<SEC-DOCUMENT>0001752724-20-108410.txt : 20200528
<SEC-HEADER>0001752724-20-108410.hdr.sgml : 20200528
<ACCEPTANCE-DATETIME>20200528165033
ACCESSION NUMBER:		0001752724-20-108410
CONFORMED SUBMISSION TYPE:	NPORT-P
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20200331
FILED AS OF DATE:		20200528
PERIOD START:           	20200930

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			TEKLA HEALTHCARE INVESTORS
		CENTRAL INDEX KEY:			0000805267
		IRS NUMBER:				046564285
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			0930

	FILING VALUES:
		FORM TYPE:		NPORT-P
		SEC ACT:		1940 Act
		SEC FILE NUMBER:	811-04889
		FILM NUMBER:		20921907

	BUSINESS ADDRESS:	
		STREET 1:		100 FEDERAL STREET
		STREET 2:		19TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110
		BUSINESS PHONE:		6177728515

	MAIL ADDRESS:	
		STREET 1:		100 FEDERAL STREET
		STREET 2:		19TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	H&Q HEALTHCARE INVESTORS
		DATE OF NAME CHANGE:	19920703
</SEC-HEADER>
<DOCUMENT>
<TYPE>NPORT-P
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/nport" xmlns:com="http://www.sec.gov/edgar/common" xmlns:ncom="http://www.sec.gov/edgar/nportcommon" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.sec.gov/edgar/nport eis_NPORT_Filer.xsd">
  <headerData>
    <submissionType>NPORT-P</submissionType>
    <isConfidential>false</isConfidential>
    <filerInfo>

      <filer>
        <issuerCredentials>
          <cik>0000805267</cik>
          <ccc>XXXXXXXX</ccc>
        </issuerCredentials>
      </filer>




    </filerInfo>
  </headerData>
  <formData>
    <genInfo>
      <regName>TEKLA HEALTHCARE INVESTORS</regName>
      <regFileNumber>811-04889</regFileNumber>
      <regCik>0000805267</regCik>
      <regLei>549300SNASESIFOS6V75</regLei>
      <regStreet1>100 FEDERAL STREET,</regStreet1>
      <regStreet2>19TH FLOOR</regStreet2>
      <regCity>BOSTON</regCity>
      <regStateConditional regCountry="US" regState="US-MA"/>
      <regZipOrPostalCode>02110</regZipOrPostalCode>
      <regPhone>617-772-8500</regPhone>
      <seriesName>TEKLA HEALTHCARE INVESTORS</seriesName>
      <seriesLei>549300SNASESIFOS6V75</seriesLei>
      <repPdEnd>2020-09-30</repPdEnd>
      <repPdDate>2020-03-31</repPdDate>
      <isFinalFiling>N</isFinalFiling>
    </genInfo>
    <fundInfo>
      <totAssets>885055966.43</totAssets>
      <totLiabs>1049367.59</totLiabs>
      <netAssets>884006598.84</netAssets>
      <assetsAttrMiscSec>0.00000000</assetsAttrMiscSec>
      <assetsInvested>0.00000000</assetsInvested>
      <amtPayOneYrBanksBorr>0.00000000</amtPayOneYrBanksBorr>
      <amtPayOneYrCtrldComp>0.00000000</amtPayOneYrCtrldComp>
      <amtPayOneYrOthAffil>0.00000000</amtPayOneYrOthAffil>
      <amtPayOneYrOther>0.00000000</amtPayOneYrOther>
      <amtPayAftOneYrBanksBorr>0.00000000</amtPayAftOneYrBanksBorr>
      <amtPayAftOneYrCtrldComp>0.00000000</amtPayAftOneYrCtrldComp>
      <amtPayAftOneYrOthAffil>0.00000000</amtPayAftOneYrOthAffil>
      <amtPayAftOneYrOther>0.00000000</amtPayAftOneYrOther>
      <delayDeliv>0.00000000</delayDeliv>
      <standByCommit>0.00000000</standByCommit>
      <liquidPref>0.00000000</liquidPref>
      <cshNotRptdInCorD>839.50000000</cshNotRptdInCorD>
      <isNonCashCollateral>N</isNonCashCollateral>
      <returnInfo>
        <monthlyTotReturns>
          <monthlyTotReturn rtn1="-3.88000000" rtn2="-3.14000000" rtn3="-6.11000000"/>
        </monthlyTotReturns>
        <monthlyReturnCats>
          <equityContracts>
            <mon1 netRealizedGain="0.00000000" netUnrealizedAppr="294201.57000000"/>
            <mon2 netRealizedGain="0.00000000" netUnrealizedAppr="18342.79000000"/>
            <mon3 netRealizedGain="0.00000000" netUnrealizedAppr="-90084.26000000"/>
            <optionCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="-91300.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="139700.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="13200.00000000"/>
            </optionCategory>
            <warrantCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="10135.60000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="-17532.58000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="-41639.78000000"/>
            </warrantCategory>
            <otherCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="375365.97000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="-103824.63000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="-61644.48000000"/>
            </otherCategory>
          </equityContracts>
          <otherContracts>
            <mon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <mon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            <warrantCategory>
              <instrMon1 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon2 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
              <instrMon3 netRealizedGain="0.00000000" netUnrealizedAppr="0.00000000"/>
            </warrantCategory>
          </otherContracts>
        </monthlyReturnCats>
        <othMon1 netRealizedGain="7909623.58000000" netUnrealizedAppr="-56717581.27000000"/>
        <othMon2 netRealizedGain="3597511.69000000" netUnrealizedAppr="-15305249.15000000"/>
        <othMon3 netRealizedGain="3337610.81000000" netUnrealizedAppr="-50084812.42000000"/>
      </returnInfo>
      <mon1Flow redemption="0.00000000" reinvestment="0.00000000" sales="0.00000000"/>
      <mon2Flow redemption="0.00000000" reinvestment="0.00000000" sales="0.00000000"/>
      <mon3Flow redemption="1599100.11000000" reinvestment="8497188.10000000" sales="0.00000000"/>


    </fundInfo>
    <invstOrSecs>
      <invstOrSec>
        <name>ILLUMINOSS INC. WARRANTS WARRANTS</name>
        <lei>N/A</lei>
        <title>ILLUMINOSS INC. WARRANTS WARRANTS</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="965HDUII8"/>
        </identifiers>
        <balance>53690.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.00000000</valUSD>
        <pctVal>0.000000</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerConditional desc="derivative" issuerCat="OTHER"/>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <derivativeInfo>
          <optionSwaptionWarrantDeriv derivCat="WAR">
            <counterparties>
              <counterpartyName>N/A</counterpartyName>
              <counterpartyLei>N/A</counterpartyLei>
            </counterparties>
            <putOrCall>Call</putOrCall>
            <writtenOrPur>Purchased</writtenOrPur>
            <descRefInstrmnt>
              <otherRefInst>
                <issuerName>ILLUMINOSS INC. SERIES AA</issuerName>
                <issueTitle>ILLUMINOSS INC. SERIES AA</issueTitle>
                <identifiers>
                  <other otherDesc="Internal Identifier - Private Company" value="976MND900"/>
                </identifiers>
              </otherRefInst>
            </descRefInstrmnt>
            <shareNo>1.00000000</shareNo>
            <exercisePrice>1.00000000</exercisePrice>
            <exercisePriceCurCd>USD</exercisePriceCurCd>
            <expDt>2029-09-27</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>0.00000000</unrealizedAppr>
          </optionSwaptionWarrantDeriv>
        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PerkinElmer Inc</name>
        <lei>549300IKL1SDPFI7N655</lei>
        <title>PerkinElmer Inc</title>
        <cusip>714046109</cusip>
        <identifiers>
          <isin value="US7140461093"/>
        </identifiers>
        <balance>10514.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>791493.92000000</valUSD>
        <pctVal>0.089534842956</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>UnitedHealth Group Inc</name>
        <lei>549300GHBMY8T5GXDE41</lei>
        <title>UnitedHealth Group Inc</title>
        <cusip>91324P102</cusip>
        <identifiers>
          <isin value="US91324P1021"/>
        </identifiers>
        <balance>40631.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10132558.78000000</valUSD>
        <pctVal>1.146208500399</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Bristol-Myers Squibb Co</name>
        <lei>HLYYNH7UQUORYSJQCN42</lei>
        <title>Bristol-Myers Squibb Co</title>
        <cusip>110122108</cusip>
        <identifiers>
          <isin value="US1101221083"/>
        </identifiers>
        <balance>189333.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10553421.42000000</valUSD>
        <pctVal>1.193817040941</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Eli Lilly &amp; Co</name>
        <lei>FRDRIPF3EKNDJ2CQJL29</lei>
        <title>Eli Lilly &amp; Co</title>
        <cusip>532457108</cusip>
        <identifiers>
          <isin value="US5324571083"/>
        </identifiers>
        <balance>21025.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2916588.00000000</valUSD>
        <pctVal>0.329928306398</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ra Pharmaceuticals Inc</name>
        <lei>549300JE4B54MQ4MWX95</lei>
        <title>Ra Pharmaceuticals Inc</title>
        <cusip>74933V108</cusip>
        <identifiers>
          <isin value="US74933V1089"/>
        </identifiers>
        <balance>15656.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>751644.56000000</valUSD>
        <pctVal>0.085027030452</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GW Pharmaceuticals PLC</name>
        <lei>213800ISBN5CNUZMHZ39</lei>
        <title>GW Pharmaceuticals PLC</title>
        <cusip>36197T103</cusip>
        <identifiers>
          <isin value="US36197T1034"/>
        </identifiers>
        <balance>32891.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2880264.87000000</valUSD>
        <pctVal>0.325819385712</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CVS Health Corp</name>
        <lei>549300EJG376EN5NQE29</lei>
        <title>CVS Health Corp</title>
        <cusip>126650100</cusip>
        <identifiers>
          <isin value="US1266501006"/>
        </identifiers>
        <balance>100776.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5979040.08000000</valUSD>
        <pctVal>0.676356951163</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Pfizer Inc</name>
        <lei>765LHXWGK1KXCLTFYQ30</lei>
        <title>Pfizer Inc</title>
        <cusip>717081103</cusip>
        <identifiers>
          <isin value="US7170811035"/>
        </identifiers>
        <balance>324369.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10587404.16000000</valUSD>
        <pctVal>1.197661213603</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Afferent Milestone Interest</name>
        <lei>N/A</lei>
        <title>AFFERENT MILESTONE INTEREST COMMON STOCK</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="930LUG902"/>
        </identifiers>
        <balance>26208.04000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>586273.85000000</valUSD>
        <pctVal>0.066320076204</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetConditional assetCat="OTHER" desc="Milestone Interest"/>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Arena Pharmaceuticals Inc</name>
        <lei>529900CVGQMPJ3A3NI85</lei>
        <title>Arena Pharmaceuticals Inc</title>
        <cusip>040047607</cusip>
        <identifiers>
          <isin value="US0400476075"/>
        </identifiers>
        <balance>14306.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>600852.00000000</valUSD>
        <pctVal>0.067969175884</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Reata Pharmaceuticals Inc</name>
        <lei>5299005F094GH9QDDD80</lei>
        <title>Reata Pharmaceuticals Inc</title>
        <cusip>75615P103</cusip>
        <identifiers>
          <isin value="US75615P1030"/>
        </identifiers>
        <balance>23541.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3397907.94000000</valUSD>
        <pctVal>0.384375856974</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Pieris Pharmaceuticals Warrant Series B</name>
        <lei>254900AJDH8PAOOI5T33</lei>
        <title>Pieris Pharmaceuticals Warrant Series B</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="930BPR906"/>
        </identifiers>
        <balance>27394.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>21641.26000000</valUSD>
        <pctVal>0.002448088060</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerConditional desc="derivative" issuerCat="OTHER"/>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <derivativeInfo>
          <optionSwaptionWarrantDeriv derivCat="WAR">
            <counterparties>
              <counterpartyName>N/A</counterpartyName>
              <counterpartyLei>N/A</counterpartyLei>
            </counterparties>
            <putOrCall>Call</putOrCall>
            <writtenOrPur>Purchased</writtenOrPur>
            <descRefInstrmnt>
              <otherRefInst>
                <issuerName>Pieris Pharmaceuticals Inc</issuerName>
                <issueTitle>Pieris Pharmaceuticals Inc</issueTitle>
                <identifiers>
                  <cusip value="720795103"/>
                  <isin value="US7207951036"/>
                </identifiers>
              </otherRefInst>
            </descRefInstrmnt>
            <shareNo>1.00000000</shareNo>
            <exercisePrice>2.00000000</exercisePrice>
            <exercisePriceCurCd>USD</exercisePriceCurCd>
            <expDt>2021-06-08</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>17948.17000000</unrealizedAppr>
          </optionSwaptionWarrantDeriv>
        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Trillium Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Trillium Therapeutics Inc</title>
        <cusip>89620X506</cusip>
        <identifiers>
          <isin value="CA89620X5064"/>
        </identifiers>
        <balance>316264.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1277706.56000000</valUSD>
        <pctVal>0.144535862252</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Spectrum Pharmaceuticals Inc</name>
        <lei>549300COU30WSP3O5I07</lei>
        <title>Spectrum Pharmaceuticals Inc</title>
        <cusip>84763A108</cusip>
        <identifiers>
          <isin value="US84763A1088"/>
        </identifiers>
        <balance>79790.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>185910.70000000</valUSD>
        <pctVal>0.021030465184</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Neurocrine Biosciences Inc</name>
        <lei>549300FECER0XBN49756</lei>
        <title>Neurocrine Biosciences Inc</title>
        <cusip>64125C109</cusip>
        <identifiers>
          <isin value="US64125C1099"/>
        </identifiers>
        <balance>135757.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11749768.35000000</valUSD>
        <pctVal>1.329149393841</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Impact Biomedicines Milestone</name>
        <lei>N/A</lei>
        <title>Impact Biomedicines Milestone Preferred Stock</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="ACI006C40"/>
        </identifiers>
        <balance>78177.95000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4751655.80000000</valUSD>
        <pctVal>0.537513612029</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetConditional assetCat="OTHER" desc="Milestone Interest"/>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ILLUMINOSS INC. CONVERTIBLE PROMISSORY NOTE</name>
        <lei>N/A</lei>
        <title>ILLUMINOSS INC. CONVERTIBLE PROMISSORY NOTE</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="965HCYII1"/>
        </identifiers>
        <balance>214762.80000000</balance>
        <units>PA</units>
        <curCd>USD</curCd>
        <valUSD>83156.16000000</valUSD>
        <pctVal>0.009406735210</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>DBT</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <debtSec>
          <maturityDt>2021-12-31</maturityDt>
          <couponKind>Fixed</couponKind>
