<SEC-DOCUMENT>0001752724-23-100529.txt : 20230515
<SEC-HEADER>0001752724-23-100529.hdr.sgml : 20230515
<ACCEPTANCE-DATETIME>20230515144144
ACCESSION NUMBER:		0001752724-23-100529
CONFORMED SUBMISSION TYPE:	NPORT-P
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20230331
FILED AS OF DATE:		20230515
DATE AS OF CHANGE:		20230515
PERIOD START:           	20230930

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			TEKLA HEALTHCARE INVESTORS
		CENTRAL INDEX KEY:			0000805267
		IRS NUMBER:				046564285
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			0930

	FILING VALUES:
		FORM TYPE:		NPORT-P
		SEC ACT:		1940 Act
		SEC FILE NUMBER:	811-04889
		FILM NUMBER:		23921077

	BUSINESS ADDRESS:	
		STREET 1:		100 FEDERAL STREET
		STREET 2:		19TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110
		BUSINESS PHONE:		6177728515

	MAIL ADDRESS:	
		STREET 1:		100 FEDERAL STREET
		STREET 2:		19TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	H&Q HEALTHCARE INVESTORS
		DATE OF NAME CHANGE:	19920703
</SEC-HEADER>
<DOCUMENT>
<TYPE>NPORT-P
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>BioCryst Pharmaceuticals Inc</name>
        <lei>549300Z0INP1Z5NP6J59</lei>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>UnitedHealth Group Inc</name>
        <lei>549300GHBMY8T5GXDE41</lei>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Mereo Biopharma Group PLC</name>
        <lei>213800U8JQHIJOS5AS09</lei>
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          <isin value="US5894921072"/>
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        <assetCat>EC</assetCat>
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        <invCountry>GB</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Intercept Pharmaceuticals Inc</name>
        <lei>254900JMB8TX5P688V24</lei>
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          <isin value="US45845P1084"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Caribou Biosciences Inc</name>
        <lei>N/A</lei>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>HOTSPOT THERAPEUTICS, INC.</name>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>G1 Therapeutics Inc</name>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ARKUDA THERAPEUTICS, INC.</name>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>AbbVie Inc</name>
        <lei>FR5LCKFTG8054YNNRU85</lei>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Prometheus Biosciences Inc</name>
        <lei>N/A</lei>
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          <isin value="US74349U1088"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>VectivBio Holding AG</name>
        <lei>N/A</lei>
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        <assetCat>EC</assetCat>
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        <invCountry>CH</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ARKUDA THERAPEUTICS,INC SER A.</name>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>Thermo Fisher Scientific Inc</name>
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        <name>Chinook Therapeutics Inc</name>
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        <name>BioMarin Pharmaceutical Inc</name>
        <lei>NSLL8ITTRR0J5HEMR848</lei>
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        <name>IO LIGHT HOLDINIGS, INC.</name>
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        <name>Spectrum Pharmaceuticals Inc</name>
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        <name>Curasen Therapeutics, Inc.</name>
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        <name>Adaptive Biotechnologies Corp</name>
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        <name>Travere Therapeutics Inc</name>
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        <name>ARISTEA THERAPEUTICS, INC.</name>
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        <name>QUELL THERAPEUTICS</name>
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        <name>Cardiovascular Systems Inc</name>
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      </invstOrSec>
      <invstOrSec>
        <name>Praxis Precision Medicines Inc</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Seagen Inc</name>
        <lei>N/A</lei>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Medtronic PLC</name>
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        <assetCat>EC</assetCat>
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        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>RECODE THERAPEUTICS</name>
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        <title>RECODE THERAPEUTICS</title>
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          <other otherDesc="Internal Identifier" value="943HUY907"/>
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        <assetCat>EP</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ETHISMOS RESEARCH, INC. MILEST</name>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Ascendis Pharma A/S</name>
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        <assetCat>EC</assetCat>
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        <invCountry>DK</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Intellia Therapeutics Inc</name>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Zoetis Inc</name>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Boston Scientific Corp</name>
        <lei>Y6ZDD9FP4P8JSSJMW954</lei>
        <title>Boston Scientific Corp</title>
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          <isin value="US1011371077"/>
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        <balance>100556.00000000</balance>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Impact Biomedicines Milestone</name>
        <lei>N/A</lei>
        <title>Impact Biomedicines Milestone Preferred Stock</title>
        <cusip>000000000</cusip>
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          <other otherDesc="Internal Identifier" value="ACI006C40"/>
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        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Elevance Health Inc</name>
        <lei>8MYN82XMYQH89CTMTH67</lei>
        <title>Elevance Health Inc</title>
        <cusip>036752103</cusip>
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          <isin value="US0367521038"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Marinus Pharmaceuticals Inc</name>
        <lei>549300NCT4OJF7JV1084</lei>
        <title>Marinus Pharmaceuticals Inc</title>
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          <isin value="US56854Q2003"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Apellis Pharmaceuticals Inc</name>
        <lei>254900HS0ZFRXXSB9D42</lei>
        <title>Apellis Pharmaceuticals Inc</title>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Biogen Inc</name>
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        <title>Biogen Inc</title>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Madrigal Pharmaceuticals Inc</name>
        <lei>549300CHIMT2EUSNJB60</lei>
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        <fairValLevel>1</fairValLevel>
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        <name>FUSION PHARMACEUTICALS, INC.</name>
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        <name>United Therapeutics Corp</name>
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        <name>Addus HomeCare Corp</name>
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        <name>IQVIA Holdings Inc</name>
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        <title>IQVIA Holdings Inc</title>
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        <name>Endo International PLC</name>
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        <title>Endo International PLC</title>
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        <assetCat>EC</assetCat>
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        <invCountry>IE</invCountry>

