    <SEC-DOCUMENT>0001628280-24-046860-index.html : 20241112
    <SEC-HEADER>0001628280-24-046860.hdr.sgml : 20241112
    <ACCEPTANCE-DATETIME>20241112073535
    ACCESSION NUMBER:		0001628280-24-046860
    CONFORMED SUBMISSION TYPE:	8-K
    PUBLIC DOCUMENT COUNT:		47
    CONFORMED PERIOD OF REPORT:	20241112
    ITEM INFORMATION:		Regulation FD Disclosure
    ITEM INFORMATION:		Other Events
    ITEM INFORMATION:		Financial Statements and Exhibits
    FILED AS OF DATE:		20241112
    DATE AS OF CHANGE:		20241112

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Spyre Therapeutics, Inc.
    		CENTRAL INDEX KEY:			0001636282
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		ORGANIZATION NAME:           	03 Life Sciences
    		IRS NUMBER:				464312787
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		8-K
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-37722
    		FILM NUMBER:		241443342

    	BUSINESS ADDRESS:
    		STREET 1:		221 CRESCENT STREET
    		STREET 2:		BUILDING 23, SUITE 105
    		CITY:			WALTHAM
    		STATE:			MA
    		ZIP:			02453
    		BUSINESS PHONE:		6176515940

    	MAIL ADDRESS:
    		STREET 1:		221 CRESCENT STREET
    		STREET 2:		BUILDING 23, SUITE 105
    		CITY:			WALTHAM
    		STATE:			MA
    		ZIP:			02453

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Aeglea BioTherapeutics, Inc.
    		DATE OF NAME CHANGE:	20150311
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>8-K
    <SEQUENCE>1
    <FILENAME>syre-20241112.htm
    <DESCRIPTION>8-K
    <TEXT>
    Document 1 - file: syre-20241112.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-99.1
    <SEQUENCE>2
    <FILENAME>exhibit991-8xkdatarelease.htm
    <DESCRIPTION>EX-99.1
    <TEXT>
    Document 2 - file: exhibit991-8xkdatarelease.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-99.2
    <SEQUENCE>3
    <FILENAME>exhibit992-8xkdatareleas.htm
    <DESCRIPTION>EX-99.2
    <TEXT>
    Document 3 - file: exhibit992-8xkdatareleas.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-101.SCH
    <SEQUENCE>4
    <FILENAME>syre-20241112.xsd
    <DESCRIPTION>XBRL TAXONOMY EXTENSION SCHEMA DOCUMENT
    <TEXT>
    Document 4 - file: syre-20241112.xsd

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-101.LAB
    <SEQUENCE>5
    <FILENAME>syre-20241112_lab.xml
    <DESCRIPTION>XBRL TAXONOMY EXTENSION LABEL LINKBASE DOCUMENT
    <TEXT>
    Document 5 - file: syre-20241112_lab.xml

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-101.PRE
    <SEQUENCE>6
    <FILENAME>syre-20241112_pre.xml
    <DESCRIPTION>XBRL TAXONOMY EXTENSION PRESENTATION LINKBASE DOCUMENT
    <TEXT>
    Document 6 - file: syre-20241112_pre.xml

