XML 82 R65.htm IDEA: XBRL DOCUMENT
v3.24.0.1

Related Party Transactions - Narrative (Details) $ / shares in Units, $ in Thousands |  |  |  |  |  | 1 Months Ended | 12 Months Ended
--- | --- | --- | --- | --- | --- | --- | ---
Dec. 14, 2023 USD ($) | Dec. 11, 2023 USD ($) | Nov. 22, 2023 installment $ / shares shares | Jun. 26, 2023 USD ($) | Jun. 22, 2023 USD ($) BOARDSEAT | May 31, 2023 USD ($) | Dec. 31, 2023 USD ($) BOARDSEAT shares | Dec. 31, 2022 USD ($) | Dec. 31, 2021 USD ($)
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |
Number of board seats held by related party | BOARDSEAT |  |  |  |  | 2 |  |  |  |
Stock compensation expense |  |  |  |  |  |  | $ 25,675 | $ 7,111 | $ 8,038
Related party accounts payable and other current liabilities |  |  |  |  |  |  | 16,584 | 0 |
Proceeds from issuance of private placement |  |  |  |  |  |  | $ 84,555 | 0 | $ 0
Granted (in shares) | shares |  |  |  |  |  |  | 8,776,245 |  |
Private Placement [Member] |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |
Proceeds from issuance of private placement |  | $ 180,000 |  | $ 210,000 |  |  | $ 180,000 |  |
Related Party |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |
Related party accounts payable and other current liabilities |  |  |  |  |  |  | 16,600 | 0 |
Paragon Agreement |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |
Related party expenses incurred prior to asset acquisition |  |  |  |  | $ 19,000 |  |  |  |
Related party expenses unpaid prior to asset acquisition |  |  |  |  | 19,000 |  |  |  |
Paragon Agreement | Related Party |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |
Related party expenses incurred prior to asset acquisition |  |  |  |  | 19,000 |  |  |  |
Research initiation fees |  |  |  |  | 3,000 | $ 3,000 |  |  |
Reimbursable research costs |  |  |  |  | 16,000 |  |  |  |
Related party expenses unpaid prior to asset acquisition |  |  |  |  | $ 19,000 |  |  |  |
Stock compensation expense |  |  |  |  |  |  | 11,400 |  |
Stock Compensation And Research And Development Expense |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |
Related party transaction amount |  |  |  |  |  |  | 48,500 |  |
Reimbursable Costs Under Paragon Agreement | Related Party |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |
Related party accounts payable and other current liabilities |  |  |  |  |  |  | 16,600 | $ 0 |
Milestone Payments |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |
Related party transaction amount |  |  |  |  |  |  | $ 39,500 |  |
Appoint Of Board Members |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |
Number of board seats held by related party | BOARDSEAT |  |  |  |  |  |  | 2 |  |
SPY002 License Agreement | Related Party |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |
Nomination fee | $ 1,500 |  |  |  |  |  |  |  |
Milestone payments | 2,500 |  |  |  |  |  |  |  |
Sale Of Stock, December 2023 PIPE | Related Party |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |
Proceeds from issuance of private placement |  |  |  |  |  |  | $ 10,000 |  |
Consulting Agreement | Related Party |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |
Granted (in shares) | shares |  |  | 477,000 |  |  |  |  |  |
Exercise price (in dollars per share) | $ / shares |  |  | $ 10.39 |  |  |  |  |  |
Number of monthly installments | installment |  |  | 48 |  |  |  |  |  |
Stock-based compensation expense |  |  |  |  |  |  | $ 100 |  |
Consulting Agreement | Related Party | Share-Based Payment Arrangement, Tranche One |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |
Vesting percentage |  |  | 25.00% |  |  |  |  |  |
Paragon Therapeutics Inc | Ownership Interest | Maximum | Related Party |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |
Percentage of ownership by noncontrolling owner |  |  |  |  |  |  | 5.00% |  |
Paragon Therapeutics Inc | SPY002 License Agreement | Maximum | Related Party |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |
Contingent obligation based on milestones | $ 22,000 |  |  |  |  |  |  |  |
Fairmount Funds Management LLC | Ownership Interest | Minimum | Related Party |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |
Percentage of ownership by noncontrolling owner |  |  |  |  | 5.00% |  | 5.00% |  |
Percentage of ownership held in third party |  |  |  |  | 5.00% |  | 5.00% |  |
Paragon and Parapyre Holding LLC | Ownership Interest | Maximum | Related Party |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |
Percentage of ownership by noncontrolling owner |  |  |  |  | 5.00% |  |  |  |

