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Stock-Based Compensation - Narrative (Details) - USD ($) |  | 1 Months Ended | 12 Months Ended |  |  |  |  |
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Jun. 22, 2023 | Nov. 30, 2023 | Feb. 28, 2023 | Jul. 31, 2020 | Oct. 31, 2018 | Jun. 30, 2018 | Feb. 28, 2018 | Apr. 30, 2016 | Mar. 31, 2015 | Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021 | Sep. 29, 2023 | Jan. 01, 2023 | Jan. 01, 2022 | Jan. 01, 2021 | Jan. 01, 2020
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Outstanding option awards (in shares) |  |  |  |  |  |  |  |  |  | 8,497,395 | 405,082 |  |  |  |  |  |
Stock compensation expense |  |  |  |  |  |  |  |  |  | $ 25,675,000 | $ 7,111,000 | $ 8,038,000 |  |  |  |  |
Tax benefits recognized |  |  |  |  |  |  |  |  |  | $ 0 | $ 0 | $ 0 |  |  |  |  |
Expected dividend yield |  |  |  |  |  |  |  |  |  | 0.00% | 0.00% | 0.00% |  |  |  |  |
Parapyre Option Obligation |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Percentage of annual grant of common stock outstanding for warrants | 1.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants term |  |  |  |  |  |  |  |  |  |  |  |  | 10 years |  |  |  |
Warrant grant date fair value | $ 11,500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Liability assumed in asset acquisition related to warrants | $ 100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock compensation expense |  |  |  |  |  |  |  |  |  | $ 11,400,000 | $ 0 | $ 0 |  |  |  |  |
Warrant unamortized expense |  |  |  |  |  |  |  |  |  | $ 0 |  |  |  |  |  |  |
Stock Options |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Weighted-average grant date fair value (in dollars per share) |  |  |  |  |  |  |  |  |  | $ 9.67 | $ 1.80 | $ 4.96 |  |  |  |  |
Intrinsic value of options exercised |  |  |  |  |  |  |  |  |  | $ 400,000 | $ 0 | $ 700,000 |  |  |  |  |
Unrecognized stock-based compensation expense for options |  |  |  |  |  |  |  |  |  | $ 64,400,000 |  |  |  |  |  |  |
Weighted average period over which unrecognized compensation is expected to be recognized |  |  |  |  |  |  |  |  |  | 3 years 6 months |  |  |  |  |  |  |
Expected dividend yield |  |  |  |  |  |  |  |  |  | 0.00% | 0.00% | 0.00% |  |  |  |  |
Stock Options | Non- Employees |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock option issued (in shares) |  |  |  |  |  |  |  |  |  | 477,000 | 0 | 0 |  |  |  |  |
Stock option vested (in shares) |  |  |  |  |  |  |  |  |  | 0 | 0 | 0 |  |  |  |  |
Restricted Stock Units (RSUs) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares, granted to employees (in shares) |  |  |  |  |  |  |  |  |  | 153,865 | 0 | 0 |  |  |  |  |
Restricted Stock Units (RSUs) | Non- Employees |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares, granted to employees (in shares) |  |  |  |  |  |  |  |  |  | 0 | 0 | 0 |  |  |  |  |
Performance Shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Expense recognized for unvested employee and non-employee awards |  |  |  |  |  |  |  |  |  | $ 0 | $ 0 | $ 0 |  |  |  |  |
2015 Equity Incentive Plan |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Percentage of market value of common stock |  |  |  |  |  |  |  |  | 100.00% |  |  |  |  |  |  |  |
Grantees with more than five years vesting term, percent |  |  |  |  |  |  |  |  | 10.00% |  |  |  |  |  |  |  |
Maximum vesting term for more than ten percent grantees |  |  |  |  |  |  |  |  | 5 years |  |  |  |  |  |  |  |
Shares subject to options outstanding (in shares) |  |  |  |  |  |  |  |  |  | 3,029 |  |  |  |  |  |  |
Available for issuance (in shares) |  |  |  |  |  |  |  | 20,395 |  |  |  |  |  |  |  |  |
2015 Equity Incentive Plan | Stock Options |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Awards granted, expiration period |  |  |  |  |  |  |  |  | 10 years |  |  |  |  |  |  |  |