          <annualizedRt>8.00000000</annualizedRt>
          <isDefault>N</isDefault>
          <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
          <isPaidKind>N</isPaidKind>
        </debtSec>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Biogen Inc</name>
        <lei>W8J5WZB5IY3K0NDQT671</lei>
        <title>Biogen Inc</title>
        <cusip>09062X103</cusip>
        <identifiers>
          <isin value="US09062X1037"/>
        </identifiers>
        <balance>181877.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>57542245.26000000</valUSD>
        <pctVal>6.509255172473</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>FIXED INC CLEARING CORP.REPO</name>
        <lei>549300H47WTHXPU08X20</lei>
        <title>FIXED INC CLEARING CORP.REPO</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="85748R009"/>
        </identifiers>
        <balance>24987000.00000000</balance>
        <units>PA</units>
        <curCd>USD</curCd>
        <valUSD>24987000.00000000</valUSD>
        <pctVal>2.826562610820</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>RA</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <repurchaseAgrmt>
          <transCat>Repurchase</transCat>
          <clearedCentCparty centralCounterparty="FIXED INC CLEARING CORP.REPO" isCleared="Y"/>
          <isTriParty>N</isTriParty>
          <repurchaseRt>0.00000000</repurchaseRt>
          <maturityDt>2020-04-01</maturityDt>
          <repurchaseCollaterals>
            <repurchaseCollateral>
              <principalAmt>24640000.00000000</principalAmt>
              <principalCd>USD</principalCd>
              <collateralVal>25491114.88000000</collateralVal>
              <collateralCd>USD</collateralCd>
              <invstCat>UST</invstCat>
            </repurchaseCollateral>
          </repurchaseCollaterals>
        </repurchaseAgrmt>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ascendis Pharma A/S</name>
        <lei>549300B66JN3W3J8GH73</lei>
        <title>Ascendis Pharma A/S</title>
        <cusip>04351P101</cusip>
        <identifiers>
          <isin value="US04351P1012"/>
        </identifiers>
        <balance>43154.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4859571.94000000</valUSD>
        <pctVal>0.549721229047</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Rainier Therapeutics Series B PREFERRED STOCK</name>
        <lei>N/A</lei>
        <title>Rainier Therapeutics Series B PREFERRED STOCK</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="931KNS905"/>
        </identifiers>
        <balance>1559715.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.00000000</valUSD>
        <pctVal>0.000000</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Amgen Inc</name>
        <lei>62QBXGPJ34PQ72Z12S66</lei>
        <title>Amgen Inc</title>
        <cusip>031162100</cusip>
        <identifiers>
          <isin value="US0311621009"/>
        </identifiers>
        <balance>286345.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>58050721.85000000</valUSD>
        <pctVal>6.566774719348</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Horizon Therapeutics Plc</name>
        <lei>N/A</lei>
        <title>Horizon Therapeutics Plc</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="IE00BQPVQZ61"/>
        </identifiers>
        <balance>248390.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7357311.80000000</valUSD>
        <pctVal>0.832268877817</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Momenta Pharmaceuticals Inc</name>
        <lei>529900BB2VMRCT4YQ588</lei>
        <title>Momenta Pharmaceuticals Inc</title>
        <cusip>60877T100</cusip>
        <identifiers>
          <isin value="US60877T1007"/>
        </identifiers>
        <balance>83575.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2273240.00000000</valUSD>
        <pctVal>0.257151926578</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VECTIVBIO HOLDING AG</name>
        <lei>N/A</lei>
        <title>VECTIVBIO HOLDING AG</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="964WMS900"/>
        </identifiers>
        <balance>875000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>691250.00000000</valUSD>
        <pctVal>0.078195117650</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Heron Therapeutics Inc</name>
        <lei>549300DR2I1DOPD2IX53</lei>
        <title>Heron Therapeutics Inc</title>
        <cusip>427746102</cusip>
        <identifiers>
          <isin value="US4277461020"/>
        </identifiers>
        <balance>90598.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1063620.52000000</valUSD>
        <pctVal>0.120318165203</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Arrowhead Pharmaceuticals Inc</name>
        <lei>549300O3CSB8T7OZ3D66</lei>
        <title>Arrowhead Pharmaceuticals Inc</title>
        <cusip>04280A100</cusip>
        <identifiers>
          <isin value="US04280A1007"/>
        </identifiers>
        <balance>40520.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1165760.40000000</valUSD>
        <pctVal>0.131872364021</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sanofi</name>
        <lei>549300E9PC51EN656011</lei>
        <title>Sanofi</title>
        <cusip>80105N105</cusip>
        <identifiers>
          <isin value="US80105N1054"/>
        </identifiers>
        <balance>149494.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6535877.68000000</valUSD>
        <pctVal>0.739347159690</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>FR</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alexion Pharmaceuticals Inc</name>
        <lei>M1YXUUZR0EIMU8T0EM75</lei>
        <title>Alexion Pharmaceuticals Inc</title>
        <cusip>015351109</cusip>
        <identifiers>
          <isin value="US0153511094"/>
        </identifiers>
        <balance>240033.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>21552563.07000000</valUSD>
        <pctVal>2.438054546004</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Stryker Corp</name>
        <lei>5493002F0SC4JTBU5137</lei>
        <title>Stryker Corp</title>
        <cusip>863667101</cusip>
        <identifiers>
          <isin value="US8636671013"/>
        </identifiers>
        <balance>22942.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3819613.58000000</valUSD>
        <pctVal>0.432079758795</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Intra-Cellular Therapies Inc</name>
        <lei>5299002U2KGF193IJA20</lei>
        <title>Intra-Cellular Therapies Inc</title>
        <cusip>46116X101</cusip>
        <identifiers>
          <isin value="US46116X1019"/>
        </identifiers>
        <balance>60156.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>924597.72000000</valUSD>
        <pctVal>0.104591721511</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Merck &amp; Co Inc</name>
        <lei>4YV9Y5M8S0BRK1RP0397</lei>
        <title>Merck &amp; Co Inc</title>
        <cusip>58933Y105</cusip>
        <identifiers>
          <isin value="US58933Y1055"/>
        </identifiers>
        <balance>190232.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14636450.08000000</valUSD>
        <pctVal>1.655694663275</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Pieris Pharmaceuticals Inc</name>
        <lei>254900AJDH8PAOOI5T33</lei>
        <title>Pieris Pharmaceuticals Inc</title>
        <cusip>720795103</cusip>
        <identifiers>
          <isin value="US7207951036"/>
        </identifiers>
        <balance>848209.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1933916.52000000</valUSD>
        <pctVal>0.218767204061</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ARKUDA THERAPEUTICS,INC</name>
        <lei>N/A</lei>
        <title>ARKUDA THERAPEUTICS,INC SER A. SERIES A PREFERRED STOCK.</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="964NDQ904"/>
        </identifiers>
        <balance>802477.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1909092.78000000</valUSD>
        <pctVal>0.215959109638</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>INNOVACARE INC COMMON STOCK</name>
        <lei>N/A</lei>
        <title>INNOVACARE INC COMMON STOCK</title>
        <cusip>457ESC010</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="457ESC010"/>
        </identifiers>
        <balance>222222.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>204755.35000000</valUSD>
        <pctVal>0.023162197009</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MyoKardia Inc</name>
        <lei>549300OLNNNZ1NI9UY54</lei>
        <title>MyoKardia Inc</title>
        <cusip>62857M105</cusip>
        <identifiers>
          <isin value="US62857M1053"/>
        </identifiers>
        <balance>13430.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>629598.40000000</valUSD>
        <pctVal>0.071221006814</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>HCA Healthcare Inc</name>
        <lei>529900PH4ZGUH2MNEU89</lei>
        <title>HCA Healthcare Inc</title>
        <cusip>40412C101</cusip>
        <identifiers>
          <isin value="US40412C1018"/>
        </identifiers>
        <balance>14868.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1335889.80000000</valUSD>
        <pctVal>0.151117627600</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sarepta Therapeutics Inc</name>
        <lei>549300IKDPIED8J8IG21</lei>
        <title>Sarepta Therapeutics Inc</title>
        <cusip>803607100</cusip>
        <identifiers>
          <isin value="US8036071004"/>
        </identifiers>
        <balance>88469.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8654037.58000000</valUSD>
        <pctVal>0.978956219484</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Centene Corp</name>
        <lei>549300Z7JJ4TQSQGT333</lei>
        <title>Centene Corp</title>
        <cusip>15135B101</cusip>
        <identifiers>
          <isin value="US15135B1017"/>
        </identifiers>
        <balance>37768.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2243796.88000000</valUSD>
        <pctVal>0.253821281757</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Bristol-Myers Squibb Co</name>
        <lei>HLYYNH7UQUORYSJQCN42</lei>
        <title>Bristol-Myers Squibb Co</title>
        <cusip>110122157</cusip>
        <identifiers>
          <isin value="US1101221570"/>
        </identifiers>
        <balance>798651.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3034873.80000000</valUSD>
        <pctVal>0.343308953121</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerConditional desc="derivative" issuerCat="OTHER"/>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <derivativeInfo>
          <othDeriv derivCat="OTH" othDesc="rights">
            <counterparties>
              <counterpartyName>N/A</counterpartyName>
              <counterpartyLei>N/A</counterpartyLei>
            </counterparties>
            <descRefInstrmnt>
              <otherRefInst>
                <issuerName>Bristol-Myers Squibb Co</issuerName>
                <issueTitle>Bristol-Myers Squibb Co</issueTitle>
                <identifiers>
                  <cusip value="110122108"/>
                  <isin value="US1101221083"/>
                </identifiers>
              </otherRefInst>
            </descRefInstrmnt>
            <terminationDt>2021-03-31</terminationDt>
            <notionalAmts>
              <notionalAmt amt="798651.00000000" curCd="USD"/>
            </notionalAmts>
            <delta>XXXX</delta>
            <unrealizedAppr>1333747.17000000</unrealizedAppr>
          </othDeriv>
        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Illuminoss Medical Inc.</name>
        <lei>N/A</lei>
        <title>ILLUMINOSS MEDICAL INC SERIES AA PREFERRED</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="976MND900"/>
        </identifiers>
        <balance>951000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.00000000</valUSD>
        <pctVal>0.000000</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Illuminoss Inc.</name>
        <lei>N/A</lei>
        <title>ILLUMINOSS INC. CONVERTIBLE PROMISSORY NOTE</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="934LZKII5"/>
        </identifiers>
        <balance>185849.35000000</balance>
        <units>PA</units>
        <curCd>USD</curCd>
        <valUSD>71960.87000000</valUSD>
        <pctVal>0.008140309144</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>DBT</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <debtSec>
          <maturityDt>2021-12-31</maturityDt>
          <couponKind>Fixed</couponKind>
          <annualizedRt>8.00000000</annualizedRt>
          <isDefault>N</isDefault>
          <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
          <isPaidKind>N</isPaidKind>
        </debtSec>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Portola Pharmaceuticals Inc</name>
        <lei>549300BM3O4O0CNBGJ64</lei>
        <title>Portola Pharmaceuticals Inc</title>
        <cusip>737010108</cusip>
        <identifiers>
          <isin value="US7370101088"/>
        </identifiers>
        <balance>66436.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>473688.68000000</valUSD>
        <pctVal>0.053584292314</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BioMarin Pharmaceutical Inc</name>
        <lei>NSLL8ITTRR0J5HEMR848</lei>
        <title>BioMarin Pharmaceutical Inc</title>
        <cusip>09061G101</cusip>
        <identifiers>
          <isin value="US09061G1013"/>
        </identifiers>
        <balance>188964.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>15967458.00000000</valUSD>
        <pctVal>1.806260046130</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Galapagos NV</name>
        <lei>549300QKJ78IY0IOV655</lei>
        <title>Galapagos NV</title>
        <cusip>36315X101</cusip>
        <identifiers>
          <isin value="US36315X1019"/>
        </identifiers>
        <balance>6543.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1281904.56000000</valUSD>
        <pctVal>0.145010745585</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>FibroGen Inc</name>
        <lei>549300Q914ULWWY95822</lei>
        <title>FibroGen Inc</title>
        <cusip>31572Q808</cusip>
        <identifiers>
          <isin value="US31572Q8087"/>
        </identifiers>
        <balance>126349.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4390627.75000000</valUSD>
        <pctVal>0.496673639739</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Incyte Corp</name>
        <lei>549300Z4WN6JVZ3T4680</lei>
        <title>Incyte Corp</title>
        <cusip>45337C102</cusip>
        <identifiers>
          <isin value="US45337C1027"/>
        </identifiers>
        <balance>233676.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>17112093.48000000</valUSD>
        <pctVal>1.935742731157</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ACADIA Pharmaceuticals Inc</name>
        <lei>529900O3044NO0PEA039</lei>
        <title>ACADIA Pharmaceuticals Inc</title>
        <cusip>004225108</cusip>
        <identifiers>
          <isin value="US0042251084"/>
        </identifiers>
        <balance>175047.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7395735.75000000</valUSD>
        <pctVal>0.836615446050</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Milestone Pharmaceuticals Inc</name>
        <lei>N/A</lei>
        <title>Milestone Pharmaceuticals Inc</title>
        <cusip>59935V107</cusip>
        <identifiers>
          <isin value="CA59935V1076"/>
        </identifiers>
        <balance>149316.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>274741.44000000</valUSD>
        <pctVal>0.031079116418</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>United Therapeutics Corp</name>
        <lei>5299005C4HZL4UWROC14</lei>
        <title>United Therapeutics Corp</title>