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        <fairValLevel>1</fairValLevel>
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        <name>Moderna Inc</name>
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        <title>Moderna Inc</title>
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        <name>Biohaven Ltd</name>
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        <title>Biohaven Ltd</title>
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        <name>Stryker Corp</name>
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        <title>Stryker Corp</title>
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        <fairValLevel>1</fairValLevel>
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        <name>HIBERCELL, INC. SERIES B</name>
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        <assetCat>EP</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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        <name>AMOLYT PHARMA SAS</name>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>Cigna Group/The</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>PARTHENON THERAPEUTICS, INC.</name>
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        <name>Denali Therapeutics Inc</name>
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      <invstOrSec>
        <name>Illumina Inc</name>
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        <name>Sutro Biopharma Inc</name>
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      <invstOrSec>
        <name>INVETX, INC.</name>
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        <name>Mirati Therapeutics Inc</name>
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        <name>Cerevel Therapeutics Holdings Inc</name>
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        <name>Guardant Health Inc</name>
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        <name>Precision BioSciences Inc</name>
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        <name>Intra-Cellular Therapies Inc</name>
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        <name>Perrigo Co PLC</name>
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        <name>THEROX MILESTONE INTEREST</name>
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        <name>Reata Pharmaceuticals Inc</name>
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        <name>HOTSPOT THERAPEUTICS, INC.</name>
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        <name>Intuitive Surgical Inc</name>
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        <name>Amgen Inc</name>
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        <name>ENDEAVOR BIOMEDICINES, INC.</name>
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        <name>Karuna Therapeutics Inc</name>
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        <name>Medpace Holdings Inc</name>
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        <name>Pyxis Oncology Inc</name>
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        <name>Abbott Laboratories</name>
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        <name>Edwards Lifesciences Corp</name>
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        <name>Argenx SE</name>
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        <name>Zai Lab Ltd</name>
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        <name>Exelixis Inc</name>
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      <invstOrSec>
        <name>Affimed NV</name>
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      <invstOrSec>
        <name>SPDR S&amp;P Biotech ETF</name>
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        <name>HCA Healthcare Inc</name>
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        <name>McKesson Corp</name>
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        <name>Humana Inc</name>
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        <name>Nexgel Inc</name>
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        <name>PRIOTHERA LIMITED</name>
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        <name>Lantheus Holdings Inc</name>
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        <name>Cytokinetics Inc</name>
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        <name>Danaher Corp</name>
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        <name>Regeneron Pharmaceuticals Inc</name>
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        <name>VYNE Therapeutics Inc</name>
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        <name>State Street Institutional US Government Money Market Fund</name>
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        <name>AMPHIVENA MILESTONE INTEREST</name>
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        <name>Syndax Pharmaceuticals Inc</name>
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        <name>Teva Pharmaceutical Industries Ltd</name>
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        <name>Alkermes PLC</name>
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        <name>West Pharmaceutical Services Inc</name>
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        <name>Eli Lilly &amp; Co</name>
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        <name>Galera Therapeutics Inc</name>
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        <name>Novavax Inc</name>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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        <name>uniQure NV</name>
        <lei>724500RPCTZLFYJZ3S98</lei>
        <title>uniQure NV</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="NL0010696654"/>
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        <balance>448264.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9028036.96000000</valUSD>
        <pctVal>0.922088046406</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cercacor Laboratories Inc</name>
        <lei>N/A</lei>
        <title>CERCACOR LABORATORIES INC</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="574992913"/>
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        <balance>160000.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>302964.48000000</valUSD>
        <pctVal>0.030943595682</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Catalent Inc</name>
        <lei>N/A</lei>
        <title>Catalent Inc</title>
        <cusip>148806102</cusip>
        <identifiers>
          <isin value="US1488061029"/>
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        <balance>6711.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>440979.81000000</valUSD>
        <pctVal>0.045039936512</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>IDEXX Laboratories Inc</name>
        <lei>OGMTXK0LUU1HKV2P0J84</lei>
        <title>IDEXX Laboratories Inc</title>
        <cusip>45168D104</cusip>
        <identifiers>
          <isin value="US45168D1046"/>
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        <balance>15551.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>7776744.08000000</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Bristol-Myers Squibb Co</name>
        <lei>HLYYNH7UQUORYSJQCN42</lei>
        <title>Bristol-Myers Squibb Co</title>
        <cusip>110122108</cusip>
        <identifiers>
          <isin value="US1101221083"/>
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        <balance>189716.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13149215.96000000</valUSD>
        <pctVal>1.343008996314</pctVal>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IMMUNEID, INC. SERIES A</name>
        <lei>N/A</lei>
        <title>IMMUNEID, INC. SERIES A</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="942RVA907"/>
        </identifiers>
        <balance>1020000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2040000.00000000</valUSD>
        <pctVal>0.208357544724</pctVal>
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        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Black Diamond Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Black Diamond Therapeutics Inc</title>
        <cusip>09203E105</cusip>
        <identifiers>
          <isin value="US09203E1055"/>
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        <balance>90404.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>170863.56000000</valUSD>
        <pctVal>0.017451329335</pctVal>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="162162.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Gilead Sciences Inc</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>Gilead Sciences Inc</title>
        <cusip>375558103</cusip>
        <identifiers>
          <isin value="US3755581036"/>
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        <balance>815795.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>67686511.15000000</valUSD>
        <pctVal>6.913232977547</pctVal>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <signature>
      <ncom:dateSigned>2023-04-24</ncom:dateSigned>
      <ncom:nameOfApplicant>TEKLA HEALTHCARE INVESTORS</ncom:nameOfApplicant>
      <ncom:signature>Laura Woodward</ncom:signature>
      <ncom:signerName>Laura Woodward</ncom:signerName>
      <ncom:title>CCO</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
