<SEC-DOCUMENT>0001752724-22-119813.txt : 20220525
<SEC-HEADER>0001752724-22-119813.hdr.sgml : 20220525
<ACCEPTANCE-DATETIME>20220525112137
ACCESSION NUMBER:		0001752724-22-119813
CONFORMED SUBMISSION TYPE:	NPORT-P
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20220331
FILED AS OF DATE:		20220525
PERIOD START:           	20220930

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			TEKLA HEALTHCARE INVESTORS
		CENTRAL INDEX KEY:			0000805267
		IRS NUMBER:				046564285
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			0930

	FILING VALUES:
		FORM TYPE:		NPORT-P
		SEC ACT:		1940 Act
		SEC FILE NUMBER:	811-04889
		FILM NUMBER:		22960423

	BUSINESS ADDRESS:	
		STREET 1:		100 FEDERAL STREET
		STREET 2:		19TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110
		BUSINESS PHONE:		6177728515

	MAIL ADDRESS:	
		STREET 1:		100 FEDERAL STREET
		STREET 2:		19TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	H&Q HEALTHCARE INVESTORS
		DATE OF NAME CHANGE:	19920703
</SEC-HEADER>
<DOCUMENT>
<TYPE>NPORT-P
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Intercept Pharmaceuticals Inc</name>
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      <invstOrSec>
        <name>Caribou Biosciences Inc</name>
        <lei>N/A</lei>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>HOTSPOT THERAPEUTICS, INC.</name>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>PerkinElmer Inc</name>
        <lei>549300IKL1SDPFI7N655</lei>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>G1 Therapeutics Inc</name>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>OCULIS SA SERIES B2 PREFERRED</name>
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        <assetCat>EP</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ARKUDA THERAPEUTICS, INC.</name>
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        <assetCat>EP</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>AbbVie Inc</name>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>VectivBio Holding AG</name>
        <lei>N/A</lei>
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          <isin value="CH1109007893"/>
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        <assetCat>EC</assetCat>
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        <invCountry>CH</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ARKUDA THERAPEUTICS,INC SER A.</name>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ChemoCentryx Inc</name>
        <lei>529900YTTXUSFQTAKY40</lei>
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          <isin value="US16383L1061"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Thermo Fisher Scientific Inc</name>
        <lei>HCHV7422L5HDJZCRFL38</lei>
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          <isin value="US8835561023"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>BioMarin Pharmaceutical Inc</name>
        <lei>NSLL8ITTRR0J5HEMR848</lei>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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        <name>IO LIGHT HOLDINIGS, INC.</name>
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        <name>Spectrum Pharmaceuticals Inc</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Curasen Therapeutics, Inc.</name>
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        <name>Adaptive Biotechnologies Corp</name>
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        <name>Travere Therapeutics Inc</name>
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        <name>MOONLAKE IMMUNOTHERAPEUTICS AG</name>
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        <name>ARISTEA THERAPEUTICS, INC.</name>
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        <name>QUELL THERAPEUTICS</name>
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        <name>PYXIS ONCOLOGY, INC.</name>
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        <name>Praxis Precision Medicines Inc</name>
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        <title>Praxis Precision Medicines Inc</title>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Horizon Therapeutics Plc</name>
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      <invstOrSec>
        <name>Seagen Inc</name>
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      <invstOrSec>
        <name>Medtronic PLC</name>
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        <isRestrictedSec>N</isRestrictedSec>