        <cusip>91307C102</cusip>
        <identifiers>
          <isin value="US91307C1027"/>
        </identifiers>
        <balance>43002.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4077664.65000000</valUSD>
        <pctVal>0.461270838402</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Blueprint Medicines Corp</name>
        <lei>5299004CC60O9T5HVM83</lei>
        <title>Blueprint Medicines Corp</title>
        <cusip>09627Y109</cusip>
        <identifiers>
          <isin value="US09627Y1091"/>
        </identifiers>
        <balance>91758.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5366007.84000000</valUSD>
        <pctVal>0.607009930360</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Y-mAbs Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Y-mAbs Therapeutics Inc</title>
        <cusip>984241109</cusip>
        <identifiers>
          <isin value="US9842411095"/>
        </identifiers>
        <balance>52706.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1375626.60000000</valUSD>
        <pctVal>0.155612707168</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Intellia Therapeutics Inc</name>
        <lei>5493002T5BCPE5DZC723</lei>
        <title>Intellia Therapeutics Inc</title>
        <cusip>45826J105</cusip>
        <identifiers>
          <isin value="US45826J1051"/>
        </identifiers>
        <balance>41016.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>501625.68000000</valUSD>
        <pctVal>0.056744562841</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AnaptysBio Inc</name>
        <lei>529900HH4WQT03IG1A12</lei>
        <title>AnaptysBio Inc</title>
        <cusip>032724106</cusip>
        <identifiers>
          <isin value="US0327241065"/>
        </identifiers>
        <balance>82022.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1158970.86000000</valUSD>
        <pctVal>0.131104322243</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ILLUMINOSS INC CONVERTIBLE PROMISSORY NOTE</name>
        <lei>N/A</lei>
        <title>ILLUMINOSS INC CONVERTIBLE PROMISSORY NOTE</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="966DJLII0"/>
        </identifiers>
        <balance>61666.67000000</balance>
        <units>PA</units>
        <curCd>USD</curCd>
        <valUSD>23877.33000000</valUSD>
        <pctVal>0.002701035267</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>DBT</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <debtSec>
          <maturityDt>2021-12-31</maturityDt>
          <couponKind>Fixed</couponKind>
          <annualizedRt>8.00000000</annualizedRt>
          <isDefault>N</isDefault>
          <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
          <isPaidKind>N</isPaidKind>
        </debtSec>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zoetis Inc</name>
        <lei>549300HD9Q1LOC9KLJ48</lei>
        <title>Zoetis Inc</title>
        <cusip>98978V103</cusip>
        <identifiers>
          <isin value="US98978V1035"/>
        </identifiers>
        <balance>46949.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5525427.81000000</valUSD>
        <pctVal>0.625043729000</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Illuminoss Medical Inc.</name>
        <lei>N/A</lei>
        <title>ILLUMINOSS MEDICAL, INC JUNIOR PREFERRED STOCK</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="ACI02I3H3"/>
        </identifiers>
        <balance>895848.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.00000000</valUSD>
        <pctVal>0.000000</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Bio-Techne Corp</name>
        <lei>54930073RLKQ51TILZ35</lei>
        <title>Bio-Techne Corp</title>
        <cusip>09073M104</cusip>
        <identifiers>
          <isin value="US09073M1045"/>
        </identifiers>
        <balance>31672.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6005644.64000000</valUSD>
        <pctVal>0.679366494309</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Illuminoss Inc.</name>
        <lei>N/A</lei>
        <title>Illuminoss Inc. Warrants</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="ACI17XW40"/>
        </identifiers>
        <balance>46462.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.00000000</valUSD>
        <pctVal>0.000000</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerConditional desc="derivative" issuerCat="OTHER"/>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <derivativeInfo>
          <optionSwaptionWarrantDeriv derivCat="WAR">
            <counterparties>
              <counterpartyName>N/A</counterpartyName>
              <counterpartyLei>N/A</counterpartyLei>
            </counterparties>
            <putOrCall>Call</putOrCall>
            <writtenOrPur>Purchased</writtenOrPur>
            <descRefInstrmnt>
              <otherRefInst>
                <issuerName>ILLUMINOSS INC. SERIES AA</issuerName>
                <issueTitle>ILLUMINOSS INC. SERIES AA</issueTitle>
                <identifiers>
                  <other otherDesc="Internal Identifier - Private Company" value="976MND900"/>
                </identifiers>
              </otherRefInst>
            </descRefInstrmnt>
            <shareNo>1.00000000</shareNo>
            <exercisePrice>1.00000000</exercisePrice>
            <exercisePriceCurCd>USD</exercisePriceCurCd>
            <expDt>2029-01-29</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>0.00000000</unrealizedAppr>
          </optionSwaptionWarrantDeriv>
        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PRA Health Sciences Inc</name>
        <lei>549300R1HR1VWWHIAK47</lei>
        <title>PRA Health Sciences Inc</title>
        <cusip>69354M108</cusip>
        <identifiers>
          <isin value="US69354M1080"/>
        </identifiers>
        <balance>78739.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6538486.56000000</valUSD>
        <pctVal>0.739642279659</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ILLUMINOSS INC. CONVERTIBLE PROMISSORY NOTE</name>
        <lei>N/A</lei>
        <title>ILLUMINOSS INC. CONVERTIBLE PROMISSORY NOTE</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="965URGII5"/>
        </identifiers>
        <balance>123333.33000000</balance>
        <units>PA</units>
        <curCd>USD</curCd>
        <valUSD>47754.67000000</valUSD>
        <pctVal>0.005402071665</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>DBT</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <debtSec>
          <maturityDt>2021-12-31</maturityDt>
          <couponKind>Fixed</couponKind>
          <annualizedRt>8.00000000</annualizedRt>
          <isDefault>N</isDefault>
          <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
          <isPaidKind>N</isPaidKind>
        </debtSec>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Avrobio Inc</name>
        <lei>N/A</lei>
        <title>Avrobio Inc</title>
        <cusip>05455M100</cusip>
        <identifiers>
          <isin value="US05455M1009"/>
        </identifiers>
        <balance>37732.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>587109.92000000</valUSD>
        <pctVal>0.066414653552</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Seattle Genetics Inc</name>
        <lei>N/A</lei>
        <title>Seattle Genetics Inc</title>
        <cusip>812578102</cusip>
        <identifiers>
          <isin value="US8125781026"/>
        </identifiers>
        <balance>140245.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16181468.10000000</valUSD>
        <pctVal>1.830469152745</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Tetraphase Pharmaceuticals Inc</name>
        <lei>529900BOHW16K9S8NC02</lei>
        <title>Tetraphase Pharmaceuticals Inc</title>
        <cusip>88165N204</cusip>
        <identifiers>
          <isin value="US88165N2045"/>
        </identifiers>
        <balance>28747.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>36796.16000000</valUSD>
        <pctVal>0.004162430466</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IDEXX Laboratories Inc</name>
        <lei>OGMTXK0LUU1HKV2P0J84</lei>
        <title>IDEXX Laboratories Inc</title>
        <cusip>45168D104</cusip>
        <identifiers>
          <isin value="US45168D1046"/>
        </identifiers>
        <balance>6736.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1631728.64000000</valUSD>
        <pctVal>0.184583309914</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Charles River Laboratories International Inc</name>
        <lei>549300BSQ0R4UZ5KX287</lei>
        <title>Charles River Laboratories International Inc</title>
        <cusip>159864107</cusip>
        <identifiers>
          <isin value="US1598641074"/>
        </identifiers>
        <balance>3527.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>445142.67000000</valUSD>
        <pctVal>0.050355129767</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Adynxx Inc</name>
        <lei>N/A</lei>
        <title>Adynxx Inc</title>
        <cusip>00784D103</cusip>
        <identifiers>
          <isin value="US00784D1037"/>
        </identifiers>
        <balance>17325.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6063.75000000</valUSD>
        <pctVal>0.000685939449</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zimmer Biomet Holdings Inc</name>
        <lei>2P2YLDVPES3BXQ1FRB91</lei>
        <title>Zimmer Biomet Holdings Inc</title>
        <cusip>98956P102</cusip>
        <identifiers>
          <isin value="US98956P1021"/>
        </identifiers>
        <balance>6068.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>613353.44000000</valUSD>
        <pctVal>0.069383355373</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ABIOMED Inc</name>
        <lei>5493001EZN4ZTB4Z5887</lei>
        <title>ABIOMED Inc</title>
        <cusip>003654100</cusip>
        <identifiers>
          <isin value="US0036541003"/>
        </identifiers>
        <balance>9421.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1367552.36000000</valUSD>
        <pctVal>0.154699338420</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Gilead Sciences Inc</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>Gilead Sciences Inc</title>
        <cusip>375558103</cusip>
        <identifiers>
          <isin value="US3755581036"/>
        </identifiers>
        <balance>941540.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>70389530.40000000</valUSD>
        <pctVal>7.962557122578</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Laboratory Corp of America Holdings</name>
        <lei>OZ7UA8IXAIFILY2VZH07</lei>
        <title>Laboratory Corp of America Holdings</title>
        <cusip>50540R409</cusip>
        <identifiers>
          <isin value="US50540R4092"/>
        </identifiers>
        <balance>6284.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>794234.76000000</valUSD>
        <pctVal>0.089844890416</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IQVIA Holdings Inc</name>
        <lei>549300W3R20NM4KQPH86</lei>
        <title>IQVIA Holdings Inc</title>
        <cusip>46266C105</cusip>
        <identifiers>
          <isin value="US46266C1053"/>
        </identifiers>
        <balance>18800.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2027768.00000000</valUSD>
        <pctVal>0.229383808068</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Align Technology Inc</name>
        <lei>549300N5YSE0U3LCP840</lei>
        <title>Align Technology Inc</title>
        <cusip>016255101</cusip>
        <identifiers>
          <isin value="US0162551016"/>
        </identifiers>
        <balance>116.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>20178.20000000</valUSD>
        <pctVal>0.002282584771</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Galera Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>GALERA THERAPEUTICS, INC. SERI SERIES C PREFERRED STOCK</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="933FSC904"/>
        </identifiers>
        <balance>206309.85800000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1763949.29000000</valUSD>
        <pctVal>0.199540285368</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Amarin Corp PLC</name>
        <lei>5493009JFIGUFEVPK217</lei>
        <title>Amarin Corp PLC</title>
        <cusip>023111206</cusip>
        <identifiers>
          <isin value="US0231112063"/>
        </identifiers>
        <balance>388635.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1554540.00000000</valUSD>
        <pctVal>0.175851628487</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Eidos Therapeutics Inc</name>
        <lei>549300VGYGU07QRG6271</lei>
        <title>Eidos Therapeutics Inc</title>
        <cusip>28249H104</cusip>
        <identifiers>
          <isin value="US28249H1041"/>
        </identifiers>
        <balance>13882.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>680079.18000000</valUSD>
        <pctVal>0.076931459662</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Deciphera Pharmaceuticals Inc</name>
        <lei>529900QR4WAPYY0CBF25</lei>
        <title>Deciphera Pharmaceuticals Inc</title>
        <cusip>24344T101</cusip>
        <identifiers>
          <isin value="US24344T1016"/>
        </identifiers>
        <balance>42334.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1742890.78000000</valUSD>
        <pctVal>0.197158118761</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PTC Therapeutics Inc</name>
        <lei>549300UJLWOIWFDGB318</lei>
        <title>PTC Therapeutics Inc</title>
        <cusip>69366J200</cusip>
        <identifiers>
          <isin value="US69366J2006"/>
        </identifiers>
        <balance>77935.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3476680.35000000</valUSD>
        <pctVal>0.393286696565</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Jazz Pharmaceuticals PLC</name>
        <lei>635400GAUMJCLEZRRV50</lei>
        <title>Jazz Pharmaceuticals PLC</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="IE00B4Q5ZN47"/>
        </identifiers>
        <balance>42253.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4214314.22000000</valUSD>
        <pctVal>0.476728819166</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Merus NV</name>
        <lei>549300W8GPUWU8QNU293</lei>
        <title>Merus NV</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="NL0011606264"/>
        </identifiers>
        <balance>14939.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>180761.90000000</valUSD>
        <pctVal>0.020448026093</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Abbott Laboratories</name>
        <lei>HQD377W2YR662HK5JX27</lei>
        <title>Abbott Laboratories</title>
        <cusip>002824100</cusip>
        <identifiers>
          <isin value="US0028241000"/>
        </identifiers>
        <balance>23195.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1830317.45000000</valUSD>
        <pctVal>0.207047939732</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Illuminoss Inc.</name>
        <lei>N/A</lei>
        <title>Illuminoss Inc Warrants</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="ACI0TCSK3"/>
        </identifiers>
        <balance>71323.54000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.00000000</valUSD>
        <pctVal>0.000000</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerConditional desc="derivative" issuerCat="OTHER"/>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <derivativeInfo>
          <optionSwaptionWarrantDeriv derivCat="WAR">
            <counterparties>
              <counterpartyName>N/A</counterpartyName>
              <counterpartyLei>N/A</counterpartyLei>
            </counterparties>
            <putOrCall>Call</putOrCall>
            <writtenOrPur>Purchased</writtenOrPur>
            <descRefInstrmnt>
              <otherRefInst>
