<SEC-DOCUMENT>0001752724-22-258405.txt : 20221121
<SEC-HEADER>0001752724-22-258405.hdr.sgml : 20221121
<ACCEPTANCE-DATETIME>20221121125446
ACCESSION NUMBER:		0001752724-22-258405
CONFORMED SUBMISSION TYPE:	NPORT-P
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20220930
FILED AS OF DATE:		20221121
DATE AS OF CHANGE:		20221121
PERIOD START:           	20220930

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			TEKLA HEALTHCARE INVESTORS
		CENTRAL INDEX KEY:			0000805267
		IRS NUMBER:				046564285
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			0930

	FILING VALUES:
		FORM TYPE:		NPORT-P
		SEC ACT:		1940 Act
		SEC FILE NUMBER:	811-04889
		FILM NUMBER:		221405025

	BUSINESS ADDRESS:	
		STREET 1:		100 FEDERAL STREET
		STREET 2:		19TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110
		BUSINESS PHONE:		6177728515

	MAIL ADDRESS:	
		STREET 1:		100 FEDERAL STREET
		STREET 2:		19TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	H&Q HEALTHCARE INVESTORS
		DATE OF NAME CHANGE:	19920703
</SEC-HEADER>
<DOCUMENT>
<TYPE>NPORT-P
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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      <invstOrSec>
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        <name>AbbVie Inc</name>
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      <invstOrSec>
        <name>VectivBio Holding AG</name>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ARKUDA THERAPEUTICS,INC SER A.</name>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ChemoCentryx Inc</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Thermo Fisher Scientific Inc</name>
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        <name>BioMarin Pharmaceutical Inc</name>
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        <fairValLevel>1</fairValLevel>
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        <name>IO LIGHT HOLDINIGS, INC.</name>
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        <name>Spectrum Pharmaceuticals Inc</name>
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        <name>Curasen Therapeutics, Inc.</name>
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        <name>Adaptive Biotechnologies Corp</name>
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        <name>Travere Therapeutics Inc</name>
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        <name>QUELL THERAPEUTICS</name>
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        <name>Cardiovascular Systems Inc</name>
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        <name>Praxis Precision Medicines Inc</name>
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        <name>Horizon Therapeutics Plc</name>
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        <name>Seagen Inc</name>
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        <title>Seagen Inc</title>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Medtronic PLC</name>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>RECODE THERAPEUTICS</name>
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        <assetCat>EP</assetCat>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>ETHISMOS RESEARCH, INC. MILEST</name>
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      <invstOrSec>
        <name>Ascendis Pharma A/S</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Intellia Therapeutics Inc</name>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Zoetis Inc</name>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Boston Scientific Corp</name>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Zimmer Biomet Holdings Inc</name>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Impact Biomedicines Milestone</name>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Elevance Health Inc</name>
        <lei>8MYN82XMYQH89CTMTH67</lei>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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        <name>Apellis Pharmaceuticals Inc</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Biogen Inc</name>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>FUSION PHARMACEUTICALS, INC.</name>
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        <name>United Therapeutics Corp</name>
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        <name>Addus HomeCare Corp</name>
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        <name>Align Technology Inc</name>
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        <name>IQVIA Holdings Inc</name>
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        <name>Endo International PLC</name>
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        <name>Moderna Inc</name>
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        <name>Stryker Corp</name>
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        <name>HIBERCELL, INC. SERIES B</name>
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        <name>AstraZeneca PLC</name>
        <lei>PY6ZZQWO2IZFZC3IOL08</lei>
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        <name>Cigna Corp</name>
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        <title>Cigna Corp</title>
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        <name>PARTHENON THERAPEUTICS, INC.</name>
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      <invstOrSec>
        <name>BIOTHERYX, INC. SERIES E</name>
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      <invstOrSec>
        <name>Fixed Income Clearing Corp</name>
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        <fairValLevel>2</fairValLevel>
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          <transCat>Repurchase</transCat>
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      <invstOrSec>
        <name>Dexcom Inc</name>
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        <name>NEUROVANCE MILESTONE INTEREST</name>
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          <other otherDesc="Internal Identifier" value="931UVM907"/>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>Pfizer Inc</name>
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          <isin value="US7170811035"/>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Jazz Pharmaceuticals PLC</name>
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        <title>Jazz Pharmaceuticals PLC</title>
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          <isin value="IE00B4Q5ZN47"/>
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        <assetCat>EC</assetCat>
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        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Molina Healthcare Inc</name>
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          <isin value="US60855R1005"/>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Sarepta Therapeutics Inc</name>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Edwards Lifesciences Corp</name>
        <lei>YA13X31F3V31L8TMPR58</lei>
        <title>Edwards Lifesciences Corp</title>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Argenx SE</name>
        <lei>7245009C5FZE6G9ODQ71</lei>
        <title>Argenx SE</title>
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          <isin value="US04016X1019"/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>NL</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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        <name>INNOVACARE INC</name>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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        <name>TETRAPHASE PHARMACEUTICALS INC</name>
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        <fairValLevel>2</fairValLevel>
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        <name>DYNACURE</name>
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        <title>DYNACURE</title>
