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Fair Value Measurements - Narrative (Details) - USD ($) $ in Thousands |  |  | 6 Months Ended | 12 Months Ended
--- | --- | --- | --- | ---
Jul. 07, 2023 | Jun. 22, 2023 | Dec. 31, 2023 | Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |  |  |  |
Issuance of Series A non-voting convertible preferred stock |  |  |  | $ 189,741 |  |
Financial liabilities measured at fair value |  |  |  |  | $ 0 |
Forward Contract Liability |  |  |  |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |  |  |  |
Fair value of liability |  | $ 106,200 |  |  |  |
Change in fair value of derivative liability |  |  |  | 83,530 | 0 | $ 0
Change in fair value |  |  | $ 83,500 |  |  |
CVR liability |  |  |  |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |  |  |  |
Change in fair value of derivative liability |  |  |  | 18,986 | $ 0 | $ 0
Change in fair value |  |  |  | $ 18,986 |  |
Series A Non Voting Convertible Preferred StockSeries A Non Voting Convertible Preferred Stock |  |  |  |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |  |  |  |
Issuance of Series A non-voting convertible preferred stock | $ 189,700 |  |  |  |  |
Spyre Therapeutics, Inc. |  |  |  |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |  |  |  |
Asset acquisition, stockholder payment period |  | 3 years |  |  |  |
Asset acquisition, cash payment, threshold period |  | 1 year |  |  |  |
Spyre Therapeutics, Inc. | Series A Non Voting Convertible Preferred StockSeries A Non Voting Convertible Preferred Stock |  |  |  |  |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |  |  |  |
Shares transferred as equity interest in asset acquisition (in shares) |  | 364,887 |  |  |  |

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