<SEC-DOCUMENT>0001104659-22-084120.txt : 20220729
<SEC-HEADER>0001104659-22-084120.hdr.sgml : 20220729
<ACCEPTANCE-DATETIME>20220729135742
ACCESSION NUMBER:		0001104659-22-084120
CONFORMED SUBMISSION TYPE:	POS EX
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20220729
DATE AS OF CHANGE:		20220729
EFFECTIVENESS DATE:		20220729

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			TEKLA HEALTHCARE INVESTORS
		CENTRAL INDEX KEY:			0000805267
		IRS NUMBER:				046564285
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			0930

	FILING VALUES:
		FORM TYPE:		POS EX
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-195327
		FILM NUMBER:		221119833

	BUSINESS ADDRESS:	
		STREET 1:		100 FEDERAL STREET
		STREET 2:		19TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110
		BUSINESS PHONE:		6177728515

	MAIL ADDRESS:	
		STREET 1:		100 FEDERAL STREET
		STREET 2:		19TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	H&Q HEALTHCARE INVESTORS
		DATE OF NAME CHANGE:	19920703
</SEC-HEADER>
<DOCUMENT>
<TYPE>POS EX
<SEQUENCE>1
<FILENAME>tm2221745d1_posex.htm
<DESCRIPTION>POS EX
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>As
filed with the Securities and Exchange Commission on July 29, 2022</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Securities
Act </B></FONT><B>File No.&nbsp;333-195327</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Investment Company Act File No.&nbsp;811-04889</B></P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"></P>