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>7
    <FILENAME>exhibit992-8xkdatareleas001.jpg
    <TEXT>
    Document 7 - file: exhibit992-8xkdatareleas001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>8
    <FILENAME>exhibit992-8xkdatareleas002.jpg
    <TEXT>
    Document 8 - file: exhibit992-8xkdatareleas002.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>9
    <FILENAME>exhibit992-8xkdatareleas003.jpg
    <TEXT>
    Document 9 - file: exhibit992-8xkdatareleas003.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>10
    <FILENAME>exhibit992-8xkdatareleas004.jpg
    <TEXT>
    Document 10 - file: exhibit992-8xkdatareleas004.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>11
    <FILENAME>exhibit992-8xkdatareleas005.jpg
    <TEXT>
    Document 11 - file: exhibit992-8xkdatareleas005.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>12
    <FILENAME>exhibit992-8xkdatareleas006.jpg
    <TEXT>
    Document 12 - file: exhibit992-8xkdatareleas006.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>13
    <FILENAME>exhibit992-8xkdatareleas007.jpg
    <TEXT>
    Document 13 - file: exhibit992-8xkdatareleas007.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>14
    <FILENAME>exhibit992-8xkdatareleas008.jpg
    <TEXT>
    Document 14 - file: exhibit992-8xkdatareleas008.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>15
    <FILENAME>exhibit992-8xkdatareleas009.jpg
    <TEXT>
    Document 15 - file: exhibit992-8xkdatareleas009.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>16
    <FILENAME>exhibit992-8xkdatareleas010.jpg
    <TEXT>
    Document 16 - file: exhibit992-8xkdatareleas010.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>17
    <FILENAME>exhibit992-8xkdatareleas011.jpg
    <TEXT>
    Document 17 - file: exhibit992-8xkdatareleas011.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>18
    <FILENAME>exhibit992-8xkdatareleas012.jpg
    <TEXT>
    Document 18 - file: exhibit992-8xkdatareleas012.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>19
    <FILENAME>exhibit992-8xkdatareleas013.jpg
    <TEXT>
    Document 19 - file: exhibit992-8xkdatareleas013.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>20
    <FILENAME>exhibit992-8xkdatareleas014.jpg
    <TEXT>
    Document 20 - file: exhibit992-8xkdatareleas014.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>21
    <FILENAME>exhibit992-8xkdatareleas015.jpg
    <TEXT>
    Document 21 - file: exhibit992-8xkdatareleas015.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>22
    <FILENAME>exhibit992-8xkdatareleas016.jpg
    <TEXT>
    Document 22 - file: exhibit992-8xkdatareleas016.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>23
    <FILENAME>exhibit992-8xkdatareleas017.jpg
    <TEXT>
    Document 23 - file: exhibit992-8xkdatareleas017.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>24
    <FILENAME>exhibit992-8xkdatareleas018.jpg
    <TEXT>
    Document 24 - file: exhibit992-8xkdatareleas018.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>25
    <FILENAME>exhibit992-8xkdatareleas019.jpg
    <TEXT>
    Document 25 - file: exhibit992-8xkdatareleas019.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>26
    <FILENAME>exhibit992-8xkdatareleas020.jpg
    <TEXT>
    Document 26 - file: exhibit992-8xkdatareleas020.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>27
    <FILENAME>exhibit992-8xkdatareleas021.jpg
    <TEXT>
    Document 27 - file: exhibit992-8xkdatareleas021.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>28
    <FILENAME>exhibit992-8xkdatareleas022.jpg
    <TEXT>
    Document 28 - file: exhibit992-8xkdatareleas022.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>29
    <FILENAME>exhibit992-8xkdatareleas023.jpg
    <TEXT>
    Document 29 - file: exhibit992-8xkdatareleas023.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>30
    <FILENAME>exhibit992-8xkdatareleas024.jpg
    <TEXT>
    Document 30 - file: exhibit992-8xkdatareleas024.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>31
    <FILENAME>exhibit992-8xkdatareleas025.jpg
    <TEXT>
    Document 31 - file: exhibit992-8xkdatareleas025.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>32
    <FILENAME>exhibit992-8xkdatareleas026.jpg
    <TEXT>
    Document 32 - file: exhibit992-8xkdatareleas026.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>33
    <FILENAME>exhibit992-8xkdatareleas027.jpg
    <TEXT>
    Document 33 - file: exhibit992-8xkdatareleas027.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>34
    <FILENAME>exhibit992-8xkdatareleas028.jpg
    <TEXT>
    Document 34 - file: exhibit992-8xkdatareleas028.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>35
    <FILENAME>exhibit992-8xkdatareleas029.jpg
    <TEXT>
    Document 35 - file: exhibit992-8xkdatareleas029.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>36
    <FILENAME>exhibit992-8xkdatareleas030.jpg
    <TEXT>
    Document 36 - file: exhibit992-8xkdatareleas030.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>37
    <FILENAME>exhibit992-8xkdatareleas031.jpg
    <TEXT>
    Document 37 - file: exhibit992-8xkdatareleas031.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>38
    <FILENAME>spyrelogo.jpg
    <TEXT>
    Document 38 - file: spyrelogo.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>40
    <FILENAME>R1.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 40 - file: R1.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EXCEL
    <SEQUENCE>41
    <FILENAME>Financial_Report.xlsx
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 41 - file: Financial_Report.xlsx

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>42
    <FILENAME>Show.js
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 42 - file: Show.js

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>43
    <FILENAME>report.css
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 43 - file: report.css

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>45
    <FILENAME>FilingSummary.xml
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 45 - file: FilingSummary.html

    Document 45 - RAW XML: FilingSummary.xml

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>JSON
    <SEQUENCE>47
    <FILENAME>MetaLinks.json
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 47 - file: MetaLinks.json

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>ZIP
    <SEQUENCE>48
    <FILENAME>0001628280-24-046860-xbrl.zip
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 48 - file: 0001628280-24-046860-xbrl.zip

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>49
    <FILENAME>syre-20241112_htm.xml
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 49 - file: syre-20241112_htm.html

    Document 49 - RAW XML: syre-20241112_htm.xml

    </DOCUMENT>
    </SEC-DOCUMENT>