X
- Definition Amount to be paid under agreement. + References No definition available. + Details
Name: | syre_AmountToBePaidUnderAgreement
Namespace Prefix: | syre_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | instant

X
- Definition Minority interest ownership percentage by noncontrolling owners held in third party. + References No definition available. + Details
Name: | syre_MinorityInterestOwnershipPercentageByNoncontrollingOwnersHeldInThirdParty
Namespace Prefix: | syre_
Data Type: | dtr-types:percentItemType
Balance Type: | na
Period Type: | instant

X
- Definition Nomination fee. + References No definition available. + Details
Name: | syre_NominationFee
Namespace Prefix: | syre_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | duration

X
- Definition Payment of milestone. + References No definition available. + Details
Name: | syre_PaymentOfMilestone
Namespace Prefix: | syre_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | duration

X
- Definition Reimbursable research costs. + References No definition available. + Details
Name: | syre_ReimbursableResearchCosts
Namespace Prefix: | syre_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

X
- Definition Related party expenses incurred prior to asset acquisition. + References No definition available. + Details
Name: | syre_RelatedPartyExpensesIncurredPriorToAssetAcquisition
Namespace Prefix: | syre_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

X
- Definition Related party expenses unpaid prior to asset acquisition. + References No definition available. + Details
Name: | syre_RelatedPartyExpensesUnpaidPriorToAssetAcquisition
Namespace Prefix: | syre_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | instant

X
- Definition Related Party Transaction, Number Of Board Seats + References No definition available. + Details
Name: | syre_RelatedPartyTransactionNumberOfBoardSeats
Namespace Prefix: | syre_
Data Type: | xbrli:integerItemType
Balance Type: | na
Period Type: | instant

X
- Definition Research initiation fees. + References No definition available. + Details
Name: | syre_ResearchInitiationFees
Namespace Prefix: | syre_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

X
- Definition Share-Based Compensation Arrangement By Share-Based Payment Award, Number Of Monthly Installments + References No definition available. + Details
Name: | syre_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfMonthlyInstallments
Namespace Prefix: | syre_
Data Type: | xbrli:integerItemType
Balance Type: | na
Period Type: | instant

X
- Definition Amount of obligations incurred classified as other, payable within one year or the normal operating cycle, if longer. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.19(a)) -Publisher FASB -URI https://asc.fasb.org//1943274/2147480566/210-10-S99-1 + Details
Name: | us-gaap_AccountsPayableOtherCurrent
Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | instant

X
- Definition Amount of expense for award under share-based payment arrangement. Excludes amount capitalized. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -Publisher FASB -URI https://asc.fasb.org//1943274/2147479830/718-10-S99-1 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -Publisher FASB -URI https://asc.fasb.org//1943274/2147480429/718-10-50-2 + Details
Name: | us-gaap_AllocatedShareBasedCompensationExpense
Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

X
- Definition The equity interest of noncontrolling shareholders, partners or other equity holders in consolidated entity. + References No definition available. + Details
Name: | us-gaap_MinorityInterestOwnershipPercentageByNoncontrollingOwners
Namespace Prefix: | us-gaap_
Data Type: | dtr-types:percentItemType
Balance Type: | na
Period Type: | instant

X
- Definition The cash inflow associated with the amount received from entity's raising of capital via private rather than public placement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 45 -Paragraph 14 -Subparagraph (a) -SubTopic 10 -Topic 230 -Publisher FASB -URI https://asc.fasb.org//1943274/2147482740/230-10-45-14 + Details
Name: | us-gaap_ProceedsFromIssuanceOfPrivatePlacement
Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