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<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES</B></P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Washington, D.C. 20549</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>FORM&nbsp;N-2</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>REGISTRATION
STATEMENT UNDER THE SECURITIES ACT OF 1933 </B></FONT><B><FONT STYLE="font-family: Wingdings">&#120;</FONT></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Pre-Effective Amendment No.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Post-Effective Amendment No.&nbsp;10</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>REGISTRATION
STATEMENT UNDER THE INVESTMENT COMPANY ACT OF 1940 </B></FONT><B><FONT STYLE="font-family: Wingdings">&#120;</FONT></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Amendment No.&nbsp;32</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>TEKLA HEALTHCARE INVESTORS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Exact Name of Registrant as Specified in
Charter)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>100 Federal Street, 19th&nbsp;Floor</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Boston, MA 02110<BR>
(617) 772-8500</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Address,&nbsp;Including Zip Code, and Telephone
Number,&nbsp;Including Area Code, of Registrant&#8217;s<BR>
Principal Executive Offices)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Daniel
R. Omstead, Ph.D.<BR>
</B></FONT><B>100 Federal Street, 19th&nbsp;Floor</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Boston, MA 02110</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name, address including zip code, and telephone
number, including area code, of agent for<BR>
service)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">With Copies to:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Christopher P. Harvey,&nbsp;Esq.<BR>
Dechert LLP<BR>
One International Place, 40th&nbsp;Floor</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>100 Oliver Street<BR>
Boston, MA 02110</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Approximate Date of Proposed Public Offering: <B>As soon as
practicable after the effective date of this Registration Statement</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">If
any securities being registered on this form will be offered on a delayed or continuous basis in reliance on Rule&nbsp;415 under
the Securities Act of 1933, other than securities offered in connection with a dividend reinvestment plan, check the following
box </FONT><FONT STYLE="font: 10pt Wingdings">&#168;</FONT>.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">This post-effective amendment will become effective immediately
pursuant to Rule&nbsp;462(d).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="margin: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>EXPLANATORY NOTE</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">This Post-Effective Amendment No. 10 to the Registration
Statement on Form&nbsp;N-2 (File No.&nbsp;333-195327) of Tekla Healthcare Investors (the &#8220;Registration Statement&#8221;) is
being filed pursuant to Rule&nbsp;462(d)&nbsp;under the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;),
solely for the purpose of filing an exhibit to the Registration Statement. No changes have been made to Part&nbsp;A, Part&nbsp;B or
Part&nbsp;C of the Registration Statement, other than the Items of Part&nbsp;C of the Registration Statement as set forth below.
Accordingly, this Post-Effective Amendment No. 10   consists only of a facing page, this explanatory note and Part&nbsp;C of the
Registration Statement on Form&nbsp;N-2 setting forth the exhibits to the Registration Statement. This Post-Effective Amendment
No. 10 does not modify any other part of the Registration Statement. The contents of the Registration Statement are hereby
incorporated by reference.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>PART&nbsp;C: OTHER INFORMATION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item&nbsp;25. Financial Statements and Exhibits</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 27pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">2.</FONT></TD><TD>Exhibits:</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 5%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">a.</FONT></TD><TD STYLE="width: 5%">(i)</TD>
                                                                                                                                             <TD STYLE="width: 85%"><A HREF="https://www.sec.gov/Archives/edgar/data/805267/0000950146-97-000010-index.html" STYLE="-sec-extract: exhibit">Amended and Restated Declaration of Trust of the Registrant, dated as of April&nbsp;21, 1987(4)</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 10%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(ii)</FONT></TD><TD STYLE="width: 85%"><A HREF="https://www.sec.gov/Archives/edgar/data/805267/000104746904011356/a2132197zex-99_aii.txt" STYLE="-sec-extract: exhibit">Notice of Change of Trustee, dated June&nbsp;2, 2003(5)</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 10%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(iii)</FONT></TD><TD STYLE="width: 85%"><A HREF="https://www.sec.gov/Archives/edgar/data/805267/000110465914028161/a14-9453_1ex99daiii.htm" STYLE="-sec-extract: exhibit">Notice of Change of Trustee, dated September&nbsp;20, 2006(1)</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 10%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(iv)</FONT></TD><TD STYLE="width: 85%"><A HREF="https://www.sec.gov/Archives/edgar/data/805267/000110465914028161/a14-9453_1ex99daiv.htm" STYLE="-sec-extract: exhibit">Notice of Change of Trustee, dated July&nbsp;2, 2007(1)</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 10%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(v)</FONT></TD><TD STYLE="width: 85%"><A HREF="https://www.sec.gov/Archives/edgar/data/805267/000110465914028161/a14-9453_1ex99dav.htm" STYLE="-sec-extract: exhibit">Notice of Change of Trustee, dated June&nbsp;8, 2010(1)</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 10%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(vi)</FONT></TD><TD STYLE="width: 85%"><A HREF="https://www.sec.gov/Archives/edgar/data/805267/000110465914028161/a14-9453_1ex99davi.htm" STYLE="-sec-extract: exhibit">Notice of Change of Trustee, dated June&nbsp;29, 2011(1)</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 10%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(vii)</FONT></TD><TD STYLE="width: 85%"><A HREF="https://www.sec.gov/Archives/edgar/data/805267/000110465911040145/a11-15950_1ex99dbaiii.htm" STYLE="-sec-extract: exhibit">Amendment Relating to Repurchase of Shares, dated July&nbsp;8, 2011(6)</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 10%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(viii)</FONT></TD><TD STYLE="width: 85%"><A HREF="https://www.sec.gov/Archives/edgar/data/805267/000110465914028161/a14-9453_1ex99daviii.htm" STYLE="-sec-extract: exhibit">Notice of Change of Trustee, dated December&nbsp;14, 2011(1)</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 10%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(ix)</FONT></TD><TD STYLE="width: 85%"><A HREF="https://www.sec.gov/Archives/edgar/data/805267/000110465914028161/a14-9453_1ex99daix.htm" STYLE="-sec-extract: exhibit">Notice of Change of Trustee, dated May&nbsp;2, 2012(1)</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 10%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(x)</FONT></TD><TD STYLE="width: 85%"><A HREF="https://www.sec.gov/Archives/edgar/data/805267/000110465918024690/a18-9973_1ex99dbax.htm" STYLE="-sec-extract: exhibit">Notice of Change of Trustee, dated December&nbsp;20, 2017(7)</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 81pt; text-indent: -27pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 10%">&nbsp;</TD>
    <TD STYLE="width: 5%">(xi)</TD>
    <TD STYLE="width: 85%"><A HREF="https://www.sec.gov/Archives/edgar/data/805267/000110465919014166/a19-3041_1ex99dbaxi.htm" STYLE="-sec-extract: exhibit">Notice of Change of Trustee, dated December 13, 2018(8)</A></TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 10%">&nbsp;</TD>
    <TD STYLE="width: 5%">(xii)</TD>
    <TD STYLE="width: 85%"><A HREF="https://www.sec.gov/Archives/edgar/data/805267/000110465919036646/a19-11733_1ex99dbaxii.htm" STYLE="-sec-extract: exhibit">Notice of Change of Trustee, dated June 20, 2019(9)</A></TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.25in; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 10%">&nbsp;</TD>
    <TD STYLE="width: 5%">(xiii) </TD>
    <TD STYLE="width: 85%"><A HREF="https://www.sec.gov/Archives/edgar/data/805267/000110465920103793/tm2030220d1_ex99-axiii.htm" STYLE="-sec-extract: exhibit">Notice of Change of Trustee, dated August 27, 2020(11)</A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(xiv) </TD>
    <TD><A HREF="https://www.sec.gov/Archives/edgar/data/805267/000110465921088745/tm2120071d1_ex99axiv.htm" STYLE="-sec-extract: exhibit">Notice of Change of Trustee, dated June 16, 2021(13)</A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(xv)</TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/805267/000110465921152531/tm2120071d1_ex99axv.htm">Notice of Change of Trustee, dated December 13, 2021(14)</A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(xvi)</TD>