                <issuerName>ILLUMINOSS INC. SERIES AA</issuerName>
                <issueTitle>ILLUMINOSS INC. SERIES AA</issueTitle>
                <identifiers>
                  <other otherDesc="Internal Identifier - Private Company" value="976MND900"/>
                </identifiers>
              </otherRefInst>
            </descRefInstrmnt>
            <shareNo>1.00000000</shareNo>
            <exercisePrice>1.00000000</exercisePrice>
            <exercisePriceCurCd>USD</exercisePriceCurCd>
            <expDt>2027-03-31</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>-331.26000000</unrealizedAppr>
          </optionSwaptionWarrantDeriv>
        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AMPHIVENA THERAPEUTICS, INC. SERIES B PREFERRED STOCK</name>
        <lei>N/A</lei>
        <title>AMPHIVENA THERAPEUTICS, INC. SERIES B PREFERRED STOCK</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="930ZPM904"/>
        </identifiers>
        <balance>326666.70000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4900000.50000000</valUSD>
        <pctVal>0.554294561424</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Madrigal Pharmaceuticals Inc</name>
        <lei>549300CHIMT2EUSNJB60</lei>
        <title>Madrigal Pharmaceuticals Inc</title>
        <cusip>558868105</cusip>
        <identifiers>
          <isin value="US5588681057"/>
        </identifiers>
        <balance>9280.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>619532.80000000</valUSD>
        <pctVal>0.070082372780</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Acceleron Pharma Inc</name>
        <lei>529900TQRID2UY164805</lei>
        <title>Acceleron Pharma Inc</title>
        <cusip>00434H108</cusip>
        <identifiers>
          <isin value="US00434H1086"/>
        </identifiers>
        <balance>24219.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2176561.53000000</valUSD>
        <pctVal>0.246215529709</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Teva Pharmaceutical Industries Ltd</name>
        <lei>549300BAFGM4RC74ZJ94</lei>
        <title>Teva Pharmaceutical Industries Ltd</title>
        <cusip>881624209</cusip>
        <identifiers>
          <isin value="US8816242098"/>
        </identifiers>
        <balance>291666.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2619160.68000000</valUSD>
        <pctVal>0.296282933118</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Rainier Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>RAINIER THERAPEUTICS, INC. PROMISSORY NOTE</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="964PDRII8"/>
        </identifiers>
        <balance>442570.00000000</balance>
        <units>PA</units>
        <curCd>USD</curCd>
        <valUSD>0.00000000</valUSD>
        <pctVal>0.000000</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>DBT</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <debtSec>
          <maturityDt>2020-01-30</maturityDt>
          <couponKind>Fixed</couponKind>
          <annualizedRt>8.00000000</annualizedRt>
          <isDefault>N</isDefault>
          <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
          <isPaidKind>N</isPaidKind>
        </debtSec>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Argenx SE</name>
        <lei>7245009C5FZE6G9ODQ71</lei>
        <title>Argenx SE</title>
        <cusip>04016X101</cusip>
        <identifiers>
          <isin value="US04016X1019"/>
        </identifiers>
        <balance>29426.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3876286.98000000</valUSD>
        <pctVal>0.438490729038</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Illuminoss Inc.</name>
        <lei>N/A</lei>
        <title>ILLUMINOSS INC. CONVERTIBLE</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="931ELZII6"/>
        </identifiers>
        <balance>95083.11000000</balance>
        <units>PA</units>
        <curCd>USD</curCd>
        <valUSD>36816.18000000</valUSD>
        <pctVal>0.004164695155</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>DBT</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <debtSec>
          <maturityDt>2021-12-31</maturityDt>
          <couponKind>Fixed</couponKind>
          <annualizedRt>8.00000000</annualizedRt>
          <isDefault>N</isDefault>
          <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
          <isPaidKind>N</isPaidKind>
        </debtSec>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Theravance Biopharma Inc</name>
        <lei>5493007VTSXP4Z6MIW52</lei>
        <title>Theravance Biopharma Inc</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="KYG8807B1068"/>
        </identifiers>
        <balance>155320.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3589445.20000000</valUSD>
        <pctVal>0.406042806095</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Nektar Therapeutics</name>
        <lei>5299005I24806IOIYE03</lei>
        <title>Nektar Therapeutics</title>
        <cusip>640268108</cusip>
        <identifiers>
          <isin value="US6402681083"/>
        </identifiers>
        <balance>147820.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2638587.00000000</valUSD>
        <pctVal>0.298480464225</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Quotient Ltd</name>
        <lei>549300BOTHGGT8D81659</lei>
        <title>Quotient Ltd</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="JE00BLG2ZQ72"/>
        </identifiers>
        <balance>138309.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>546320.55000000</valUSD>
        <pctVal>0.061800505869</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Illuminoss Inc.</name>
        <lei>N/A</lei>
        <title>ILLUMINOSS INC. CONVERTIBLE PR 06/18 FIXED 8</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="931GXUII9"/>
        </identifiers>
        <balance>285294.16000000</balance>
        <units>PA</units>
        <curCd>USD</curCd>
        <valUSD>110465.90000000</valUSD>
        <pctVal>0.012496049254</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>DBT</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <debtSec>
          <maturityDt>2021-12-31</maturityDt>
          <couponKind>Fixed</couponKind>
          <annualizedRt>8.00000000</annualizedRt>
          <isDefault>N</isDefault>
          <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
          <isPaidKind>N</isPaidKind>
        </debtSec>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Puma Biotechnology Inc</name>
        <lei>N/A</lei>
        <title>Puma Biotechnology Inc</title>
        <cusip>74587V107</cusip>
        <identifiers>
          <isin value="US74587V1070"/>
        </identifiers>
        <balance>35515.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>299746.60000000</valUSD>
        <pctVal>0.033907733312</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Pieris Pharmaceuticals Warrant Series A</name>
        <lei>254900AJDH8PAOOI5T33</lei>
        <title>Pieris Pharmaceuticals Warrant Series A</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="930ECL907"/>
        </identifiers>
        <balance>54790.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>31230.30000000</valUSD>
        <pctVal>0.003532812994</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerConditional desc="derivative" issuerCat="OTHER"/>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <derivativeInfo>
          <optionSwaptionWarrantDeriv derivCat="WAR">
            <counterparties>
              <counterpartyName>N/A</counterpartyName>
              <counterpartyLei>N/A</counterpartyLei>
            </counterparties>
            <putOrCall>Call</putOrCall>
            <writtenOrPur>Purchased</writtenOrPur>
            <descRefInstrmnt>
              <otherRefInst>
                <issuerName>Pieris Pharmaceuticals Inc</issuerName>
                <issueTitle>Pieris Pharmaceuticals Inc</issueTitle>
                <identifiers>
                  <cusip value="720795103"/>
                  <isin value="US7207951036"/>
                </identifiers>
              </otherRefInst>
            </descRefInstrmnt>
            <shareNo>1.00000000</shareNo>
            <exercisePrice>3.00000000</exercisePrice>
            <exercisePriceCurCd>USD</exercisePriceCurCd>
            <expDt>2021-06-08</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>23843.86000000</unrealizedAppr>
          </optionSwaptionWarrantDeriv>
        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Exelixis Inc</name>
        <lei>N/A</lei>
        <title>Exelixis Inc</title>
        <cusip>30161Q104</cusip>
        <identifiers>
          <isin value="US30161Q1040"/>
        </identifiers>
        <balance>352719.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6073821.18000000</valUSD>
        <pctVal>0.687078715019</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Epizyme Inc</name>
        <lei>549300TNFWF88O4U4605</lei>
        <title>Epizyme Inc</title>
        <cusip>29428V104</cusip>
        <identifiers>
          <isin value="US29428V1044"/>
        </identifiers>
        <balance>135974.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2108956.74000000</valUSD>
        <pctVal>0.238567986117</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Danaher Corp</name>
        <lei>S4BKK9OTCEWQ3YHPFM11</lei>
        <title>Danaher Corp</title>
        <cusip>235851102</cusip>
        <identifiers>
          <isin value="US2358511028"/>
        </identifiers>
        <balance>29262.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4050153.42000000</valUSD>
        <pctVal>0.458158731542</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Bluebird Bio Inc</name>
        <lei>N/A</lei>
        <title>Bluebird Bio Inc</title>
        <cusip>09609G100</cusip>
        <identifiers>
          <isin value="US09609G1004"/>
        </identifiers>
        <balance>50270.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2310409.20000000</valUSD>
        <pctVal>0.261356555825</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Allergan PLC</name>
        <lei>635400FWJZQC1IPYUH69</lei>
        <title>Allergan PLC</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="IE00BY9D5467"/>
        </identifiers>
        <balance>8583.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1520049.30000000</valUSD>
        <pctVal>0.171949994716</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Insmed Inc</name>
        <lei>529900Q55QAG41CCAC11</lei>
        <title>Insmed Inc</title>
        <cusip>457669307</cusip>
        <identifiers>
          <isin value="US4576693075"/>
        </identifiers>
        <balance>61149.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>980218.47000000</valUSD>
        <pctVal>0.110883614589</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AQUAMED TECHNOLOGIES INC COMMON STOCK</name>
        <lei>N/A</lei>
        <title>AQUAMED TECHNOLOGIES INC COMMON STOCK</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="935LTY900"/>
        </identifiers>
        <balance>103950.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5561.33000000</valUSD>
        <pctVal>0.000629105032</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Intuitive Surgical Inc</name>
        <lei>54930052SRG011710797</lei>
        <title>Intuitive Surgical Inc</title>
        <cusip>46120E602</cusip>
        <identifiers>
          <isin value="US46120E6023"/>
        </identifiers>
        <balance>7180.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3555607.80000000</valUSD>
        <pctVal>0.402215074487</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ILLUMINOSS INC. WARRANTS</name>
        <lei>N/A</lei>
        <title>ILLUMINOSS INC. WARRANTS</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="966DKJII3"/>
        </identifiers>
        <balance>15416.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.00000000</valUSD>
        <pctVal>0.000000</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerConditional desc="derivative" issuerCat="OTHER"/>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <derivativeInfo>
          <optionSwaptionWarrantDeriv derivCat="WAR">
            <counterparties>
              <counterpartyName>N/A</counterpartyName>
              <counterpartyLei>N/A</counterpartyLei>
            </counterparties>
            <putOrCall>Call</putOrCall>
            <writtenOrPur>Purchased</writtenOrPur>
            <descRefInstrmnt>
              <otherRefInst>
                <issuerName>ILLUMINOSS INC. SERIES AA</issuerName>
                <issueTitle>ILLUMINOSS INC. SERIES AA</issueTitle>
                <identifiers>
                  <other otherDesc="Internal Identifier - Private Company" value="966DKJII3"/>
                </identifiers>
              </otherRefInst>
            </descRefInstrmnt>
            <shareNo>1.00000000</shareNo>
            <exercisePrice>1.00000000</exercisePrice>
            <exercisePriceCurCd>USD</exercisePriceCurCd>
            <expDt>2030-03-06</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>0.00000000</unrealizedAppr>
          </optionSwaptionWarrantDeriv>
        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Illuminoss Inc.</name>
        <lei>N/A</lei>
        <title>Illuminoss Inc Wts Call Exp 06Sept 27</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="ACI14WWT0"/>
        </identifiers>
        <balance>59426.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.00000000</valUSD>
        <pctVal>0.000000</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerConditional desc="derivative" issuerCat="OTHER"/>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <derivativeInfo>
          <optionSwaptionWarrantDeriv derivCat="WAR">
            <counterparties>
              <counterpartyName>N/A</counterpartyName>
              <counterpartyLei>N/A</counterpartyLei>
            </counterparties>
            <putOrCall>Call</putOrCall>
            <writtenOrPur>Purchased</writtenOrPur>
            <descRefInstrmnt>
              <otherRefInst>
                <issuerName>ILLUMINOSS INC. SERIES AA</issuerName>
                <issueTitle>ILLUMINOSS INC. SERIES AA</issueTitle>
                <identifiers>
                  <other otherDesc="Internal Identifier - Private Company" value="976MND900"/>
                </identifiers>
              </otherRefInst>
            </descRefInstrmnt>
            <shareNo>1.00000000</shareNo>
            <exercisePrice>1.00000000</exercisePrice>
            <exercisePriceCurCd>USD</exercisePriceCurCd>
            <expDt>2027-09-06</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>0.00000000</unrealizedAppr>
          </optionSwaptionWarrantDeriv>
        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Global Blood Therapeutics Inc</name>
        <lei>549300U4G0QKK99GRT15</lei>
        <title>Global Blood Therapeutics Inc</title>
        <cusip>37890U108</cusip>
        <identifiers>
          <isin value="US37890U1088"/>
        </identifiers>
        <balance>77990.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3984509.10000000</valUSD>
        <pctVal>0.450732958920</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Xencor Inc</name>
        <lei>549300V5IF65437JKG30</lei>
        <title>Xencor Inc</title>
        <cusip>98401F105</cusip>
        <identifiers>
          <isin value="US98401F1057"/>
        </identifiers>
        <balance>74157.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2215811.16000000</valUSD>
        <pctVal>0.250655499959</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Revance Therapeutics Inc</name>
        <lei>549300N33TFDZHS81H11</lei>
        <title>Revance Therapeutics Inc</title>
        <cusip>761330109</cusip>
        <identifiers>
          <isin value="US7613301099"/>
        </identifiers>
        <balance>59240.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>876752.00000000</valUSD>
