<SEC-DOCUMENT>0001974078-23-000006.txt : 20230508
<SEC-HEADER>0001974078-23-000006.hdr.sgml : 20230508
<ACCEPTANCE-DATETIME>20230508173835
ACCESSION NUMBER:		0001974078-23-000006
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20230508
DATE AS OF CHANGE:		20230508

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Prime Medicine, Inc.
		CENTRAL INDEX KEY:			0001894562
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-41536
		FILM NUMBER:		23899152

	BUSINESS ADDRESS:	
		STREET 1:		21 ERIE ST.
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139
		BUSINESS PHONE:		617-465-0013

	MAIL ADDRESS:	
		STREET 1:		21 ERIE ST.
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GV 2019, L.P.
		CENTRAL INDEX KEY:			0001845041
		IRS NUMBER:				384092634
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144

	BUSINESS ADDRESS:	
		STREET 1:		1600 AMPHITHEATRE PKWY
		CITY:			MOUNTAIN VIEW
		STATE:			CA
		ZIP:			94043
		BUSINESS PHONE:		650-335-5278

	MAIL ADDRESS:	
		STREET 1:		1600 AMPHITHEATRE PKWY
		CITY:			MOUNTAIN VIEW
		STATE:			CA
		ZIP:			94043
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001845041</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001894562</issuerCik>
      <issuerName>Prime Medicine, Inc.</issuerName>
      <secFileNumber>001-41536</secFileNumber>
      <issuerAddress>
        <com:street1>21 ERIE ST.</com:street1>
        <com:city>CAMBRIDGE</com:city>
        <com:stateOrCountry>MA</com:stateOrCountry>
        <com:zipCode>02139</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>617-465-0013</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>GV 2019, L.P.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>10% Stockholder</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>RAYMOND JAMES &amp; ASSOCIATES INC</name>
        <address>
          <com:street1>880 CARILLON PARKWAY</com:street1>
          <com:city>ST. PETERSBURG</com:city>
          <com:stateOrCountry>FL</com:stateOrCountry>
          <com:zipCode>33716</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>1121197</noOfUnitsSold>
      <aggregateMarketValue>16055541.00</aggregateMarketValue>
      <noOfUnitsOutstanding>97227809</noOfUnitsOutstanding>
      <approxSaleDate>05/08/2023</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>09/26/2019</acquiredDate>
      <natureOfAcquisitionTransaction>STOCK PURCHASE</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>932369</amountOfSecuritiesAcquired>
      <paymentDate>09/26/2019</paymentDate>
      <natureOfPayment>CASH</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>11/12/2020</acquiredDate>
      <natureOfAcquisitionTransaction>STOCK PURCHASE</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>3263293</amountOfSecuritiesAcquired>
      <paymentDate>11/12/2020</paymentDate>
      <natureOfPayment>CASH</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>04/01/2021</acquiredDate>
      <natureOfAcquisitionTransaction>STOCK PURCHASE</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6526586</amountOfSecuritiesAcquired>
      <paymentDate>04/01/2021</paymentDate>
      <natureOfPayment>CASH</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>05/08/2023</noticeDate>
      <signature>Tracey Cornelison, as duly authorized representative of Raymond James &amp; Associates, Inc., as attorney-in-fact for GV 2019, L.P.</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