    <TD><A HREF="http://www.sec.gov/Archives/edgar/data/805267/000110465922076520/tm2219130d1_ex99axvi.htm" STYLE="-sec-extract: exhibit">Notice of Change of Trustee, dated June 16th, 2022(15)</A></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(xvii)</TD>
    <TD><A HREF="tm2221745d1_ex99axvii.htm" STYLE="-sec-extract: exhibit">Notice of Change of Trustee, filed herewith</A></TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 5%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">b.</FONT></TD><TD><A HREF="https://www.sec.gov/Archives/edgar/data/805267/000110465921000875/tm2039334d1_ex99b.htm" STYLE="-sec-extract: exhibit">By-Laws of the Registrant, as amended(12)</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 5%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">c.</FONT></TD><TD>Not Applicable</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 5%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">d.</FONT></TD><TD STYLE="width: 5%">(i)</TD>
                                                                                                                                         <TD><A HREF="https://www.sec.gov/Archives/edgar/data/805267/000104746904018612/a2136845zex-99_di.txt" STYLE="-sec-extract: exhibit">Specimen certificate for Shares of Beneficial Interest is incorporated by reference from Form&nbsp;N-2 Registration Statement (File No.&nbsp;333-114322), filed May&nbsp;26, 2004</A></TD></TR>                                                                                                                                                                                                                                                                                                                     <TR STYLE="vertical-align: top">
<TD>&nbsp;</TD><TD>&nbsp;</TD><TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD>&nbsp;</TD><TD>&nbsp;</TD><TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(ii)</FONT></TD>
                              <TD><A HREF="https://www.sec.gov/Archives/edgar/data/805267/000110465914041981/a14-9453_1ex99dddii.htm" STYLE="-sec-extract: exhibit">Form&nbsp;of Exercise Form(3)</A></TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 5%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">e.</FONT></TD><TD><A HREF="https://www.sec.gov/Archives/edgar/data/805267/0000950146-97-000010-index.html" STYLE="-sec-extract: exhibit">Dividend Reinvestment Plan of the Registrant dated May&nbsp;1995 is incorporated by reference to Exhibit&nbsp;(e)&nbsp;to Registrant&rsquo;s registration statement on Form&nbsp;N-2 (File No.&nbsp;333-19247), filed January&nbsp;3, 1997</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 5%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">f.</FONT></TD><TD>Not Applicable</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 5%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">g.</FONT></TD><TD><A HREF="https://www.sec.gov/Archives/edgar/data/805267/000110465914028161/a14-9453_1ex99dg.htm" STYLE="-sec-extract: exhibit">Investment Advisory Agreement, dated as of July&nbsp;1, 2009, between the Registrant and Tekla Capital Management LLC (formerly known as Hambrecht&nbsp;&amp; Quist Capital Management, LLC) (1)</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 5%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">h.</FONT></TD><TD>Not Applicable</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 5%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">i.</FONT></TD><TD>Not Applicable</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 5%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">j.</FONT></TD><TD STYLE="text-align: left"><A HREF="https://www.sec.gov/Archives/edgar/data/805267/000110465914028161/a14-9453_1ex99dj.htm" STYLE="-sec-extract: exhibit">Custodian Agreement, dated September&nbsp;30, 2004, between the Registrant and State Street Bank and Trust Company(1)</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 5%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">k.</FONT></TD><TD STYLE="width: 5%">(i)</TD>
                                                                                                                                             <TD STYLE="text-align: left; width: 85%"><A HREF="https://www.sec.gov/Archives/edgar/data/805267/000110465914028161/a14-9453_1ex99dki.htm" STYLE="-sec-extract: exhibit">Administration Agreement between Registrant and State Street Bank and Trust Company, dated as of July&nbsp;1, 2005(1)</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<TD STYLE="width: 10%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(ii)</FONT></TD><TD STYLE="width: 85%"><A HREF="https://www.sec.gov/Archives/edgar/data/805267/000110465914028161/a14-9453_1ex99dkii.htm" STYLE="-sec-extract: exhibit">Transfer Agency and Service Agreement between Registrant, Computershare Trust Company, N.A. and Computershare Shareholder Services,&nbsp;Inc. (formerly known as EquiServe,&nbsp;Inc.), dated as of March&nbsp;1, 2006(1)</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 10%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(iii)</FONT></TD><TD STYLE="width: 85%"><A HREF="https://www.sec.gov/Archives/edgar/data/805267/000110465914041323/a14-9453_1ex99dkdiii.htm" STYLE="-sec-extract: exhibit">Information Agent Agreement between the Registrant and AST Fund Solutions, LLC dated April&nbsp;21, 2014(2)</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<TD STYLE="width: 10%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(iv)</FONT></TD><TD STYLE="width: 85%"><A HREF="https://www.sec.gov/Archives/edgar/data/805267/000110465914041323/a14-9453_1ex99dkdiv.htm" STYLE="-sec-extract: exhibit">Subscription Agent Agreement between the Registrant and Boston Financial Data Services,&nbsp;Inc. dated April&nbsp;30, 2014(2)</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 10%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(v)</FONT></TD><TD STYLE="width: 85%"><A HREF="https://www.sec.gov/Archives/edgar/data/805267/000110465917040134/a17-15119_1ex99dbkv.htm" STYLE="-sec-extract: exhibit">Support Services Agreement between the Registrant and Destra Capital Investments LLC dated January&nbsp;1, 2016 (10)</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<TD STYLE="width: 10%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(vi)</FONT></TD><TD STYLE="width: 85%"><A HREF="https://www.sec.gov/Archives/edgar/data/805267/000110465918024690/a18-9973_1ex99dbkvi.htm" STYLE="-sec-extract: exhibit">Assignment of the Support Services Agreement with Destra Capital Investments LLC to Destra Capital Advisors LLC dated April&nbsp;2, 2018(7)</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<TD STYLE="width: 5%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">l.</FONT></TD><TD><A HREF="https://www.sec.gov/Archives/edgar/data/805267/000110465914041323/a14-9453_1ex99dld.htm" STYLE="-sec-extract: exhibit">Opinion and Consent of Dechert LLP(2)</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 5%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">m.</FONT></TD><TD>Not Applicable</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 5%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">n.</FONT></TD><TD STYLE="width: 4.5%">(i)</TD>
                                                                                                                                             <TD STYLE="width: 85.5%"><A HREF="https://www.sec.gov/Archives/edgar/data/805267/000110465914041981/a14-9453_1ex99dndi.htm">Consent of Deloitte&nbsp;&amp; Touche LLP(3)</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<TD STYLE="width: 5%">&nbsp;</TD>
<TD STYLE="width: 5%">&nbsp;</TD><TD STYLE="width: 4.5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(ii)</FONT></TD><TD STYLE="width: 85.5%"><A HREF="http://www.sec.gov/Archives/edgar/data/805267/000110465914028161/a14-9453_1ex99dnii.htm" STYLE="-sec-extract: exhibit">Powers of Attorney dated March 28, 2014 and April&nbsp;2, 2014(1)</A>; <A HREF="http://www.sec.gov/Archives/edgar/data/805267/000110465918024690/a18-9973_1ex99dbnii.htm" STYLE="-sec-extract: exhibit">Power of Attorney dated April&nbsp;9, 2018(7)</A>; <A HREF="http://www.sec.gov/Archives/edgar/data/805267/000110465919014166/a19-3041_1ex99dbnii.htm" STYLE="-sec-extract: exhibit">Power of Attorney dated December 13, 2018(8)</A>; <A HREF="http://www.sec.gov/Archives/edgar/data/805267/000110465920103793/tm2030220d1_ex99-nii.htm" STYLE="-sec-extract: exhibit">Power of Attorney dated August 27, 2020(11)</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/805267/000110465921152531/tm2120071d1_ex99nii.htm" STYLE="-sec-extract: exhibit">Power of Attorney dated November 30, 2021(14)</A>, <A HREF="http://www.sec.gov/Archives/edgar/data/805267/000110465922076520/tm2219130d1_ex99nii.htm" STYLE="-sec-extract: exhibit">Power of Attorney dated June 9, 2022(15)</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 5%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">o.</FONT></TD><TD>Not Applicable</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 5%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">p.</FONT></TD><TD>Not Applicable</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 5%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">q.</FONT></TD><TD>Not Applicable</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

