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Consolidated Statements of Changes in Convertible Preferred Stock and Stockholders’ Equity - USD ($) $ in Thousands | Total | Private Placement | Conversion Of Series A Non-Voting Convertible Preferred Stock | Series A Non-Voting Convertible Preferred Stock | Series A Non-Voting Convertible Preferred Stock Series A Non-Voting Convertible Preferred Stock | Series A Non-Voting Convertible Preferred Stock Series A Non-Voting Convertible Preferred Stock Conversion Of Series A Non-Voting Convertible Preferred Stock | Common Stock | Common Stock Private Placement | Common Stock Conversion Of Series A Non-Voting Convertible Preferred Stock | Common Stock Conversion Of Pre-Funded Warrants | Additional Paid-in Capital | Additional Paid-in Capital Private Placement | Additional Paid-in Capital Conversion Of Series A Non-Voting Convertible Preferred Stock | Accumulated Other Comprehensive (Loss) Income | Accumulated Deficit
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Beginning balance (in shares) at Dec. 31, 2020 | 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Beginning balance at Dec. 31, 2020 | $ 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending balance (in shares) at Dec. 31, 2021 | 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending balance at Dec. 31, 2021 | $ 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Beginning balance (in shares) at Dec. 31, 2020 |  |  |  |  | 0 |  |  |  |  |  |  |  |  |  |
Beginning balance (in shares) at Dec. 31, 2020 |  |  |  |  |  |  | 1,918,000 |  |  |  |  |  |  |  |
Beginning balance at Dec. 31, 2020 | 139,832 |  |  |  | $ 0 |  | $ 5 |  |  |  | $ 415,824 |  |  | $ 11 | $ (276,008)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock upon conversion (in shares) |  |  |  |  |  |  | 40,000 |  |  |  |  |  |  |  |
Issuance of common stock in connection with exercise of stock options and employee stock purchase plan (in shares) |  |  |  |  |  |  | 16,000 |  |  |  |  |  |  |  |
Issuance of common stock in connection with exercise of stock options and employee stock purchase plan | 1,903 |  |  |  |  |  |  |  |  |  | 1,903 |  |  |  |
Stock-based compensation expense | 8,038 |  |  |  |  |  |  |  |  |  | 8,038 |  |  |  |
Foreign currency translation adjustment | (1) |  |  |  |  |  |  |  |  |  |  |  |  | (1) |
Unrealized gain (loss) on marketable securities | (30) |  |  |  |  |  |  |  |  |  |  |  |  | (30) |
Net loss | (65,801) |  |  |  |  |  |  |  |  |  |  |  |  |  | (65,801)
Ending balance (in shares) at Dec. 31, 2021 |  |  |  |  | 0 |  |  |  |  |  |  |  |  |  |
Ending balance (in shares) at Dec. 31, 2021 |  |  |  |  |  |  | 1,974,000 |  |  |  |  |  |  |  |
Ending balance at Dec. 31, 2021 | $ 83,941 |  |  |  | $ 0 |  | $ 5 |  |  |  | 425,765 |  |  | (20) | (341,809)
Ending balance (in shares) at Dec. 31, 2022 | 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending balance at Dec. 31, 2022 | $ 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock and pre-funded warrants in connection with registered direct offering, net of offering costs (in shares) |  |  |  |  |  |  | 430,000 |  |  |  |  |  |  |  |
Issuance of common stock and pre-funded warrants in connection with registered direct offering, net of offering costs | 42,874 |  |  |  |  |  | $ 1 |  |  |  | 42,873 |  |  |  |
Issuance of common stock upon conversion (in shares) |  |  |  |  |  |  | 204,000 |  |  |  |  |  |  |  |
Issuance of common stock in connection with employee stock purchase plan (in shares) |  |  |  |  |  |  | 6,000 |  |  |  |  |  |  |  |
Issuance of common stock in connection with employee stock purchase plan | 222 |  |  |  |  |  |  |  |  |  | 222 |  |  |  |
Stock-based compensation expense | 7,111 |  |  |  |  |  |  |  |  |  | 7,111 |  |  |  |
Foreign currency translation adjustment | (35) |  |  |  |  |  |  |  |  |  |  |  |  | (35) |
