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Licensing Agreements (Details) - USD ($)				3 Months Ended		6 Months Ended		12 Months Ended
		Oct. 11, 2024	May 14, 2024	Jun. 30, 2026	Jun. 30, 2025	Jun. 30, 2026	Jun. 30, 2025	Dec. 31, 2025
Related Party Transaction [Line Items]
Research and development	[1]			$ 65,503,000	$ 40,145,000	$ 125,914,000	$ 81,768,000
Related Party
Related Party Transaction [Line Items]
Research and development				$ 0	0	$ 3,100,000	2,600,000
Paragon Agreement | Related Party
Related Party Transaction [Line Items]
Campaign timeline, minimum term (in years)						5 years
Royalty step-down (as percent)				33.00%		33.00%
Royalty term expiration period (in years)						12 years
Termination notice period (in days)						60 days
Cash milestone payments				$ 0	2,500,000	$ 3,000,000.0	2,500,000
Milestone payments, outstanding and payable				0		0		$ 0
Payment for sublicensing fee				0	0	0	500,000
SPY001 License Agreement | Related Party
Related Party Transaction [Line Items]
First milestone payment			$ 3,000,000.0
SPY002 and SPY072 License Agreement | Related Party
Related Party Transaction [Line Items]
First milestone payment			3,000,000.0
SPY003 License Agreement | Related Party
Related Party Transaction [Line Items]
First milestone payment		$ 3,000,000.0
License Agreement | Related Party
Related Party Transaction [Line Items]
Research and development				$ 0	$ 0	3,000,000.0	$ 2,500,000
Sublicensing fee, outstanding and payable						0		$ 0
Maximum | SPY001 License Agreement | Related Party
Related Party Transaction [Line Items]
Contingent obligation based on milestones			22,000,000.0
Maximum | SPY002 and SPY072 License Agreement | Related Party
Related Party Transaction [Line Items]
Contingent obligation based on milestones			$ 22,000,000.0
Sublicensing fee						$ 20,000,000
Maximum | SPY003 License Agreement | Related Party
Related Party Transaction [Line Items]
Contingent obligation based on milestones		$ 22,000,000.0
[1] Includes de minimis related party expenses for the three months ended June 30, 2026 and 2025. Includes related party expenses of $3.1 million and $2.6 million for the six months ended June 30, 2026 and 2025, respectively.

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