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Proc-Type: 2001,MIC-CLEAR
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<SEC-DOCUMENT>0001209191-09-020998.txt : 20090408
<SEC-HEADER>0001209191-09-020998.hdr.sgml : 20090408
<ACCEPTANCE-DATETIME>20090408160832
ACCESSION NUMBER:		0001209191-09-020998
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20090406
FILED AS OF DATE:		20090408
DATE AS OF CHANGE:		20090408

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Fidler Josh E
		CENTRAL INDEX KEY:			0001300594

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-22873
		FILM NUMBER:		09740019

	MAIL ADDRESS:	
		STREET 1:		4750 OWINGS MILLS BLVD.
		CITY:			OWINGS MILLS
		STATE:			MD
		ZIP:			21117

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Roshko Peter
		CENTRAL INDEX KEY:			0001455295

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-22873
		FILM NUMBER:		09740016

	MAIL ADDRESS:	
		STREET 1:		C/O BOULDER VENTURES
		STREET 2:		1900 NINTH STREET, STE 200
		CITY:			BOULDER
		STATE:			CO
		ZIP:			80302

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Macks Lawrence M
		CENTRAL INDEX KEY:			0001455470

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-22873
		FILM NUMBER:		09740023

	MAIL ADDRESS:	
		STREET 1:		C/O BOULDER VENTURES
		STREET 2:		1900 NINTH STREET, STE 200
		CITY:			BOULDER
		STATE:			CO
		ZIP:			80302

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			JONES ANDREW E
		CENTRAL INDEX KEY:			0001119346

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-22873
		FILM NUMBER:		09740018

	MAIL ADDRESS:	
		STREET 1:		C/O INTERLAND INC
		STREET 2:		101 MARIETTA ST. #200
		CITY:			ATLANTA
		STATE:			GA
		ZIP:			30303

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ARCA biopharma, Inc.
		CENTRAL INDEX KEY:			0000907654
		STANDARD INDUSTRIAL CLASSIFICATION:	IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES [2835]
		IRS NUMBER:				363855489
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		8001 ARISTA PLACE
		STREET 2:		SUITE 200
		CITY:			BROOMFIELD
		STATE:			CO
		ZIP:			80021
		BUSINESS PHONE:		720-940-2200

	MAIL ADDRESS:	
		STREET 1:		8001 ARISTA PLACE
		STREET 2:		SUITE 200
		CITY:			BROOMFIELD
		STATE:			CO
		ZIP:			80021

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NUVELO INC
		DATE OF NAME CHANGE:	20030203

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	HYSEQ INC
		DATE OF NAME CHANGE:	19970610

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			LEFKOFF KYLE
		CENTRAL INDEX KEY:			0001191818

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-22873
		FILM NUMBER:		09740017

	MAIL ADDRESS:	
		STREET 1:		3200 WALNUT ST
		CITY:			BOULDER
		STATE:			CO
		ZIP:			80301

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			BV PARTNERS IV, L.L.C.
		CENTRAL INDEX KEY:			0001455393
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-22873
		FILM NUMBER:		09740020

	BUSINESS ADDRESS:	
		STREET 1:		1900 NINTH STREET, SUITE 200
		CITY:			BOULDER
		STATE:			CO
		ZIP:			80302
		BUSINESS PHONE:		303 444 6950

	MAIL ADDRESS:	
		STREET 1:		1900 NINTH STREET, SUITE 200
		CITY:			BOULDER
		STATE:			CO
		ZIP:			80302

	FORMER NAME:	
		FORMER CONFORMED NAME:	BV Partners IV, L.L.C.
		DATE OF NAME CHANGE:	20090204

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			BOULDER VENTURES IV LP
		CENTRAL INDEX KEY:			0001165196
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-22873
		FILM NUMBER:		09740021

	BUSINESS ADDRESS:	
		STREET 1:		1900 NINTH STREET, SUITE 200
		CITY:			BOULDER
		STATE:			CO
		ZIP:			80302
		BUSINESS PHONE:		3034446950

	MAIL ADDRESS:	
		STREET 1:		1900 NINTH STREET, SUITE 200
		CITY:			BOULDER
		STATE:			CO
		ZIP:			80302

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			BOULDER VENTURES IV ANNEX LP
		CENTRAL INDEX KEY:			0001165197
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-22873
		FILM NUMBER:		09740022

	BUSINESS ADDRESS:	
		STREET 1:		1900 NINTH STREET, SUITE 200
		CITY:			BOULDER
		STATE:			CO
		ZIP:			80302
		BUSINESS PHONE:		3034446950

