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Sale of Pegzilarginase to Immedica (Details) - USD ($) $ in Thousands |  | 12 Months Ended
--- | --- | ---
Jul. 27, 2023 | Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items] |  |  |  |
Proceeds from sale of intangible assets |  | $ 15,000 | $ 0 | $ 0
Gain on sale of in-process research and development asset |  | $ 16,449 | $ 0 | $ 0
Disposal Group, Disposed of by Sale, Not Discontinued Operations | Global Rights To Pegzilarginase |  |  |  |
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items] |  |  |  |
Proceeds from sale of intangible assets | $ 15,000 |  |  |
Contingent consideration | 100,000 |  |  |
Carrying value of assets | 0 |  |  |
Gain on sale of in-process research and development asset | 16,400 |  |  |
Contingent reimbursement of pre-paid manufacturing costs | 1,800 |  |  |
Derecognition of nonfinancial assets and liabilities | $ 400 |  |  |

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