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<TD STYLE="width: 5%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">r.</FONT></TD><TD><A HREF="https://www.sec.gov/Archives/edgar/data/805267/000110465914028161/a14-9453_1ex99dr.htm" STYLE="-sec-extract: exhibit">Code of Ethics of Registrant and its Investment Adviser(1)</A></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="padding-top: 2pt; width: 5%"></TD><TD STYLE="padding-top: 2pt; width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(1)</FONT></TD><TD STYLE="padding-top: 2pt">Incorporated by reference from&nbsp;Form&nbsp;N-2 Registration Statement (File No.&nbsp;333-195327), filed April&nbsp;16, 2014.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 5%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(2)</FONT></TD><TD>Incorporated by reference from Form&nbsp;N-2 Registration Statement (File No.&nbsp;333-195327), filed on May&nbsp;23, 2014.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 5%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(3)</FONT></TD><TD>Incorporated by reference from Form&nbsp;N-2 Registration Statement (File No.&nbsp;333-195327), filed on May&nbsp;28, 2014.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 5%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(4)</FONT></TD><TD>Incorporated by reference from Form&nbsp;N-2 Registration Statement (File No.&nbsp;333-19247), filed January 3, 1997.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 5%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(5)</FONT></TD><TD>Incorporated by reference from Form&nbsp;N-2 Registration Statement (File No.&nbsp;333-114322), filed April&nbsp;8, 2004.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 5%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(6)</FONT></TD><TD>Incorporated by reference from Form&nbsp;N-2/A Registration Statement (File No.&nbsp;811-04889), filed July&nbsp;21, 2011.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 5%"></TD><TD STYLE="width: 5%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(7)</FONT></TD><TD>Incorporated by reference from Form&nbsp;N-2 Registration Statement (File No.&nbsp;333-195327), filed April&nbsp;18, 2018.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in; text-indent: -27pt">&nbsp;</P>