2016 Equity Incentive Plan |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Initial reserves of common stock (in shares) |  |  |  |  |  |  |  | 44,000 |  |  |  |  |  |  |  |  |
Increase in common stock reserved for issuance (in shares) |  |  |  |  | 70,384 |  |  |  |  |  |  |  |  |  |  |  |
Annual percentage of additional shares |  | 5.00% |  |  | 4.00% |  |  |  |  |  |  |  |  |  |  |  |
Additional common stock available for issuance (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  | 104,561 | 78,968 | 76,735 |
Additional shares authorized (in shares) |  | 4,481,152 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Annual limit for non-employee director compensation (in shares) |  |  |  |  |  |  |  | 4,000 |  |  |  |  |  |  |  |  |
Annual limit for non-employee director compensation |  | $ 750,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Non-employee director compensation |  | $ 1,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares reserved for issuance (in shares) |  |  |  |  |  |  |  |  |  | 5,019,177 |  |  |  |  |  |  |
Outstanding option awards (in shares) |  |  |  |  |  |  |  |  |  | 3,294,962 |  |  |  |  |  |  |
2016 Equity Incentive Plan | Restricted Stock Units (RSUs) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares, granted to employees (in shares) |  |  |  | 9,128 |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation expense |  |  |  |  |  |  |  |  |  | $ 0 |  |  |  |  |  |  |
Equity instruments other than options, vested (in shares) |  |  |  |  |  |  |  |  |  | 0 |  |  |  |  |  |  |
2018 Equity Inducement Plan |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Initial reserves of common stock (in shares) |  |  |  |  |  |  | 44,000 |  |  |  |  |  |  |  |  |  |
Additional shares authorized (in shares) |  |  |  |  |  |  |  |  |  | 6,000,000 |  |  |  |  |  |  |
Shares reserved for issuance (in shares) |  |  |  |  |  |  |  |  |  | 6,044,000 |  |  |  |  |  |  |
Outstanding option awards (in shares) |  |  |  |  |  |  |  |  |  | 5,350,595 |  |  |  |  |  |  |
2018 Plan, 2016 Plan and 2015 Plan | Service Based Awards |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Awards granted, expiration period |  |  |  |  |  |  | 10 years |  |  |  |  |  |  |  |  |  |
Awards granted, vesting period |  |  |  |  |  |  | 4 years |  |  |  |  |  |  |  |  |  |
Spyre 2023 Equity Incentive Plan |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Outstanding option awards (in shares) | 2,734 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
2016 Employee Stock Purchase Plan |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Awards granted, expiration period |  |  |  |  |  |  |  | 10 years |  |  |  |  |  |  |  |  |
Additional common stock available for issuance (in shares) |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 26,140 | 19,742 | 19,184
Shares reserved for issuance (in shares) |  |  |  |  |  |  |  | 6,600 |  | 72,404 |  |  |  |  |  |  |
Percentage of fair market value of common stock |  |  |  |  |  |  |  | 85.00% |  |  |  |  |  |  |  |  |
Percentage of discount through payroll deductions to eligible employees to purchase common stock |  |  |  |  |  |  |  | 15.00% |  |  |  |  |  |  |  |  |
Maximum purchase value per employee under employee stock purchase plan |  |  |  |  |  |  |  | $ 25,000 |  |  |  |  |  |  |  |  |
Additional annual percentage increase of common stock |  |  |  |  |  | 1.00% |  |  |  |  |  |  |  |  |  |  |
Maximum shares purchased under employee stock purchase plan (in shares) |  |  | 400 |  |  |  |  | 80 |  |  |  |  |  |  |  |  |
Stock-based compensation expense |  |  |  |  |  |  |  |  |  | $ 0 | $ 100,000 | $ 200,000 |  |  |  |  |
Expected dividend yield |  |  |  |  |  |  |  |  |  | 0.00% | 0.00% | 0.00% |  |  |  |  |

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