	MAIL ADDRESS:	
		STREET 1:		1900 NINTH STREET, SUITE 200
		CITY:			BOULDER
		STATE:			CO
		ZIP:			80302
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
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<FILENAME>c83693_4x1.xml
<DESCRIPTION>MAIN DOCUMENT DESCRIPTION
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<XML>
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<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2009-04-06</periodOfReport>

    <notSubjectToSection16>1</notSubjectToSection16>

    <issuer>
        <issuerCik>0000907654</issuerCik>
        <issuerName>ARCA biopharma, Inc.</issuerName>
        <issuerTradingSymbol>ABIO</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001165197</rptOwnerCik>
            <rptOwnerName>BOULDER VENTURES IV ANNEX LP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>1900 NINTH STREET, STE 200</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BOULDER</rptOwnerCity>
            <rptOwnerState>CO</rptOwnerState>
            <rptOwnerZipCode>80302</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001165196</rptOwnerCik>
            <rptOwnerName>BOULDER VENTURES IV LP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>1900 NINTH STREET, STE 200</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BOULDER</rptOwnerCity>
            <rptOwnerState>CO</rptOwnerState>
            <rptOwnerZipCode>80302</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001455393</rptOwnerCik>
            <rptOwnerName>BV PARTNERS IV, L.L.C.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>1900 NINTH STREET, STE 200</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BOULDER</rptOwnerCity>
            <rptOwnerState>CO</rptOwnerState>
            <rptOwnerZipCode>80302</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001300594</rptOwnerCik>
            <rptOwnerName>Fidler Josh E</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>1900 NINTH STREET, STE 200</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BOULDER</rptOwnerCity>
            <rptOwnerState>CO</rptOwnerState>
            <rptOwnerZipCode>80302</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001119346</rptOwnerCik>
            <rptOwnerName>JONES ANDREW E</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>1900 NINTH STREET, STE 200</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BOULDER</rptOwnerCity>
            <rptOwnerState>CO</rptOwnerState>
            <rptOwnerZipCode>80302</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001191818</rptOwnerCik>
            <rptOwnerName>LEFKOFF KYLE</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>1900 NINTH STREET, STE 200</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BOULDER</rptOwnerCity>
            <rptOwnerState>CO</rptOwnerState>
            <rptOwnerZipCode>80302</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001455470</rptOwnerCik>
            <rptOwnerName>Macks Lawrence M</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>1900 NINTH STREET, STE 200</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BOULDER</rptOwnerCity>
            <rptOwnerState>CO</rptOwnerState>
            <rptOwnerZipCode>80302</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001455295</rptOwnerCik>
            <rptOwnerName>Roshko Peter</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>1900 NINTH STREET, STE 200</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BOULDER</rptOwnerCity>
            <rptOwnerState>CO</rptOwnerState>
            <rptOwnerZipCode>80302</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2009-04-06</value>
            </transactionDate>
            <deemedExecutionDate>
                <value>2009-04-06</value>
            </deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>J</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F3"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>49708</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>675403</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2009-04-06</value>
            </transactionDate>
            <deemedExecutionDate>
                <value>2009-04-06</value>
            </deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>J</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F4"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>3292</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>44715</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By Boulder Ventures IV, L.P.</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2009-04-06</value>
            </transactionDate>
            <deemedExecutionDate>
                <value>2009-04-06</value>
            </deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>J</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F3"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>518</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>518</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By BV Partners IV, LLC</value>
                    <footnoteId id="F1"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2009-04-06</value>
            </transactionDate>
            <deemedExecutionDate>
                <value>2009-04-06</value>
            </deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>J</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F4"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>31</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>549</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By BV Partners IV, LLC</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">The shares are owned by Boulder Ventures IV (Annex), L.P. (&quot;BV IV Annex&quot;) which is under common control with Boulder Ventures IV, L.P. (&quot;BV IV LP&quot;).  BV Partners IV, L.L.C. (&quot;BV IV LLC&quot;) serves as the sole General Partner of BV IV Annex, and has sole voting and investment control over the respective shares owned by BV IV Annex, and may be deemed to own beneficially the shares held by BV IV Annex. Josh E. Fidler (&quot;Fidler&quot;), Andrew E. Jones (&quot;Jones&quot;), Kyle Lefkoff (&quot;Lefkoff&quot;), Lawrence M. Macks (&quot;Macks&quot;) and Peter Roshko (&quot;Roshko&quot;) are Managing Members of BV IV LLC and share voting and dispositive power over the shares held by BV IV Annex and BV IV LP.  Each of these individuals disclaims beneficial ownership of the shares reported herein, except to the extent of his respective pecuniary interest therein.</footnote>
        <footnote id="F2">The shares are owned by BV IV LP which is under common control with Boulder IV Annex.  BV IV LLC serves as the sole General Partner, and has sole voting and investment control over the respective shares owned by BV IV LP, and may be deemed to own beneficially the shares held by BV IV LP.  Fidler, Jones, Lefkoff, Macks and Roshko are Managing Members of BV IV LLC and share voting and dispositive power over the shares held by BV IV LP.  Each of these individuals disclaims beneficial ownership of the shares reported herein, except to the extent of his respective pecuniary interest therein.</footnote>
        <footnote id="F3">Represents a pro rata in-kind distribution by BV IV Annex without consideration to its limited and general partners in accordance with the terms of its Limited Partnership Agreement.  Includes 518 shares distributed to BV IV LLC, its general partner.</footnote>
        <footnote id="F4">Represents a pro rata in-kind distribution by BV IV LP without consideration to its limited and general partners in accordance with the terms of its Limited Partnership Agreement.  Includes 31 shares distributed to BV IV LLC, its general partner.</footnote>
    </footnotes>

