<SEC-DOCUMENT>0001752724-21-235884.txt : 20211112
<SEC-HEADER>0001752724-21-235884.hdr.sgml : 20211112
<ACCEPTANCE-DATETIME>20211112112921
ACCESSION NUMBER:		0001752724-21-235884
CONFORMED SUBMISSION TYPE:	NPORT-P
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20210930
FILED AS OF DATE:		20211112
PERIOD START:           	20210930

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			TEKLA HEALTHCARE INVESTORS
		CENTRAL INDEX KEY:			0000805267
		IRS NUMBER:				046564285
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			0930

	FILING VALUES:
		FORM TYPE:		NPORT-P
		SEC ACT:		1940 Act
		SEC FILE NUMBER:	811-04889
		FILM NUMBER:		211401552

	BUSINESS ADDRESS:	
		STREET 1:		100 FEDERAL STREET
		STREET 2:		19TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110
		BUSINESS PHONE:		6177728515

	MAIL ADDRESS:	
		STREET 1:		100 FEDERAL STREET
		STREET 2:		19TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	H&Q HEALTHCARE INVESTORS
		DATE OF NAME CHANGE:	19920703
</SEC-HEADER>
<DOCUMENT>
<TYPE>NPORT-P
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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      <invstOrSec>
        <name>Caribou Biosciences Inc</name>
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      <invstOrSec>
        <name>PerkinElmer Inc</name>
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        <name>G1 Therapeutics Inc</name>
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        <name>AbbVie Inc</name>
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      <invstOrSec>
        <name>VectivBio Holding AG</name>
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      <invstOrSec>
        <name>ARKUDA THERAPEUTICS,INC SER A.</name>
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        <name>ChemoCentryx Inc</name>
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        <name>Thermo Fisher Scientific Inc</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Theravance Biopharma Inc</name>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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        <name>BioMarin Pharmaceutical Inc</name>
        <lei>NSLL8ITTRR0J5HEMR848</lei>
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        <name>IO LIGHT HOLDINIGS, INC.</name>
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        <name>Spectrum Pharmaceuticals Inc</name>
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        <name>Curasen Therapeutics, Inc.</name>
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        <name>Adaptive Biotechnologies Corp</name>
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        <name>Travere Therapeutics Inc</name>
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        <name>ARISTEA THERAPEUTICS, INC.</name>
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        <name>Praxis Precision Medicines Inc</name>
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        <name>Horizon Therapeutics Plc</name>
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        <name>Seagen Inc</name>
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        <title>Seagen Inc</title>
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        <name>Medtronic PLC</name>
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        <name>ETHISMOS RESEARCH, INC. MILEST</name>
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        <name>Zoetis Inc</name>
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        <name>Impact Biomedicines Milestone</name>
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        <name>Anthem Inc</name>
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        <name>Options Clearing Corp.</name>
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        <name>Apellis Pharmaceuticals Inc</name>
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        <name>Biogen Inc</name>
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        <name>United Therapeutics Corp</name>
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        <name>Addus HomeCare Corp</name>
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        <name>Endo International PLC</name>
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        <name>Moderna Inc</name>
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        <name>Stryker Corp</name>
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        <name>Atreca Inc</name>
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        <name>AstraZeneca PLC</name>
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        <name>Cigna Corp</name>
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        <name>PARTHENON THERAPEUTICS, INC.</name>
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        <name>CRISPR Therapeutics AG</name>
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        <name>Denali Therapeutics Inc</name>
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      <invstOrSec>
        <name>Illumina Inc</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Sutro Biopharma Inc</name>
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      <invstOrSec>
        <name>INVETX, INC.</name>
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        <fairValLevel>3</fairValLevel>
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        <name>Mirati Therapeutics Inc</name>
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        <name>Guardant Health Inc</name>
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        <name>Zogenix Inc</name>
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        <name>Precision BioSciences Inc</name>
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        <name>Intra-Cellular Therapies Inc</name>
