of private placement |  |  |  |  |  | $ 84,555 | 0 | 0
Granted (in shares) | shares |  |  |  |  |  | 8,776,245 |  |
Related Party |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |
Related party accounts payable and other current liabilities |  |  |  |  |  | $ 16,600 | 0 |
Appoint Of Board Members |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |
Number of board seats held by related party | seat |  |  |  |  |  | 2 |  |
Paragon Agreement |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |
Related party expenses incurred prior to asset acquisition |  |  |  | $ 19,000 |  |  |  |
Related party expenses unpaid prior to asset acquisition |  |  |  | 19,000 |  |  |  |
Paragon Agreement | Related Party |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |
Research initiation fees |  |  |  | 3,000 | $ 3,000 |  |  |
Reimbursable research costs |  |  |  | $ 16,000 |  |  |  |
Stock compensation expense |  |  |  |  |  | $ 11,400 |  |
Stock Compensation And Research And Development Expense |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |
Related party transaction amount |  |  |  |  |  | 48,500 |  |
Reimbursable Costs Under Paragon Agreement | Related Party |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |
Related party accounts payable and other current liabilities |  |  |  |  |  | 16,600 | 0 |
Milestone Payments |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |
Related party transaction amount |  |  |  |  |  | 39,500 |  |
SPY001 License Agreement | Related Party |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |
Nomination fee |  |  | $ 1,500 |  |  |  |  |
Milestone payments |  |  | 2,500 |  |  |  |  |
SPY002 License Agreement | Related Party |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |
Nomination fee | $ 1,500 |  |  |  |  |  |  |
Milestone payments | 2,500 |  |  |  |  |  |  |
Sale Of Stock, December 2023 PIPE | Related Party |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |
Proceeds from issuance of private placement |  |  |  |  |  | 10,000 |  |
Consulting Agreement | Related Party |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |
Granted (in shares) | shares |  | 477,000 |  |  |  |  |  |
Exercise price (in dollars per share) | $ / shares |  | $ 10.39 |  |  |  |  |  |
Number of monthly installments | installment |  | 48 |  |  |  |  |  |
Stock-based compensation expense |  |  |  |  |  | $ 100 | $ 0 | $ 0
Consulting Agreement | Related Party | Share-Based Payment Arrangement, Tranche One |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |
Vesting percentage |  | 25.00% |  |  |  |  |  |
Awards granted, vesting period |  | 1 year |  |  |  |  |  |
Paragon Therapeutics Inc | Ownership Interest | Maximum | Related Party |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |
Percentage of ownership by noncontrolling owner |  |  |  |  |  | 5.00% |  |
Paragon Therapeutics Inc | SPY001 License Agreement | Maximum | Related Party |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |
Contingent obligation based on milestones |  |  | $ 22,000 |  |  |  |  |
Paragon Therapeutics Inc | SPY002 License Agreement | Maximum | Related Party |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |
Contingent obligation based on milestones | $ 22,000 |  |  |  |  |  |  |
Fairmount Funds Management LLC | Ownership Interest | Minimum | Related Party |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |
Percentage of ownership by noncontrolling owner |  |  |  |  |  | 5.00% |  |
Percentage of ownership held in third party |  |  |  |  |  | 5.00% |  |

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