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<TD STYLE="width: 5%"></TD><TD STYLE="width: 5%">(8)</TD><TD>Incorporated by reference from Form N-2 Registration Statement (File No. 333-195327), filed March 12, 2019.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in; text-indent: -27pt">&nbsp;</P>

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<TD STYLE="width: 5%"></TD><TD STYLE="width: 5%">(9)</TD><TD>Incorporated by reference from Form N-2 Registration Statement (File No. 333-195327), filed June 20, 2019.</TD></TR>                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   <TR STYLE="vertical-align: top">
<TD>&nbsp;</TD><TD>&nbsp;</TD><TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD>&nbsp;</TD><TD>(10)</TD><TD>Incorporated by reference from Form N-2 Registration Statement (File No. 333-195327), filed June 19, 2017.</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt">
<TR STYLE="vertical-align: top">
<TD STYLE="width: 5%">&nbsp;</TD><TD STYLE="width: 5%">(11)</TD><TD>Incorporated by reference from Form N-2 Registration Statement (File No. 333-195327), filed September 10, 2020.</TD></TR>
<TR STYLE="vertical-align: top">
<TD>&nbsp;</TD><TD>&nbsp;</TD><TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD>&nbsp;</TD><TD>(12)</TD><TD> Incorporated by reference from Form N-2 Registration Statement (File No. 333-195327), filed January 5, 2021.</TD></TR>

<TR STYLE="vertical-align: top">
<TD>&nbsp;</TD><TD>&nbsp;</TD><TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">(13)</TD><TD STYLE="text-align: justify">Incorporated by reference from Form N-2 Registration Statement
(File No. 333-195327), filed July 2, 2021.</TD>
</TR><TR STYLE="vertical-align: top; text-align: justify">
<TD>&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: justify">&nbsp;</TD></TR>
     <TR STYLE="vertical-align: top; text-align: justify">
<TD>&nbsp;</TD><TD STYLE="text-align: left">(14)</TD><TD STYLE="text-align: justify">Incorporated by reference from Form N-2 Registration Statement (File No. 333-195327), filed December 22, 2021.</TD></TR>
     <TR STYLE="vertical-align: top; text-align: justify">
<TD>&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: justify">&nbsp;</TD></TR>
     <TR STYLE="vertical-align: top; text-align: justify">
<TD>&nbsp;</TD><TD STYLE="text-align: left">(15) </TD><TD STYLE="text-align: justify">Incorporated by reference from Form N-2 Registration Statement (File No. 333-195327), filed July 1, 2022.</TD></TR>
     </TABLE>