    <remarks>This report is being filed jointly by Boulder Ventures IV (Annex), L.P., Boulder Ventures IV, L.P., BV Partners IV, L.L.C., Josh E.
Fidler, Andrew E. Jones, Kyle Lefkoff, Lawrence M. Macks and Peter Roshko as of the date hereof and relates to the same transaction.
Exhibit 99.1 Joint Filer Information</remarks>

    <ownerSignature>
        <signatureName>BOULDER VENTURES IV (ANNEX), L.P. By: BV Partners IV, L.L.C., its General Partner By: /s/ Kyle Lefkoff, Managing Member</signatureName>
        <signatureDate>2009-04-08</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>BOULDER VENTURES IV, L.P. By: BV Partners IV, L.L.C., its General Partner By:/s/ Kyle Lefkoff, Managing Member</signatureName>
        <signatureDate>2009-04-08</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>BV PARTNERS IV, L.L.C. By:/s/ Kyle Lefkoff, Managing Member</signatureName>
        <signatureDate>2009-04-08</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Josh E. Fidler</signatureName>
        <signatureDate>2009-04-08</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Andrew E. Jones</signatureName>
        <signatureDate>2009-04-08</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Kyle Lefkoff</signatureName>
        <signatureDate>2009-04-08</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Lawrence M. Macks</signatureName>
        <signatureDate>2009-04-08</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Peter Roshko</signatureName>
        <signatureDate>2009-04-08</signatureDate>
    </ownerSignature>
</ownershipDocument>
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<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>c83693_99x1.htm
<DESCRIPTION>ADDITIONAL EXHIBITS
<TEXT>
<html>
<head>
	<title>Exhibit 99.1</title>
</head>

<body><DIV
style="margin-left: 0.25in; width: 7.2in; font-family: 'Times New Roman',Times,serif">

<P style="font-size: 10pt" align="right"><B>Exhibit&nbsp;99.1</B>

<P style="font-size: 10pt" align="center"><B>FORM 4 JOINT FILER INFORMATION</B>

<P align="justify" style="font-size: 10pt">Name of
<DIV align="justify" style="font-size: 10pt">&#8220;Reporting
Persons&#8221;:
</DIV>
<DIV align="justify" style="font-size: 10pt; margin-left: 25%; font-size: 10pt">Boulder Ventures IV (Annex), L.P. (&#8220;BV IV
Annex&#8221;)</DIV>
<DIV align="justify" style="font-size: 10pt; margin-left: 25%; font-size: 10pt">Boulder Ventures IV, L.P. (&#8220;BV IV LP&#8221;) </DIV>
<DIV align="justify" style="font-size: 10pt; margin-left: 25%; font-size: 10pt">BV Partners IV, L.L.C. (&#8220;BV IV LLC&#8221;) </DIV>
<DIV align="justify" style="font-size: 10pt; margin-left: 25%; font-size: 10pt">Josh E. Fidler (&#8220;Fidler&#8221;) </DIV>
<DIV align="justify" style="font-size: 10pt; margin-left: 25%; font-size: 10pt">Andrew E. Jones (&#8220;Jones&#8221;) </DIV>
<DIV align="justify" style="font-size: 10pt; margin-left: 25%; font-size: 10pt">Kyle Lefkoff (&#8220;Lefkoff&#8221;) </DIV>
<DIV align="justify" style="font-size: 10pt; margin-left: 25%; font-size: 10pt">Lawrence M. Macks (&#8220;Macks&#8221;) </DIV>
<DIV align="justify" style="font-size: 10pt; margin-left: 25%; font-size: 10pt">Peter Roshko (&#8220;Roshko&#8221;)</DIV>

