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Description of the Business and Summary of Significant Accounting Policies - Additional Information (Details) $ / shares in Units, $ in Thousands |  |  |  |  | 1 Months Ended | 3 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | --- | --- | --- | ---
Dec. 11, 2023 USD ($) | Sep. 08, 2023 | Jun. 26, 2023 USD ($) shares | Jun. 22, 2023 USD ($) $ / shares shares | Apr. 30, 2023 employee | Jun. 30, 2023 | Dec. 31, 2023 USD ($) $ / shares | Dec. 31, 2022 USD ($) $ / shares | Dec. 31, 2021 USD ($) | May 31, 2023
Organization Consolidation And Presentation Of Financial Statements [Line Items] |  |  |  |  |  |  |  |  |  |
Stockholders' equity, reverse stock split |  | 1-for-25 |  |  |  |  |  |  |  |
Cost to acquire asset |  |  |  | $ 113,200 |  |  |  |  |  |
Acquired in-process research and development |  |  |  |  |  |  | $ 130,188 | $ 0 | $ 0 |
Employee workforce, termination percentage |  |  |  |  | 83.00% | 83.00% |  |  |  |
Number of employees retained | employee |  |  |  |  | 10 |  |  |  |  |
Gross proceeds received in private placement |  |  |  |  |  |  | 84,555 | 0 | $ 0 |
cash and cash equivalents |  |  |  | 3,000 |  |  | 188,893 | $ 34,863 |  |
U.S. Banking Institution |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements [Line Items] |  |  |  |  |  |  |  |  |  |
Cash |  |  |  | $ 2,800 |  |  |  |  |  |
Private Placement |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements [Line Items] |  |  |  |  |  |  |  |  |  |
Gross proceeds received in private placement | $ 180,000 |  | $ 210,000 |  |  |  | $ 180,000 |  |  |
Parapyre Option Obligation |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements [Line Items] |  |  |  |  |  |  |  |  |  |
Percentage of annual equity grant of options |  |  |  | 1.00% |  |  |  |  |  | 1.00%
Series A Non Voting Convertible Preferred Stock |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements [Line Items] |  |  |  |  |  |  |  |  |  |
Preferred stock, par value | $ / shares |  |  |  |  |  |  | $ 0.0001 | $ 0.0001 |  |
Conversion basis |  |  |  | 40 |  |  |  |  |  |
Series A Non Voting Convertible Preferred Stock | Private Placement |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements [Line Items] |  |  |  |  |  |  |  |  |  |
Number of shares sold in private placement | shares |  |  | 721,452 |  |  |  |  |  |  |
Gross proceeds received in private placement |  |  | $ 210,000 |  |  |  |  |  |  |
Placement agent and other offering expenses in private placement |  |  | $ 12,700 |  |  |  |  |  |  |
Asset Acquisition |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements [Line Items] |  |  |  |  |  |  |  |  |  |
Fixed exchange ratio |  |  |  | 0.5494488 |  |  |  |  |  |
Asset Acquisition | Spyre 2023 Equity Incentive Plan |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements [Line Items] |  |  |  |  |  |  |  |  |  |
Number of outstanding and unexercised stock options to purchase (in shares) | shares |  |  |  | 2,734 |  |  |  |  |  |
Asset Acquisition | Common Stock |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements [Line Items] |  |  |  |  |  |  |  |  |  |
Number of shares transferred as equity interest in asset acquisition | shares |  |  |  | 517,809 |  |  |  |  |  |
Asset Acquisition | Series A Non Voting Convertible Preferred Stock |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements [Line Items] |  |  |  |  |  |  |  |  |  |
Number of shares transferred as equity interest in asset acquisition | shares |  |  |  | 364,887 |  |  |  |  |  |
Preferred stock, par value | $ / shares |  |  |  | $ 0.0001 |  |  |  |  |  |
Conversion basis |  |  |  | 40 |  |  |  |  |  |
Spyre Therapeutics, Inc. |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements [Line Items] |  |  |  |  |  |  |  |  |  |
Fixed exchange ratio |  |  |  | 0.5494488 |  |  |  |  |  |
Cost to acquire asset |  |  |  | $ 113,176 |  |  |  |  |  |
Asset acquisition consideration transferred issuable shares of common stock on an as-converted basis | shares |  |  |  | 14,595,480 |  |  |  |  |  |
Acquired in-process research and development |  |  |  | $ 130,188 |  |  |  |  |  |
Asset Acquisition, net liabilities assumed |  |  |  | $ 17,000 |  |  |  |  |  |
Spyre Therapeutics, Inc. | Common Stock |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements [Line Items] |  |  |  |  |  |  |  |  |  |
Number of shares transferred as equity interest in asset acquisition | shares |  |  |  | 517,809 |  |  |  |  |  |
Shares issued, price per share (in dollars per share) | $ / shares |  |  |  | $ 7.277 |  |  |  |  |  |
Spyre Therapeutics, Inc. | Spyre 2023 Equity Incentive Plan |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements [Line Items] |  |  |  |  |  |  |  |  |  |
Number of outstanding and unexercised stock options to purchase (in shares) | shares |  |  |  | 2,734 |  |  |  |  |  |
Spyre Therapeutics, Inc. | Common Stock |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements [Line Items] |  |  |  |  |  |  |  |  |  |
Number of shares transferred as equity interest in asset acquisition | shares |  |  |  | 517,809 |  |  |  |  |  |
Spyre Therapeutics, Inc. | Series A Non Voting Convertible Preferred Stock |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements [Line Items] |  |  |  |  |  |  |  |  |  |
Number of shares transferred as equity interest in asset acquisition | shares |  |  |  | 364,887 |  |  |  |  |  |
Preferred stock, par value | $ / shares |  |  |  | $ 0.0001 |  |  |  |  |  |
Conversion basis |  |  |  | 40 |  |  |  |  |  |
Shares issued, price per share (in dollars per share) | $ / shares |  |  |  | $ 291.08 |  |  |  |  |  |

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