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Stock-Based Compensation - Stock-Based Compensation Expense (Details) - USD ($) $ in Thousands | 3 Months Ended
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Mar. 31, 2025 | Mar. 31, 2024
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items] |  |
Total stock-based compensation expense | $ 8,859 | $ 13,835
Stock-based compensation | 8,859 | 13,835
Aeglea Employees and Directors |  |
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items] |  |
Stock-based compensation |  | 2,900
Parapyre Option Obligation |  |
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items] |  |
Stock-based compensation | 0 | 5,400
Research and Development Expense |  |
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items] |  |
Total stock-based compensation expense | 3,512 | 6,857
General and administrative |  |
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items] |  |
Total stock-based compensation expense | $ 5,347 | $ 6,978

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- Definition Amount of expense for award under share-based payment arrangement. Excludes amount capitalized. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -Publisher FASB -URI https://asc.fasb.org/1943274/2147479830/718-10-S99-1 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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