<DIV align="justify" style="font-size: 10pt">Address: </DIV>
<DIV align="justify" style="font-size: 10pt; margin-left: 25%; font-size: 10pt">c/o Boulder Ventures </DIV>
<DIV align="justify" style="font-size: 10pt; margin-left: 25%; font-size: 10pt">1900 Ninth Street, Suite&nbsp;200 </DIV>
<DIV align="justify" style="font-size: 10pt; margin-left: 25%; font-size: 10pt">Boulder, Colorado 80302</DIV>

<DIV align="justify" style="font-size: 10pt">Designated Filer: </DIV>
<DIV align="justify" style="font-size: 10pt; margin-left: 25%; font-size: 10pt">Boulder Ventures IV (Annex), L.P.</DIV>


<DIV align="justify" style="font-size: 10pt">Issuer and Ticker Symbol: </DIV>
<DIV align="justify" style="font-size: 10pt; margin-left: 25%; font-size: 10pt">ARCA biopharma, Inc. (ABIO)</DIV>

<DIV align="justify" style="font-size: 10pt">Date of Event: </DIV>
<DIV align="justify" style="font-size: 10pt; margin-left: 25%; font-size: 10pt">April&nbsp;6, 2009</DIV>


<P style="font-size: 10pt" align="justify">Each of the following is a Joint
Filer with BV IV Annex and may be deemed to share indirect beneficial ownership
in the securities set forth on the attached Form&nbsp;4:

<P style="font-size: 10pt" align="justify">BV IV LLC serves as the sole general
partner of BV IV Annex. BV IV LLC has sole voting and investment control over
the respective shares owned by BV IV Annex and may be deemed to own
beneficially the shares held by BV IV Annex. Fidler, Jones, Lefkoff, Macks and
Roshko are Managing Members of BV IV LLC and share voting and dispositive power
over the shares held by BV IV Annex.

<P style="font-size: 10pt" align="justify">BV IV LLC serves as the sole general
partner of BV IV LP. BV IV LLC has sole voting and investment control over the
respective shares owned by BV IV LP, and may be deemed to own beneficially the
shares held by BV IV LP. Fidler, Jones, Lefkoff, Macks and Roshko are Managing
Members of BV IV LLC and share voting and dispositive power over the shares
held by BV IV LP.

<P style="font-size: 10pt" align="justify">Each reporting person disclaims
beneficial ownership of the shares reported herein, except to the extent of his
respective pecuniary interest therein. The filing of this statement shall not
be deemed an admission that, for purposes of Section&nbsp;16 of the Securities
Exchange Act of 1934, or otherwise, any of the Reporting Persons are the
beneficial owner of all of the equity securities covered by this statement.

<P style="font-size: 10pt" align="center">&nbsp;

<P style="display: none; font-size: 10pt" align="center">1
</DIV>

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<DIV
style="margin-left: 0.25in; width: 7.2in; font-family: 'Times New Roman',Times,serif">

<P style="font-size: 10pt" align="justify">Each of the Reporting Persons listed
above has designated Boulder Venture IV (Annex), L.P. as its designated filer
of Forms 3, 4 and 5 in accordance with Section 16(a) of the Securities Exchange
Act of 1934 and the rules thereunder.

<P style="font-size: 10pt" align="justify">BOULDER VENTURES IV, L.P.
<P style="font-size: 10pt" align="justify">By: BV Partners IV, LLC <BR>
Its: General Partner
<P style="font-size: 10pt" align="justify">By:<U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;/s/ Kyle
Lefkoff&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U>
<DIV style="font-size: 10pt; text-indent: 2%" align="justify">Kyle Lefkoff, Managing Member </DIV>

<P style="font-size: 10pt" align="justify">BV PARTNERS IV, LLC
<P style="font-size: 10pt"
align="justify">By:<U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;/s/ Kyle Lefkoff&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U>
<DIV style="font-size: 10pt; text-indent: 2%" align="justify">Kyle Lefkoff, Managing Member </DIV>

<P style="font-size: 10pt"
align="justify"><U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;/s/ Josh E.
Fidler&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U>

<DIV style="font-size: 10pt" align="justify">Josh E. Fidler</DIV>

<P style="font-size: 10pt"
align="justify"><U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;/s/
Andrew E.
Jones&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U><BR>
Andrew
E. Jones

<P style="font-size: 10pt" align="justify"><U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;/s/
Kyle
Lefkoff&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U>

<DIV style="font-size: 10pt" align="justify">Kyle Lefkoff </DIV>

<P style="font-size: 10pt"
align="justify"><U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;/s/
Lawrence M.
Macks&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U>

<DIV style="font-size: 10pt" align="justify">Lawrence M. Macks </DIV>

<P style="font-size: 10pt"
align="justify"><U>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;/s/
Peter
Roshko&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U>

<DIV style="font-size: 10pt" align="justify">Peter Roshko </DIV>

<P style="display: none; font-size: 10pt" align="center">2
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