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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2025 | Jun. 30, 2024
Cash flows used in operating activities: |  |
Net loss | $ (104,481) | $ (101,088)
Adjustments to reconcile net loss to net cash used in operating activities |  |
Stock-based compensation expense | 12,006 | 13,300
Non cash lease expense | 4,761 | 7,917
Depreciation expense | 3,564 | 2,853
Change in fair value of short-term investment — related party | 1,561 | 759
Amortization of premiums and discount on short-term investments | (575) | (2,079)
Deferred income taxes | 0 | 0
Changes in operating assets and liabilities: |  |
Collaboration receivable — related party | (120) | 0
Prepaid expenses and other current assets | 652 | (2,519)
Accounts payable | (1,461) | (9,230)
Accrued expenses and other current liabilities | (1,690) | (3,939)
Accrued settlement payment — related party | 0 | (13,500)
Deferred revenue — related party | (2,433) | 0
Lease liabilities | (2,053) | (5,672)
Net cash used in operating activities | (90,269) | (113,198)
Cash flows used in investing activities: |  |
Maturities of investments | 14,250 | 110,000
Purchases of investments | (55,227) | (135,912)
Purchases of property and equipment | (3,994) | (4,226)
Net cash used in investing activities | (44,971) | (30,138)
Cash flows provided by financing activities: |  |
Proceeds from research and development funding liability | 6,000 | 6,000
Proceeds from follow-on offering, net of issuance costs | 0 | 132,055
Proceeds from issuance of pre-funded warrants, net of issuance costs | 0 | 18,800
Proceeds from ESPP offerings | 197 | 436
Net proceeds from stock option exercises | 0 | 71
Net cash provided by financing activities | 6,197 | 157,362
Net change in cash, cash equivalents, and restricted cash | (129,043) | 14,026
Cash, cash equivalents, and restricted cash at beginning of period | 196,538 | 55,070
Cash, cash equivalents, and restricted cash at end of period | 67,495 | 69,096
Reconciliation of cash, cash equivalents and restricted cash: |  |
Cash, cash equivalents, and restricted cash at end of period | 67,495 | 69,096
Less: restricted cash | 13,691 | 13,496
Total cash, and cash equivalents | 53,804 | 55,600
Supplemental cash flow information: |  |
Right-of-use assets obtained in exchange for new operating lease liabilities | 83,757 | 44,935
Decrease in right-of-use assets due to lease termination | 3,120 | 0
Supplemental disclosure of non-cash investing and financing activities: |  |
Purchases of property and equipment included in accounts payable and accrued expenses | $ 148 | $ 355

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