        <pctVal>0.099179350148</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cercacor Laboratories Inc</name>
        <lei>N/A</lei>
        <title>CERCACOR LABORATORIES INC COMMON STOCK</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="574992913"/>
        </identifiers>
        <balance>160000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1053671.36000000</valUSD>
        <pctVal>0.119192703016</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ResMed Inc</name>
        <lei>529900T3QE5253CCXF22</lei>
        <title>ResMed Inc</title>
        <cusip>761152107</cusip>
        <identifiers>
          <isin value="US7611521078"/>
        </identifiers>
        <balance>3823.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>563089.67000000</valUSD>
        <pctVal>0.063697450984</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Illuminoss Inc.</name>
        <lei>N/A</lei>
        <title>ILLUMINOSS INC, CONVERTIBLE PR</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="932PUMII9"/>
        </identifiers>
        <balance>190166.13000000</balance>
        <units>PA</units>
        <curCd>USD</curCd>
        <valUSD>73632.33000000</valUSD>
        <pctVal>0.008329386918</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>DBT</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <debtSec>
          <maturityDt>2021-12-31</maturityDt>
          <couponKind>Fixed</couponKind>
          <annualizedRt>8.00000000</annualizedRt>
          <isDefault>N</isDefault>
          <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
          <isPaidKind>N</isPaidKind>
        </debtSec>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>RAINIER THERAPEUTICS, INC CONVERTIBLE PROMISSORY NOTE</name>
        <lei>N/A</lei>
        <title>RAINIER THERAPEUTICS, INC CONVERTIBLE PROMISSORY NOTE</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="965JFRII9"/>
        </identifiers>
        <balance>127500.00000000</balance>
        <units>PA</units>
        <curCd>USD</curCd>
        <valUSD>90792.75000000</valUSD>
        <pctVal>0.010270596409</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>DBT</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <debtSec>
          <maturityDt>2020-03-31</maturityDt>
          <couponKind>Fixed</couponKind>
          <annualizedRt>8.00000000</annualizedRt>
          <isDefault>N</isDefault>
          <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
          <isPaidKind>N</isPaidKind>
        </debtSec>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Biohaven Pharmaceutical Holding Co Ltd</name>
        <lei>5299007STZTNN32O9920</lei>
        <title>Biohaven Pharmaceutical Holding Co Ltd</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="VGG111961055"/>
        </identifiers>
        <balance>31254.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1063573.62000000</valUSD>
        <pctVal>0.120312859812</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>VG</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>uniQure NV</name>
        <lei>N/A</lei>
        <title>uniQure NV</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="NL0010696654"/>
        </identifiers>
        <balance>24098.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1143450.10000000</valUSD>
        <pctVal>0.129348593268</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sage Therapeutics Inc</name>
        <lei>5493000JX4BJS9W6CN35</lei>
        <title>Sage Therapeutics Inc</title>
        <cusip>78667J108</cusip>
        <identifiers>
          <isin value="US78667J1088"/>
        </identifiers>
        <balance>62470.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1794138.40000000</valUSD>
        <pctVal>0.202955317568</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>WaVe Life Sciences Ltd</name>
        <lei>54930070006GPKFYZ813</lei>
        <title>WaVe Life Sciences Ltd</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="SG9999014716"/>
        </identifiers>
        <balance>87566.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>820493.42000000</valUSD>
        <pctVal>0.092815304894</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>SG</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>RAINIER THERAPEUTICS, INC. CONVERTIBLE PROMISSORY NOTE</name>
        <lei>N/A</lei>
        <title>RAINIER THERAPEUTICS, INC. CONVERTIBLE PROMISSORY NOTE</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="964YGZ907"/>
        </identifiers>
        <balance>510142.74000000</balance>
        <units>PA</units>
        <curCd>USD</curCd>
        <valUSD>363272.65000000</valUSD>
        <pctVal>0.041093884420</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>DBT</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <debtSec>
          <maturityDt>2020-03-31</maturityDt>
          <couponKind>Fixed</couponKind>
          <annualizedRt>8.00000000</annualizedRt>
          <isDefault>N</isDefault>
          <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
          <isPaidKind>N</isPaidKind>
        </debtSec>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Agios Pharmaceuticals Inc</name>
        <lei>529900ONJHY8EOGYT555</lei>
        <title>Agios Pharmaceuticals Inc</title>
        <cusip>00847X104</cusip>
        <identifiers>
          <isin value="US00847X1046"/>
        </identifiers>
        <balance>123156.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4369574.88000000</valUSD>
        <pctVal>0.494292111137</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Esperion Therapeutics Inc</name>
        <lei>549300OFU56UKEWVUS92</lei>
        <title>Esperion Therapeutics Inc</title>
        <cusip>29664W105</cusip>
        <identifiers>
          <isin value="US29664W1053"/>
        </identifiers>
        <balance>26244.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>827473.32000000</valUSD>
        <pctVal>0.093604880448</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Endo International PLC</name>
        <lei>5493007TBMWZWGZIB256</lei>
        <title>Endo International PLC</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="IE00BJ3V9050"/>
        </identifiers>
        <balance>465507.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1722375.90000000</valUSD>
        <pctVal>0.194837448301</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Axsome Therapeutics Inc</name>
        <lei>549300EXGR0XLRJEIB95</lei>
        <title>Axsome Therapeutics Inc</title>
        <cusip>05464T104</cusip>
        <identifiers>
          <isin value="US05464T1043"/>
        </identifiers>
        <balance>21807.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1282905.81000000</valUSD>
        <pctVal>0.145124008314</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AmerisourceBergen Corp</name>
        <lei>AI8GXW8LG5WK7E9UD086</lei>
        <title>AmerisourceBergen Corp</title>
        <cusip>03073E105</cusip>
        <identifiers>
          <isin value="US03073E1055"/>
        </identifiers>
        <balance>12760.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1129260.00000000</valUSD>
        <pctVal>0.127743390318</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Kodiak Sciences Inc</name>
        <lei>N/A</lei>
        <title>Kodiak Sciences Inc</title>
        <cusip>50015M109</cusip>
        <identifiers>
          <isin value="US50015M1099"/>
        </identifiers>
        <balance>15966.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>761578.20000000</valUSD>
        <pctVal>0.086150736996</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Allogene Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Allogene Therapeutics Inc</title>
        <cusip>019770106</cusip>
        <identifiers>
          <isin value="US0197701065"/>
        </identifiers>
        <balance>159332.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3097414.08000000</valUSD>
        <pctVal>0.350383592618</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sangamo Therapeutics Inc</name>
        <lei>2549006WMRKRC4G32Z67</lei>
        <title>Sangamo Therapeutics Inc</title>
        <cusip>800677106</cusip>
        <identifiers>
          <isin value="US8006771062"/>
        </identifiers>
        <balance>103856.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>661562.72000000</valUSD>
        <pctVal>0.074836853126</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Axonics Modulation Technologies Inc</name>
        <lei>549300LJY4X7N57VJL05</lei>
        <title>Axonics Modulation Technologies Inc</title>
        <cusip>05465P101</cusip>
        <identifiers>
          <isin value="US05465P1012"/>
        </identifiers>
        <balance>19400.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>492954.00000000</valUSD>
        <pctVal>0.055763610887</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Mylan NV</name>
        <lei>549300A0CD4KNFGIIS89</lei>
        <title>Mylan NV</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="NL0011031208"/>
        </identifiers>
        <balance>555772.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8286560.52000000</valUSD>
        <pctVal>0.937386726623</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Illuminoss Inc.</name>
        <lei>N/A</lei>
        <title>Illuminoss Inc. Warrants</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="962ULE908"/>
        </identifiers>
        <balance>47541.53000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.00000000</valUSD>
        <pctVal>0.000000</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerConditional desc="derivative" issuerCat="OTHER"/>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <derivativeInfo>
          <optionSwaptionWarrantDeriv derivCat="WAR">
            <counterparties>
              <counterpartyName>N/A</counterpartyName>
              <counterpartyLei>N/A</counterpartyLei>
            </counterparties>
            <putOrCall>Call</putOrCall>
            <writtenOrPur>Purchased</writtenOrPur>
            <descRefInstrmnt>
              <otherRefInst>
                <issuerName>ILLUMINOSS INC. SERIES AA</issuerName>
                <issueTitle>ILLUMINOSS INC. SERIES AA</issueTitle>
                <identifiers>
                  <other otherDesc="Internal Identifier - Private Company" value="976MND900"/>
                </identifiers>
              </otherRefInst>
            </descRefInstrmnt>
            <shareNo>1.00000000</shareNo>
            <exercisePrice>1.00000000</exercisePrice>
            <exercisePriceCurCd>USD</exercisePriceCurCd>
            <expDt>2028-02-06</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>0.00000000</unrealizedAppr>
          </optionSwaptionWarrantDeriv>
        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Editas Medicine Inc</name>
        <lei>5299000AON4Q9NT2JE42</lei>
        <title>Editas Medicine Inc</title>
        <cusip>28106W103</cusip>
        <identifiers>
          <isin value="US28106W1036"/>
        </identifiers>
        <balance>80468.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1595680.44000000</valUSD>
        <pctVal>0.180505489675</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Illuminoss Inc.</name>
        <lei>N/A</lei>
        <title>ILLUMINOSS INC. CONVERTIBLE PR</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="963QENII5"/>
        </identifiers>
        <balance>190166.13000000</balance>
        <units>PA</units>
        <curCd>USD</curCd>
        <valUSD>73632.33000000</valUSD>
        <pctVal>0.008329386918</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>DBT</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <debtSec>
          <maturityDt>2021-12-31</maturityDt>
          <couponKind>Fixed</couponKind>
          <annualizedRt>8.00000000</annualizedRt>
          <isDefault>N</isDefault>
          <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
          <isPaidKind>N</isPaidKind>
        </debtSec>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ETHISMOS RESEARCH, INC. MILEST</name>
        <lei>N/A</lei>
        <title>ETHISMOS RESEARCH, INC. MILEST</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="932TYG909"/>
        </identifiers>
        <balance>1180.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.00000000</valUSD>
        <pctVal>0.000000</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetConditional assetCat="OTHER" desc="Milestone Interest"/>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Hologic Inc</name>
        <lei>549300DYP6F5ZJL0LB74</lei>
        <title>Hologic Inc</title>
        <cusip>436440101</cusip>
        <identifiers>
          <isin value="US4364401012"/>
        </identifiers>
        <balance>10945.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>384169.50000000</valUSD>
        <pctVal>0.043457763833</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Moderna Inc</name>
        <lei>549300EI6OKH5K5Q2G38</lei>
        <title>Moderna Inc</title>
        <cusip>60770K107</cusip>
        <identifiers>
          <isin value="US60770K1079"/>
        </identifiers>
        <balance>175043.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5242537.85000000</valUSD>
        <pctVal>0.593042841182</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Baxter International Inc</name>
        <lei>J5OIVXX3P24RJRW5CK77</lei>
        <title>Baxter International Inc</title>
        <cusip>071813109</cusip>
        <identifiers>
          <isin value="US0718131099"/>
        </identifiers>
        <balance>22237.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1805422.03000000</valUSD>
        <pctVal>0.204231736773</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Evolent Health Inc</name>
        <lei>549300CZOCFHQ2BBTR11</lei>
        <title>Evolent Health Inc</title>
        <cusip>30050B101</cusip>
        <identifiers>
          <isin value="US30050B1017"/>
        </identifiers>
        <balance>231027.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1254476.61000000</valUSD>
        <pctVal>0.141908059469</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Curasen Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>CURASEN THERAPEUTICS, INC. SERIES A PREFERRED STOCK</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="934MMA908"/>
        </identifiers>
        <balance>6346328.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6999999.78000000</valUSD>
        <pctVal>0.791849267775</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Immunomedics Inc</name>
        <lei>5493007ZU7DDO8PSIM59</lei>
        <title>Immunomedics Inc</title>
        <cusip>452907108</cusip>
        <identifiers>
          <isin value="US4529071080"/>
        </identifiers>
        <balance>334273.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4506000.04000000</valUSD>
        <pctVal>0.509724706344</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Bridgebio Pharma Inc</name>
        <lei>54930028YG89VTY2J114</lei>
        <title>Bridgebio Pharma Inc</title>
        <cusip>10806X102</cusip>
        <identifiers>
          <isin value="US10806X1028"/>
        </identifiers>
        <balance>27027.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>783783.00000000</valUSD>
        <pctVal>0.088662573450</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Exact Sciences Corp</name>
        <lei>549300VM3X1FYD4N9Z14</lei>
        <title>Exact Sciences Corp</title>
        <cusip>30063P105</cusip>
        <identifiers>
          <isin value="US30063P1057"/>
        </identifiers>
        <balance>15944.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>924752.00000000</valUSD>
        <pctVal>0.104609173869</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Galera Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Galera Therapeutics Inc</title>
