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Stock-Based Compensation - Narrative (Details) - USD ($) $ / shares in Units, $ in Thousands |  | 3 Months Ended | 12 Months Ended |  |  |  |
--- | --- | --- | --- | --- | --- | --- | ---
Jun. 22, 2023 | Mar. 31, 2025 | Mar. 31, 2024 | Dec. 31, 2016 | Dec. 31, 2024 | Sep. 30, 2024 | Jan. 01, 2024 | Jan. 01, 2023
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |
Stock-based compensation |  | $ 8,859 | $ 13,835 |  |  |  |  |
2015 and 2016 and 2018 Equity Inducement Plan | Service Based Awards |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |
Vest period grant date |  | 4 years |  |  |  |  |  |
Share-based payment award, term |  | 10 years |  |  |  |  |  |
2015 Equity Incentive Plan |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |
Shares subject to options outstanding (in shares) |  | 952 |  |  |  |  |  |
2016 Equity Incentive Plan |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |
Annual percentage of additional shares |  |  |  | 5.00% |  |  |  |
Additional number of shares available for issuance (in shares) |  |  |  |  |  |  | 3,814,905 | 3,023,650
Common stock available for future issuance (in shares) |  | 11,007,869 |  |  |  |  |  |
Outstanding option awards (in shares) |  | 4,817,317 |  |  |  |  |  |
2018 Equity Inducement Plan |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |
Common stock available for future issuance (in shares) |  | 6,856,811 |  |  |  |  |  |
Outstanding option awards (in shares) |  | 6,300,368 |  |  |  |  |  |
2018 Equity Inducement Plan, Amended |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |
Common stock available for future issuance, additional amount authorized (in shares) |  |  |  |  |  | 1,000,000 |  |
Spyre 2023 Equity Incentive Plan | Asset Acquisition |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |
Number of outstanding and unexercised stock options to purchase (in shares) | 2,734 |  |  |  |  |  |  |
Parapyre Option Obligation |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |
Stock-based compensation |  | $ 0 | $ 5,400 |  |  |  |  |
2024 Parapyre Option Obligation | Outstanding Parapyre warrants |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |
Warrants to purchase shares (in shares) |  | 1,532,591 |  |  | 848,184 |  |  |
Exercise price per warrant (in dollars per share) |  | $ 22.49 |  |  | $ 23.28 |  |  |
2016 Employee Stock Purchase Plan | Employee Stock |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |
Number of shares issued (in shares) |  | 16,877 |  |  |  |  |  |
2016 Employee Stock Purchase Plan | 2016 ESPP | Employee Stock |  |  |  |  |  |  |  |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |
Number of shares sold (in shares) |  | 16,877 | 2,330 |  |  |  |  |
Sale of stock, proceeds received |  | $ 300 | $ 0 |  |  |  |  |

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