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Equity - Summary of Stock-Based Compensation Expense Recognized for Stock Options and Restricted Stock Included in Consolidated Statements of Operations (Detail) - USD ($) $ in Thousands | 3 Months Ended
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Mar. 31, 2018 | Mar. 31, 2017
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |
Stock based compensation expense | $ 1,624 | $ 1,130
Research and development expense |  |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |
Stock based compensation expense | 18 | 43
General and administrative expense |  |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |
Stock based compensation expense | $ 1,606 | $ 1,087

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