        <cusip>36338D108</cusip>
        <identifiers>
          <isin value="US36338D1081"/>
        </identifiers>
        <balance>137500.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1306250.00000000</valUSD>
        <pctVal>0.147764734077</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Aerie Pharmaceuticals Inc</name>
        <lei>529900SFXHDHUO324R09</lei>
        <title>Aerie Pharmaceuticals Inc</title>
        <cusip>00771V108</cusip>
        <identifiers>
          <isin value="US00771V1089"/>
        </identifiers>
        <balance>46285.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>624847.50000000</valUSD>
        <pctVal>0.070683578699</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Illuminoss Inc.</name>
        <lei>N/A</lei>
        <title>ILLUMINOSS INC. CONVERTIBLE PROMISSORY NOTE</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="964FJE902"/>
        </identifiers>
        <balance>51858.44000000</balance>
        <units>PA</units>
        <curCd>USD</curCd>
        <valUSD>20079.59000000</valUSD>
        <pctVal>0.002271429876</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>DBT</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <debtSec>
          <maturityDt>2021-12-31</maturityDt>
          <couponKind>Fixed</couponKind>
          <annualizedRt>8.00000000</annualizedRt>
          <isDefault>N</isDefault>
          <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
          <isPaidKind>N</isPaidKind>
        </debtSec>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Illuminoss Inc.</name>
        <lei>N/A</lei>
        <title>ILLUMINOSS INC CONVERTIBLE PROMISSORY NOTE</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="933KYLII7"/>
        </identifiers>
        <balance>237707.79000000</balance>
        <units>PA</units>
        <curCd>USD</curCd>
        <valUSD>92040.46000000</valUSD>
        <pctVal>0.010411739021</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>DBT</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <debtSec>
          <maturityDt>2021-12-31</maturityDt>
          <couponKind>Fixed</couponKind>
          <annualizedRt>8.00000000</annualizedRt>
          <isDefault>N</isDefault>
          <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
          <isPaidKind>N</isPaidKind>
        </debtSec>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Regeneron Pharmaceuticals Inc</name>
        <lei>549300RCBFWIRX3HYQ56</lei>
        <title>Regeneron Pharmaceuticals Inc</title>
        <cusip>75886F107</cusip>
        <identifiers>
          <isin value="US75886F1075"/>
        </identifiers>
        <balance>91552.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>44703926.08000000</valUSD>
        <pctVal>5.056967463666</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Fate Therapeutics Inc</name>
        <lei>549300L14Q4UHOODLA90</lei>
        <title>Fate Therapeutics Inc</title>
        <cusip>31189P102</cusip>
        <identifiers>
          <isin value="US31189P1021"/>
        </identifiers>
        <balance>106511.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2365609.31000000</valUSD>
        <pctVal>0.267600865548</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ILLUMINOSS INC. CONVERTIBLE PROMISSORY NOTE</name>
        <lei>N/A</lei>
        <title>ILLUMINOSS INC. CONVERTIBLE PROMISSORY NOTE</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="935SRWII2"/>
        </identifiers>
        <balance>37000.00000000</balance>
        <units>PA</units>
        <curCd>USD</curCd>
        <valUSD>14326.40000000</valUSD>
        <pctVal>0.001620621386</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>DBT</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <debtSec>
          <maturityDt>2021-12-31</maturityDt>
          <couponKind>Fixed</couponKind>
          <annualizedRt>8.00000000</annualizedRt>
          <isDefault>N</isDefault>
          <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
          <isPaidKind>N</isPaidKind>
        </debtSec>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Vertex Pharmaceuticals Inc</name>
        <lei>54930015RAQRRZ5ZGJ91</lei>
        <title>Vertex Pharmaceuticals Inc</title>
        <cusip>92532F100</cusip>
        <identifiers>
          <isin value="US92532F1003"/>
        </identifiers>
        <balance>266848.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>63496481.60000000</valUSD>
        <pctVal>7.182806291640</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Halozyme Therapeutics Inc</name>
        <lei>529900242I3SV9AGM753</lei>
        <title>Halozyme Therapeutics Inc</title>
        <cusip>40637H109</cusip>
        <identifiers>
          <isin value="US40637H1095"/>
        </identifiers>
        <balance>48143.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>866092.57000000</valUSD>
        <pctVal>0.097973541276</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
        <title>BIOGEN INC JUN20 350 CALL</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="ADI184046"/>
        </identifiers>
        <balance>110.00000000</balance>
        <units>NC</units>
        <curCd>USD</curCd>
        <valUSD>187000.00000000</valUSD>
        <pctVal>0.021153688246</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerConditional desc="derivative" issuerCat="OTHER"/>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <derivativeInfo>
          <optionSwaptionWarrantDeriv derivCat="OPT">
            <counterparties>
              <counterpartyName>Options Clearing Corp.</counterpartyName>
              <counterpartyLei>549300CII6SLYGKNHA04</counterpartyLei>
            </counterparties>
            <putOrCall>Call</putOrCall>
            <writtenOrPur>Purchased</writtenOrPur>
            <descRefInstrmnt>
              <otherRefInst>
                <issuerName>Biogen Inc</issuerName>
                <issueTitle>Biogen Inc</issueTitle>
                <identifiers>
                  <cusip value="09062X103"/>
                  <isin value="US09062X1037"/>
                </identifiers>
              </otherRefInst>
            </descRefInstrmnt>
            <shareNo>100.00000000</shareNo>
            <exercisePrice>350.00000000</exercisePrice>
            <exercisePriceCurCd>USD</exercisePriceCurCd>
            <expDt>2020-06-19</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>-381637.40000000</unrealizedAppr>
          </optionSwaptionWarrantDeriv>
        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Decipher Biosciences, Inc.</name>
        <lei>N/A</lei>
        <title>DECIPHER BIOSCIENCES, INC. SERIES II CONVERTIBLE</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="964DAK902"/>
        </identifiers>
        <balance>968076.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2429967.57000000</valUSD>
        <pctVal>0.274881157356</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zai Lab Ltd</name>
        <lei>549300P2UYQ9U5LY1T58</lei>
        <title>Zai Lab Ltd</title>
        <cusip>98887Q104</cusip>
        <identifiers>
          <isin value="US98887Q1040"/>
        </identifiers>
        <balance>26021.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1339561.08000000</valUSD>
        <pctVal>0.151532927667</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Johnson &amp; Johnson</name>
        <lei>549300G0CFPGEF6X2043</lei>
        <title>Johnson &amp; Johnson</title>
        <cusip>478160104</cusip>
        <identifiers>
          <isin value="US4781601046"/>
        </identifiers>
        <balance>110428.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14480423.64000000</valUSD>
        <pctVal>1.638044745254</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Illuminoss Inc.</name>
        <lei>N/A</lei>
        <title>ILLUMINOSS INC CONVERTIBLE PROMISSORY NOTE</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="964WJSII5"/>
        </identifiers>
        <balance>81881.45000000</balance>
        <units>PA</units>
        <curCd>USD</curCd>
        <valUSD>31704.50000000</valUSD>
        <pctVal>0.003586455128</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>DBT</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <debtSec>
          <maturityDt>2021-12-31</maturityDt>
          <couponKind>Fixed</couponKind>
          <annualizedRt>8.00000000</annualizedRt>
          <isDefault>N</isDefault>
          <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
          <isPaidKind>N</isPaidKind>
        </debtSec>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NEUROVANCE MILESTONE INTEREST</name>
        <lei>N/A</lei>
        <title>NEUROVANCE MILESTONE INTEREST</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="931UVM907"/>
        </identifiers>
        <balance>49006.12000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2781587.37000000</valUSD>
        <pctVal>0.314656855916</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetConditional assetCat="OTHER" desc="Milestone Interest"/>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ILLUMINOSS INC. WARRANTS WARRANTS</name>
        <lei>N/A</lei>
        <title>ILLUMINOSS INC. WARRANTS WARRANTS</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="965DWXII0"/>
        </identifiers>
        <balance>9250.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.00000000</valUSD>
        <pctVal>0.000000</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerConditional desc="derivative" issuerCat="OTHER"/>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <derivativeInfo>
          <optionSwaptionWarrantDeriv derivCat="WAR">
            <counterparties>
              <counterpartyName>N/A</counterpartyName>
              <counterpartyLei>N/A</counterpartyLei>
            </counterparties>
            <putOrCall>Call</putOrCall>
            <writtenOrPur>Purchased</writtenOrPur>
            <descRefInstrmnt>
              <otherRefInst>
                <issuerName>ILLUMINOSS INC. SERIES AA</issuerName>
                <issueTitle>ILLUMINOSS INC. SERIES AA</issueTitle>
                <identifiers>
                  <other otherDesc="Internal Identifier - Private Company" value="976MND900"/>
                </identifiers>
              </otherRefInst>
            </descRefInstrmnt>
            <shareNo>1.00000000</shareNo>
            <exercisePrice>1.00000000</exercisePrice>
            <exercisePriceCurCd>USD</exercisePriceCurCd>
            <expDt>2029-08-28</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>0.00000000</unrealizedAppr>
          </optionSwaptionWarrantDeriv>
        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Coherus Biosciences Inc</name>
        <lei>5493007IL8W5MV932D26</lei>
        <title>Coherus Biosciences Inc</title>
        <cusip>19249H103</cusip>
        <identifiers>
          <isin value="US19249H1032"/>
        </identifiers>
        <balance>63660.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1032565.20000000</valUSD>
        <pctVal>0.116805146178</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Acadia Healthcare Co Inc</name>
        <lei>5493005CW985Y9D0NC11</lei>
        <title>Acadia Healthcare Co Inc</title>
        <cusip>00404A109</cusip>
        <identifiers>
          <isin value="US00404A1097"/>
        </identifiers>
        <balance>54500.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1000075.00000000</valUSD>
        <pctVal>0.113129811622</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alnylam Pharmaceuticals Inc</name>
        <lei>529900S3ZI14OWRJII50</lei>
        <title>Alnylam Pharmaceuticals Inc</title>
        <cusip>02043Q107</cusip>
        <identifiers>
          <isin value="US02043Q1076"/>
        </identifiers>
        <balance>86213.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9384285.05000000</valUSD>
        <pctVal>1.061562782711</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Allakos Inc</name>
        <lei>549300S6ZD1W6BPMDY37</lei>
        <title>Allakos Inc</title>
        <cusip>01671P100</cusip>
        <identifiers>
          <isin value="US01671P1003"/>
        </identifiers>
        <balance>42209.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1877878.41000000</valUSD>
        <pctVal>0.212428098666</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>OCULIS SA</name>
        <lei>N/A</lei>
        <title>OCULIS SA SERIES B2 PREFERRED PREFERRED STOCK</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="963MZB906"/>
        </identifiers>
        <balance>277444.00000000</balance>
        <units>NS</units>
        <currencyConditional curCd="CHF" exchangeRt="0.96250000"/>
        <valUSD>2399998.69000000</valUSD>
        <pctVal>0.271491037866</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Anthem Inc</name>
        <lei>8MYN82XMYQH89CTMTH67</lei>
        <title>Anthem Inc</title>
        <cusip>036752103</cusip>
        <identifiers>
          <isin value="US0367521038"/>
        </identifiers>
        <balance>20602.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4677478.08000000</valUSD>
        <pctVal>0.529122529870</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>DENTSPLY SIRONA Inc</name>
        <lei>9NHEHR1SOZCYXDO8HO28</lei>
        <title>DENTSPLY SIRONA Inc</title>
        <cusip>24906P109</cusip>
        <identifiers>
          <isin value="US24906P1093"/>
        </identifiers>
        <balance>21888.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>849911.04000000</valUSD>
        <pctVal>0.096143065121</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ILLUMINOSS INC. WARRANTS WARRANTS</name>
        <lei>N/A</lei>
        <title>ILLUMINOSS INC. WARRANTS WARRANTS</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="964WMN901"/>
        </identifiers>
        <balance>28301.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.00000000</valUSD>
        <pctVal>0.000000</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerConditional desc="derivative" issuerCat="OTHER"/>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <derivativeInfo>
          <optionSwaptionWarrantDeriv derivCat="WAR">
            <counterparties>
              <counterpartyName>N/A</counterpartyName>
              <counterpartyLei>N/A</counterpartyLei>
            </counterparties>
            <putOrCall>Call</putOrCall>
            <writtenOrPur>Purchased</writtenOrPur>
            <descRefInstrmnt>
              <otherRefInst>
                <issuerName>ILLUMINOSS INC. SERIES AA</issuerName>
                <issueTitle>ILLUMINOSS INC. SERIES AA</issueTitle>
                <identifiers>
                  <other otherDesc="Internal Identifier - Private Company" value="976MND900"/>
                </identifiers>
              </otherRefInst>
            </descRefInstrmnt>
            <shareNo>1.00000000</shareNo>
            <exercisePrice>1.00000000</exercisePrice>
            <exercisePriceCurCd>USD</exercisePriceCurCd>
            <expDt>2029-07-02</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>0.00000000</unrealizedAppr>
          </optionSwaptionWarrantDeriv>
        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AbbVie Inc</name>
        <lei>FR5LCKFTG8054YNNRU85</lei>
        <title>AbbVie Inc</title>
        <cusip>00287Y109</cusip>
        <identifiers>
          <isin value="US00287Y1091"/>
        </identifiers>
        <balance>11814.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>900108.66000000</valUSD>
        <pctVal>0.101821486534</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ILLUMINOSS INC. WARRANTS</name>
        <lei>N/A</lei>
        <title>ILLUMINOSS INC. WARRANTS</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="965UNT900"/>
        </identifiers>
        <balance>30833.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.00000000</valUSD>
