<SEC-DOCUMENT>0001894562-25-000049.txt : 20250805
<SEC-HEADER>0001894562-25-000049.hdr.sgml : 20250805
<ACCEPTANCE-DATETIME>20250805204327
ACCESSION NUMBER:		0001894562-25-000049
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20250801
FILED AS OF DATE:		20250805
DATE AS OF CHANGE:		20250805

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			NELSEN ROBERT
		CENTRAL INDEX KEY:			0001219042
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-41536
		FILM NUMBER:		251186956

	MAIL ADDRESS:	
		STREET 1:		8755 W. HIGGINS ROAD
		STREET 2:		SUITE 1025
		CITY:			CHICAGO
		STATE:			IL
		ZIP:			60631

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Prime Medicine, Inc.
		CENTRAL INDEX KEY:			0001894562
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		60 FIRST ST.
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02141
		BUSINESS PHONE:		617-465-0013

	MAIL ADDRESS:	
		STREET 1:		60 FIRST ST.
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02141
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>wk-form4_1754441003.xml
<DESCRIPTION>FORM 4
<TEXT>
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        <issuerCik>0001894562</issuerCik>
        <issuerName>Prime Medicine, Inc.</issuerName>
        <issuerTradingSymbol>PRME</issuerTradingSymbol>
    </issuer>

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            <rptOwnerName>NELSEN ROBERT</rptOwnerName>
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        <reportingOwnerAddress>
            <rptOwnerStreet1>8755 WEST HIGGINS ROAD, SUITE 1025</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>CHICAGO</rptOwnerCity>
            <rptOwnerState>IL</rptOwnerState>
            <rptOwnerZipCode>60631</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>0</aff10b5One>

    <nonDerivativeTable></nonDerivativeTable>

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            </securityTitle>
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            <transactionDate>
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    <footnotes>
        <footnote id="F1">Effective as of August 1, 2025 (the &quot;Repricing Date&quot;), the Issuer's stockholders approved a one-time repricing of certain outstanding stock options (the &quot;Repriced Options&quot;) granted under the Issuer's 2019 Stock Option and Grant Plan, as amended (the &quot;2019 Plan&quot;) and/or the 2022 Stock Option and Incentive Plan (the &quot;2022 Plan&quot; and, together with the 2019 Plan, the &quot;Plans&quot;), which reduced the per share exercise price of each Repriced Option to $4.04, representing the closing price of the Issuer's common stock on The Nasdaq Global Market on the Repricing Date (the &quot;Option Repricing&quot;). Except as modified by the Option Repricing, all other terms and conditions of the Repriced Options, including, without limitation, any provisions with respect to vesting and term of the Repriced Options, remain in full force and effect.</footnote>
        <footnote id="F2">This stock option award was issued pursuant to the 2019 Plan and/or the 2022 Plan, as applicable, and becomes exercisable in accordance with the vesting schedule specified in the award agreement and as previously reported on applicable Form 4, subject to the Reporting Person's continued service with the Issuer as of the applicable vesting date.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ Ryan Brown, attorney-in-fact</signatureName>
        <signatureDate>2025-08-05</signatureDate>
    </ownerSignature>
</ownershipDocument>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