X
- Definition Amount of transactions with related party during the financial reporting period. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 850 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 1 -Subparagraph (c) -Publisher FASB -URI https://asc.fasb.org//1943274/2147483326/850-10-50-1 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 850 -SubTopic 10 -Section 50 -Paragraph 3 -Publisher FASB -URI https://asc.fasb.org//1943274/2147483326/850-10-50-3 + Details
Name: | us-gaap_RelatedPartyTransactionAmountsOfTransaction
Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

X
- Definition Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 946 -SubTopic 220 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SX 210.6-07(2)(c)(2)(i)) -Publisher FASB -URI https://asc.fasb.org//1943274/2147483575/946-220-S99-1 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 946 -SubTopic 220 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SX 210.6-07(2)(c)(2)(ii)) -Publisher FASB -URI https://asc.fasb.org//1943274/2147483575/946-220-S99-1 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Topic 946 -SubTopic 220 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SX 210.6-07(2)(g)(3)) -Publisher FASB -URI https://asc.fasb.org//1943274/2147483575/946-220-S99-1 + Details
Name: | us-gaap_RelatedPartyTransactionLineItems
Namespace Prefix: | us-gaap_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

X
- Definition Amount of noncash expense for share-based payment arrangement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 45 -Paragraph 28 -Subparagraph (a) -SubTopic 10 -Topic 230 -Publisher FASB -URI https://asc.fasb.org//1943274/2147482740/230-10-45-28 + Details
Name: | us-gaap_ShareBasedCompensation
Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration

X
- Definition Agreed-upon price for the exchange of the underlying asset relating to the share-based payment award. + References No definition available. + Details
Name: | us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExercisePrice
Namespace Prefix: | us-gaap_
Data Type: | dtr-types:perShareItemType
Balance Type: | na
Period Type: | instant

X
- Definition Gross number of share options (or share units) granted during the period. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (c)(1)(iv)(01) -Publisher FASB -URI https://asc.fasb.org//1943274/2147480429/718-10-50-2 + Details
Name: | us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross
Namespace Prefix: | us-gaap_
Data Type: | xbrli:sharesItemType
Balance Type: | na
Period Type: | duration

X
- Definition Percentage of vesting of award under share-based payment arrangement. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (a)(1) -Publisher FASB -URI https://asc.fasb.org//1943274/2147480429/718-10-50-2 + Details
Name: | us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage
Namespace Prefix: | us-gaap_
Data Type: | dtr-types:percentItemType
Balance Type: | na
Period Type: | duration

X
- Details
Name: | us-gaap_SubsidiarySaleOfStockAxis=us-gaap_PrivatePlacementMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_RelatedPartyTransactionsByRelatedPartyAxis=us-gaap_RelatedPartyMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_RelatedPartyTransactionAxis=syre_ParagonAgreementMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_RelatedPartyTransactionAxis=syre_StockCompensationAndResearchAndDevelopmentExpenseMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_RelatedPartyTransactionAxis=syre_ReimbursableCostsUnderParagonAgreementMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_RelatedPartyTransactionAxis=syre_MilestonePaymentsMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_RelatedPartyTransactionAxis=syre_AppointOfBoardMembersMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_RelatedPartyTransactionAxis=syre_SPY002LicenseAgreementMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_RelatedPartyTransactionAxis=syre_SaleOfStockDecember2023PIPEMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_RelatedPartyTransactionAxis=syre_ConsultingAgreementMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_VestingAxis=us-gaap_ShareBasedCompensationAwardTrancheOneMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | srt_OwnershipAxis=syre_ParagonTherapeuticsIncMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | us-gaap_RelatedPartyTransactionAxis=syre_OwnershipInterestMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | srt_RangeAxis=srt_MaximumMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | srt_OwnershipAxis=syre_FairmountFundsManagementLlcMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | srt_RangeAxis=srt_MinimumMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |

X
- Details
Name: | srt_OwnershipAxis=syre_ParagonAndParapyreHoldingLlcMember
Namespace Prefix: |
Data Type: | na
Balance Type: |
Period Type: |