        <pctVal>0.000000</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerConditional desc="derivative" issuerCat="OTHER"/>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <derivativeInfo>
          <optionSwaptionWarrantDeriv derivCat="WAR">
            <counterparties>
              <counterpartyName>N/A</counterpartyName>
              <counterpartyLei>N/A</counterpartyLei>
            </counterparties>
            <putOrCall>Call</putOrCall>
            <writtenOrPur>Purchased</writtenOrPur>
            <descRefInstrmnt>
              <otherRefInst>
                <issuerName>ILLUMINOSS INC. SERIES AA</issuerName>
                <issueTitle>ILLUMINOSS INC. SERIES AA</issueTitle>
                <identifiers>
                  <other otherDesc="Internal Identifier - Private Company" value="976MND900"/>
                </identifiers>
              </otherRefInst>
            </descRefInstrmnt>
            <shareNo>1.00000000</shareNo>
            <exercisePrice>1.00000000</exercisePrice>
            <exercisePriceCurCd>USD</exercisePriceCurCd>
            <expDt>2030-01-08</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>0.00000000</unrealizedAppr>
          </optionSwaptionWarrantDeriv>
        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Amicus Therapeutics Inc</name>
        <lei>549300MRD1SMUTNBPQ53</lei>
        <title>Amicus Therapeutics Inc</title>
        <cusip>03152W109</cusip>
        <identifiers>
          <isin value="US03152W1099"/>
        </identifiers>
        <balance>256431.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2369422.44000000</valUSD>
        <pctVal>0.268032211875</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Becton Dickinson and Co</name>
        <lei>ICE2EP6D98PQUILVRZ91</lei>
        <title>Becton Dickinson and Co</title>
        <cusip>075887109</cusip>
        <identifiers>
          <isin value="US0758871091"/>
        </identifiers>
        <balance>13209.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3035031.93000000</valUSD>
        <pctVal>0.343326840996</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>RALLYBIO HOLDINGS, LLC SERIES B PREFERRED STOCK</name>
        <lei>N/A</lei>
        <title>RALLYBIO HOLDINGS, LLC SERIES B PREFERRED STOCK</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="966GZH903"/>
        </identifiers>
        <balance>4654614.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6899999.79000000</valUSD>
        <pctVal>0.780537136154</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Molecular Templates Inc</name>
        <lei>529900VZKP6N0B8U5F61</lei>
        <title>Molecular Templates Inc</title>
        <cusip>608550109</cusip>
        <identifiers>
          <isin value="US6085501095"/>
        </identifiers>
        <balance>24052.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>319651.08000000</valUSD>
        <pctVal>0.036159354513</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>McKesson Corp</name>
        <lei>549300WZWOM80UCFSF54</lei>
        <title>McKesson Corp</title>
        <cusip>58155Q103</cusip>
        <identifiers>
          <isin value="US58155Q1031"/>
        </identifiers>
        <balance>13913.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1881872.38000000</valUSD>
        <pctVal>0.212879901854</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cymabay Therapeutics Inc</name>
        <lei>549300YT9GNL852E7F84</lei>
        <title>Cymabay Therapeutics Inc</title>
        <cusip>23257D103</cusip>
        <identifiers>
          <isin value="US23257D1037"/>
        </identifiers>
        <balance>55466.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>82089.68000000</valUSD>
        <pctVal>0.009286093577</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>THEROX MILESTONE INTEREST</name>
        <lei>N/A</lei>
        <title>THEROX MILESTONE INTEREST</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="964RTG900"/>
        </identifiers>
        <balance>93.60000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6905.81000000</valUSD>
        <pctVal>0.000781194394</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Menlo Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Menlo Therapeutics Inc</title>
        <cusip>586858102</cusip>
        <identifiers>
          <isin value="US5868581027"/>
        </identifiers>
        <balance>124725.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>334263.00000000</valUSD>
        <pctVal>0.037812274301</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Aerpio Pharmaceuticals Inc</name>
        <lei>549300G3U7TKW1M58L09</lei>
        <title>Aerpio Pharmaceuticals Inc</title>
        <cusip>00810B105</cusip>
        <identifiers>
          <isin value="US00810B1052"/>
        </identifiers>
        <balance>178012.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>97871.00000000</valUSD>
        <pctVal>0.011071297446</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BeiGene Ltd</name>
        <lei>549300JFUK6FRD5MH739</lei>
        <title>BeiGene Ltd</title>
        <cusip>07725L102</cusip>
        <identifiers>
          <isin value="US07725L1026"/>
        </identifiers>
        <balance>48392.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5957539.12000000</valUSD>
        <pctVal>0.673924734025</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Illuminoss Inc.</name>
        <lei>N/A</lei>
        <title>ILLUMINOSS INC. WARRANTS WARRANTS</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="964MPE900"/>
        </identifiers>
        <balance>20470.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.00000000</valUSD>
        <pctVal>0.000000</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerConditional desc="derivative" issuerCat="OTHER"/>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <derivativeInfo>
          <optionSwaptionWarrantDeriv derivCat="WAR">
            <counterparties>
              <counterpartyName>N/A</counterpartyName>
              <counterpartyLei>N/A</counterpartyLei>
            </counterparties>
            <putOrCall>Call</putOrCall>
            <writtenOrPur>Purchased</writtenOrPur>
            <descRefInstrmnt>
              <otherRefInst>
                <issuerName>ILLUMINOSS INC. SERIES AA</issuerName>
                <issueTitle>ILLUMINOSS INC. SERIES AA</issueTitle>
                <identifiers>
                  <other otherDesc="Internal Identifier - Private Company" value="976MND900"/>
                </identifiers>
              </otherRefInst>
            </descRefInstrmnt>
            <shareNo>1.00000000</shareNo>
            <exercisePrice>1.00000000</exercisePrice>
            <exercisePriceCurCd>USD</exercisePriceCurCd>
            <expDt>2029-05-13</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>0.00000000</unrealizedAppr>
          </optionSwaptionWarrantDeriv>
        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Iovance Biotherapeutics Inc</name>
        <lei>549300220Z2GHH33XL82</lei>
        <title>Iovance Biotherapeutics Inc</title>
        <cusip>462260100</cusip>
        <identifiers>
          <isin value="US4622601007"/>
        </identifiers>
        <balance>135768.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4064215.08000000</valUSD>
        <pctVal>0.459749405189</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sutro Biopharma Inc</name>
        <lei>5493005U6P15VD25P851</lei>
        <title>Sutro Biopharma Inc</title>
        <cusip>869367102</cusip>
        <identifiers>
          <isin value="US8693671021"/>
        </identifiers>
        <balance>447797.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4567529.40000000</valUSD>
        <pctVal>0.516684989228</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ILLUMINOSS INC. CONVERTIBLE PROMISSORY NOTE</name>
        <lei>N/A</lei>
        <title>ILLUMINOSS INC. CONVERTIBLE PROMISSORY NOTE</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="964ZDNII5"/>
        </identifiers>
        <balance>113204.94000000</balance>
        <units>PA</units>
        <curCd>USD</curCd>
        <valUSD>43832.95000000</valUSD>
        <pctVal>0.004958441493</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>DBT</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <debtSec>
          <maturityDt>2021-12-31</maturityDt>
          <couponKind>Fixed</couponKind>
          <annualizedRt>8.00000000</annualizedRt>
          <isDefault>N</isDefault>
          <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
          <isPaidKind>N</isPaidKind>
        </debtSec>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Illuminoss Inc.</name>
        <lei>N/A</lei>
        <title>ILLUMINOSS INC. WARRANTS</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="964FKS909"/>
        </identifiers>
        <balance>12964.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.00000000</valUSD>
        <pctVal>0.000000</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerConditional desc="derivative" issuerCat="OTHER"/>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <derivativeInfo>
          <optionSwaptionWarrantDeriv derivCat="WAR">
            <counterparties>
              <counterpartyName>N/A</counterpartyName>
              <counterpartyLei>N/A</counterpartyLei>
            </counterparties>
            <putOrCall>Call</putOrCall>
            <writtenOrPur>Purchased</writtenOrPur>
            <descRefInstrmnt>
              <otherRefInst>
                <issuerName>ILLUMINOSS INC. SERIES AA</issuerName>
                <issueTitle>ILLUMINOSS INC. SERIES AA</issueTitle>
                <identifiers>
                  <other otherDesc="Internal Identifier - Private Company" value="976MND900"/>
                </identifiers>
              </otherRefInst>
            </descRefInstrmnt>
            <shareNo>1.00000000</shareNo>
            <exercisePrice>1.00000000</exercisePrice>
            <exercisePriceCurCd>USD</exercisePriceCurCd>
            <expDt>2029-04-29</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>0.00000000</unrealizedAppr>
          </optionSwaptionWarrantDeriv>
        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>THERACHON MILESTONE INTEREST</name>
        <lei>N/A</lei>
        <title>THERACHON MILESTONE INTEREST</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="964WMT908"/>
        </identifiers>
        <balance>32777.35000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3360661.70000000</valUSD>
        <pctVal>0.380162512860</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Rubius Therapeutics Inc</name>
        <lei>549300ER84PB0QV6HZ76</lei>
        <title>Rubius Therapeutics Inc</title>
        <cusip>78116T103</cusip>
        <identifiers>
          <isin value="US78116T1034"/>
        </identifiers>
        <balance>96273.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>428414.85000000</valUSD>
        <pctVal>0.048462856562</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Pacific Biosciences of California Inc</name>
        <lei>N/A</lei>
        <title>Pacific Biosciences of California Inc</title>
        <cusip>69404D108</cusip>
        <identifiers>
          <isin value="US69404D1081"/>
        </identifiers>
        <balance>344015.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1052685.90000000</valUSD>
        <pctVal>0.119081226472</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Turning Point Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Turning Point Therapeutics Inc</title>
        <cusip>90041T108</cusip>
        <identifiers>
          <isin value="US90041T1088"/>
        </identifiers>
        <balance>3911.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>174665.26000000</valUSD>
        <pctVal>0.019758366083</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Rocket Pharmaceuticals Inc</name>
        <lei>549300R7VV82YUIN4Y93</lei>
        <title>Rocket Pharmaceuticals Inc</title>
        <cusip>77313F106</cusip>
        <identifiers>
          <isin value="US77313F1066"/>
        </identifiers>
        <balance>144100.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2010195.00000000</valUSD>
        <pctVal>0.227395926980</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Atreca Inc</name>
        <lei>549300B5CQV1OOXFLU71</lei>
        <title>Atreca Inc</title>
        <cusip>04965G109</cusip>
        <identifiers>
          <isin value="US04965G1094"/>
        </identifiers>
        <balance>117638.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1946908.90000000</valUSD>
        <pctVal>0.220236919334</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Intercept Pharmaceuticals Inc</name>
        <lei>N/A</lei>
        <title>Intercept Pharmaceuticals Inc</title>
        <cusip>45845P108</cusip>
        <identifiers>
          <isin value="US45845P1084"/>
        </identifiers>
        <balance>21332.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1343062.72000000</valUSD>
        <pctVal>0.151929037833</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Humana Inc</name>
        <lei>529900YLDW34GJAO4J06</lei>
        <title>Humana Inc</title>
        <cusip>444859102</cusip>
        <identifiers>
          <isin value="US4448591028"/>
        </identifiers>
        <balance>4697.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1474951.94000000</valUSD>
        <pctVal>0.166848521485</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Genmab A/S</name>
        <lei>529900MTJPDPE4MHJ122</lei>
        <title>Genmab A/S</title>
        <cusip>372303206</cusip>
        <identifiers>
          <isin value="US3723032062"/>
        </identifiers>
        <balance>11382.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>241184.58000000</valUSD>
        <pctVal>0.027283119867</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Illuminoss Inc.</name>
        <lei>N/A</lei>
        <title>Illuminoss Inc. Warrants Call Exp 11Jan28</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="ACI0ZYHR5"/>
        </identifiers>
        <balance>47541.53000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.00000000</valUSD>
        <pctVal>0.000000</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerConditional desc="derivative" issuerCat="OTHER"/>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <derivativeInfo>
          <optionSwaptionWarrantDeriv derivCat="WAR">
            <counterparties>
              <counterpartyName>N/A</counterpartyName>
              <counterpartyLei>N/A</counterpartyLei>
            </counterparties>
            <putOrCall>Call</putOrCall>
            <writtenOrPur>Purchased</writtenOrPur>
            <descRefInstrmnt>
              <otherRefInst>
                <issuerName>ILLUMINOSS INC. SERIES AA</issuerName>
                <issueTitle>ILLUMINOSS INC. SERIES AA</issueTitle>
                <identifiers>
                  <other otherDesc="Internal Identifier - Private Company" value="976MND900"/>
                </identifiers>
              </otherRefInst>
            </descRefInstrmnt>
            <shareNo>1.00000000</shareNo>
            <exercisePrice>1.00000000</exercisePrice>
            <exercisePriceCurCd>USD</exercisePriceCurCd>
            <expDt>2028-01-11</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>-28.60000000</unrealizedAppr>
          </optionSwaptionWarrantDeriv>
        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Medpace Holdings Inc</name>
        <lei>549300H8TYEUVTW14A54</lei>
        <title>Medpace Holdings Inc</title>
        <cusip>58506Q109</cusip>
        <identifiers>
          <isin value="US58506Q1094"/>
        </identifiers>
        <balance>13049.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>957535.62000000</valUSD>
        <pctVal>0.108317700485</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Decipher Biosciences, Inc.</name>
        <lei>N/A</lei>
