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Commitments and Contingencies (Details Textual) (USD $)
 1 Months Ended 3 Months Ended 6 Months Ended 9 Months Ended 12 Months Ended 126 Months Ended 1 Months Ended
Jul. 31, 2008
Feb. 28, 2007
Jun. 30, 2012
Jun. 30, 2012
Jun. 30, 2011
Sep. 30, 2011
Dec. 31, 2010
Jun. 30, 2012
Dec. 31, 2011
Jun. 14, 2011
sqft
Feb. 08, 2008
sqft
Feb. 29, 2004
Feb. 29, 2004
Nuvelo [Member]
Commitments and Contingencies (Textual) [Abstract]                          
Upfront fee paid                         $ 4,000,000
Upfront fee paid in cash                         500,000
Issuance of common stock for cash, net of offering costs, value           4,017,000 7,182,000           3,500,000
Commitments and Contingencies (Additional Textual) [Abstract]                          
Area of office facilities taken on lease                   4,500 15,000    
Lease term       5 years                  
Extended lease term       3 years                  
Rights to Extend Term       Two additional three year periods                  
One-time payment to landlord for new leased premises       200,000,000                  
Deferred rent     593,000,000 593,000,000       593,000,000 16,000        
Unamortized deferred rent     33,000,000 33,000,000       33,000,000          
Rent expense       24,000,000 70,000,000                
Operating leases rent expense net since inception               491,000,000          
Allow to terminate agreement notice period     3 months                    
Term of license agreement   10 years                      
Share Issued   16,698                      
Milestone payment made by company 500,000,000                        
Expected milestone payments upon approval 8,000,000                        
Another expected milestone payments upon approval 5,000,000                        
Milestone payment due period 6 months                        
Minimum percentage of royalty obligation 12.50%                        
Maximum percentage of royalty obligation 25.00%                        
Percentage of royalty obligated to pay under its original license agreement 5.00%                        
Minimum Percentage of range of royalties that can be buy down 12.50%                        
Maximum Percentage of range of royalties that can be buy down 17.00%                        
Maximum future milestone payments                       $ 23,500,000