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Income Taxes - Income Tax Provision (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Income Tax Disclosure [Abstract]      
Tax benefit at federal statutory rate $ (43,747) $ (15,664) $ (17,102)
State taxes, net of federal benefit (4,431) 21 10
Research and other credits (2,305) (1,245) (1,643)
VA release related to Title365 PPA (34,462) 0 0
Change in valuation allowance 38,188 16,431 16,388
Section 162(m) adjustment 10,241 0 0
Non-deductible transaction costs 1,252 0 0
Stock-based compensation (2,828) 572 1,739
Other (794) (89) 621
Income tax benefit (expense) $ (38,886) $ 26 $ 13