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    PUBLIC DOCUMENT COUNT:		19
    CONFORMED PERIOD OF REPORT:	20240513
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    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Spyre Therapeutics, Inc.
    		CENTRAL INDEX KEY:			0001636282
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		ORGANIZATION NAME:           	03 Life Sciences
    		IRS NUMBER:				464312787
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

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    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-37722
    		FILM NUMBER:		24809164

    	BUSINESS ADDRESS:
    		STREET 1:		221 CRESCENT STREET
    		STREET 2:		BUILDING 23, SUITE 105
    		CITY:			WALTHAM
    		STATE:			MA
    		ZIP:			02453
    		BUSINESS PHONE:		6176515940

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    		STREET 1:		221 CRESCENT STREET
    		STREET 2:		BUILDING 23, SUITE 105
    		CITY:			WALTHAM
    		STATE:			MA
    		ZIP:			02453

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    		FORMER CONFORMED NAME:	Aeglea BioTherapeutics, Inc.
    		DATE OF NAME CHANGE:	20150311
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