Unrealized gain (loss) on marketable securities | 7 |  |  |  |  |  |  |  |  |  |  |  |  | 7 |
Net loss | $ (83,815) |  |  |  |  |  |  |  |  |  |  |  |  |  | (83,815)
Ending balance (in shares) at Dec. 31, 2022 |  |  |  | 0 | 0 |  |  |  |  |  |  |  |  |  |
Ending balance (in shares) at Dec. 31, 2022 | 2,614,014 |  |  |  |  |  | 2,614,000 |  |  |  |  |  |  |  |
Ending balance at Dec. 31, 2022 | $ 50,305 |  |  |  | $ 0 |  | $ 6 |  |  |  | 475,971 |  |  | (48) | (425,624)
Series B Non-Voting Convertible Preferred Stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of Series B non-voting convertible preferred stock in connection with private placement, net of financing costs (in shares) | 150,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of Series B non-voting convertible preferred stock in connection with private placement, net of financing costs | $ 84,555 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending balance (in shares) at Dec. 31, 2023 | 150,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending balance at Dec. 31, 2023 | $ 84,555 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock upon conversion (in shares) |  |  |  |  |  | (649,000) |  |  | 25,972,000 | 905,000 |  |  |  |  |
Issuance of common stock upon conversion |  |  | $ 0 |  |  | $ (202,178) |  |  | $ 3 |  |  |  | $ 202,175 |  |
Issuance of stock (in shares) |  |  |  |  | 721,000 |  |  | 6,000,000 |  |  |  |  |  |  |
Issuance of stock | 197,364 | $ 84,555 |  |  | $ 197,364 |  |  |  |  |  |  | $ 84,555 |  |  |
Issuance of Series A non-voting convertible preferred stock in connection with the asset acquisition of Spyre and settlement of related forward contract (in shares) |  |  |  |  | 365,000 |  |  |  |  |  |  |  |  |  |
Issuance of Series A non-voting convertible preferred stock in connection with the asset acquisition of Spyre and settlement of related forward contract | 189,741 |  |  |  | $ 189,741 |  |  |  |  |  |  |  |  |  |
Issuance of common stock in connection with the asset acquisition of Spyre (in shares) |  |  |  |  |  |  | 518,000 |  |  |  |  |  |  |  |
Issuance of common stock in connection with the asset acquisition of Spyre | 3,768 |  |  |  |  |  | $ 1 |  |  |  | 3,767 |  |  |  |
Issuance of common stock in connection with exercise of stock options and employee stock purchase plan (in shares) |  |  |  |  |  |  | 48,000 |  |  |  |  |  |  |  |
Issuance of common stock in connection with exercise of stock options and employee stock purchase plan | 405 |  |  |  |  |  |  |  |  |  | 405 |  |  |  |
CVR distribution to common stockholders | (29,500) |  |  |  |  |  |  |  |  |  | (29,500) |  |  |  |
Stock-based compensation expense | 14,347 |  |  |  |  |  |  |  |  |  | 14,347 |  |  |  |
Issuance of Parapyre Option Obligation warrants | 11,471 |  |  |  |  |  |  |  |  |  | 11,471 |  |  |  |
Foreign currency translation adjustment | 37 |  |  |  |  |  |  |  |  |  |  |  |  | 37 |
Unrealized gain (loss) on marketable securities | 313 |  |  |  |  |  |  |  |  |  |  |  |  | 313 |
Net loss | $ (338,790) |  |  |  |  |  |  |  |  |  |  |  |  |  | (338,790)
Ending balance (in shares) at Dec. 31, 2023 |  |  |  | 437,037 | 437,000 |  |  |  |  |  |  |  |  |  |
Ending balance (in shares) at Dec. 31, 2023 | 36,057,109 |  |  |  |  |  | 36,057,000 |  |  |  |  |  |  |  |
Ending balance at Dec. 31, 2023 | $ 184,016 |  |  |  | $ 184,927 |  | $ 10 |  |  |  | $ 763,191 |  |  | $ 302 | $ (764,414)

