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License and Asset Purchase Agreements - Additional Information (Detail) - USD ($) | 1 Months Ended | 12 Months Ended
--- | --- | ---
Aug. 31, 2021 | Feb. 29, 2020 | Dec. 31, 2021 | Dec. 31, 2020
Collaborative Agreements And Contracts [Line Items] |  |  |  |
R&D expense |  |  | $ 28,500,000 | $ 17,424,000
Aerpio Pharmaceuticals, Inc [Member] |  |  |  |
Collaborative Agreements And Contracts [Line Items] |  |  |  |
Non-refundable and non-creditable upfront cash payment | $ 450,000 |  |  |
R&D expense |  |  | 450,000 |
Equinox Science, LLC [Member] |  |  |  |
Collaborative Agreements And Contracts [Line Items] |  |  |  |
Non-refundable and non-creditable upfront cash payment |  | $ 1,000,000.0 |  |
R&D expense |  |  | $ 0 | $ 1,000,000.0
Equinox Science, LLC [Member] | Maximum [Member] |  |  |  |
Collaborative Agreements And Contracts [Line Items] |  |  |  |
Payment upon achievement of development and regulatory milestones |  | $ 50,000,000 |  |

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- Definition Milestone payments upon achievement of certain development and regulatory milestones. + References No definition available. + Details
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- Definition The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 912 -SubTopic 730 -Section 25 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6472174&loc=d3e58812-109433 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 985 -SubTopic 20 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6501960&loc=d3e128462-111756 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 730 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6420194&loc=d3e21568-108373 + Details
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