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        <invCountry>FR</invCountry>
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        <name>Zai Lab Ltd</name>
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        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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        <name>Fusion Pharmaceuticals Inc</name>
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        <invCountry>CA</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>I-Mab</name>
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        <title>I-Mab</title>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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        <name>Ultragenyx Pharmaceutical Inc</name>
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        <name>Owens &amp; Minor Inc</name>
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        <name>INVETX, INC.</name>
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        <name>THERACHON MILESTONE INTEREST</name>
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        <title>THERACHON MILESTONE INTEREST</title>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>Arcutis Biotherapeutics Inc</name>
        <lei>N/A</lei>
        <title>Arcutis Biotherapeutics Inc</title>
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        <fairValLevel>1</fairValLevel>
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        <name>Design Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Design Therapeutics Inc</title>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Laboratory Corp of America Holdings</name>
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      <invstOrSec>
        <name>Arvinas Inc</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Neurocrine Biosciences Inc</name>
        <lei>549300FECER0XBN49756</lei>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Affimed NV</name>
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        <invCountry>NL</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>HealthEquity Inc</name>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>SPDR S&amp;P Biotech ETF</name>
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          <isin value="US78464A8707"/>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>HCA Healthcare Inc</name>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>McKesson Corp</name>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>AMPHIVENA THERAPEUTICS, INC.</name>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Humana Inc</name>
        <lei>529900YLDW34GJAO4J06</lei>
        <title>Humana Inc</title>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Nexgel Inc</name>
        <lei>N/A</lei>
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          <isin value="US65344E1073"/>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>PRIOTHERA LIMITED</name>
        <lei>N/A</lei>
        <title>PRIOTHERA LIMITED</title>
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        <assetCat>EP</assetCat>
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        <invCountry>IE</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Lantheus Holdings Inc</name>
        <lei>5299005HUB5IOJGO7S39</lei>
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          <isin value="US5165441032"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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        <name>Danaher Corp</name>
        <lei>S4BKK9OTCEWQ3YHPFM11</lei>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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        <name>Regeneron Pharmaceuticals Inc</name>
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        <name>VYNE Therapeutics Inc</name>
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        <name>State Street Institutional US Government Money Market Fund</name>
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        <name>Biohaven Pharmaceutical Holding Co Ltd</name>
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        <name>Teva Pharmaceutical Industries Ltd</name>
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        <invCountry>IL</invCountry>
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        <name>Alkermes PLC</name>
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        <name>Merck &amp; Co Inc</name>
        <lei>4YV9Y5M8S0BRK1RP0397</lei>
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        <name>Scholar Rock Holding Corp</name>
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        <name>Eli Lilly &amp; Co</name>
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        <title>Eli Lilly &amp; Co</title>
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        <name>Galera Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Galera Therapeutics Inc</title>
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        <fairValLevel>1</fairValLevel>
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        <name>Novavax Inc</name>
        <lei>529900J4GJHPEPQ23205</lei>
        <title>Novavax Inc</title>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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        <name>uniQure NV</name>
        <lei>724500RPCTZLFYJZ3S98</lei>
        <title>uniQure NV</title>
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        <invCountry>NL</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Cercacor Laboratories Inc</name>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>IDEXX Laboratories Inc</name>
        <lei>OGMTXK0LUU1HKV2P0J84</lei>
        <title>IDEXX Laboratories Inc</title>
        <cusip>45168D104</cusip>
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          <isin value="US45168D1046"/>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Bristol-Myers Squibb Co</name>
        <lei>HLYYNH7UQUORYSJQCN42</lei>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Xencor Inc</name>
        <lei>549300V5IF65437JKG30</lei>
        <title>Xencor Inc</title>
        <cusip>98401F105</cusip>
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        <balance>101994.00000000</balance>
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        <valUSD>2649804.12000000</valUSD>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>IMMUNEID, INC. SERIES A</name>
        <lei>N/A</lei>
        <title>IMMUNEID, INC. SERIES A</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="942RVA907"/>
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        <balance>1020000.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>2040000.00000000</valUSD>
        <pctVal>0.222570446693</pctVal>
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        <assetCat>EP</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Black Diamond Therapeutics Inc</name>
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        <title>Black Diamond Therapeutics Inc</title>
        <cusip>09203E105</cusip>
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          <isin value="US09203E1055"/>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      </invstOrSec>
      <invstOrSec>
        <name>Gilead Sciences Inc</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>Gilead Sciences Inc</title>
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          <isin value="US3755581036"/>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
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      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>

    </explntrNotes>
    <signature>
      <ncom:dateSigned>2022-10-26</ncom:dateSigned>
      <ncom:nameOfApplicant>TEKLA HEALTHCARE INVESTORS</ncom:nameOfApplicant>
      <ncom:signature>Laura Woodward</ncom:signature>
      <ncom:signerName>Laura Woodward</ncom:signerName>
      <ncom:title>CCO</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
