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Description of the Business and Summary of Significant Accounting Policies - Summary of Asset Acquisition Cost (Details) - USD ($) $ in Thousands |  | 12 Months Ended
--- | --- | ---
Jun. 22, 2023 | Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Asset Acquisition [Line Items] |  |  |  |
Acquired in-process research and development |  | $ 130,188 | $ 0 | $ 0
Cash acquired |  | $ 3,035 | $ 0 | $ 0
Cost to acquire asset | $ 113,200 |  |  |
Spyre Therapeutics, Inc. |  |  |  |
Asset Acquisition [Line Items] |  |  |  |
Consideration transferred in Series A Preferred Stock and common stock | 109,979 |  |  |
Transaction costs incurred by Aeglea | 3,197 |  |  |
Acquired in-process research and development | 130,188 |  |  |
Cash acquired | 3,035 |  |  |
Accrued liabilities | (20,047) |  |  |
Cost to acquire asset | $ 113,176 |  |  |

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