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Stock-Based Compensation - Schedule of Total Stock-Based Compensation Expense (Details) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended
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Sep. 30, 2025 | Sep. 30, 2024 | Sep. 30, 2025 | Sep. 30, 2024
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items] |  |  |  |
Total stock-based compensation expense | $ 9,566 | $ 13,100 | $ 27,803 | $ 35,617
Stock-based compensation |  | 13,100 | 27,803 | 35,617
Aeglea Employees and Directors |  |  |  |
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items] |  |  |  |
Stock-based compensation |  | 100 |  | 3,600
Parapyre Option Obligation |  |  |  |
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items] |  |  |  |
Stock-based compensation |  | 6,100 |  | 13,000
Research and development |  |  |  |
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items] |  |  |  |
Total stock-based compensation expense | 4,248 | 8,555 | 11,860 | 18,863
General and administrative |  |  |  |
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items] |  |  |  |
Total stock-based compensation expense | $ 5,318 | $ 4,545 | $ 15,943 | $ 16,754

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