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Income Taxes - Additional Information (Detail) £ in Millions | 12 Months Ended |
--- | --- | ---
Dec. 31, 2021 USD ($) | Dec. 31, 2020 USD ($) | Dec. 31, 2019 | Dec. 31, 2017 | Dec. 31, 2021 GBP (£)
Statutory federal corporate income tax rate | 21.00% | 21.00% | 21.00% | 34.00% |
Changes in valuation allowance | $ 15,748,000 | $ 13,068,000 |  |  |
Unrecognized tax benefits | 0 | 0 |  |  |
Accrued penalties or interest related to uncertain tax positions | 0 | $ 0 |  |  |
U.S. Federal [Member] |  |  |  |  |
Operating loss carry forwards | 301,200,000 |  |  |  |
Net operating loss carry forwards | $ 151,800,000 |  |  |  |
Operating loss carry forwards, expiration range start dates | 2023 |  |  |  |
Operating loss carry forwards, expiration range end dates | 2038 |  |  |  |
Tax years that remain subject to examination | 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 |  |  |  |
State [Member] |  |  |  |  |
Operating loss carry forwards | $ 222,600,000 |  |  |  |
Operating loss carry forwards, expiration range start dates | 2033 |  |  |  |
Operating loss carry forwards, expiration range end dates | 2038 |  |  |  |
United Kingdom Tax Authority [Member] |  |  |  |  |
Operating loss carry forwards | $ 27,600,000 |  |  |  | £ 20.9
Tax years that remain subject to examination | 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 |  |  |  |
Federal and State Research and Development Tax Credit Carryforward [Member] |  |  |  |  |
Research and development tax credit carry forwards | $ 5,700,000 |  |  |  |
Federal And State Tax [Member] |  |  |  |  |
Research and development tax credit carry forwards expiration begin date | 2021 |  |  |  |
Research and development tax credit carry forwards expiration end date | 2038 |  |  |  |
Icon Bioscience Inc [Member] | U.S. Federal [Member] |  |  |  |  |
Operating loss carry forwards | $ 49,300,000 |  |  |  |

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