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CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020
Revenues: |  |
Total revenues | $ 36,939 | $ 34,437
Operating expenses: |  |
Cost of sales, excluding amortization of acquired intangible assets | 8,177 | 5,824
Research and development | 28,500 | 17,424
Sales and marketing | 27,503 | 25,293
General and administrative | 25,575 | 20,726
Amortization of acquired intangible assets | 2,460 | 2,460
Total operating expenses | 92,215 | 71,727
Loss from operations | (55,276) | (37,290)
Other income (expense): |  |
Interest and other income, net | 292 | 58
Interest expense | (5,498) | (7,257)
Gain (loss) on extinguishment of debt | 2,065 | (905)
Total other expense, net | (3,141) | (8,104)
Net loss | $ (58,417) | $ (45,394)
Net loss per share: |  |
Basic and diluted | $ (2.03) | $ (3.54)
Weighted average common shares outstanding: |  |
Basic and diluted | 28,758 | 12,836
Net loss | $ (58,417) | $ (45,394)
Other comprehensive income (loss): |  |
Foreign currency translation adjustments |  | 1
Other comprehensive income (loss) |  | 1
Comprehensive loss | (58,417) | (45,393)
Product [Member] |  |
Revenues: |  |
Total revenues | 35,312 | 20,831
License and Collaboration Agreement [Member] |  |
Revenues: |  |
Total revenues | 756 | 11,942
Royalty Income [Member] |  |
Revenues: |  |
Total revenues | $ 871 | $ 1,664

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