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        <name>Perrigo Co PLC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>THEROX MILESTONE INTEREST</name>
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        <name>HOTSPOT THERAPEUTICS, INC.</name>
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        <name>Fate Therapeutics Inc</name>
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        <name>Intuitive Surgical Inc</name>
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        <name>TCR2 Therapeutics Inc</name>
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        <name>ICON PLC</name>
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        <name>Fixed Income Clearing Corp</name>
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        <name>Amgen Inc</name>
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        <name>Karuna Therapeutics Inc</name>
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        <name>Corbus Pharmaceuticals Holdings Inc</name>
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        <name>Organon &amp; Co</name>
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      <invstOrSec>
        <name>Abbott Laboratories</name>
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      <invstOrSec>
        <name>AMPHIVENA THERAPEUTICS, INC.</name>
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        <name>Options Clearing Corp.</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Options Clearing Corp.</name>
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      <invstOrSec>
        <name>Xenon Pharmaceuticals Inc</name>
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        <name>Stoke Therapeutics Inc</name>
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        <name>OCULIS SA SERIES C</name>
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        <name>BIOTHERYX, INC. SERIES E</name>
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        <fairValLevel>3</fairValLevel>
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        <name>Dexcom Inc</name>
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        <fairValLevel>1</fairValLevel>
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        <name>NEUROVANCE MILESTONE INTEREST</name>
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      <invstOrSec>
        <name>Jazz Pharmaceuticals PLC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Molina Healthcare Inc</name>
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        <name>Sarepta Therapeutics Inc</name>
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        <name>Edwards Lifesciences Corp</name>
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        <name>Argenx SE</name>
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        <name>Helix Acquisition Corp</name>
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        <name>TETRAPHASE PHARMACEUTICALS INC</name>
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        <name>DYNACURE</name>
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        <name>Zai Lab Ltd</name>
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        <title>Zai Lab Ltd</title>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Fusion Pharmaceuticals Inc</name>
        <lei>N/A</lei>
        <title>Fusion Pharmaceuticals Inc</title>
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          <isin value="CA36118A1003"/>
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        <assetCat>EC</assetCat>
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        <invCountry>CA</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>I-Mab</name>
        <lei>549300L1A5T19703RR64</lei>
        <title>I-Mab</title>
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          <isin value="US44975P1030"/>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Ultragenyx Pharmaceutical Inc</name>
        <lei>529900EV44GVDN1DCX77</lei>
        <title>Ultragenyx Pharmaceutical Inc</title>
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          <isin value="US90400D1081"/>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Owens &amp; Minor Inc</name>
        <lei>549300LMT5KQQXCEZ733</lei>
        <title>Owens &amp; Minor Inc</title>
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          <isin value="US6907321029"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>RALLYBIO HOLDINGS, LLC</name>
        <lei>N/A</lei>
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          <other otherDesc="Internal Identifier" value="966GZH903"/>
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        <fairValLevel>2</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>THERACHON MILESTONE INTEREST</name>
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          <other otherDesc="Internal Identifier" value="964WMT908"/>
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        <assetCat>EP</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Arcutis Biotherapeutics Inc</name>
        <lei>N/A</lei>
        <title>Arcutis Biotherapeutics Inc</title>
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          <isin value="US03969K1088"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Vir Biotechnology Inc</name>
        <lei>N/A</lei>
        <title>Vir Biotechnology Inc</title>
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          <isin value="US92764N1028"/>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>CARIBOU BIOSCIENCES</name>
        <lei>N/A</lei>
        <title>CARIBOU BIOSCIENCES</title>
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          <other otherDesc="Internal Identifier" value="942KKD007"/>