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- Definition Carrying amount, attributable to parent, of an entity's issued and outstanding stock which is not included within permanent equity. Temporary equity is a security with redemption features that are outside the control of the issuer, is not classified as an asset or liability in conformity with GAAP, and is not mandatorily redeemable. Includes any type of security that is redeemable at a fixed or determinable price or on a fixed or determinable date or dates, is redeemable at the option of the holder, or has conditions for redemption which are not solely within the control of the issuer. Includes stock with a put option held by an ESOP and stock redeemable by a holder only in the event of a change in control of the issuer. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 944 -SubTopic 210 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SX 210.7-03(a)(23)(a)(1)) -Publisher FASB -URI https://asc.fasb.org//1943274/2147479440/944-210-S99-1 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.E.Q2) -Publisher FASB -URI https://asc.fasb.org//1943274/2147479830/718-10-S99-1 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Topic 470 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1A -Subparagraph (SX 210.13-01(a)(4)(i)) -Publisher FASB -URI https://asc.fasb.org//1943274/2147480097/470-10-S99-1A Reference 4: http://www.xbrl.org/2003/role/disclosureRef -Topic 470 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1A -Subparagraph (SX 210.13-01(a)(4)(iv)) -Publisher FASB -URI https://asc.fasb.org//1943274/2147480097/470-10-S99-1A Reference 5: http://www.xbrl.org/2003/role/disclosureRef -Topic 470 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1A -Subparagraph (SX 210.13-01(a)(5)) -Publisher FASB -URI https://asc.fasb.org//1943274/2147480097/470-10-S99-1A Reference 6: http://www.xbrl.org/2003/role/disclosureRef -Topic 470 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1B -Subparagraph (SX 210.13-02(a)(4)(i)) -Publisher FASB -URI https://asc.fasb.org//1943274/2147480097/470-10-S99-1B Reference 7: http://www.xbrl.org/2003/role/disclosureRef -Topic 470 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1B -Subparagraph (SX 210.13-02(a)(4)(iv)) -Publisher FASB -URI https://asc.fasb.org//1943274/2147480097/470-10-S99-1B Reference 8: http://www.xbrl.org/2003/role/disclosureRef -Topic 470 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1B -Subparagraph (SX 210.13-02(a)(5)) -Publisher FASB -URI https://asc.fasb.org//1943274/2147480097/470-10-S99-1B + Details
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- Definition The number of securities classified as temporary equity that have been issued and are held by the entity's shareholders. Securities outstanding equals securities issued minus securities held in treasury. Temporary equity is a security with redemption features that are outside the control of the issuer, is not classified as an asset or liability in conformity with GAAP, and is not mandatorily redeemable. Includes any type of security that is redeemable at a fixed or determinable price or on a fixed or determinable date or dates, is redeemable at the option of the holder, or has conditions for redemption which are not solely within the control of the issuer. If convertible, the issuer does not control the actions or events necessary to issue the maximum number of shares that could be required to be delivered under the conversion option if the holder exercises the option to convert the stock to another class of equity. If the security is a warrant or a rights issue, the warrant or rights issue is considered to be temporary equity if the issuer cannot demonstrate that it would be able to deliver upon the exercise of the option by the holder in all cases. Includes stock with put option held by ESOP and stock redeemable by holder only in the event of a change in control of the issuer. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 210 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(27)(b)) -Publisher FASB -URI https://asc.fasb.org//1943274/2147480566/210-10-S99-1 + Details
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- Definition Value of new stock classified as temporary equity issued during the period. + References No definition available. + Details
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