Exhibit 99.1
 
Appendix 3Y
Change of Director’s Interest Notice
Rule 3.19A.2
Appendix 3Y

Change of Director’s Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public.
 
Introduced 30/9/2001.

Name of entity pSivida Limited
ABN  78 009 232 026

 We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director
Heather Zampatti
Date of last notice
16 January 2006

  Part 1 - Change of director’s relevant interests in securities
  In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Direct or indirect interest
 
Direct Interest
Nature of indirect interest
(including registered holder)
Note: Provide details of the circumstances giving rise to the relevant interest.
  
Date of change
 
21 February 2006
No. of securities held prior to change
A contractual interest in 200,000 unlisted options to be issued under the ESOP at an exercise price and expiry date to be determined subject to shareholder approval.
 
Class
 
Ordinary Fully Paid Shares
Number acquired
 
151,271
Number disposed
 
 
  
Value/Consideration
Note: If consideration is non-cash, provide details and estimated valuation
$104,410.61
 
 + See chapter 19 for defined terms.
 
30/9/2001
Appendix 3Y Page 1
 

 Appendix 3Y
 Change of Director’s Interest Notice
 
No. of securities held after change
 
 
 
 
 
A contractual interest in 200,000 unlisted options to be issued under the ESOP at an exercise price and expiry date to be determined subject to shareholder approval.
 
151,271 ordinary shares
Nature of change
Example: on-market trade, off-market trade, exercise of options, issue of securities under dividend reinvestment plan, participation in buy-back
On-market acquisition of ordinary shares.

  Part 2 - Change of director’s interests in contracts

Detail of contract
 
  
Nature of interest
 
  
Name of registered holder
(if issued securities)
 
  
Date of change
 
  
No. and class of securities to which interest related prior to change
Note: Details are only required for a contract in relation to which the interest has changed
 
  
Interest acquired
 
  
Interest disposed
 
  
Value/Consideration
Note: If consideration is non-cash, provide details and an estimated valuation
 
  
Interest after change
 
  
 
 + See chapter 19 for defined terms.
 
Appendix 3Y Page 2
30/9/2001