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        <curCd>USD</curCd>
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        <assetCat>EP</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Laboratory Corp of America Holdings</name>
        <lei>OZ7UA8IXAIFILY2VZH07</lei>
        <title>Laboratory Corp of America Holdings</title>
        <cusip>50540R409</cusip>
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          <isin value="US50540R4092"/>
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        <balance>15929.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Arvinas Inc</name>
        <lei>N/A</lei>
        <title>Arvinas Inc</title>
        <cusip>04335A105</cusip>
        <identifiers>
          <isin value="US04335A1051"/>
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        <balance>51378.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>4222244.04000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>BeiGene Ltd</name>
        <lei>549300JFUK6FRD5MH739</lei>
        <title>BeiGene Ltd</title>
        <cusip>07725L102</cusip>
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          <isin value="US07725L1026"/>
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        <balance>37582.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>13642266.00000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Neurocrine Biosciences Inc</name>
        <lei>549300FECER0XBN49756</lei>
        <title>Neurocrine Biosciences Inc</title>
        <cusip>64125C109</cusip>
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          <isin value="US64125C1099"/>
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        <balance>81617.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>7827886.47000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Affimed NV</name>
        <lei>5493004V4FSXT1D04610</lei>
        <title>Affimed NV</title>
        <cusip>000000000</cusip>
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          <isin value="NL0010872420"/>
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        <balance>367414.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2270618.52000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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        <name>HCA Healthcare Inc</name>
        <lei>529900PH4ZGUH2MNEU89</lei>
        <title>HCA Healthcare Inc</title>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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        <name>McKesson Corp</name>
        <lei>549300WZWOM80UCFSF54</lei>
        <title>McKesson Corp</title>
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        <balance>48115.00000000</balance>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>AMPHIVENA THERAPEUTICS, INC.</name>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>Humana Inc</name>
        <lei>529900YLDW34GJAO4J06</lei>
        <title>Humana Inc</title>
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        <name>Forma Therapeutics Holdings Inc</name>
        <lei>N/A</lei>
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        <name>PRIOTHERA LIMITED</name>
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        <invCountry>IE</invCountry>
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        <name>Danaher Corp</name>
        <lei>S4BKK9OTCEWQ3YHPFM11</lei>
        <title>Danaher Corp</title>
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        <name>Regeneron Pharmaceuticals Inc</name>
        <lei>549300RCBFWIRX3HYQ56</lei>
        <title>Regeneron Pharmaceuticals Inc</title>
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        <name>VYNE Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>VYNE Therapeutics Inc</title>
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      <invstOrSec>
        <name>State Street Institutional US Government Money Market Fund</name>
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        <title>State Street Institutional US Government Money Market Fund</title>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>VECTIVBIO HOLDING AG</name>
        <lei>N/A</lei>
        <title>VECTIVBIO HOLDING AG</title>
        <cusip>000000000</cusip>
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        <fairValLevel>2</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>Biohaven Pharmaceutical Holding Co Ltd</name>
        <lei>5299007STZTNN32O9920</lei>
        <title>Biohaven Pharmaceutical Holding Co Ltd</title>
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        <invCountry>VG</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Arena Pharmaceuticals Inc</name>
        <lei>529900CVGQMPJ3A3NI85</lei>
        <title>Arena Pharmaceuticals Inc</title>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Teva Pharmaceutical Industries Ltd</name>
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          <isin value="US8816242098"/>
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        <assetCat>EC</assetCat>
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        <invCountry>IL</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Aurinia Pharmaceuticals Inc</name>
        <lei>5299008YP2BW4570ML28</lei>
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          <isin value="CA05156V1022"/>
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        <assetCat>EC</assetCat>
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        <invCountry>CA</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Amicus Therapeutics Inc</name>
        <lei>549300MRD1SMUTNBPQ53</lei>
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          <isin value="US03152W1099"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Merck &amp; Co Inc</name>
