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Income Taxes - Additional Information (Detail) £ in Millions	12 Months Ended
	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)	Dec. 31, 2019	Dec. 31, 2017	Dec. 31, 2021 GBP (£)
Statutory federal corporate income tax rate	21.00%	21.00%	21.00%	34.00%
Changes in valuation allowance	$ 15,748,000	$ 13,068,000
Unrecognized tax benefits	0	0
Accrued penalties or interest related to uncertain tax positions	0	$ 0
U.S. Federal [Member]
Operating loss carry forwards	301,200,000
Net operating loss carry forwards	$ 151,800,000
Operating loss carry forwards, expiration range start dates	2023
Operating loss carry forwards, expiration range end dates	2038
Tax years that remain subject to examination	2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020
State [Member]
Operating loss carry forwards	$ 222,600,000
Operating loss carry forwards, expiration range start dates	2033
Operating loss carry forwards, expiration range end dates	2038
United Kingdom Tax Authority [Member]
Operating loss carry forwards	$ 27,600,000				£ 20.9
Tax years that remain subject to examination	2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020
Federal and State Research and Development Tax Credit Carryforward [Member]
Research and development tax credit carry forwards	$ 5,700,000
Federal And State Tax [Member]
Research and development tax credit carry forwards expiration begin date	2021
Research and development tax credit carry forwards expiration end date	2038
Icon Bioscience Inc [Member] | U.S. Federal [Member]
Operating loss carry forwards	$ 49,300,000

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