        <title>DECIPHER BIOSCIENCES, INC. SERIES III CONVERTIBLE PFD</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="964DAS905"/>
        </identifiers>
        <balance>962412.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2415750.36000000</valUSD>
        <pctVal>0.273272887687</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Guardant Health Inc</name>
        <lei>N/A</lei>
        <title>Guardant Health Inc</title>
        <cusip>40131M109</cusip>
        <identifiers>
          <isin value="US40131M1099"/>
        </identifiers>
        <balance>16290.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1133784.00000000</valUSD>
        <pctVal>0.128255151204</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ultragenyx Pharmaceutical Inc</name>
        <lei>529900EV44GVDN1DCX77</lei>
        <title>Ultragenyx Pharmaceutical Inc</title>
        <cusip>90400D108</cusip>
        <identifiers>
          <isin value="US90400D1081"/>
        </identifiers>
        <balance>67710.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3008355.30000000</valUSD>
        <pctVal>0.340309145197</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Illuminoss Inc.</name>
        <lei>N/A</lei>
        <title>Illuminoss Inc. Warrants Call Exp 20Nov27</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="ACI0Z2C17"/>
        </identifiers>
        <balance>23770.78000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.00000000</valUSD>
        <pctVal>0.000000</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerConditional desc="derivative" issuerCat="OTHER"/>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <derivativeInfo>
          <optionSwaptionWarrantDeriv derivCat="WAR">
            <counterparties>
              <counterpartyName>N/A</counterpartyName>
              <counterpartyLei>N/A</counterpartyLei>
            </counterparties>
            <putOrCall>Call</putOrCall>
            <writtenOrPur>Purchased</writtenOrPur>
            <descRefInstrmnt>
              <otherRefInst>
                <issuerName>ILLUMINOSS INC. SERIES AA</issuerName>
                <issueTitle>ILLUMINOSS INC. SERIES AA</issueTitle>
                <identifiers>
                  <other otherDesc="Internal Identifier - Private Company" value="976MND900"/>
                </identifiers>
              </otherRefInst>
            </descRefInstrmnt>
            <shareNo>1.00000000</shareNo>
            <exercisePrice>1.00000000</exercisePrice>
            <exercisePriceCurCd>USD</exercisePriceCurCd>
            <expDt>2027-11-20</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>-87.53000000</unrealizedAppr>
          </optionSwaptionWarrantDeriv>
        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Edwards Lifesciences Corp</name>
        <lei>YA13X31F3V31L8TMPR58</lei>
        <title>Edwards Lifesciences Corp</title>
        <cusip>28176E108</cusip>
        <identifiers>
          <isin value="US28176E1082"/>
        </identifiers>
        <balance>8223.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1551022.26000000</valUSD>
        <pctVal>0.175453697069</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zogenix Inc</name>
        <lei>54930089H3HF4C32SK78</lei>
        <title>Zogenix Inc</title>
        <cusip>98978L204</cusip>
        <identifiers>
          <isin value="US98978L2043"/>
        </identifiers>
        <balance>143456.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3547666.88000000</valUSD>
        <pctVal>0.401316787075</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>VECTIVBIO HOLDING AG CONVERTIBLE PROMISSORY NOTE</name>
        <lei>N/A</lei>
        <title>VECTIVBIO HOLDING AG CONVERTIBLE PROMISSORY NOTE</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="965TCCII3"/>
        </identifiers>
        <balance>661638.00000000</balance>
        <units>PA</units>
        <curCd>USD</curCd>
        <valUSD>661638.00000000</valUSD>
        <pctVal>0.074845368899</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>DBT</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <debtSec>
          <maturityDt>2021-12-19</maturityDt>
          <couponKind>Fixed</couponKind>
          <annualizedRt>4.00000000</annualizedRt>
          <isDefault>N</isDefault>
          <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
          <isPaidKind>N</isPaidKind>
        </debtSec>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Mirati Therapeutics Inc</name>
        <lei>529900GYRW59IDQV6N54</lei>
        <title>Mirati Therapeutics Inc</title>
        <cusip>60468T105</cusip>
        <identifiers>
          <isin value="US60468T1051"/>
        </identifiers>
        <balance>51657.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3970873.59000000</valUSD>
        <pctVal>0.449190491927</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Aurinia Pharmaceuticals Inc</name>
        <lei>5299008YP2BW4570ML28</lei>
        <title>Aurinia Pharmaceuticals Inc</title>
        <cusip>05156V102</cusip>
        <identifiers>
          <isin value="CA05156V1022"/>
        </identifiers>
        <balance>60088.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>871876.88000000</valUSD>
        <pctVal>0.098627870102</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CRISPR Therapeutics AG</name>
        <lei>506700O6IRRIQLT3W370</lei>
        <title>CRISPR Therapeutics AG</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="CH0334081137"/>
        </identifiers>
        <balance>52574.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2229663.34000000</valUSD>
        <pctVal>0.252222476950</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Medtronic PLC</name>
        <lei>549300GX3ZBSQWUXY261</lei>
        <title>Medtronic PLC</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="IE00BTN1Y115"/>
        </identifiers>
        <balance>62062.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5596751.16000000</valUSD>
        <pctVal>0.633111921035</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>FOAMIX PHARMACEUTICALS LTD COMMON STOCK NPV</name>
        <lei>5493002Q77A4N554AD44</lei>
        <title>FOAMIX PHARMACEUTICALS LTD COMMON STOCK NPV</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="USM46CVR0117"/>
        </identifiers>
        <balance>210543.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>126325.80000000</valUSD>
        <pctVal>0.014290142196</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerConditional desc="derivative" issuerCat="OTHER"/>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <derivativeInfo>
          <othDeriv derivCat="OTH" othDesc="rights">
            <counterparties>
              <counterpartyName>N/A</counterpartyName>
              <counterpartyLei>N/A</counterpartyLei>
            </counterparties>
            <descRefInstrmnt>
              <otherRefInst>
                <issuerName>Foamix Pharmaceuticals Ltd</issuerName>
                <issueTitle>Foamix Pharmaceuticals Ltd</issueTitle>
                <identifiers>
                  <isin value="IL0011334385"/>
                </identifiers>
              </otherRefInst>
            </descRefInstrmnt>
            <terminationDt>2099-12-31</terminationDt>
            <notionalAmts>
              <notionalAmt amt="210543.00000000" curCd="USD"/>
            </notionalAmts>
            <delta>XXXX</delta>
            <unrealizedAppr>-421037.43000000</unrealizedAppr>
          </othDeriv>
        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Rainier Therapeutics Series A PREFERRED STOCK</name>
        <lei>N/A</lei>
        <title>Rainier Therapeutics Series A PREFERRED STOCK</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="976MMT906"/>
        </identifiers>
        <balance>2692309.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.00000000</valUSD>
        <pctVal>0.000000</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AMPHIVENA THERAPEUTICS, INC. SERIES C PREFERRED STOCK</name>
        <lei>N/A</lei>
        <title>AMPHIVENA THERAPEUTICS, INC. SERIES C PREFERRED STOCK</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="933QVT909"/>
        </identifiers>
        <balance>525972.38000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1887315.13000000</valUSD>
        <pctVal>0.213495592960</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>RAINIER THERAPEUTICS, INC. CONVERTIBLE PROMISSORY NOTE</name>
        <lei>N/A</lei>
        <title>RAINIER THERAPEUTICS, INC. CONVERTIBLE PROMISSORY NOTE</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="964TJFII0"/>
        </identifiers>
        <balance>442570.00000000</balance>
        <units>PA</units>
        <curCd>USD</curCd>
        <valUSD>0.00000000</valUSD>
        <pctVal>0.000000</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>DBT</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <debtSec>
          <maturityDt>2020-01-30</maturityDt>
          <couponKind>Fixed</couponKind>
          <annualizedRt>8.00000000</annualizedRt>
          <isDefault>N</isDefault>
          <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
          <isPaidKind>N</isPaidKind>
        </debtSec>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alkermes PLC</name>
        <lei>N/A</lei>
        <title>Alkermes PLC</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="IE00B56GVS15"/>
        </identifiers>
        <balance>109838.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1583863.96000000</valUSD>
        <pctVal>0.179168793771</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Thermo Fisher Scientific Inc</name>
        <lei>HCHV7422L5HDJZCRFL38</lei>
        <title>Thermo Fisher Scientific Inc</title>
        <cusip>883556102</cusip>
        <identifiers>
          <isin value="US8835561023"/>
        </identifiers>
        <balance>16295.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4621262.00000000</valUSD>
        <pctVal>0.522763292272</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Syneos Health Inc</name>
        <lei>549300F1ZGKDS8P6GU13</lei>
        <title>Syneos Health Inc</title>
        <cusip>87166B102</cusip>
        <identifiers>
          <isin value="US87166B1026"/>
        </identifiers>
        <balance>83190.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3279349.80000000</valUSD>
        <pctVal>0.370964402788</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ImmunoGen Inc</name>
        <lei>54930084U0R1OP766Y02</lei>
        <title>ImmunoGen Inc</title>
        <cusip>45253H101</cusip>
        <identifiers>
          <isin value="US45253H1014"/>
        </identifiers>
        <balance>117030.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>399072.30000000</valUSD>
        <pctVal>0.045143588353</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ionis Pharmaceuticals Inc</name>
        <lei>549300SI4ZGLG0BLUZ92</lei>
        <title>Ionis Pharmaceuticals Inc</title>
        <cusip>462222100</cusip>
        <identifiers>
          <isin value="US4622221004"/>
        </identifiers>
        <balance>118058.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5581782.24000000</valUSD>
        <pctVal>0.631418616933</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cigna Corp</name>
        <lei>549300VIWYMSIGT1U456</lei>
        <title>Cigna Corp</title>
        <cusip>125523100</cusip>
        <identifiers>
          <isin value="US1255231003"/>
        </identifiers>
        <balance>25532.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4523759.76000000</valUSD>
        <pctVal>0.511733709446</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Novocure Ltd</name>
        <lei>213800YPP55UMHWA4826</lei>
        <title>Novocure Ltd</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="JE00BYSS4X48"/>
        </identifiers>
        <balance>67580.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4550837.20000000</valUSD>
        <pctVal>0.514796745405</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Boston Scientific Corp</name>
        <lei>Y6ZDD9FP4P8JSSJMW954</lei>
        <title>Boston Scientific Corp</title>
        <cusip>101137107</cusip>
        <identifiers>
          <isin value="US1011371077"/>
        </identifiers>
        <balance>99148.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3235199.24000000</valUSD>
        <pctVal>0.365970032830</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AC Immune SA</name>
        <lei>967600VLQ0ZC2HSOG765</lei>
        <title>AC Immune SA</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="CH0329023102"/>
        </identifiers>
        <balance>119074.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>822801.34000000</valUSD>
        <pctVal>0.093076379868</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Apellis Pharmaceuticals Inc</name>
        <lei>254900HS0ZFRXXSB9D42</lei>
        <title>Apellis Pharmaceuticals Inc</title>
        <cusip>03753U106</cusip>
        <identifiers>
          <isin value="US03753U1060"/>
        </identifiers>
        <balance>113906.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3051541.74000000</valUSD>
        <pctVal>0.345194452621</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ovid therapeutics Inc</name>
        <lei>549300H36NUI4L6U8F17</lei>
        <title>Ovid therapeutics Inc</title>
        <cusip>690469101</cusip>
        <identifiers>
          <isin value="US6904691010"/>
        </identifiers>
        <balance>260913.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>777520.74000000</valUSD>
        <pctVal>0.087954178285</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Inogen Inc</name>
        <lei>549300J8WJIVTOJ8IH97</lei>
        <title>Inogen Inc</title>
        <cusip>45780L104</cusip>
        <identifiers>
          <isin value="US45780L1044"/>
        </identifiers>
        <balance>11476.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>592850.16000000</valUSD>
        <pctVal>0.067063997121</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ligand Pharmaceuticals Inc</name>
        <lei>5493008K7TB0IKP37H79</lei>
        <title>Ligand Pharmaceuticals Inc</title>
        <cusip>53220K504</cusip>
        <identifiers>
          <isin value="US53220K5048"/>
        </identifiers>
        <balance>18606.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1353028.32000000</valUSD>
        <pctVal>0.153056359734</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Illumina Inc</name>
        <lei>SQ95QG8SR5Q56LSNF682</lei>
        <title>Illumina Inc</title>
        <cusip>452327109</cusip>
        <identifiers>
          <isin value="US4523271090"/>
        </identifiers>
        <balance>149344.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>40788833.28000000</valUSD>
        <pctVal>4.614086968753</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>
      <explntrNote note="Conversion of Illuminoss Medical, Inc. notes are dependent upon unknown future events therefore underlying reference instrument cannot be determined at this time.                                                                    Conversion of Rainier Therapeutics, Inc. notes are dependent upon unknown future events therefore underlying reference instrument cannot be determined at this time.                                                                             Conversion of Vectibio Holding AG notes are dependent upon unknown future events therefore underlying reference instrument cannot be determined at this time." noteItem="C.9.f.iii"/>
    </explntrNotes>
    <signature>
      <ncom:dateSigned>2020-04-29</ncom:dateSigned>
      <ncom:nameOfApplicant>TEKLA HEALTHCARE INVESTORS</ncom:nameOfApplicant>
      <ncom:signature>Laura Woodward</ncom:signature>
      <ncom:signerName>Laura Woodward</ncom:signerName>
      <ncom:title>CCO</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
