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Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
CASH FLOWS FROM OPERATING ACTIVITIES |  |  |
Net loss | $ (338,790) | $ (83,815) | $ (65,801)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 744 | 1,567 | 1,576
Stock-based compensation | 25,675 | 7,111 | 8,038
Acquired in-process research and development | 130,188 | 0 | 0
Gain on sale of in-process research and development asset | (16,449) | 0 | 0
Lease ROU asset and leasehold improvement impairment loss | 2,580 | 0 | 0
Loss on disposal of long-lived assets | 915 | 0 | 0
Net (accretion of discount) amortization of premium on marketable securities | (2,318) | (327) | 548
Amortization of operating lease assets | 220 | 397 | 425
Other | 15 | 426 | (335)
Changes in operating assets and liabilities: |  |  |
Development receivables | 375 | 440 | (815)
Accounts payable | 218 | (2,641) | 1,065
Prepaid expenses and other assets | 3,245 | (1,144) | (1,216)
Deferred revenue | 575 | (880) | 3,576
Operating lease liabilities | (2,326) | (435) | (404)
Accrued and other liabilities | (4,891) | (843) | (373)
Related party payable | (2,402) | 0 | 0
Net cash used in operating activities | (99,910) | (80,144) | (53,716)
CASH FLOWS FROM INVESTING ACTIVITIES |  |  |
Cash assumed from asset acquisition of Spyre | 3,035 | 0 | 0
Proceeds from sale of in-process research & development asset | 15,000 | 0 | 0
Purchases of property and equipment | 0 | (38) | (573)
Proceeds from the sale of property plant and equipment | 475 | 0 | 0
Purchases of marketable securities | (166,803) | (39,500) | (133,079)
Proceeds from maturities and sales of marketable securities | 39,900 | 96,546 | 111,033
Net cash provided by (used in) investing activities | (108,393) | 57,008 | (22,619)
CASH FLOWS FROM FINANCING ACTIVITIES |  |  |
Proceeds from issuance of Series A non-voting convertible preferred stock in connection with private placement, net of placement and other offering costs | 197,364 | 0 | 0
Proceeds from issuance of Series B non-voting convertible preferred stock in connection with private placement, net of placement and other offering costs | 84,555 | 0 | 0
Proceeds from issuance of common stock in connection with private placement, net of placement and other offering costs | 84,555 | 0 | 0
Payment of contingent value rights liability | (5,786) | 0 | 0
Proceeds from issuance of common stock and pre-funded warrants in registered direct offering, net of offering costs | 0 | 42,874 | 0
Proceeds from employee stock plan purchases and stock option exercises | 405 | 222 | 1,903
Principal payments on finance lease obligation | (16) | (418) | (510)
Net cash provided by financing activities | 361,077 | 42,678 | 1,393
Effect of exchange rate on cash, cash equivalents, and restricted cash | 25 | (106) | (15)
NET INCREASE (DECREASE) IN CASH, CASH EQUIVALENTS, AND RESTRICTED CASH | 152,799 | 19,436 | (74,957)
CASH, CASH EQUIVALENTS, AND RESTRICTED CASH |  |  |
Beginning of period | 36,416 | 16,980 | 91,937
End of period | 189,215 | 36,416 | 16,980
Supplemental Disclosure of Non-Cash Investing and Financing Information: |  |  |
Settlement of forward contract liability and issuance of Series A non-voting convertible preferred stock in connection with the asset acquisition of Spyre | 189,741 | 0 | 0
Conversion of Series A non-voting convertible preferred stock into common stock | 202,178 | 0 | 0
Leased assets obtained in exchange for lease obligations | 0 | 21 | 872
CVR liability |  |  |
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Change in fair value of derivative liability | 18,986 | 0 | 0
Forward Contract Liability |  |  |
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Change in fair value of derivative liability | $ 83,530 | $ 0 | $ 0

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