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v3.25.3

Segment Reporting - Schedule of Significant Expenses Provided to the CODM on a Regular Basis (Details) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2025 | Jun. 30, 2025 | Mar. 31, 2025 | Sep. 30, 2024 | Jun. 30, 2024 | Mar. 31, 2024 | Sep. 30, 2025 | Sep. 30, 2024
Segment, Reconciliation of Other Items from Segments to Consolidated [Line Items] |  |  |  |  |  |  |  |  |
Stock-based compensation |  |  |  |  | $ 13,100 |  |  | $ 27,803 | $ 35,617
Net loss |  | $ 11,183 | $ 36,717 | $ 44,773 | 69,028 | $ 38,837 | $ 43,857 | 92,673 | 151,722
Reconciliation of net loss |  |  |  |  |  |  |  |  |
Adjustments and reconciling items |  | 11,183 | 36,717 | 44,773 | 69,028 | 38,837 | 43,857 | 92,673 | 151,722
Net loss |  | 11,183 | $ 36,717 | $ 44,773 | 69,028 | $ 38,837 | $ 43,857 | 92,673 | 151,722
Research and development | [1] | 45,247 |  |  | 44,744 |  |  | 127,015 | 112,308
Gain recognized within operating expenses |  | 0 |  |  | 0 |  |  | 10,000 | 0
(Decrease) increase in fair value of CVR liability |  | (40,400) |  |  | 18,700 |  |  | (42,200) | 19,600
Related Party |  |  |  |  |  |  |  |  |
Segment, Reconciliation of Other Items from Segments to Consolidated [Line Items] |  |  |  |  |  |  |  |  |
Stock-based compensation |  | 300 |  |  | 6,400 |  |  | 800 | 13,800
Related Party | Paragon and License Agreement |  |  |  |  |  |  |  |  |
Reconciliation of net loss |  |  |  |  |  |  |  |  |
Research and development |  | 7,000 |  |  | 1,600 |  |  | 9,600 | 21,200
Reportable Segment |  |  |  |  |  |  |  |  |
Segment, Reconciliation of Other Items from Segments to Consolidated [Line Items] |  |  |  |  |  |  |  |  |
Net loss |  | 11,183 |  |  | 69,028 |  |  | 92,673 | 151,722
Reconciliation of net loss |  |  |  |  |  |  |  |  |
Adjustments and reconciling items |  | 11,183 |  |  | 69,028 |  |  | 92,673 | 151,722
Net loss |  | 11,183 |  |  | 69,028 |  |  | 92,673 | 151,722
Operating Segments | Reportable Segment |  |  |  |  |  |  |  |  |
Segment, Reconciliation of Other Items from Segments to Consolidated [Line Items] |  |  |  |  |  |  |  |  |
Compensation |  | 9,397 |  |  | 5,960 |  |  | 24,507 | 15,015
Stock-based compensation |  | 9,566 |  |  | 13,100 |  |  | 27,803 | 35,617
Research and development, excluding compensation and share-based compensation |  | 34,769 |  |  | 32,920 |  |  | 99,069 | 85,831
Other segment items |  | (42,549) |  |  | 17,048 |  |  | (58,706) | 15,259
Net loss |  | 11,183 |  |  | 69,028 |  |  | 92,673 | 151,722
Reconciliation of net loss |  |  |  |  |  |  |  |  |
Adjustments and reconciling items |  | 11,183 |  |  | 69,028 |  |  | 92,673 | 151,722
Net loss |  | 11,183 |  |  | 69,028 |  |  | 92,673 | 151,722
Adjustments and reconciling items | Reportable Segment |  |  |  |  |  |  |  |  |
Segment, Reconciliation of Other Items from Segments to Consolidated [Line Items] |  |  |  |  |  |  |  |  |
Net loss |  | 0 |  |  | 0 |  |  | 0 | 0
Reconciliation of net loss |  |  |  |  |  |  |  |  |
Adjustments and reconciling items |  | 0 |  |  | 0 |  |  | 0 | 0
Net loss |  | $ 0 |  |  | $ 0 |  |  | $ 0 | $ 0
[1] | Includes $7.0 million and $9.6 million in related party expenses for the three and nine months ended September 30, 2025, respectively, and $7.7 million and $34.2 million related party expenses for the three and nine months ended September 30, 2024, respectively.

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