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<P STYLE="text-align: center; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SIGNATURES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Pursuant to the requirements of the Securities Act of 1933 and the
Investment Company Act of 1940, the Registrant has duly caused this Post-Effective Amendment No. 10 to be signed on its behalf by
the undersigned, thereunto duly authorized, in the City of Boston and Commonwealth of Massachusetts on the 14<SUP>th</SUP> day of July,
2022.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>TEKLA HEALTHCARE INVESTORS</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 51%">&nbsp;</TD>
    <TD STYLE="width: 4%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">By:</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; width: 45%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">/s/ Daniel R. Omstead</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">President</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Pursuant to the requirements of the Securities Act of 1933,
this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-bottom: Black 1pt solid; width: 28%; text-align: center; font-size: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Name</B></FONT></TD>
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; width: 38%; text-align: center; font-size: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Title</B></FONT></TD>
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; width: 28%; text-align: center; font-size: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Date</B></FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">/s/ Daniel R. Omstead</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Trustee and President (Principal Executive Officer)</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 10pt">July 29, 2022</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; font-size: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Daniel R. Omstead</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">/s/ Laura Woodward</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Treasurer (Principal Financial Officer)</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 10pt">July 29, 2022</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; font-size: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Laura Woodward</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>

<TR>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">/s/ Jeffrey A. Bailey ***</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 10pt">Trustee and Chairman of the Board</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 10pt">July 29, 2022</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; font-size: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Jeffrey A. Bailey</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="border-bottom: Black 0.5pt solid; vertical-align: bottom; font-size: 10pt">/s/ Kathleen L. Goetz****</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Trustee</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD>July 29, 2022</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; font-size: 10pt">Kathleen L. Goetz</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">/s/ Rakesh K. Jain*</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Trustee</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 10pt">July 29, 2022</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; font-size: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Rakesh K. Jain</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">/s/ Thomas M. Kent**</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Trustee</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 10pt">July 29, 2022</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; font-size: 10pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Thomas M. Kent</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>

<TR>
    <TD STYLE="vertical-align: bottom; width: 28%">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; width: 3%">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; width: 38%">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; width: 3%">&nbsp;</TD>
    <TD STYLE="width: 28%">&nbsp;</TD></TR>

<TR STYLE="vertical-align: bottom">
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; width: 28%">/s/ W. Mark Watson*****</TD>
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; width: 38%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Trustee</FONT></TD>
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; width: 28%">July 29, 2022</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom; font-size: 10pt">W. Mark Watson</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
</TABLE>

<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">*By: Daniel R. Omstead as attorney-in-fact of each person so
indicated and pursuant to the power of attorney previously filed on April&nbsp;16, 2014.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">**By: Daniel R. Omstead as attorney-in-fact of each person so
indicated and pursuant to the power of attorney previously filed on April 18, 2018.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">*** By: Daniel R. Omstead as attorney-in-fact of each person
so indicated and pursuant to the power of attorney previously filed on September 10, 2020.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">**** By: Daniel R. Omstead as attorney-in-fact of each person so indicated and pursuant to the power of attorney previously filed on December
22, 2021.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">*****By: Daniel R. Omstead as attorney-in-fact of each person so
indicated and pursuant to the power of attorney previously filed on July 1, 2022.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>EXHIBIT&nbsp;LIST</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

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<TR>
    <TD STYLE="white-space: nowrap; vertical-align: top; font-size: 10pt; width: 5%"><A HREF="tm2221745d1_ex99axvii.htm" STYLE="-sec-extract: exhibit">(a)(xvii)</A></TD>
    <TD STYLE="vertical-align: bottom; width: 3%">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; font-size: 10pt; width: 92%"><A HREF="tm2221745d1_ex99axvii.htm" STYLE="-sec-extract: exhibit">Notice of Change of Trustee</A></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