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        <name>RECODE THERAPEUTICS</name>
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      <invstOrSec>
        <name>ETHISMOS RESEARCH, INC. MILEST</name>
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      <invstOrSec>
        <name>Ascendis Pharma A/S</name>
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        <name>Intellia Therapeutics Inc</name>
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        <name>Zoetis Inc</name>
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      <invstOrSec>
        <name>Boston Scientific Corp</name>
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        <name>Zimmer Biomet Holdings Inc</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Impact Biomedicines Milestone</name>
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        <name>Anthem Inc</name>
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        <name>Apellis Pharmaceuticals Inc</name>
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        <name>Biogen Inc</name>
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        <name>Fixed Income Clearing Corp</name>
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        <name>United Therapeutics Corp</name>
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        <name>Addus HomeCare Corp</name>
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        <name>Align Technology Inc</name>
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        <name>Syneos Health Inc</name>
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        <name>IQVIA Holdings Inc</name>
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        <title>IQVIA Holdings Inc</title>
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        <name>Endo International PLC</name>
        <lei>5493007TBMWZWGZIB256</lei>
        <title>Endo International PLC</title>
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        <name>Moderna Inc</name>
        <lei>549300EI6OKH5K5Q2G38</lei>
        <title>Moderna Inc</title>
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        <name>Stryker Corp</name>
        <lei>5493002F0SC4JTBU5137</lei>
        <title>Stryker Corp</title>
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        <name>Mirati Therapeutics Inc</name>
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        <name>Guardant Health Inc</name>
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        <name>Precision BioSciences Inc</name>
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        <name>Intra-Cellular Therapies Inc</name>
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        <name>Pfizer Inc</name>
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        <name>Zai Lab Ltd</name>
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        <name>Owens &amp; Minor Inc</name>
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        <name>Arcutis Biotherapeutics Inc</name>
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        <name>Laboratory Corp of America Holdings</name>
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        <name>Affimed NV</name>
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        <name>SPDR S&amp;P Biotech ETF</name>
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        <name>State Street Institutional US Government Money Market Fund</name>
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        <name>Aurinia Pharmaceuticals Inc</name>
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        <name>Alkermes PLC</name>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Merck &amp; Co Inc</name>
        <lei>4YV9Y5M8S0BRK1RP0397</lei>
        <title>Merck &amp; Co Inc</title>
        <cusip>58933Y105</cusip>
        <identifiers>
          <isin value="US58933Y1055"/>
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        <balance>71668.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>5880359.40000000</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Scholar Rock Holding Corp</name>
        <lei>549300Z1FLPGL4OWJ459</lei>
        <title>Scholar Rock Holding Corp</title>
        <cusip>80706P103</cusip>
        <identifiers>
          <isin value="US80706P1030"/>
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        <balance>68117.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>878028.13000000</valUSD>
        <pctVal>0.086342884583</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Waters Corp</name>
        <lei>5T547R1474YC9HOD8Q74</lei>
        <title>Waters Corp</title>
        <cusip>941848103</cusip>
        <identifiers>
          <isin value="US9418481035"/>
        </identifiers>
        <balance>8360.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2594860.40000000</valUSD>
        <pctVal>0.255171473866</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Eli Lilly &amp; Co</name>
        <lei>FRDRIPF3EKNDJ2CQJL29</lei>
        <title>Eli Lilly &amp; Co</title>
        <cusip>532457108</cusip>
        <identifiers>
          <isin value="US5324571083"/>
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        <balance>37913.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10857145.81000000</valUSD>
        <pctVal>1.067662020785</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Galera Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Galera Therapeutics Inc</title>
        <cusip>36338D108</cusip>
        <identifiers>
          <isin value="US36338D1081"/>
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        <balance>296462.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>705579.56000000</valUSD>
        <pctVal>0.069384763918</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Novavax Inc</name>
        <lei>529900J4GJHPEPQ23205</lei>
        <title>Novavax Inc</title>
        <cusip>670002401</cusip>
        <identifiers>
          <isin value="US6700024010"/>
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        <balance>37188.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2738896.20000000</valUSD>
        <pctVal>0.269335560449</pctVal>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="2599845.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>uniQure NV</name>
        <lei>N/A</lei>
        <title>uniQure NV</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="NL0010696654"/>
        </identifiers>
        <balance>357080.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6452435.60000000</valUSD>
        <pctVal>0.634514867189</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cercacor Laboratories Inc</name>
        <lei>N/A</lei>
        <title>CERCACOR LABORATORIES INC</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="574992913"/>
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        <balance>160000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>778215.20000000</valUSD>
        <pctVal>0.076527554071</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>IDEXX Laboratories Inc</name>
        <lei>OGMTXK0LUU1HKV2P0J84</lei>
        <title>IDEXX Laboratories Inc</title>
        <cusip>45168D104</cusip>
        <identifiers>
          <isin value="US45168D1046"/>
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        <balance>15824.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8656677.44000000</valUSD>
        <pctVal>0.851273980346</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Hologic Inc</name>
        <lei>549300DYP6F5ZJL0LB74</lei>
        <title>Hologic Inc</title>
        <cusip>436440101</cusip>
        <identifiers>
          <isin value="US4364401012"/>
        </identifiers>
        <balance>10945.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>840794.90000000</valUSD>
        <pctVal>0.082681470591</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Bristol-Myers Squibb Co</name>
        <lei>HLYYNH7UQUORYSJQCN42</lei>
        <title>Bristol-Myers Squibb Co</title>
        <cusip>110122108</cusip>
        <identifiers>
          <isin value="US1101221083"/>
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        <balance>188556.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13770244.68000000</valUSD>
        <pctVal>1.354128195296</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Xencor Inc</name>
        <lei>549300V5IF65437JKG30</lei>
        <title>Xencor Inc</title>
        <cusip>98401F105</cusip>
        <identifiers>
          <isin value="US98401F1057"/>
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        <balance>79511.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2121353.48000000</valUSD>
        <pctVal>0.208608098564</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IMMUNEID, INC. SERIES A</name>
        <lei>N/A</lei>
        <title>IMMUNEID, INC. SERIES A</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="942RVA907"/>
        </identifiers>
        <balance>1020000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2040000.00000000</valUSD>
        <pctVal>0.200608019871</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Black Diamond Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Black Diamond Therapeutics Inc</title>
        <cusip>09203E105</cusip>
        <identifiers>
          <isin value="US09203E1055"/>
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        <balance>90404.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>250419.08000000</valUSD>
        <pctVal>0.024625527341</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="233511.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Gilead Sciences Inc</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>Gilead Sciences Inc</title>
        <cusip>375558103</cusip>
        <identifiers>
          <isin value="US3755581036"/>
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        <balance>854746.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>50814649.70000000</valUSD>
        <pctVal>4.996973655290</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>

    </explntrNotes>
    <signature>
      <ncom:dateSigned>2022-04-21</ncom:dateSigned>
      <ncom:nameOfApplicant>TEKLA HEALTHCARE INVESTORS</ncom:nameOfApplicant>
      <ncom:signature>Laura Woodward</ncom:signature>
      <ncom:signerName>Laura Woodward</ncom:signerName>
      <ncom:title>CCO</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