        <lei>4YV9Y5M8S0BRK1RP0397</lei>
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          <isin value="US58933Y1055"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Scholar Rock Holding Corp</name>
        <lei>549300Z1FLPGL4OWJ459</lei>
        <title>Scholar Rock Holding Corp</title>
        <cusip>80706P103</cusip>
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          <isin value="US80706P1030"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Waters Corp</name>
        <lei>5T547R1474YC9HOD8Q74</lei>
        <title>Waters Corp</title>
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          <isin value="US9418481035"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Eli Lilly &amp; Co</name>
        <lei>FRDRIPF3EKNDJ2CQJL29</lei>
        <title>Eli Lilly &amp; Co</title>
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          <isin value="US5324571083"/>
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        <balance>37913.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Galera Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Galera Therapeutics Inc</title>
        <cusip>36338D108</cusip>
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          <isin value="US36338D1081"/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Novavax Inc</name>
        <lei>529900J4GJHPEPQ23205</lei>
        <title>Novavax Inc</title>
        <cusip>670002401</cusip>
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          <isin value="US6700024010"/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>uniQure NV</name>
        <lei>N/A</lei>
        <title>uniQure NV</title>
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        <curCd>USD</curCd>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
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      </invstOrSec>
      <invstOrSec>
        <name>Options Clearing Corp.</name>
        <lei>549300CII6SLYGKNHA04</lei>
        <title>MODERNA INC</title>
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          <other otherDesc="Bloomberg Identifier" value="BBG011WWXX29"/>
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        <curCd>USD</curCd>
        <valUSD>-1766400.00000000</valUSD>
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        <assetCat>DE</assetCat>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <derivativeInfo>
          <optionSwaptionWarrantDeriv derivCat="OPT">
            <counterparties>
              <counterpartyName>Options Clearing Corp.</counterpartyName>
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            <putOrCall>Call</putOrCall>
            <writtenOrPur>Written</writtenOrPur>
            <descRefInstrmnt>
              <otherRefInst>
                <issuerName>Moderna Inc</issuerName>
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            <shareNo>100.00000000</shareNo>
            <exercisePrice>460.00000000</exercisePrice>
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            <expDt>2022-01-21</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>1843852.93000000</unrealizedAppr>
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        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Cercacor Laboratories Inc</name>
        <lei>N/A</lei>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Catalent Inc</name>
        <lei>N/A</lei>
        <title>Catalent Inc</title>
        <cusip>148806102</cusip>
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        <fairValLevel>1</fairValLevel>
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        <name>IDEXX Laboratories Inc</name>
        <lei>OGMTXK0LUU1HKV2P0J84</lei>
        <title>IDEXX Laboratories Inc</title>
        <cusip>45168D104</cusip>
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          <isin value="US45168D1046"/>
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        <fairValLevel>1</fairValLevel>
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        <name>Hologic Inc</name>
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        <name>Bristol-Myers Squibb Co</name>
        <lei>HLYYNH7UQUORYSJQCN42</lei>
        <title>Bristol-Myers Squibb Co</title>
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        <fairValLevel>1</fairValLevel>
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      </invstOrSec>
      <invstOrSec>
        <name>IMMUNEID, INC. SERIES A</name>
        <lei>N/A</lei>
        <title>IMMUNEID, INC. SERIES A</title>
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          <other otherDesc="Internal Identifier" value="942RVA907"/>
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        <valUSD>2040000.00000000</valUSD>
        <pctVal>0.176333014584</pctVal>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>Black Diamond Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Black Diamond Therapeutics Inc</title>
        <cusip>09203E105</cusip>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Gilead Sciences Inc</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>Gilead Sciences Inc</title>
        <cusip>375558103</cusip>
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          <isin value="US3755581036"/>
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        <fairValLevel>1</fairValLevel>
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      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>

    </explntrNotes>
    <signature>
      <ncom:dateSigned>2021-10-28</ncom:dateSigned>
      <ncom:nameOfApplicant>TEKLA HEALTHCARE INVESTORS</ncom:nameOfApplicant>
      <ncom:signature>Laura Woodward</ncom:signature>
      <ncom:signerName>Laura Woodward</ncom:signerName>
      <ncom:title>CCO</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