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<TYPE>EX-99.(A)(XVII)
<SEQUENCE>2
<FILENAME>tm2221745d1_ex99axvii.htm
<DESCRIPTION>EXHIBIT 99.(A)(XVII)
<TEXT>
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<BODY STYLE="font: 10pt Times New Roman, Times, Serif">

<P STYLE="margin: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1.5in; text-align: right; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B>Exhibit</B></FONT><B>&nbsp;<FONT STYLE="font-family: Times New Roman, Times, Serif">(a)(xvii)</FONT></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><B>TEKLA HEALTHCARE INVESTORS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Amendment to Declaration of Trust</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B><U>Notice of Change of Trustee</U></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">WHEREAS, upon the death of Oleg M. Pohotsky on July&nbsp;13, 2022,
Tekla Healthcare Investors (the &#8220;Fund&#8221;) issues this notice in accordance with the terms of the Declaration of Trust of the
Fund, dated and filed with the Secretary of State of the Commonwealth of Massachusetts on October&nbsp;31, 1986, as amended;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">NOW, THEREFORE, as a result of the foregoing Trustee death, the six
Trustees of the Tekla Healthcare Investors are:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font-size: 10pt; border-collapse: collapse; width: 100%">
  <TR STYLE="font-size: 10pt; vertical-align: bottom">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 40%; text-align: left">Jeffrey A. Bailey</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; width: 60%; text-align: left">100 Federal Street, 19<SUP>th</SUP> Floor</TD>
    </TR>
  <TR STYLE="font-size: 10pt; vertical-align: bottom">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">Boston, MA 02110</TD>
    </TR>
  <TR STYLE="font-size: 10pt; vertical-align: bottom">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD>
    </TR>
  <TR STYLE="font-size: 10pt; vertical-align: bottom">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Kathleen L. Goetz</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">100 Federal Street, 19<SUP>th</SUP> Floor</TD>
    </TR>
  <TR STYLE="font-size: 10pt; vertical-align: bottom">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">Boston, MA 02110</TD>
    </TR>
  <TR STYLE="font-size: 10pt; vertical-align: bottom">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD>
    </TR>
  <TR STYLE="font-size: 10pt; vertical-align: bottom">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Rakesh K. Jain, Ph.D.</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">100 Federal Street, 19<SUP>th</SUP> Floor</TD>
    </TR>
  <TR STYLE="font-size: 10pt; vertical-align: bottom">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Boston, MA 02110</TD>
    </TR>
  <TR STYLE="font-size: 10pt; vertical-align: bottom">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD>
    </TR>
  <TR STYLE="font-size: 10pt; vertical-align: bottom">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Thomas M. Kent</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">100 Federal Street, 19<SUP>th</SUP> Floor</TD>
    </TR>
  <TR STYLE="font-size: 10pt; vertical-align: bottom">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Boston, MA 02110</TD>
    </TR>
  <TR STYLE="font-size: 10pt; vertical-align: bottom">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD>
    </TR>
  <TR STYLE="font-size: 10pt; vertical-align: bottom">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Daniel R. Omstead, Ph.D.</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">100 Federal Street, 19<SUP>th</SUP> Floor</TD>
    </TR>
  <TR STYLE="font-size: 10pt; vertical-align: bottom">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Boston, MA 02110</TD>
    </TR>
  <TR STYLE="font-size: 10pt; vertical-align: bottom">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD>
    </TR>
  <TR STYLE="font-size: 10pt; vertical-align: bottom">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">W. Mark Watson</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">100 Federal Street, 19<SUP>th</SUP> Floor</TD>
    </TR>
  <TR STYLE="font-size: 10pt; vertical-align: bottom">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left">Boston, MA 02110</TD>
    </TR>
  </TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">IN WITNESS WHEREOF, this Notice has been subscribed this 14th day of
July, 2022, by the undersigned who affirms that the statements made herein are true under the penalties of perjury.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font-size: 10pt; border-collapse: collapse; width: 100%">
  <TR STYLE="font-size: 10pt; vertical-align: bottom">
    <TD STYLE="border-bottom: Black 1pt solid; font: 10pt Times New Roman, Times, Serif; width: 50%">/s/ Laura Woodward</TD>
    <TD STYLE="font-size: 10pt; width: 50%">&nbsp;</TD></TR>
  <TR STYLE="font-size: 10pt; vertical-align: bottom">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">Laura Woodward, Secretary</TD>
    <TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
  </TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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